Title: Senior Director, Global Value & Access Strategy - Povetacicept Lead Location: Boston MA United States Full-time Job Description: Background and Job Description: Vertex Pharmaceuticals operates at the forefront of scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF), Casgevy, a gene therapy for sickle cell disease and beta-thalassemia and Journavx, a novel new treatment for moderate to severe acute pain. Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in kidney diseases, Type 1 diabetes, among others. Povetacicept is a highly potent and effective dual antagonist of BAFF and APRIL pathways with potential best-in-class efficacy in patients with IgA nephropathy (IgAN). IgAN is a serious, progressive, autoimmune disease of the kidney that can lead to end-stage-renal disease. IgAN is the most common cause of primary (idiopathic) glomerulonephritis worldwide. Due to its mechanism of action as a dual BAFF/APRIL antagonist, povetacicept holds the potential to benefit patients for multiple additional serious diseases including other autoimmune kidney diseases and autoimmune cytopenias such as primary membranous nephropathy (pMN) and generalized myasthenia gravis (gMG). Vertex is seeking a Senior Director of Global Value & Access Strategy (GVAS) for povetacicept, reporting to the ED Kidney Lead, to join our dynamic team in Boston, MA. The Senior Director will be the Market Access Asset Lead for povetacicept in IgA nephropathy (IgAN) and future indications, including pMN and gMG. In this capacity, the individual will be responsible for evolving the global price and access strategy (P&MA) for IgAN and driving development of the LCM/portfolio P&MA strategy, as well as leading the cross-functional, cross-regional Value & Access Strategy Working Team.  The successful candidate will serve as the voice of the payer internally to ensure that P&MA implications are considered in key program decisions. This role will also be accountable for leadership of cross-portfolio capability building and thought leadership projects that advance knowledge of and readiness for the rapidly evolving global payer environment. The successful candidate will be strategic, demonstrate strong cross-functional leadership, thrive in complexity, and have a problem-solving mindset backed by strong analytical skills. The candidate must share our passion for science-based brands that can dramatically improve patients' lives. As a senior member on the GVAS team, the successful candidate must be able to role model Vertex's ethics & culture and be committed to developing the next generation of leaders. They will also manage two direct reports. Key Responsibilities: - Responsible for evolving the overall development and communication of the Global pricing & market access strategy for povetacicept within cross functional, cross-regional commercialization processes. - Ensure global market access launch readiness for IgAN lead indication - Ensure delivery of differentiated branded, branded payer value communications and supportive training - Lead the evolution of the global price and market access strategy in IgAN - Partner cross-functionally and cross-regionally to ensure robust integrated evidence plans to support global market access and reimbursement at launch and over time - Responsible for development of the P&MA strategies for future indications/portfolio - Partner within commercial to develop overall LCM strategy, including indication sequencing - Ensure P&MA strategies are supported by payer insights and robust global payer plans - Identify, prioritize and champion evidence required for access enabling trials and value optimization - Provide leadership within the Global Commercial Model and shape commercial strategy; contribute directly to Commercialization Strategy Team and the Disease Strategy Team to ensure the payer position is consistently represented - Lead cross-portfolio capability building and thought leadership projects that advance knowledge of and readiness for the rapidly evolving Global payer environment - Effectively lead cross-functionally and cross-Regionally, particularly across Market Access teams, HEOR, Real World Evidence, Government Affairs and Public Policy and to ensure alignment around and delivery against access goals - Provide direct, "hands-on" development of strategic and tactical deliverables as required - Manage 2 direct reports Experience & Qualifications: - Bachelor's degree required, ideally in life sciences, post graduate preferred - 12+ years of direct biotechnology / pharmaceutical industry experience; 5+ years of supervisory/management experience preferred - Deep working knowledge of both US and ex-US healthcare systems required; experience in a comparable global and/or specialty disease area role, especially involving product launches in highly competitive markets with potential for expansion into multiple indications, considered a plus - Demonstrated ability to think strategically and make sound pricing and market access recommendations - Strong practical, quantitative and analytical skills combined with a sound understanding of how to successfully apply pricing & reimbursement / HEOR principles to support Vertex - Exhibits outstanding written and oral communication skills, including the ability to effectively write and deliver presentations to professionals at all levels within Vertex - Demonstrated ability to manage initiatives that require cross-functional collaboration and relationships at all levels of the organization and across geographies - General experience in commercialization and drug development - Recognized as a team player with excellent interpersonal skills who is flexible and reliable - Displays sound ethics and a fit for Vertex's core values and culture Pay Range: $240,000 - $360,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition.

