Title: Director, Quality Assurance, GCP Location: Boston Department: Development - R&D Operations Base Salary $216.4K – $234.9K • Offers Equity • Offers Bonus Job Description: Who We Are: Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. About the Role: We are seeking a Director, Quality Assurance, GCP/GLP to join our team. We are building our Quality function to support Xenon’s clinical development programs, as well as expand quality initiatives across the company. This person will provide Quality leadership primarily in support of early-stage clinical programs (pre-phase 3) and non-clinical studies. This position will contribute to inspection readiness initiatives and for ensuring compliance within R&D Program. The successful candidate must have a strong clinical/non-clinical quality background, including providing Quality support for study teams, auditing, and inspections. This position must have exceptional interpersonal skills, excellent communication skills, and a collaborative and pragmatic approach to Quality. This position reports to the Executive Director, Quality Assurance, GCP and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. RESPONSIBILITIES: · Lead and manage quality oversight of the Company’s GLP programs, including the GLP audit program, collaborating with Quality Systems to develop an annual GLP audit plan. · Lead and manage quality oversight of the Company’s early phase clinical programs. · Provide expert GLP/GCP compliance interpretation, consultation, training, root cause analysis, and other supportive services necessary to maintain and improve the quality of the Company’s R&D programs to safeguard study participants’ safety and rights and ensure the quality, integrity, and credibility of data generated. · Identify and escalate critical quality issues appropriately to QA Management. · Assist with the preparation and coordination of regulatory inspections held remotely and onsite at the Company’s offices, clinical trial sites, and contract service provider facilities, as needed. · Maintain respectful, inclusive, and effective cross-functional communications, collaborating with internal and external stakeholders on strategy and implementation of quality principles and regulatory requirements while remaining independent. · Ensure compliance with relevant legislation and regulations. · Develop and propose short- and long-term objectives for the GLP/GCP functions in accordance with overall Company and Quality strategies. · Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies. · Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices · Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any · Other duties as assigned QUALIFICATIONS: · Bachelor’s degree in a scientific or health field with at least 10 years of GxP QA experience, 8+ years GCP QA, supporting both development and commercial programs in the pharmaceutical or biotechnology industry. · A minimum of 5 years’ management level experience in a pharma or biotech environment. Job level commensurate with years of experience. · Contemporary knowledge of GLP/GCP/GVP regulations, guidelines, current industry trends, standards, and methodologies. · Experience interacting with regulatory inspectorates (e.g., FDA, Health Canada, EMA, MHRA) is desirable. · Sound understanding of all phases of the drug development process and the interdependencies with other functional areas. · Experience in conducting audits, adapting issues into effective CAPAs, and evaluating trends to mitigate risks. · Ability to prioritize work effectively to manage several complex projects in parallel, and successfully achieve critical milestones and expected deliverables within established timelines and budgets. · Must be able to demonstrate strategic thinking, excellent organizational skills and be able to drive project teams forward while having willingness to do hands on work to achieve goals. · Demonstrated ability to interact professionally and communicate clearly, concisely, and consistently both verbally and in writing with internal and external stakeholders. · Proven ability to work independently and collaboratively as part of a multidisciplinary team. · Proficient people management skills including mentorship, negotiation, and conflict resolution. Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions. Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

