Vertex Pharmaceuticals

Principal Engineer, Artificial Intelligence Authoring Location Boston, Massachusetts Employment Type Full-time Work Arrangement Hybrid (Hybrid-Eligible or On-Site Eligible) - Hybrid: Work remotely up to 2 days per week OR - On-Site: Work 5 days per week on-site Salary $166,640–$250,000 annually Job Description: Position Summary: We are seeking a highly skilled and visionary Principal Engineer, AI Authoring to join our AI Authoring Platform team. Reporting to the Director of AI Authoring Platform, you will lead the design, development, and optimization of Vertex’s AI-driven content generation engine. This role is pivotal in shaping the technical architecture of our platform, ensuring the performance, accuracy, and scalability of our LLM-powered authoring tools. You will tackle complex engineering challenges, including automated document workflows and Retrieval-Augmented Generation (RAG)-based architectures, to support the creation of high-quality, compliant, and efficient regulatory documents. Key Duties and Responsibilities - Design and maintain the end-to-end technical architecture for AI-assisted document generation, focusing on modular LLM integration, prompt engineering, and retrieval pipelines, while partnering closely with the AI Architect to ensure alignment with enterprise standards and scalability. - Build and optimize sophisticated Retrieval-Augmented Generation (RAG) systems that accurately pull from vast clinical and regulatory data sources to assist in document creation. - Engineer the data connectors and transformations required to feed structured and unstructured data into AI models for automated document population. - Develop and implement automated testing and validation frameworks to ensure AI-authored outputs meet the strict safety and compliance standards of the Life Sciences industry. - Rapidly prototype new AI authoring features, such as automated summarization or cross-document consistency checks, to determine technical viability before full-scale development. - Serve as the final escalation point for complex technical blockers, from debugging model hallucinations to optimizing cloud infrastructure for high-compute AI workloads. Knowledge and Skills - Proven experience in designing and implementing AI-driven platforms, particularly those leveraging LLMs and RAG architectures. - Expertise in prompt engineering, retrieval pipelines, and modular AI system design. - Strong background in engineering data workflows, including structured and unstructured data integration. - Experience with automated testing and validation frameworks, particularly in regulated industries. - Proficiency in cloud infrastructure optimization for AI workloads. - Exceptional problem-solving skills, with the ability to address complex technical challenges. - Strong collaboration and communication skills to work effectively with cross-functional teams - Familiarity with the Life Sciences industry and its compliance requirements (preferred). - Experience with automated document workflows and AI-based content generation (preferred). Education and Experience - 8+ years of experience in software engineering, with a focus on AI, machine learning, or technical platform development. - Proven track record of leading the design and implementation of AI-driven systems, including LLM-based platforms and RAG architectures. - Bachelor’s or Master’s degree in Computer Science, Artificial Intelligence, Data Science, or a related technical field. - Hands-on experience with cloud platforms (e.g., AWS, Azure, or GCP) and distributed computing systems. - Demonstrated expertise in building and deploying production-grade AI/ML systems in complex, data-intensive environments. - Experience working in regulated industries, such as Life Sciences, is a strong plus. Why Join Us? At Vertex, you will have the opportunity to work on cutting-edge technologies that make a real difference in people’s lives. We offer a collaborative and innovative work environment, competitive compensation, and opportunities for professional growth. If you are passionate about leveraging AI to revolutionize content generation and thrive in solving complex engineering challenges, we encourage you to apply and join our mission to transform lives through innovation. #LI-HYBRID Pay Range: $166,640 - $250,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Title: Associate Director, Contracting Location: 5000 - Vertex US - Fan Pier Job Description: Job Description General Summary: The Managed Care Contracting Associate Director will provide leadership and management oversight of Market Access Contract processes by facilitating negotiation and administration of all Payer, Provider and Trade & Distribution contracts. This person will partner with, among others, Account Management, Finance, Government Pricing & Rebate Operations, GTN, Legal, Marketing and Payer Marketing to ensure appropriate identification and evaluation of contracting opportunities. These responsibilities will apply across all Vertex marketed product lines and pipeline products. Key Duties and Responsibilities: - Manage the end-to-end Payer contract development process, including working with cross-functional partners on pre-deal analytics, negotiations, and post-deal analytics as well as the logging, tracking, reporting and facilitation of contract opportunities through the governance, negotiation/redlining and legal review processes - Develop, maintain and improve strong internal processes and documentation working across the Finance, Legal and Market Access teams - Maintain calendar and matrix of bids/offers and coordinate communication of contract development and execution status - Facilitate the transition of executed contracts to the appropriate operational team for implementation and/or adjudication, including outlining key terms and providing detailed explanations, as necessary - Provide insights to the business that inform GTN forecasting, contracting, and pricing decisions and strategies, and general business planning - Strong cross functional collaboration in support of internal contract processing, review, and reporting - Assist Account Managers with ad-hoc analysis, business planning, and contract performance review - Use financial models to perform and verify calculations for business scenarios, as needed - Advise on strategic and operational issues and requirements related to contract administration including any matters relating to rebate analysis and payments, as well as resolution of disputes on rebate claims Knowledge and Skills: - Progressive business experience in finance, accounting, sales, government pricing, contracting, or other related area - Understanding of pharmaceutical pricing government programs and associated regulations and the ability to determine the impact of contracts on them - Highly analytical and detail oriented, with the ability to define problems, research proposed solutions, analyze the short- and long-term implications, propose and present the results to key stakeholders and implement solutions - Advanced Microsoft Excel, Word and PowerPoint skills - Superior organizational and project management skills as well as polished written and verbal communication skills - Excellent interpersonal skills, customer service commitment, and detail orientation with the ability to work across the organization and external subject matter experts - Be self-motivated, requiring minimal supervision, and able to contribute as a team player - Ability to multitask, shift gears and pivot when necessary, and be comfortable working under constant deadlines - Deep working knowledge of the pharmaceutical and managed care industry including market dynamics and the competitive landscape of formulary coverage, market share and profitability Education and Experience: - Bachelor’s Degree in a business discipline required - Typically requires 8 years minimum experience in payer contracting, contract administration and/or analytics experience in the Pharmaceutical, Life Science or related Industries or the equivalent combination of education and experience Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