Role Description The role of the Regional Access Director (RAD) is to minimize access and reimbursement barriers for patients and providers related to VYKAT™ XR (diazoxide choline) extended-release tablets. They will accomplish this by executing the market access reimbursement plan in the assigned geographic area with physicians, office staff and institutional customers. The RAD will work closely with internal and external partners including HCPs and their staff involved in securing appropriate access for VYKAT XR. - Proactively educate prescriber office personnel on programs and processes to facilitate patient access to VYKAT XR via in person and virtual interactions. - Reactively address patient specific issues and provide issue resolution across geography. - Enhance awareness and understanding of patient support offerings and specialty pharmacy (SP) processes. - Champion and manage the appropriate utilization of patient support services and reimbursement programs to ensure compliance with legal and regulatory requirements. - Demonstrate deep knowledge in reimbursement and access across VYKAT XR patient support offerings. - Collaborate closely with the payor team to understand payer policies and facilitate patient access. - Ensure providers understand prior authorization requirements, appeals processes and clinical criteria relevant to VYKAT XR. - Work closely with external and internal customers to troubleshoot any Hub/SP-related issues. - Ensure timely follow-up that demonstrates urgency to both the patient and Provider. - Develop and execute an action plan consisting of prioritized activities to best meet the needs of patients. - Interact with patients to support their access needs as appropriate. - Develop and maintain strong working relationships with key opinion leaders/provider advocates. - Stay current on industry patient support programs, requirements, and payer trends. - Work cross functionally to analyze reimbursement/access issues. - Frequently communicate trends, issues, and best practices to management, sales and marketing teams. - Contribute to prelaunch activities in support of patient services program build. - Represent the organization at various industry functions and with patient advocacy groups. - The RAD must work effectively with both internal and external stakeholders to achieve target objectives and meet established MBOs/goals. Qualifications - Must be located within region and live near major airport: AZ, CO, IA, ID, KS, MN, MO, MT, ND, NE, NM, OK, SD, UT, WI, WY. - BA/BS Degree and at least 5 years of pharma or biopharmaceutical experience calling on field-based customers. If no degree, at least ten years in industry or in a field related to patient access. - At least two years of reimbursement related or relevant managed care experience. - Proven ability to thrive in both an independent setting and within a collaborative cross functional team. - Excellent analytical skills focusing on patients and customers, identifying trends and solutions. - Strong prioritization skills aligned with good decision-making capabilities. - Ability to condense complex reimbursement issues into simple solutions. - Excellent verbal and written communication skills. - Ability to lead without authority. - Ability to travel and cover large multistate geography territories; approximately 30 to 50% travel required, based on geography and business need. Salary Range $180K - $210K (Actual salary at the time of hire may vary and may be above or below the range based on various factors, including, but not limited to, the candidate’s relevant qualifications, skills, and experience, as well as the location where this position may be filled.)

