Bicycle Therapeutics

• Your mission is to apply your deep expertise in in vivo pharmacology to drive the preclinical evaluation of our innovative Bicycle® Radio Conjugates (BRCs). • Independently execute and interpret key preclinical studies to generate critical data needed to understand their activity, guide their optimization, and support the advancement of our next-generation cancer therapies. • Design, execution, and interpretation of in vivo pharmacology studies to evaluate the biodistribution, mechanism of action, and PK/PD/efficacy relationships of our BRCs. • Manage the execution of in vivo studies through a network of CROs and academic collaborators, ensuring timely delivery of high-quality data. • Act as a key technical expert on cross-functional project teams, collaborating with chemistry, biology, DMPK, and toxicology experts to contribute to project goals. • Contribute to the identification and validation of pharmacodynamic biomarkers to support preclinical and clinical development. • Perform hands-on in vivo experimental work as required to support project progression and ensure timely data delivery. • Effectively document and communicate complex study results and their interpretation to project teams and in broader scientific forums. • Contribute to publications for peer-reviewed journals and present data at scientific conferences. • Act as a source of technical expertise for the team, sharing best practices in in vivo techniques and radiopharmaceutical handling.