Vertex Pharmaceuticals

Title: Commercial Supply Chain Manager, Small Molecule Location: Boston United States Job Description: Job Description General Summary: The Commercial Supply Chain Manager will support commercial supply chain execution for a late-stage small molecule program. As Vertex expands its portfolio and advances new therapies toward commercialization, this role will play a key part in monthly supply planning, the S&OP process, planning system setup, inventory management, Long Range Plans (LRP) and cross-functional supply chain coordination. The position is responsible for delivering the monthly supply planning tasks, support in the S&OP process, setting up planning & execution systems and partnering with cross-functional teams to align material, capacity, and operational requirements to support on-time manufacturing execution and product supply. The role will also support process integration, system testing, and continuous improvement efforts to help build a best-in-class supply chain. This position reports to the Associate Director, Commercial Supply Chain - Pipeline, within Supply Chain Management and the Biopharmaceutical Sciences and Manufacturing Operations (BSMO) division, and is based at Vertex's corporate headquarters in Boston, MA. Key Duties and Responsibilities: - Deliver monthly end to end Supply and Inventory build plans using Kinaxis Maestro / Rapid Response, taking into consideration supplier capacity, demand uncertainty, and overall risk management. - Support the commercial and late-stage small molecules program including scenario planning to facilitate data driven decisions. The scenario planning includes supply projections, 5+ year forward looking assessments of forecast / supply scenarios, and inventory planning to support life cycle management initiatives. - Support implementation, testing and improvement of planning and execution systems functionality to further advance technology and planning processes optimization / efficiency. Serve as Planning super user for Kinaxis Maestro / Rapid Response. - Support the Sales & Operations Planning (S&OP) process to enable robust material and capacity investments including network expansion. Proactively assess risks across the small molecule network and develop mitigation plans. - Support supply chain strategic initiatives such as implementing safety stock for materials, monitoring operational readiness, capacity analysis, and integration of different systems requirements - Led creation and maintenance of master data, including lead times, pricing, and approved vendor lists and perform periodic review of master data and ensure alignment with department policies and guidelines - Drive excellence in end-to-end operations through management of key supply chain KPI's. Identify operational efficiency and continuous improvement opportunities across the supply chain to deliver a best-in-class supply chain. - Represent the Supply Chain on project sub-teams and task forces, executing supply chain production activities with general guidance. Build strong relationships with External Manufacturing, Quality, Logistics, Finance, Commercial and other functions, foster team culture and build trust with colleagues to deliver uninterrupted supplies to patients. - Champion the culture of quality and ensure that all activities and documentation comply with global regulatory requirements - Performs other duties as assigned. Knowledge and Skills: - 5+ years progressive experience in supply chain planning in the pharmaceutical industry - Demonstrated experience in supply planning using Kinaxis Maestro / Rapid Response. - Experience managing and navigating a complex global supply chain network. - Strong analytical and problem-solving skills, often addressing novel/unusual situations and exercising judgement based on significant technical experience. - Proven ability to innovate and implement practical, compliant solutions, work seamlessly across teams, and develop excellent partnerships with peers. - Demonstrated understanding of the principles and regulations associated with small molecule supply chain operations. - Sense of urgency to deliver quality results in a highly ethical and professional manner. - Excellent communication and interpersonal skills with the ability to communicate complex issues and solutions. - Demonstrated ability to anticipate different scenarios and provide contingency plans to address potential adversities. - Excellent and reliable team player. Demonstrated ability to collaborate with other functional areas, build, and sustain trust at all levels of the organization. - Experience in Oracle E-Business Suite Process Manufacturing (OPM) or SAP - Flexibility and versatility as the Commercial supply chain team and business evolve. Education and Experience: - Bachelor's degree in a scientific or business discipline Pay Range: $116,200 - $174,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Title: Project Management & Strategic Operations Senior Manager locations Boston, MA time type Full time job requisition id REQ-28989 Job Description: General Summary: The Project Management & Strategic Senior Manager is responsible for multiple department projects and provides centralized operational support for the U.S. Commercial team. By