Title: Deputy Director, Yale Alumni Fund Hybrid Full time job requisition id: 135142WD Job Description: Working at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven-based community, eligible for opportunities through the New Haven Hiring Initiative, or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale! Overview Yale University seeks an experienced and successful manager to join the university’s division of Alumni Affairs and Development. Yale’s annual fund programs, including Yale College, Yale Parents, and the Graduate School and Professional Schools, play a vital role in raising unrestricted funds that support the university’s fundamental priorities. These priorities encompass financial aid, the enhancement of student life, and the advancement of teaching and research. As a senior leader within the Alumni Fund team, the Deputy Director offers strategic leadership and guidance to a dedicated team charged with advancing fundraising and engagement efforts throughout Yale’s annual fund programs. This position is not only a frontline fundraiser but also oversees both staff and volunteers, ensuring that projects and priorities are managed effectively to increase donor participation and provide essential support for the university’s core needs. Reporting directly to the Managing Director of the Yale Alumni Fund, the Deputy Director works collaboratively across the institution, acting as a resource for team members and campus partners. This collaborative approach helps foster a culture of innovation and continuous improvement, which is crucial for sustaining and enhancing engagement and fundraising outcomes among students, alumni, and parents. The ideal candidate for this role will have a proven track record in fundraising, effective staff management, and demonstrated success as a collaborative leader. The Yale Alumni Fund serves as an integral part of Yale University's For Humanity Campaign, a university-wide fundraising initiative designed to address pressing global challenges. This campaign is scheduled to conclude in June 2026. Required Skills and Abilities 1. Proven ability to mentor and guide staff to collaborate with colleagues and execute immediate strategies and long-term projects. Experience in leading, coaching and motivating other professionals. Ability to maintain strict confidentiality. 2. Proven track record in fundraising. Demonstrated accomplishment in managing or executing a wide range of solicitation, marketing, or stewardship activities. 3. Possesses excellent written, oral and presentation skills. Experience synthesizing and prioritizing information from a wide array of sources while maintaining attention to detail and effectively managing workflow. 4. Excellent organizational and analytical skills and the ability to improve business practices and processes. 5. Proactive, productive team contributor with a positive attitude. 6. Possesses initiative, creativity, a data-driven work ethic, and willingness to take personal responsibility for outcomes. Results-oriented, driven to succeed, innovative, and inspired by challenging goals. Principal Responsibilities 1. Directs and grows a team of development professionals responsible for generating an increased volume of successful development activities and establishing a culture that encourages ever- improving levels of performance and responsiveness to donors. 2. Works closely with senior management to develop both short- and long-term fundraising goals and strategies. 3. Works with staff to develop and implement plans to carry out the organization's goals and strategies, including establishing specific activity goals for all phases of the donor/prospect life- cycle (cultivation, solicitation, closure and stewardship). 4. Manages engagement of faculty, administrators, and University officials in fundraising efforts. 5. Personally maintains a portfolio of gift prospects. 6. Works regularly and cooperatively with other development offices to ensure overall development priorities, plans, and initiatives are coordinated. 7. May travel (possibly extensively) commensurate with Yale’s standard expectations for fundraising activity, contact and travel. 8. Performs additional development-related activities/efforts at the request of manager. 9. May perform other duties as assigned. Required Education and Experience Bachelor’s Degree and six or more years of related work experience in an academic institution or an equivalent combination of education and experience. Experience in managing/leading a team of fundraising professionals in an academic setting is preferred. Required License(s) or Certification(s) Valid driver’s license required. Physical Requirements: Physical Requirements: Job Category: Manager Bargaining Unit: NON Compensation Grade: Development Compensation Grade Profile: Deputy Director, Major Gifts (Ungraded) Salary Range: 0.00 - 0.00 Time Type: Full time Duration Type: Staff Work Model: Hybrid Background Check Requirements All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks basedon the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website. Health Requirements Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy. Posting Disclaimer Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions. The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the position. Employees will be assigned specific job-related duties throughtheir hiring department. The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.

Role Description As a Director of Customer Success, you will lead our expansion efforts in a named set of existing accounts by connecting at the level of CXO’s. You will be responsible for: - Participating in Value Engineering and Centres of Excellence exercises in large accounts. - Identifying business problems and working cross-functionally to provide solutions. - Building relationships with important decision-makers within the current accounts. - Generating new opportunities and closing deals in existing accounts. - Demonstrating value realization & ROI of SHIELD through Executive Business Reviews and other channels. - Collaborating effectively with Sales, Engineering, Business Development, Marketing, and Product teams. - Proactively identifying and resolving account success blockers. - Hands-on troubleshooting and debugging to ensure timely resolution of clients' technical challenges. - Periodic review of account performance and identifying improvement opportunities. Qualifications - 8+ years of SaaS Enterprise Sales and/or Account Management experience with large enterprise accounts. - Proven ability to create new opportunities. - Hands-on experience and good knowledge in SDK, HTTP, JavaScript, RESTful APIs, JSON, OAuth, and SQL is a plus. - Strong executive presence and ability to develop executive-level (CxO) relationships. - Excellent verbal/written communication skills. - Adept at identifying issues and providing effective solutions. - Proactive in spotting new opportunities or addressing potential issues. - Ability to collaborate effectively with cross-functional teams. Requirements - Strong communication skills to convey complex information clearly. - Understanding of clients’ business goals, monetization strategies, and performance metrics. - Support sales team to increase revenue & strengthen client relationships. - Problem-solving ability to ensure client satisfaction and campaign success. - Team collaboration skills to deliver seamless service to advertisers.

• Build a robust pipeline of foundations with the capacity to make 5-7+ figure gifts. • Develop and execute a comprehensive institutional giving strategy aligned with Crisis Text Line's mission, priorities, and annual revenue goals. • Identify and prioritize a diverse mix of private and family foundations. • Take the lead on cultivating and stewarding funder relationships. • Oversee high-quality grant writing and reporting. • Manage the foundation calendar to ensure timely, high-quality submissions across the portfolio. • Take ownership of advancing prospects through the donor lifecycle by developing tailored engagement strategies. • Shepherd internal stakeholders’ involvement and coordinate input from program leaders and C-suite executives.