• Build trust and credibility for Oura and our products for members, physicians, scientists and health systems. • Collaborate closely with engineering, product, design, data science and algorithm teams to define clinical features aligned with metabolic health, including integrations with continuous glucose monitors (CGM) and laboratory testing, and alignment with related teams such as sleep, activity and women’s health. • Collaborate on clinical feature specifications: Translate your metabolic health knowledge and existing literature into real-world informed performance goals, working closely with science and product teams. • Design and oversee clinical validation studies (feasibility, observational, real-world) to demonstrate product performance and clinical relevance in the metabolic space. • Work with regulatory, quality and clinical outcomes teams to build protocols, drive submissions and ensure compliance in applicable markets, and adapt to the changing regulatory environment in major markets. • Engage cross-functionally: proactively anticipate risks, communicate clearly about challenges, adjust plans, and maintain a collaborative mindset. • Serve as a clinical voice across the organization: staying abreast of the newest and most relevant medical insights, weaving this science into product decisions, translating this into company knowledge and features. • Guide the team on inclusion of appropriate biometrics and ground truth data, clinical endpoints, and study design. Uplevel internal knowledge across teams related to this domain of medicine and science. • Represent Oura externally to scientific audiences, payors, partners, clinicians and health systems.

• Enterprise Health System Engagement — Build executive relationships across major IDNs, AMCs, and specialty health systems, and drive enterprise evaluations through clinical governance and procurement pathways. • Strategic Market Leadership — Shape Heidi's US clinical strategy and track health policy developments (CMS, HIPAA, ONC/TEFCA, AI guidance) to inform commercial direction. • Thought Leadership & National Presence — Represent Heidi at major industry and specialty conferences (HIMSS, HLTH, JPM Healthcare, and more) and publish clinical content that builds national credibility. • Commercial Impact — Actively originate and support enterprise deals, arming health system buyers with clinical narratives, ROI frameworks, and procurement-ready materials. • Clinical Advisory Council — Co-own the US Clinical Advisory Council and manage Heidi's specialty advisor network across Urology, Orthopaedics, Cardiology, and Primary Care. • Product & Workflow Influence — Guide US-specific EHR workflow configuration (Epic, Oracle Health, Athenahealth) and translate regulatory requirements into product specs.

Title: Patient Safety Associate Medical Director Location: Boston, MA Job Description: Job Description General Summary: The Patient Safety Associate Medical Director will provide medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development). This role will optimizes patient safety of Vertex products and maintenance of compliance with the Pharmacovigilance regulations of Regulatory Agencies around the globe, through the effective and timely completion of Safety activities through the product life cycle. Key Duties and Responsibilities: - Provides medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development) - Responsible for the safety assessment activities of assigned products under the supervision of a GPS Disease-area Safety Head - Monitors the benefit risk profile of assigned products/portfolio in an ongoing fashion and in accordance GPS processes and procedures - Leads the safety and risk management processes including chairing assigned Disease-area Safety and Product Safety Teams - Identifies, prioritizes and analyzes clinical safety signals, in accordance with GPS procedures - Performs ongoing review of emerging safety data from various sources including single case reports, published literature, aggregate reports, and other sources - Represents the department as medical safety lead on cross-functional study and program teams for assigned products and studies, providing guidance regarding safety matters and issues - Conducts medical evaluation of relevant safety-related information from Toxicology, Non-Clinical studies, as well as Product Quality complaints, as needed - Participates in protocol development, specifically the monitoring and collection of safety information in clinical trial protocols, as well as statistical analysis plans - Participates in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports - Contributes to preparation and review of periodic reports (DSUR, PSUR, PADER) contributing medical strategy and expertise to content, authoring applicable analysis and content - Review and provides medical content, as needed, for key study-related documents, e.g. IB, ICF, IDMC Charter - Assists in departmental development activities including SOP and Work Instructions development - Provides guidance to staff regarding optimal practice regarding collection, evaluation and processing of adverse experience reports, from a medical perspective - Provides support in Partner /Affiliate agreements and interactions, as needed - Other activities as needed or as requested by GPS management Knowledge and Skills: - Broad and extensive knowledge of medicine, pharmacovigilance and relevant regulations - Extensive evidence of effective delivery of high quality safety relevant documents. - Broad knowledge of relevant concepts in data management and systems, pharmacoepidemiology and statistics, including the interpretation of complex data and information - Communicates complex issues in an understandable, effective and relevant manner. - Strong influencing skills with the ability to explain and defend positions regarding significant issues in the face of opposition - Strategic focus regarding activities, with proactive planning and prioritization skills. - Takes ownership of appropriate issues and appropriately delegates - Technical expertise in pharmacovigilance and clinical safety - Excellent analytical and problem solving skills, with sound autonomy and applied judgment - Appropriate experience with Regulatory Agency and key stakeholder interactions - Experience with ICSR case review and Aggregate Safety analysis and reports Education and Experience: - MD, DO or equivalent ex-US medical degree - Typically requires 3 years of experience with relevant experience in Safety/Pharmacovigilance, or the equivalent combination of education and experience Pay Range: $200,000 - $300,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Title: Medical