partnering with departmental management and cross-functional project teams, the Senior Manager develops and maintains integrated project plans and operational processes in accordance with project/department objectives, and are within budget. The Senior Manager is also responsible for comprehensive communication, including status reporting, risk management, and department processes to cross-functional stakeholders and department senior leaders. The Senior Manager partners closely with the Chief of Staff, U.S. Commercial to execute on strategic, operational, and organizational matters. Key Duties and Responsibilities: - Leads multiple departmental projects and is responsible for departmental program/process operations - Develops plans, goals, processes and logistics for projects, gaining cooperation and alignment - Works closely with department leadership to continue to maximize process efficiency and align department goals and strategy - Regularly interacts with functional areas beyond own department - Conducts complex scenario planning to proactively provide analysis, make process improvement recommends on alternative development plans - Effectively summarizes key information such as program progress, timeline updates, risk opportunity assessments and SOPs - Develops and maintains project and departmental budgets and is accountable for understanding and communicating forecast variance, risks and opportunities - Compiles succinct reports and prepares minutes for internal meetings; methodically tracks all actions items, and finds new ways to stay abreast of multi-dimensional tasks - Contributes to the best practices of project management and departmental operations to support the continued success and evolution of the department Knowledge and Skills: - Experience in cross-functional execution including medium to large-scale projects - Critical thought partner and proven ability to connect people and ideas to drive outcomes - Ability to connect with over divisions and functions throughout Vertex - Self-motivated; acts independently and prioritizes appropriately; embraces unexpected changes or challenges and drives to improved solutions - Ability to manage multiple priorities/projects at a given time, ensuring deadlines, budgets and status updates - Developed communication skills and the ability to synthesize data and information into meaningful insights - Very detail oriented and strong project/operation management skills - Ability to handle ambiguity Education and Experience: - Typically requires a bachelor's degree - Typically requires 6 years of experience or the equivalent combination of education and experience Pay Range: $139,200 - $208,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Title : Regulatory Strategy Director Location: Boston United States Job Description: Job Description General Summary: The Regulatory Strategy Director will be responsible for the development and implementation of innovative global/regional regulatory strategies for assigned projects within the Vertex portfolio. This position will play a major role in shaping cohesive regulatory strategy for assigned program(s) and ensuring effective integration of broad regulatory ideas/tactics supporting program strategy. This roles assignments may be global, regional or local depending on the position and assigned region. This role will understand and translate regulatory, scientific, operational and business knowledge into effective implementation plans and strategy. Key Duties and Responsibilities: - Leads the development of regulatory strategy for assigned projects/regions in development (from first-in-human to post marketing application stage) outlined in Global Regulatory Strategy Documents - Represents GRA on core development functional teams, project teams, and collaborate with regional leaders and teams to ensure unified regulatory input into clinical programs and commercial strategy - Addresses complex issues, providing innovative regulatory solutions and guidance to cross-functional teams and align communication to and from cross-functional teams, GRA functional team and GRA leadership - Anticipates global regulatory changes and develops proactive strategy accordingly - Shapes the regulatory strategy for regulatory submission documents and Health Authority communications - Counsels and advises GRA leadership on status of global Regulatory Affairs strategies and tactics, procedures and practices - Ensures the global regulatory strategy for a given project is consistent with the business objectives and is compliant with current regulations and guidance - Manages project plans and timelines to ensure all projects are appropriately prioritized and key goals are met on time - Contributes to the continuous improvement of existing department processes and strategies, providing recommendations in area of expertise - Provides regulatory leadership to the GRA functional team(s) or projects with moderate resource requirements or complexity Knowledge and Skills: - Experienced in Regulatory Affairs strategy in assigned geographic region, including direct interactions with a variety of stakeholders - Advanced technical skill in regulatory affairs science including knowledge of regulatory frameworks and external environments. Advanced