• Provide operational, administrative, and process support to the Audit and Inspection Management team. • Collaborate with cross-functional and external stakeholders to facilitate audit planning. • Maintain audit-related records and documentation, and assist in ensuring timely progression and closure of audit deliverables. • Support the management and progression of audit and inspection observation and CAPA records within the applicable quality management system. • Lead coordination of recurring team meetings and prepare meeting agendas and supporting materials. • Maintain and organize team SharePoint sites, document repositories, folders, tools, templates, and reference materials.

Role Description The Regulatory Publishing Manager supports document-level regulatory publishing activities within a global Veeva Vault Publishing environment. This role focuses on preparing submission-ready regulatory documents through advanced Microsoft Word formatting, dynamic linking within Veeva, and compliant PDF generation. This position works within submission documents to ensure technical accuracy, formatting quality, and alignment with global regulatory standards. The role partners closely with document authors and regulatory stakeholders to embed quality into source documents, reduce time-to-file, and improve document reusability. This is an evolving environment requiring a self-starter comfortable working with refining templates, checklists, and processes. - Format complex regulatory documents in Microsoft Word to meet submission-ready standards. - Apply structured formatting, hyperlinks, bookmarks, cross-references, and linking best practices. - Convert Word source files into compliant, high-quality PDFs. - Work within Veeva Vault Publishing to manage document workflows and dynamic linking functionality. - Support report-level publishing (e.g., clinical reports, protocols, periodic reports). - Ensure alignment with global regulatory publishing standards and eCTD requirements. - Partner with document authors and SMEs to build quality into Word source documents early. - Provide guidance on submission-ready formatting standards. - Support refinement of evolving submission checklists and templates. - Manage multiple concurrent document priorities independently. Qualifications - 5–7 years of global regulatory publishing experience. - Strong knowledge of eCTD structure and electronic submission requirements. - Experience with Veeva Vault Publishing (direct experience strongly preferred). - Advanced Microsoft Word formatting expertise. - Experience generating submission-ready PDFs. - Ability to work independently in a developing, non–cookie-cutter environment. - Strong attention to detail and quality mindset. - Effective cross-functional communication skills. Requirements - Bachelor’s degree preferred but not required. - Experience supporting global regulatory submissions required. - Experience working in a system transition or evolving publishing environment preferred. Benefits - Contract Length: Through the end of the year, with the chance to extend. - Pay Range: $65/hr. - $75/hr. - Shift/Hours: Monday - Friday. Remote. EST hours.

