Title: Director, CMC, Drug Product Location: Boston Department: Development - R&D Operations Job Description: Who We Are: Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. About the Role: We are seeking a Director, CMC, Drug Product to join our team. The Director, CMC, Drug Product manages and oversees the late phase process development, validation and commercial manufacturing of cGMP drug products for deployment in late-stage clinical trials and commercial distribution. The Director, CMC, Drug Product will be a key member of a highly collaborative internal CMC team, primarily managing drug product process validation, launch and commercial manufacturing through CDMOs and CROs. This position reports to the Executive Director, CMC, Drug Product and will be based out of our Boston, MA, USA in our Needham office or in our Burnaby, BC, Canada office. We will consider other jurisdictions for exceptional candidates. This role is a hybrid position; hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week. The level of the position will be commensurate with the candidate’s education and industry experience. RESPONSIBILITIES: · Lead teams in late-stage process development and scale up, process validation (PPQ) and commercial manufacturing of small molecule drug products. · Oversee late phase development and manufacturing processes, ensuring compliance with quality and regulatory standards. · Manage development activities related to late-stage process development and scale up, FMEA analysis, process validation (PPQ) and preparation for commercial launch of small molecules drug products at partner CDMOs and CMO. · Manage on going commercial manufacturing and primary packaging of approved small molecule drug products by working with supply chain, quality and regulatory groups. Serve as CMC SME of commercial drug product supply. · Manage the selection of late-stage and commercial CDMOs while considering capabilities, capacities, redundancy and quality. · Provide input for drug product stability programs and help select appropriate packaging for clinical development and commercial use. · Evaluate, recommend, and manage qualified CDMOs for manufacturing drug products for late-stage clinical trials, scale-up, registration, validation and commercial use. Collaborate with Quality Assurance to manage audits and inspections of CDMOs and on manufacturing investigations. · Author and review core CMC documents/modules and other submissions and responses to FDA and other Competent Authorities, ensuring strategic oversight and consistency for regulatory interactions, including IND/NDA/MAA/IMPD filings and periodic updates. · Stay informed on pharmaceutical development and manufacturing industry science, regulatory guidelines and competitive trends to provide informed recommendations. · Develop and propose objectives in alignment with overall company strategies and plans. · Collaborate with development and commercial partnerships, including ex-US collaborations, to ensure global alignment and integration of strategies. · Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies. · Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices. · Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any. · Some domestic and international travel will be required. · Other duties as assigned. QUALIFICATIONS: · PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Pharmaceutics, or a related discipline with at least 10 years of relevant management experience in a pharma or biotech environment. Candidates with an MSc and relevant experience may also be considered. · Extensive experience in managing late-stage drug product manufacturing and commercialization activities (registration, process scale up, validation and launch), including oversight of external Contract Manufacturing Organizations (CMOs). · Experience in developing formulations of small molecule solid oral and parenteral dosage forms is a plus. · Strong background in drug product manufacturing sciences with experience with multiple solid oral manufacturing approaches such as capsules, tablets, spray drying, granulation, blending, bottling and blistering. · Demonstrated success in transitioning development assets to commercial products and ongoing support of commercial manufacturing. · Experience contributing to and developing CMC sections in US and ex-US regulatory filings. · In-depth knowledge of cGMP regulations, guidance, principles, and best practices related to drug product development and manufacture. · Proficiency in Failure Modes Effect Analysis (FMEA) and establishment of Critical Process Parameters (CPPs). · Experience with CDMO selection, management, contracting, and issue resolution. · Excellent oral and written communication, leadership, and interpersonal skills, with the ability to build credibility and trust both inside and outside the company. · Proven ability to build and develop high-performing teams, with strong delegation and conflict resolution skills. Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions. Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

• Direct all reactor disassembly/reassembly and refueling activities for your respective shift • Installs, troubleshoots, assembles and disassembles, repairs and maintains tooling and equipment at customer sites • Conducts a variety of complex field tasks including operating specialized equipment, taking measurements, compiling data, and performing without error in high stress environments • Develops calculations, tables, reports and related data; maintains maintenance logs and certification documents • Develops procedures, problem reports, job hazard analyses, and field schedules • Participates in planning and executing projects and may be responsible for pre-outage preparations • Directs technicians which includes on the job training, conducting pre-job briefs, defining task requirements, performance management and coaching, documenting performance, managing conflicts between coworkers, and ensuring safety and compliance of individuals and plant equipment • Complies with all applicable safety and health rules including personal dose compliance • Responsible for the safety and well-being of personnel supervising • Works flexible hours and shifts, as required, to ensure timely service • Requires travel to a variety of remote job sites • Requires unescorted nuclear access (includes background check, psychological exam, and drug screen)