knowledge of global/regional/local regulatory legislation, laws, procedure and guidance for pharmaceutical development of medicines for human use. - Proficient knowledge of the research and development, preclinical and clinical requirements related to drug development, registration, and maintenance of human pharmaceuticals - Proficiency in analyzing and interpreting data, protocols, safety reporting, labeling and other activities related to the phases of drug development for assigned products. - Advanced skill in creating and assessing proposals to regulatory authorities on regulatory paths and clinical plans, guiding development teams with recommendations for changes/refinements based on ongoing regulatory outcomes throughout development, and in leading productive health authority interactions, including well organized preparation of cross functional teams. - Actively uses expertise to develop others by providing coaching, guidance and mentoring. - A strong collaborative partner with cross functional colleagues with the ability to build consensus through the ability to present a clear and compelling case for ideas - Demonstrates excellent communication skills with ability to impact and influence the decisions of a team Education and Experience: - Bachelor's degree in Biology, Chemistry, or other related discipline - Typically requires 10 years of relevant pharmaceutical or biotech industry experience within regulatory affairs, or the equivalent combination of education and experience #LI-TC1 #LI-Hybrid Pay Range: $196,800 - $295,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

Title: Digital Communications Specialist Location: Paddington, Boston United States time type: Full time job requisition id: REQ-28709 Job Description: We are seeking a highly motivated and detail-oriented Digital Communications Specialist to join our team. In this role, you will play a key part in managing and executing our digital communication strategies, including social media, website content, and digital campaigns. You will collaborate with cross-functional teams and external partners to ensure the delivery of high-quality, engaging, and impactful digital content that aligns with our brand and business objectives. Key Duties & Responsibilities - Maintain the social media content calendar, coordinating assets, approvals, and publishing for organic and paid content with a high level of accuracy, consistency, and channel-appropriate voice. - Support community management and social monitoring, identifying and flagging issues or trends for the broader team. - Help manage the Vertex web estate, including publishing, and maintaining site inventory. - Edit content across channels, ensuring accuracy, consistency, and adherence to channel‑specific voice and tone. - Support paid digital media campaigns by coordinating assets, timelines, and updates with agency partners. - Coordinate reviews and gather inputs from subject matter experts and stakeholders to ensure timely execution of deliverables. - Support the regulatory review process by preparing and submitting materials, tracking feedback, and implementing approved changes. - Help track and compile performance metrics, supporting basic reporting and optimization efforts. Required Education Level - Bachelor's degree in Communications, Marketing, Digital Media, or related field. Required Experience - Strong experience in digital communications, social media, or a related role. - Agency experience is an asset. Required Knowledge/Skills - Strong organizational skills and attention to detail, with reliable follow through. - Hands on experience executing social media content. - Ability to manage multiple workstreams in a fast paced environment. - Collaborative, responsive, and open to feedback. - Familiarity with social platforms, content management system (CMS) tools, and basic analytics. - Clear written and verbal communication skills. - Experience proofreading various styles of copy and editing for grammar and voice. - Curious, proactive, and motivated to build a broad digital communications toolkit. Other Requirements - Ability to work effectively in a global, highly regulated environment. - Strong written and verbal communication skills in English. - Flexibility to adapt to changing priorities and manage multiple projects simultaneously. - This role is based in London, UK with a hybrid schedule (3 days/week on-site). - Willingness and ability to work an adjusted schedule up to 1-2 days per week as needed to enable collaboration with global teams based in US EST.. #LI-SG1 #LI-Hybrid #LI-LE1 Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Title: Distribution Strategy Associate Director - Pain Location: Boston United States Job Description: Job Description Vertex currently operates at the forefront of rare disease scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF), Sickle Cell Disease, Transfusion-Dependent Beta Thalassemia and Acute Pain. