Title: Manager, External Manufacturing Location: NJ Corporate Headquarters Work Type: Remote, Full Time Job ID: R3132 Job Description: At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK About the Role: Manager, External Manufacturing will be responsible for the development, optimization, scale-up, and routine execution of manufacturing operations for pharmaceutical products. A focus for this role is some on-site presence at contract manufacturing organizations (CMOs) during production in Greenville, NC). You will collaborate with cross-functional teams, including R&D, manufacturing, quality assurance, regulatory CMC, and CMOs to ensure robust and compliant production processes. What You'll Do: In this role, you will have the opportunity to provide CMO Oversight: Real-time and on-site supervision of CMOs execution of routine manufacturing as well as technology transfer, optimization, and validation activities. You will also: - Process Development & Optimization: Design, develop, and optimize manufacturing processes for pharmaceutical APIs and formulations; with an emphasis on oral solid tableting. - Scale-Up & Tech Transfer: Contribute to the transition of tablet manufacturing and other drug product processes from pilot and commercial scale at primary and secondary CMOs. - Equipment & Operations: Troubleshoot of drug product process equipment, ensuring efficiency and compliance with GMP regulations. - Process Validation: Develop and execute validation protocols (IQ, OQ, PQ) for oral solid tableting manufacturing and other drug product processes. Prepare finalized tablet processes for product registration, validation, and commercial readiness. - Cross-Functional Collaboration: Work closely with formulation scientists, manufacturing teams, and regulatory affairs to ensure smooth product development and commercialization. - Regulatory Compliance: Ensure all processes comply with FDA, EMA, and ICH guidelines for pharmaceutical manufacturing. - Data Analysis & Reporting: Analyze process data, identify critical process parameters, and prepare technical reports for internal and regulatory submissions. Who You Are: You have a minimum of a Bachelor’s degree in Chemical Engineering or equivalent as well as 5+ years of experience in pharmaceutical process engineering, leading teams tasked with implementation of pharmaceutical manufacturing technology improvements within a regulated environment. You also have: - Experience with late phase clinical and commercial CMO operations. - Strong background in oral solid tablet manufacturing and primary packaging a plus. - Working knowledge of quality systems, validation principles, engineering design, and statistical process control fundamentals. - Proven ability to identify, assess, and solve problems using root cause analysis methodology and document investigation and outcomes in a compliant manner. - Familiarity with DOE (Design of Experiments) and statistical process control. - Experience with GMP manufacturing, technology transfer, process scale-up, and validation. - High energy, innovative “can do” attitude is required. - Ability to work independently, remote from central leadership. - Abilty to be onsite at CMO in Greenville, NC (at least 25%) and some international travel. Where You’ll Work This is a fully remote role. It can be performed effectively from anywhere while staying connected to your Insmed team and community. Occasional travel for team meetings or events will be expected. Travel Requirements This position involves frequent domestic & some international travel up to 25%. #REMOTE #LI-BA1 Pay Range: $124,000.00-161,000.00 Annual Life at Insmed At Insmed, you’ll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself. Highlights of our U.S. offerings include: - Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP) - Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration - 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance - Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities - Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

• Responsible for implementing the project per the plans • Contributes to defining, planning, orchestrating and delivering the project • Manages all parts for the project life cycle and works with BU IT partners to oversee all SDLC phases of a project • Manages scope to ensure commitments are achieved within agreed on time, cost and quality parameters and escalates at the right time to the PM III, Director IT or Program Manager • Works with the sponsor to validate financial forecasts and provides reconciliation of resources and other project related expenditures • Develops communication plans and interfaces to execute on responsibilities • Prepared input for key stakeholders on different aspects of assigned initiatives • Represents project in various project governance and inter- department forums • Chairs weekly Core Team and monthly Operating Committee meetings to review progress with key constituents • Tracks milestone while developing, maintaining, and reporting on an overall integrated delivery plan and report deviations • Develops the project documents for review by the sponsor

Role Description Brown Technologies is currently seeking a Technical Project Manager to support the Cloud Services Office by planning, coordinating, and delivering cloud infrastructure and platform initiatives. This role ensures technical projects are executed efficiently, align with enterprise architecture and security requirements, and meet program objectives, schedules, and budgets. The Technical Project Manager works closely with Cloud Engineering, Architecture, Operations, Security, FinOps, and customer stakeholders to manage complex cloud initiatives such as: - Cloud migrations - Platform deployments - Security implementations - Enterprise cloud service improvements The role requires strong technical understanding of cloud and data center environments combined with disciplined project management practices. Responsibilities - Lead the planning and execution of cloud infrastructure, platform, and service initiatives. - Develop project plans, milestones, schedules, and deliverables for cloud programs and initiatives. - Coordinate cross-functional teams responsible for engineering, operations, networking, security, and architecture activities. - Translate technical architecture and engineering requirements into executable project plans. - Facilitate coordination between technical teams to ensure dependencies, integrations, and delivery timelines are aligned. - Track project progress and ensure technical deliverables meet scope, schedule, and performance expectations. - Serve as the primary coordination point between technical teams, program leadership, and customer stakeholders. - Facilitate project meetings, technical reviews, and status briefings. - Communicate risks, dependencies, and progress to leadership and stakeholders. - Maintain project RAID logs (Risks, Assumptions, Issues, Dependencies). - Identify potential technical and operational risks and develop mitigation strategies. - Coordinate resolution of cross-team blockers affecting delivery. - Provide regular status reporting including milestone progress, risks, schedule health, and financial status. - Produce leadership-ready reports and dashboards for program management and governance reviews. - Identify opportunities to improve project delivery processes, cloud operational workflows, and coordination between teams. - Promote adoption of standardized project management and delivery practices across the Cloud Services Office. - Oversee the execution of single or multiple task orders; responsible for staffing, project planning, production, quality, project financials, and staff direction and oversight. - Manage the client interface at the COR level and assist the Program Manager as required in managing contract performance. Qualifications - Bachelor's degree in Information Technology, Computer Science, Engineering, Business, or a related discipline, or equivalent experience. - 8 years of experience managing technical infrastructure or cloud-related projects. - Strong understanding of cloud computing platforms and enterprise IT environments. - Demonstrated experience coordinating cross-functional technical teams. - Experience managing schedules, milestones, risks, and deliverables across multiple stakeholders. - Strong written and verbal communication skills. Preferred Qualifications - Experience supporting cloud service organizations or enterprise shared services teams. - Experience managing cloud consolidation, migration, or modernization initiatives. - Familiarity with major cloud platforms (AWS, Azure, GCP, OCI, IBM Cloud). - Experience working in regulated or compliance-driven environments (e.g., federal, FISMA). - Knowledge of IT governance, change management, and architecture review processes. - Experience with Agile, hybrid Agile/Waterfall, or SAFe delivery models. Company Description Brown Technologies is a rapidly growing company with a proven record of success supporting complex, cutting-edge programs. We are an employee-centric company that understands the individuals who comprise our workforce are our most important asset, and we are proudly recognized as one of "The Best Place for Working Parents." Come join our team of experienced, dedicated, and committed professionals whose focus is to solve the mission-critical problems of our customers.

• Managing IT or Cybersecurity projects including hardware/software implementation/upgrades and process maturity • Development and maintenance of project-related artifacts including roadmap and budget • Providing on-demand status updates and problem resolution • Managing schedules and assignments of project members within a matrix structure • Developing communication management plans and performing stakeholder analysis • Measuring and reporting progress regularly