Director, Value Based Care Location: Chattanooga, Tennessee, 37411, United States Department: Medical Leadership Job Description: Job Category: Medical Leadership Requisition Number: MEDIC002450 - Full-Time - Hybrid - Locations Showing more locations Chattanooga, TN 37411, USA Chattanooga, TN 37421, USA Nashville, TN 37209, USA less locations Job Details Description ABOUT US Founded in 2017 and headquartered in Nashville, Tennessee, Upperline Health delivers comprehensive care through a growing national network, with teams spanning podiatry, endocrine, primary care, urgent care, wound, vascular and more. The organization’s mission is to integrate and transform specialty care for chronically ill, high-risk patients through frequent specialist engagement and coordinated, value-based programs. With a patient-centered approach, Upperline delivers care across 21 states and has been recognized as one of the nation’s largest multi-specialty physician practices. The platform has demonstrated meaningful improvements in outcomes, such as lowering hospitalization rates, decreasing total cost of care, reducing amputations, and accelerating wound-healing times, supported in part by its optimized EHR and analytics infrastructure.  Our Upperline Plus program is the value-based care pillar of Upperline, which allows for the integration of primary and specialty care. Patients are part of full risk arrangements with Medicare and MA plans, and the Upperline Plus interdisciplinary team extends an extra layer of support for high-risk patients. This care model - a full interdisciplinary team (physicians, APPs, RNs, pharmacists, social workers) working across clinics, home, and telehealth - reduces avoidable utilization and total cost of care. The Upperline team enhances the healthcare experience by living our Upperline CARES values—fostering strong Connections, holding ourselves to the highest level of Accountability, demonstrating Resilience in navigating and tackling complex challenges, committing to Excellence in patient care, and focusing on a Service mentality that places patients at the heart of everything we do. ABOUT THE MEDICAL DIRECTOR, VALUE BASED CARE Upperline is seeking a Medical Director, Value Based Care (VBC) to join the clinical leadership team in developing, implementing, and growing our unique value-based care model in Tennessee. The VBC Medical Director will serve as a clinical leader partnering with Operations and Population Health leaders to deliver successful value-based care results across the region. The majority of clinics are in the Chattanooga area. Residing in Chattanooga or Nashville is ideal. What You’ll Do - Oversee the care management and medical management of the Upperline Plus patients being seen by Upperline’s Nurse Practitioners in the in the market or region - Responsible for supervising medical management of patients in the region including clinical quality review of providers and serving as the collaborating physician for APPs in the region (as necessary based on state law) - Accountable for value-based care outcomes (e.g., ADK, total cost of care), medical management, care management, utilization management, and quality improvement tools and processes in the region - Manage and drive value-based care initiatives with APPs and doctors ensuring positive impact on patient outcomes - Analyze population health data and identify gaps and develop solutions to improve delivery of care, decrease hospitalizations and reduce medical costs - Educate providers on value-based care metrics and best practices and foster a culture that prioritizes accountability around outcomes-based performance - Ensure the region is meeting VBC operations metrics such as addressing Quality gaps, accurate documentation, patient engagement and retention - Design, implement and manage new value-based care programs and service lines in collaboration with population health and operations teams - Conduct interdisciplinary team meetings to discuss management of the most complex patients (including high cost and high-risk patients) - Establish and maintain relationships with VBC team, specialists, and PCPs in the region; educate on Upperline Plus program and advocate for collaborative partnerships benefiting patients - Support onboarding and training of new providers and provide onsite and virtual clinical coaching and feedback with a focus on ensuring consistency and continuous improvement of managing patients more efficiently - Build relationships in the region and identify best partners (e.g., other specialists, home health agencies, hospitals) for Upperline to send referrals when needed - Develop clinical compliance guidelines and protocols Required Experience and Qualifications - Doctor of Medicine (M.D.) or Doctor of Osteopathic Medicine (D.O.) - Board certified in Internal Medicine, Family Medicine, Preventative Medicine, or Geriatrics - Active license in Tennessee and willing to pursue multi-state licensure if needed - Fellowship training in Geriatrics and/or other advanced degrees (e.g., M.B.A., M.P.H., M.H.A.) valued but not required - ~ 5 years of outpatient practice experience - Clinical leadership experience in a VBC or Population Health company - Experience with managed care and familiarity with payer-provider collaboration - Owned or been part of creating, improving, and/or implementing clinical processes, protocols, or evidence-based guidelines - Experience or exposure to rolling out and/ or managing VBC programs (e.g. Transitional Care Management, Complex Care Management, ED Diversion, Advanced Care Planning, High Risk Patient Outreach) - Talent for synthesizing information and solving complex problems; can independently translate high-level goals into actionable plans - Proven leadership skills and servant leadership mentality with a passion for people and culture - Ability to communicate, collaborate and work effectively with staff, providers, and organizational leaders - Self-starter with a bias for action orientation; demonstrates a service excellence mindset - Exceptional organizational and project management skills and the ability to prioritize and multi-task autonomously - Comfortable working in Excel; able to analyze data and present findings - Must be willing and able to routinely visit clinics and providers within the region; Residing in the market or region is strongly preferred BENEFITS Comprehensive benefit options include medical, dental and vision, 401K, PTO, and parental leave. COMPENSATION Compensation is commensurate to compensation for similar positions in the region and based on prior training and experience. Job Type: Full-time Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.