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in Diabetic Peripheral Neuropathy, Type 1 Diabetes, IgA Nephropathy (IgAN), APOL-1 Mediated Kidney Disease, and Muscular Dystrophy, among others. The Associate Director Trade and Distribution Strategy is accountable for the design, implementation and evolution of the channel distribution strategy for the pain portfolio. This individual will lead strategic planning considering country-specific regulations and policies, program sustainability, strategic alliances, patient and customer access, data, class of trade and setting of care. They will inform distribution service agreement design to support maximum access and distribution efficiency. The ideal candidate combines deep pharmaceutical channel distribution expertise with strategic acumen, cross-functional leadership and the ability to navigate complex trade and emerging therapy models. Key Duties and Primary Responsibilities - Lead the tactical execution of design planning, informing the development of scalable, effective distribution strategies to serve short and long-term expectations while considering financial impacts and patient/customer experience - Collaborate and drive alignment across key stakeholders on distribution and channel strategy development; apply subject matter expertise to maximize patient access and achieve corporate goals - Partner with the Trade and Distribution account team and functional business partners to support Vertex's understanding of distribution capabilities, market expertise and differentiation - Produce business cases and recommendations on channel design, limited distribution and open network designs, strategic alliances (third party logistics providers, specialty pharmacy, wholesaler, specialty distributor, channel data aggregators). - Support in identifying and defining timely evolution of current Vertex distribution programs with a focus on new product launch, risk mitigation, changes in market dynamics, competition, and/or regulatory and legislative changes - Maintain a deep understanding of the distribution channel; understand pharmacy and hospital capabilities and the competitive marketplace to ensure Vertex maintains an industry leading approach - Exercise sound judgment in all activities to ensure integrity and compliance with company policies. Promote Vertex core values, leading by example, developing and fostering exceptional collaboration and promoting enterprise thinking to drive breakthrough results Knowledge and Skills: - Current knowledge of drug distribution channels including retail distribution including digital pharmacy. - Proven track record of meeting or exceeding objectives & goals, both as an individual and as part of a team - Proven ability to develop and lead strategic initiatives and projects both internally and with external consultant support. - Relevant experience with distribution networks, new product launches, trade processes, and understanding of pharmaceutical supply chain. - Demonstrated understanding of the US commercial and government healthcare and reimbursement environment, including product and fund flow, patient support and government programs - Excellent communication skills with experience presenting to customers and internal leadership - Demonstrated ability to successfully navigate cross-functional teams, influencing without direct authority, with the interpersonal skills to foster collaboration and succeed in a highly matrixed environment - Ability to perform in a fast-paced environment, manage multiple priorities simultaneously, and work effectively across cross-functional teams - Excellent analytical skills with solid understanding of trade channel data. Education and Experience: - Bachelor's degree in relevant field, master's degree preferred - Specialty/Biotech industry experience with at least 5+ years in Commercial Market Access and/or Retail Trade and Distribution - Experience with GPO's and IDN classes of trade. Location: - HQ or Hybrid Schedule (3 days a week in HQ) - Ability and willingness to travel up to 20% of the time. Pay Range: $148,000 - $222,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Lead complex HEOR evidence generation, synthesize insights from stakeholders, design observational research studies, and collaborate on publication strategies to maximize the impact of health economics and outcomes research initiatives.

Title: Director, Heme CGT Operations Location: Boston United States Full time Job Description: About Vertex: At Vertex, we are relentless in our pursuit of transformative medicines to improve the lives of people with serious diseases. Building on a strong foundation of advancing therapies for cystic fibrosis, Vertex continues to expand its leadership across multiple disease areas, including cell and gene therapies, with the goal of delivering meaningful impact for patients worldwide. Our Global Heme Cell and Gene Therapy (CGT) Operations team is at the forefront of innovation, commercial strategy, and operational excellence, driving the evolution of the global, cross-functional, "vein to vein" business process for CASGEVY, the only CRISPR-based autologous gene therapy approved for people living with Sickle Cell Disease and Transfusion dependent beta thalassemia. Position Summary: We are seeking a Director, Heme CGT Operations to lead global operational strategy for CASGEVY. This critical role will lead a team responsible for owning the global end-to-end business process, order management system, and treatment center strategy and communications, essential to delivering a vein-to-vein, autologous product. As CASGEVY