Title: Director, Global Clinical Physician - Late Oncology Princeton - NJ - US Madison - Giralda - NJ - US Cambridge Crossing - MA - US Location: Princeton United States Job Description: Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Director, Global Clinical Physician sits within Clinical Development, which is a global organization dedicated to the effective design and execution of drug development. Clinical Development drives clinical development strategy, design, execution, and interpretation of clinical trials. Position Summary / Objective - Serves as a primary source of medical accountability and oversight for multiple clinical trials - Matrix management responsibilities across the internal and external network Position Responsibilities 1) Medical Monitoring - Contributes to and is a key member of a high performing Study Delivery Team (SDT) and may be a member of the Clinical Development Team (CDT) - Leads medical data review of trial data, including eligibility review - Holds responsibility for site interactions in partnership with other GCPs and Global Clinical Scientists (GCSs) for medical questions and education (including safety management guidelines) - Holds responsibility for assessment of key safety-related serious adverse events in partnership with Worldwide Patient Safety and oversees safety narratives - Leads collaboration with GCS and inputs into protocols, providing medical strategic oversight in protocol development (input on inclusion/exclusion and other safety-related clinical considerations) - Fulfills GCP and compliance obligations for clinical conduct and maintains all required training 2) Clinical Development Expertise & Strategy - In collaboration with the Clinical Development Indication Lead, designs and develops clinical plans and protocols with a strong strategic focus based on knowledge of asset/drug, disease area and relevant science in order to meet regulatory and disease strategy targets - Provides oversight and medical accountability for a group of studies - Leads the analysis of benefit/risk for clinical development protocols in a matrix team environment working with other GCPs and Global Clinical Scientists (GCSs) - Partners with other GPCs / GCSs to support executional delivery of studies (e.g., site activation, enrollment status, as well as adjudication for protocol violations, significant, non-significant deviations etc. - Identifies and builds relationships with principal investigators. Identifies and cultivates thought leaders in order to gain their inputs on emerging science in drug and biomarker research, disease knowledge, and design of clinical development studies and programs - Maintains a strong medical/scientific reputation within the disease area. Has in-depth knowledge of etiology, natural history, diagnosis, and treatment of the disorder. Holds strong expertise in the disease area by attending scientific conferences and ongoing review of the literature - Keeps abreast of development and regulatory issues related to other competitive or relevant compounds in development and how our portfolio fits into the competitive landscape - Provides ongoing medical education in partnership with collaborating Clinical Scientists to allow for protocol-specific training, supporting the study team, investigators, and others 3) Health Authority Interactions & Publications - Contributes to and serves as medical point of expertise in key Health Authority interactions and advisory board meetings as Director, Global Clinical Physician - Authors/drafts clinical content for CSRs, regulatory reports, briefing books and submission documents to support closure, clinical narratives, reporting and filling of the study in partnership with other GCPs / GCSs Degree Requirements MD required (or x-US equivalent) Experience Requirements 5 or more years of Industry experience and/or clinical trials experience is required Key Competency Requirements - Ability to communicate information clearly and lead presentations in scientific and clinical settings - Subspecialty training in applicable therapeutic area desired - Expertise in the scientific method to test hypotheses, including statistical design, analysis, and interpretation - Expertise in drug development process - Expertise in the components needed to execute an effective clinical plan and protocols - Strong leadership skills with proven ability to lead and work effectively in a team environment Travel Required Domestic and International travel may be required. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge Crossing: $308,700 - $374,075 Madison - Giralda - NJ - US: $275,630 - $333,998 Princeton - NJ - US: $275,630 - $333,998 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: - Health Coverage: Medical, pharmacy, dental, and vision care. - Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). - Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work-life benefits include: Paid Time Off - US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) - Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. - Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley. R1602717 : Director, Global Clinical Physician - Late Oncology

