Bicycle Precision Guided Therapeutics.
Senior Scientist, In Vivo Pharmacology – Radiopharmaceuticals
Location
United Kingdom
Posted
2 days ago
Salary
0
Seniority
Senior
Job Description
Senior Scientist, In Vivo Pharmacology – Radiopharmaceuticals
Bicycle Therapeutics
• Your mission is to apply your deep expertise in in vivo pharmacology to drive the preclinical evaluation of our innovative Bicycle® Radio Conjugates (BRCs). • Independently execute and interpret key preclinical studies to generate critical data needed to understand their activity, guide their optimization, and support the advancement of our next-generation cancer therapies. • Design, execution, and interpretation of in vivo pharmacology studies to evaluate the biodistribution, mechanism of action, and PK/PD/efficacy relationships of our BRCs. • Manage the execution of in vivo studies through a network of CROs and academic collaborators, ensuring timely delivery of high-quality data. • Act as a key technical expert on cross-functional project teams, collaborating with chemistry, biology, DMPK, and toxicology experts to contribute to project goals. • Contribute to the identification and validation of pharmacodynamic biomarkers to support preclinical and clinical development. • Perform hands-on in vivo experimental work as required to support project progression and ensure timely data delivery. • Effectively document and communicate complex study results and their interpretation to project teams and in broader scientific forums. • Contribute to publications for peer-reviewed journals and present data at scientific conferences. • Act as a source of technical expertise for the team, sharing best practices in in vivo techniques and radiopharmaceutical handling.
Job Requirements
- Strong experience in in vivo pharmacology and tumour biology, gained in a biopharmaceutical or academic setting.
- Essential hands-on experience in preclinical radiopharmaceutical assessment, including PET/SPECT imaging and ex vivo biodistribution analysis.
- Experience working with external CROs or academic collaborators to execute studies.
- Experience with radionuclide- or toxin-conjugates (e.g., radiopharmaceuticals, ADCs) and a background in cancer biology is required.
- Excellent attention to detail and strong organizational and communication skills.
- Knowledge of radiochemistry, radiolabelling, or dosimetry would be an advantage.
- A current Home Office Personal License (PIL) is highly desirable
Benefits
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover
- Enhanced parental leave policies
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
Related Guides
Related Categories
Related Job Pages
More General Jobs
• Uphold highest level of communication as first point of contact for equipment in field • Ensure all equipment is level & clean on a weekly basis • Provide troubleshooting (w/support from UL Solutions) and when requested, repair(s) for low-medium complexity issues • Ensure there is no debris obstructing the system (depending on site/region, grass cutting, snow removal, or clearing brush) • Confirm the system is secure and hasn’t been tampered with • Each maintenance visit should take 60-90 minutes • UL Solutions requires a weekly excel logbook uploaded via internet along with photos and other documentation to support the visit which should take 45-90 minutes • The entire process is estimated to require between 2-4 hours each week, including travel time to and from site • Occasionally, UL Solutions may request your assistance in replacing or troubleshooting equipment
• Ensure all equipment is level; • Ensure all equipment is clean; • Ensure there is no debris obstructing the system (depending on site/region, grass cutting, snow removal, or clearing brush); • Confirm the system is secure and hasn’t been tampered with. • Each maintenance visit should take 15-30 minutes. • UL requires a weekly excel logbook uploaded via internet along with photos and other documentation to support the visit which should take 30-45 minutes. • The entire process should take between 2-4 hours each week depending on your travel time to and from site. • Occasionally, UL may request your assistance in replacing or troubleshooting equipment. A Senior Engineer would contact you to walk you through the process. They will support you while onsite and review data after the equipment repair.
Campaign Specialist
Avery DennisonWe are a global materials science and digital identification solutions company.
• The Campaign Specialist plays a key role in supporting Retailer and CPG funded Shopper Marketing initiatives with Vestcom accounts utilizing our proprietary shelfAdz® media solution. • Client and/or Territory assignment and scope will vary based on the account opportunities and candidate background. • The Campaign Specialist working autonomously, regularly exercising independent judgment and discretion with limited supervision is responsible for ensuring client business objectives and schedules are met through proactive planning and thorough project management, thus ensuring an exceptional client experience. • The incumbent autonomously provides answers and solutions for questions, problems and requests raised by clients, establishes, and maintains good relationships with all concerned parties and may identify new business opportunities for Vestcom with all groups and departments within the client account. • This role is responsible for managing one or more client accounts and will own and independently manage all assigned duties relating to client(s) needs. • Provides administrative support to Group Sales Director (s), Sales Director(s) and Account Manager (s) as needed. • Works closely with Vestcom's client service, programming, IT, creative, delivery and production teams across all Vestcom solutions and client deliverables. • Builds relationships with process owners across all functional areas between client and Vestcom. • Communicates effectively, plans, organizes and manages multiple projects in a timely manner. • Manages project timelines to completion with internal and external cross functional team member; establish and communicate clear and realistic expectations. • Insure all deliverables to client are error-free. • Evaluate and independently determine when to elevate concerns and provides recommended resolutions to Vestcom management in a timely manner. • Uses independent decision-making to determine, identify and research inefficiencies and inaccuracies in business processes and provides recommendations and best practices to both client and Vestcom. • Measures performance against process requirements, service level agreements and/or quality goals. • Participates in the strategic account planning process with Vestcom Commercial team. • Oversees and provides direction and guidance on status updates of projects and accomplishments. • Communicates with CPG client and retail locations as needed to insure effective and efficient tag processing. • Collaborates with internal stakeholders on tag related changes needed for client’s system. • Communicates (both verbally and in writing) in a clear, effective and professional manner at all times with all client and Vestcom cross functional partners.
• Oversee WGSN's Japanese localised content and site updates • Collaborate with Marketing, Design and Product departments to localise assets for digital publishing on WGSN product sites • Work closely with the Tech team to incorporate machine translation systems for optimising localisation workflow • Manage translated Japanese content for various verticals and brand-related marketing materials • Collaborate with internal Product and Tech teams to assist machine learning development • Manage linguistic resources: 6 glossaries and 2 style guides • Monitor content quality and implement necessary changes to improve the in-house machine translation system • Guide freelancers and part-time staff by offering instructions, constructive feedback • Report regularly on project status to localisation managers, and support communication with the Japanese commercial team