continues to scale across 9+ markets globally, the successful candidate will bring a strategic, operational, and collaborative mindset, provide cross-functional leadership and drive alignment among international and US Heme Business Units, Manufacturing, Quality, and Technology teams involved in CASGEVY delivery. Key Responsibilities: - Lead Global operational strategy and spearhead forward-looking workstreams to advance business priorities emerging from the Disease Strategy Team and commercial business units to drive key program KPIs, developing and executing operational plans in close partnership with regional commercial teams and with senior leadership input and awareness - Shape evolution of end-to-end business process and chain-of-identify / chain-of-custody order management portal ("Vertex Connects") critical to vein-to-vein delivery of CASGEVY across markets, overseeing execution of optimizations and ensuring business readiness and GxP compliance for launch of process and system changes - Collaborate closely with regional commercial teams to address in-market needs and operational challenges based on customer feedback and analytics, designing and operationalizing solutions in partnership with quality, manufacturing, and technology teams - Manage evolution of global treatment center strategy, requirements, and communications to ensure seamless and consistent CASGEVY treatment journey globally and drive external transparency around process and operations - Lead Global Cell and Gene Therapy Ops cross-functional team, a sub-team of the Disease Strategy Team, driving internal alignment on business process and priorities and serving as subject matter expert, liaison, and facilitator to ensure integration of commercial strategy into business operations and vice versa - Manage Global CGT Ops team, setting strategy and priorities, managing and coaching team and ensuring responsible management of external spend & vendors Qualifications and Experience: - 10+ years of relevant experience in biotechnology, pharmaceuticals, or advanced therapy operations. - Strong analytical and problem-solving skills with the ability to translate strategy into execution. - Demonstrated success working in cross-functional, matrixed organizations with multiple stakeholders. - Strong leadership, communication, and influencing skills with the ability to operate effectively at both strategic and execution levels. - Proven ability to manage competing priorities and drive results in a fast-paced environment. - Experience supporting commercialization or launch planning for advanced therapies, such as autologous gene therapies - Experience influencing senior leaders and presenting within executive governance forums. - Continuous improvement mindset with the ability to optimize processes across complex organizations. Pay Range: $196,000 - $294,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition.

• Support the Quality Risk Management Quality System owner for project coordination on strategic initiatives • Ensure compliance with regulatory requirements, industry standards and company policies • Analyze QMS trends and KPIs to identify opportunities for continuous improvement • Support the Quality system owner in compliance related activities • Own, track and/or facilitate the completion of CAPAs, inspection/audit commitments, etc. • Assist in authoring and revising SOPs, work instructions, and training materials • Provide administrative support to the Global Quality systems team • Collaborate with cross-functional teams to ensure timely and compliant execution of Quality Risk management activities

Title: Director, Strategic Sourcing - Technology Location: Boston, MA Hybrid Full time Job Description: As a key leader in the Strategic Sourcing function, the Director, Data, Technology & Engineering (DTE) is responsible for enabling enterprise value delivery through the development and execution of global category strategies, strategic supplier partnerships, and advanced commercial outcomes that directly support the company’s digital and AI-driven transformation vision. This role delivers strategic, scalable, and future-ready sourcing solutions across software, cloud, data platforms, AI/ML capabilities, digital engineering, and technology-enabled services, with a focus on accelerating innovation, speed-to-value, and enterprise capability building in support of next-generation data and technology priorities. This leader plays a critical role in shaping and advancing the sourcing strategy and supplier ecosystem that underpin the organization’s DTE transformation agenda, ensuring external partnerships are leveraged to inform, enable, and scale digital and AI abilities. In close partnership with the SVP of DTE and other DTE senior leaders, the Director will proactively influence technology investment decisions, operating models, and partner strategies to enable transformative outcomes. The role is accountable for optimizing external spend, elevating supplier performance, and unlocking innovation through strategic partnerships, while balancing enterprise priorities including speed, quality, risk management, and total cost of ownership. As a trusted advisor, this individual brings market insight and commercial perspective to help shape solution