Block is one company built from many blocks, all united by the same purpose of economic empowerment. The blocks that form our foundational teams - People, Finance, Counsel, Hardware, Information Security, Platform Infrastructure Engineering, and more - provide support and guidance at the corporate level. They work across business groups and around the globe, spanning time zones and disciplines to develop inclusive People policies, forecast finances, give legal counsel, safeguard systems, nurture new initiatives, and more. Every challenge creates possibilities, and we need different perspectives to see them all. Bring yours to Block. The Role The Core Experience design team shapes the future of Cash App by defining the fundamental flows, frameworks, and surfaces that tens of millions of customers rely on every day. We are a team that drives the strategic step-changes pushing our product forward. As the Design Lead for Core Experience, you will report to Cam Worboys (Head of Product Design, Cash App and Afterpay) and lead a team of 10+ designers. This is a hybrid player-coach and DRI role: you will set an exceptionally high craft bar while staying hands-on with the most critical work. You will partner with senior leadership across product, engineering, and research to define long-term vision, drive roadmaps, and ship experiences that redefine what a financial product can feel like. You Will - Define and uphold craft excellence for Core Experience - staying close to the details, leading critique, and ensuring every shipped experience meets the highest quality bar - Drive long-term vision, strategy, and roadmaps in partnership with senior product and engineering leadership - Lead and grow your team - mentoring designers, fostering accountability, and developing people across career stages and disciplines - Get hands-on with the most complex, ambiguous design challenges while empowering your team to deliver exceptional work independently - Build trusted partnerships with senior cross-functional peers, championing Design as a critical driver of business strategy - Drive adoption of emerging tools and AI-driven approaches that accelerate your team's craft and velocity You Have - 12+ years of experience in product design with a portfolio demonstrating exceptional craft, taste, and ability to make complex systems feel simple - Track record leading design teams, including experience as a player-coach - directing strategy while personally driving critical projects - Demonstrated ability to craft long-term vision and customer-focused strategies for products at scale - Deep expertise in designing consumer financial products or similarly complex, trust-dependent systems - Outstanding partnership and communication skills that inspire alignment across senior leadership, product, engineering, and research - Experience attracting, developing, and retaining strong design talent Portfolio Please submit a link to your portfolio as part of your application. be sure to include the password, if necessary. We're working to build a more inclusive economy where our customers have equal access to opportunity, and we strive to live by these same values in building our workplace. Block is an equal opportunity employer evaluating all employees and job applicants without regard to identity or any legally protected class. We will consider qualified applicants with arrest or conviction records for employment in accordance with state and local laws and "fair chance" ordinances. We believe in being fair, and are committed to an inclusive interview experience, including providing reasonable accommodations to disabled applicants throughout the recruitment process. We encourage applicants to share any needed accommodations with their recruiter, who will treat these requests as confidentially as possible. Want to learn more about what we're doing to build a workplace that is fair and square? Check out our I+D page . While there is no specific deadline to apply for this role, U.S. roles are typically open for an average of 55 days before being filled by a successful candidate. Please refer to the date listed at the top of this job page for when this role was first posted. Block takes a market-based approach to pay, and pay may vary depending on your location. U.S. locations are categorized into one of four zones based on a cost of labor index for that geographic area. The successful candidate's starting pay will be determined based on job-related skills, experience, qualifications, work location, and market conditions. These ranges may be modified in the future. To find a location's zone designation, please refer to this resource . If a location of interest is not listed, please speak with a recruiter for additional information. Zone A: $304,500 - $456,700 USD Zone B: $304,500 - $456,700 USD Zone C: $304,500 - $456,700 USD Zone D: $304,500 - $456,700 USD Application Guidelines Candidates may submit up to 9 active applications within a 60-day period. Reapplications to the same role are accepted 90 days after a previous application has been reviewed. Use of AI in Our Hiring Process We may use automated AI tools to evaluate job applications for efficiency and consistency. These tools comply with local regulations, including bias audits, and we handle all personal data in accordance with state and local privacy laws. Contact us here with hiring practice or data usage questions. Every benefit we offer is designed with one goal: empowering you to do the best work of your career while building the life you want. Remote work, medical insurance, flexible time off, retirement savings plans, and modern family planning are just some of our offering. Check out our other benefits at Block. Block, Inc. (NYSE: XYZ) builds technology to increase access to the global economy. Each of our brands unlocks different aspects of the economy for more people. Square makes commerce and financial services accessible to sellers. Cash App is the easy way to spend, send, and store money. Afterpay is transforming the way customers manage their spending over time. TIDAL is a music platform that empowers artists to thrive as entrepreneurs. Bitkey is a simple self-custody wallet built for bitcoin. Proto is a suite of bitcoin mining products and services. Together, we're helping build a financial system that is open to everyone.