Role Description You’re a creative leader. You can see the tiniest seed of an idea and help a creative team nurture it into existence. Your feedback is considered, clear and actionable. You put a premium on the most thoughtful and guiding notes - tuning your approach to meet the needs of the creative team. You are a champion of a diverse team, helping them make the best work possible by actively listening, communicating and removing any blockers that emerge along the way. When we say TED meets Vox meets The Hustle meets Carl Sagan meets VICE, you know what we mean. You are curious. You could wake up every day with the mission to make science accessible and cool (while also fully understanding the importance of integrity and the nuance of precision). You’re a writer by trade. You’ve told a lot of stories, written a lot of taglines, scripts, captions, and subject lines. You’re ready for something that satisfies and expands and piques your intellect, your interpersonal talents, and of course, your microbiome. This is a leadership role reporting to the SVP, Creative. And an opportunity to do amazing work alongside a wonderful assemblage of talented and kind human beings. What You’ll Do: - Create Big Ideas: You’ll be a catalyst for big thinking. Sometimes leading with creative foundations. Sometimes rolling up your sleeves and getting in there. - Lead: You’ll mentor and guide your creative team to their best work. And put a premium on their growth and development. - The Brand: You’ll be a guardian of the brand’s creative standards - tone, voice, look, feel, vibe. Striving for consistency and awesomeness across touchpoints. - Collaborate: You’ll serve as a cross-functional partner working directly with Organic, Growth, Product, Product Marketing, etc. You’ll operate across channels. - Multi-Channel: Oversee advertising and design projects in all its forms. You’ll have a key role in our social channels. - Standard Operating Procedure: Good to each other. Hard on the work. Qualifications - Experience: Ten-plus years experience - either agency or brand-side - with a portfolio that’s filled with original thinking, immaculate craft and audacious swings. - Skills: You’re an excellent writer. A writer’s writer. Big on craft, a conscientious editor, a headline machine. You have range - able to go long when necessary. - The People: You operate from a place of empathy. You’re generous with your time. You’re deeply invested in the professional growth and personal wellbeing of your people. - Communication: You strive for clarity. And consistent connection. You put a premium on relationships. You strive to bring people together. - Culture: You’re curious. You’re dialed into what’s happening in culture. You’re tuned into the zeitgeist. - Production: You’re production savvy - from quick turn low budget affairs to brand campaigns. Requirements - The annual pay range for this full-time position is $180k-$200k + equity + benefits across all US locations (this position is 100% remote-US). - Our pay ranges are guided by discipline, level and experience required. Within the range, individual pay may vary based on additional factors, including: your specific location, desired skills/technical competency, relevant experience and advanced education/training. Benefits - Health & Wellness: Choose from multiple medical, dental, and vision plans, with generous employer contributions and coverage options to meet your needs. Enjoy access to top-tier virtual care and a complimentary Aaptiv membership for fitness and mental wellness. We also provide an HSA with employer contributions, along with Fullscript discounts for supplements. - Mental Health Support: All employees and eligible dependents receive 12 free therapy sessions per year, plus coaching, meditation, and 24/7 access to Spring Health’s digital tools and care navigation. - Long Term Wealth Planning: Invest in your future with our 401(k) plan through Betterment, featuring a 100% match on the first 3% and 50% on the next 2% of contributions—fully vested from day one. - Supporting Families: Our Parental Leave Policy includes 18 weeks of fully paid leave, with the flexibility to phase your return. We also offer four weeks of paid transition time at 80% capacity or four days per week. - Time to Recharge: Seed offers 15 vacation days, 7 sick/safe days, 2 personal days, 10 Recharge Days (Summer + Winter), and 15 paid company holidays each year. - Work Flexibly: Thrive in a remote-first culture that prioritizes autonomy and clarity. You’ll also receive a $750 one-time remote work setup stipend and ongoing access to a $450 quarterly wellness and workplace stipends via JOON. - And More: Access pet insurance, life and disability coverage, learning & development, and a vibrant culture rooted in science and impact.

• responsible for developing and executing business development strategies to grow wholesale business across work and hunt brands • lead a team of territory sales managers and territory account reps • ensure effective execution of the strategies in the field • attain revenue and profitability goals • build and maintain strong relationships with key customers • manage assigned staff and oversee their performance