design, demand strategies, and make vs. buy decisions that accelerate transformation. The ideal candidate is a forward-thinking leader with deep expertise in technology sourcing and a strong understanding of digital, data, and AI ecosystems, combined with advanced commercial acumen and a demonstrated ability to structure and negotiate complex, transformation-oriented agreements. This individual will lead and develop a team of sourcing professionals and elevate the function from transactional execution to a strategic, insight-driven partner that actively informs and enables the company’s digital and AI transformation at scale. Key Duties & Responsibilites: Transformation Partnership & Strategic Alignment - Serve as a trusted thought partner to the SVP of DTE and other DTE senior leaders, aligning sourcing strategies to the enterprise DTE transformation vision and roadmap. - Proactively shape and influence technology investment strategies, operating models, and partner selection decisions to enable transformative outcomes. - Translate evolving DTE priorities (e.g., digital, data, AI/ML, engineering transformation) into forward-looking sourcing strategies and supplier ecosystem design. - Embed Strategic Sourcing as a core enabler of transformation, shifting engagement upstream into strategy development versus downstream execution. Category Strategy & Value Creation - Define and lead multi-year, transformation-aligned category strategies across DTE spend areas, integrating innovation, scalability, and speed-to-value. - Identify and utilize non-traditional value levers, including innovation access, capability building, speed acceleration, and risk reduction—beyond cost savings. - Leverage deep market intelligence to position suppliers as strategic enablers of transformation. - Establish KPIs that reflect business impact (e.g., time-to-deploy, innovation outcomes, platform scalability) in addition to financial metrics. Strategic Sourcing & Commercial Outcomes - Lead high-impact, complex sourcing initiatives that enable transformation programs, including cloud modernization, data platforms, and digital engineering. - Design and negotiate innovative commercial models (e.g., outcome-based, consumption-based, co-investment, and partnership models) aligned to transformation goals. - Move beyond traditional RFx approaches by deploying flexible, partnership-oriented sourcing strategies that prioritize capability, speed, and long-term value. - Provide executive oversight on deal strategy, ensuring alignment with enterprise transformation objectives and risk tolerance. Strategic Supplier Partnerships - Design and operationalize a strategic partner ecosystem aligned to DTE transformation priorities, including global cloud providers, platform providers, and technology engineering partners. - Establish deep, executive-level partnerships focused on co-innovation, roadmap alignment, and joint value creation. - Lead governance models that enable continuous innovation, performance transparency, and strategic alignment with key suppliers. - Drive intentional supplier consolidation and elevation, focusing on fewer, higher-impact strategic partners. Business Partnering & Demand Management - Act as a strategic thought-partner to DTE leadership, influencing demand, solution design, and sourcing approaches to maximize enterprise outcomes. - Partner with stakeholders to reframe requirements from specifications to outcomes, enabling more innovative and flexible supplier solutions. - Support make-versus-buy and build-versus-partner decisions in the context of long-term transformation goals. - Ensure procurement is embedded in key transformation programs, investment decisions, and governance forums. Risk, Compliance & Transformation Governance - Balance innovation and speed with robust risk management, ensuring alignment with cybersecurity, data privacy, and third-party risk frameworks. - Embed risk considerations into strategic partner selection and commercial models, particularly for emerging technologies and new delivery models. - Establish governance mechanisms that support agility while maintaining compliance and control. Leadership & Capability Evolution - Lead, develop, and elevate a team of sourcing professionals to operate as strategic advisors and category leaders, setting clear expectations for performance, accountability, and impact aligned to the DTE transformation agenda. - Define and drive capability development priorities across the team, including advanced commercial acumen, technology domain expertise (cloud, data, AI/ML, engineering), and executive stakeholder engagement, ensuring the team can effectively support complex, transformation-oriented initiatives. - Establish clear prioritization frameworks and resource allocation models to focus team efforts on the highest-value transformation-critical initiatives, balancing speed, capacity, and business impact across a dynamic portfolio of work. - Implement scalable tools, playbooks, and standardized ways of working that enable consistent, high-quality category management and sourcing execution across DTE, while allowing flexibility for strategic, partnership-driven engagements. - Actively coach and mentor team members, providing hand-on guidance in strategy development, deal structuring, and stakeholder management to accelerate individual growth and elevate overall team performance. - Foster a high-performance culture grounded in innovation, agility, and continuous learning, embedding data-driven decision making, knowledge sharing, and continuous improvement as core ways of working. Measures of Success - Define and track KPIs that measure transformation impact, including innovation enablement, speed-to-market, and partner performance. - Deliver measurable outcomes across the value creation continuum (e.g. cost, supplier innovation, and stakeholder satisfaction). - Continuously refine sourcing strategies and supplier models to align with evolving transformation priorities. Required Education Level: - Bachelor’s degree in Business, Supply Chain, Technology, or related field (MBA or advanced degree preferred). Required Experience: - 10+ years of progressive experience in procurement, supply chain, or technology-enablement roles, with at least 5 years in leadership. - Deep expertise in developing and leading multi-year, global category strategies across complex spend areas, with the ability to integrate market intelligence, supplier capabilities, and business priorities into actionable strategies that drive enterprise value. - Demonstrated ability to operate as a trusted advisor to senior stakeholders (e.g., CIO, CTO, SVP-level leaders), shaping business strategies, influencing demand, and aligning sourcing approaches to transformation objectives. - Expertise in structuring and negotiating complex, enterprise-level agreements, including software, cloud, and services-based models; ability to design innovative, value-based commercial approaches aligned to business outcomes. - Proven ability to design and manage strategic supplier ecosystems, including development of high-impact partnerships, executive governance models, and performance management frameworks that drive innovation and accountability. - Experience enabling enterprise transformation initiatives through sourcing, including supporting new operating models, digital capabilities, and scalable external partnerships; ability to balance innovation, speed, and risk. - Strong understanding of technology sourcing categories, including enterprise software, cloud platforms, data and analytics, and engineering services, as well as underlying commercial constructs and cost drivers. - Advanced analytical capabilities, including the ability to leverage data, benchmarking, and market intelligence to inform strategies, quantify value, and support executive decision-making. - Strong knowledge of Source-to-Pay (S2P) processes, procurement technologies, and digital tools, with the ability to leverage these capabilities to enhance sourcing effectiveness and transparency. - Strong understanding of contracting principles, risk management frameworks, and regulatory considerations. - Proven ability to lead, coach, and develop high-performing teams, while establishing clear priorities, accountability, and a culture of continuous improvement and strategic thinking. - Expert communication skills, with the ability to clearly articulate complex ideas, influence senior stakeholders, and lead cross-functional alignment in a global, matrixed environment. - Ability to lead cross-functional, enterprise-wide initiatives, manage competing priorities, and drive change in a dynamic, transformation-oriented environment. #LI-Hybrid Pay Range: $180,000 - $270,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Title: Director, S2P COE - Strategy, Governance & Excellence Location: Boston United States Job Description: Job Description The Director, S2P - Strategy, Governance & Excellence is a critical leadership role responsible for establishing the foundational operating model, governance, and standards for the Source‑to‑Pay (S2P) Center of Excellence. This role serves as the architect, steward, and driver of procurement excellence, ensuring scalable processes, strong governance, digital enablement, and continuous capability advancement across the enterprise. This leader will operate at the intersection of strategy, execution, and influence, partnering closely with Sourcing leadership, Finance, Legal, Sustainability, Digital/IT, and business stakeholders to elevate departments impact and maturity. The role directly supports enterprise value creation through supplier relationship management (SRM), small business engagement, supplier excellence, and capability building. The Director will be accountable for Process Design & Optimization, Supplier Programs, and Capability & Change, and will play a visible role in shaping enterprise‑wide procurement transformation. Key Responsibilities - Set the Foundation: Strategy, Governance & Operating Model - Be accountable for end‑to‑end CoE outcomes, including progress against maturity goals, governance effectiveness, and value enablement. - Design and establish enterprise‑level governance frameworks, policies, and standards for Procurement and S2P activities. - Define and maintain the Procurement / S2P CoE operating model, including decision rights, controls, forums, and escalation mechanisms. - Serve as the custodian of procurement standards, ensuring consistency, compliance, and scalability across regions and business units. - Partner with Legal, Finance, Risk, and Compliance to ensure governance frameworks align with regulatory, contractual, and audit requirements. - Drive clarity in roles, accountabilities, and ways of working across the Procurement ecosystem. - Process Excellence & Optimization - Lead end‑to‑end S2P process design, optimization, and standardization, grounded in leading practices and enterprise needs. - Apply a market and benchmarking lens to evaluate S2P maturity, inform standards, prioritize capability investments, and guide future‑state design decisions. - Establish a culture of continuous improvement, leveraging Lean, process excellence, and data‑driven performance insights. - Define and track process performance metrics to monitor efficiency, effectiveness, and user experience. - Ensure process designs are digitally enabled, scalable, and aligned with future‑state technology roadmaps. - Enable External Value & Supplier Excellence - Advance Strategic Supplier Relationship Management (SRM) frameworks to deepen collaboration, innovation, and value realization with key suppliers. - Oversee supplier performance management, development programs, and continuous improvement initiatives. - Champion small business engagement strategies, including program design, governance, reporting, and stakeholder alignment. - Embed sustainability, ESG, and responsible sourcing considerations into supplier governance, performance, and development models. - Partner with category leaders and business stakeholders to move Procurement from transactional execution to strategic value creation. - Capability Building & Change Leadership - Design and execute a Procurement capability‑building strategy, covering skills, behaviors, tools, and career pathways. - Develop structured learning, enablement, and knowledge‑sharing programs across the function. - Lead enterprise‑level change management efforts tied to process, technology, and operating model transformations. - Act as a thought leader and coach, raising the overall maturity and confidence of procurement professionals. - Reinforce a culture of innovation, accountability, and continuous learning. - Performance, Insight & Value Governance - Define the enterprise performance framework for Procurement and S2P, including value, risk, compliance, supplier performance, and maturity indicators. - Establish standards for KPIs, scorecards, and management insights required to enable effective governance, SRM, supplier excellence, and leadership decision‑making. - Act as the business owner of "what must be measured and why," ensuring metrics align to strategy and external value objectives. - Partner with the S2P Process, Controls & Analytics Director on how insights are produced and governed, without owning operational reporting or analytics execution. - Partner with the User Orchestration, AI & Innovation Director to ensure insights influence behavior, adoption, and decision flow, without owning experience design or technology enablement. - Use performance insights to shape priorities, maturity roadmaps, capability investments, and continuous improvement agendas. - People Leadership & Stakeholder Influence - Lead and develop a team of three managers across: - Process Design & Excellence - Small Business Engagement - Capability Building & Change Management - Set clear objectives, empower leaders, and create strong cross‑functional collaboration. - Act as a trusted advisor to senior Procurement and enterprise leaders. - Represent the CoE in executive forums, SteerCos, and cross‑functional governance bodies. - Lead complex negotiations and influence outcomes across senior stakeholders, balancing competing priorities related to governance, risk, capability investment, and business impact. Qualifications & Experience Required - 10+ years of progressive experience in strategic leadership roles within Procurement, S2P, Supply Chain, or adjacent functional domains. - Deep experience in governance frameworks, policy development, and process design within complex organizations. - Demonstrated expertise in Supplier Relationship Management (SRM), supplier performance, and external value creation. - Strong background in capability building, organizational change, and transformation leadership. - Proven ability to operate in highly visible, ambiguous, and matrixed environments. - High proficiency in digital enablement, data, metrics, and performance management. - Track record of building and leading high‑performing teams. Preferred - Experience establishing or scaling a Center of Excellence. - Familiarity with small business programs, diversity sourcing, or supplier sustainability initiatives. - Exposure to global or enterprise‑scale procurement transformations. Leadership Attributes - Enterprise thinker with the ability to balance strategy and execution. - Strong influencer who can lead without authority. - Comfortable operating in complexity and driving clarity. - Credible, confident communicator at executive level. - Passionate about building foundations that enable long‑term excellence and value. Pay Range: $180,000 - $270,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: - Hybrid: work remotely up to two days per week; or select - On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.