Title: Patient Safety Associate Medical Director Location: Boston, MA Job Description: Job Description General Summary: The Patient Safety Associate Medical Director will provide medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development). This role will optimizes patient safety of Vertex products and maintenance of compliance with the Pharmacovigilance regulations of Regulatory Agencies around the globe, through the effective and timely completion of Safety activities through the product life cycle. Key Duties and Responsibilities: - Provides medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development) - Responsible for the safety assessment activities of assigned products under the supervision of a GPS Disease-area Safety Head - Monitors the benefit risk profile of assigned products/portfolio in an ongoing fashion and in accordance GPS processes and procedures - Leads the safety and risk management processes including chairing assigned Disease-area Safety and Product Safety Teams - Identifies, prioritizes and analyzes clinical safety signals, in accordance with GPS procedures - Performs ongoing review of emerging safety data from various sources including single case reports, published literature, aggregate reports, and other sources - Represents the department as medical safety lead on cross-functional study and program teams for assigned products and studies, providing guidance regarding safety matters and issues - Conducts medical evaluation of relevant safety-related information from Toxicology, Non-Clinical studies, as well as Product Quality complaints, as needed - Participates in protocol development, specifically the monitoring and collection of safety information in clinical trial protocols, as well as statistical analysis plans - Participates in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports - Contributes to preparation and review of periodic reports (DSUR, PSUR, PADER) contributing medical strategy and expertise to content, authoring applicable analysis and content - Review and provides medical content, as needed, for key study-related documents, e.g. IB, ICF, IDMC Charter - Assists in departmental development activities including SOP and Work Instructions development - Provides guidance to staff regarding optimal practice regarding collection, evaluation and processing of adverse experience reports, from a medical perspective - Provides support in Partner /Affiliate agreements and interactions, as needed - Other activities as needed or as requested by GPS management Knowledge and Skills: - Broad and extensive knowledge of medicine, pharmacovigilance and relevant regulations - Extensive evidence of effective delivery of high quality safety relevant documents. - Broad knowledge of relevant concepts in data management and systems, pharmacoepidemiology and statistics, including the interpretation of complex data and information - Communicates complex issues in an understandable, effective and relevant manner. - Strong influencing skills with the ability to explain and defend positions regarding significant issues in the face of opposition - Strategic focus regarding activities, with proactive planning and prioritization skills. - Takes ownership of appropriate issues and appropriately delegates - Technical expertise in pharmacovigilance and clinical safety - Excellent analytical and problem solving skills, with sound autonomy and applied judgment - Appropriate experience with Regulatory Agency and key stakeholder interactions - Experience with ICSR case review and Aggregate Safety analysis and reports Education and Experience: - MD, DO or equivalent ex-US medical degree - Typically requires 3 years of experience with relevant experience in Safety/Pharmacovigilance, or the equivalent combination of education and experience Pay Range: $200,000 - $300,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

• Track and report GCP privacy events within RDQ in accordance with established procedures and workflows. • Manage a shared Privacy mailbox and related correspondence, ensuring timely tracking and follow up of related items. • Support Privacy Event Management, including initial assessments, guidance through resolution, and documentation to closure. • Analyze privacy risks and help implement appropriate mitigation strategies. • Provide documentation and coordination support to the RDQ Governance & Risk Management team. • Design, build, and maintain a centralized SharePoint site for the RDQ Governance & Risk Management team.

• Develop and maintain an integrated OCM plan for Quality transformation programs. • Develop and maintain a portfolio-level view of OCM demand, priorities, risks, and resource needs across multiple Quality transformation initiatives. • Translate project scope, timeline, document changes, system releases, and process changes into a clear adoption roadmap. • Define OCM activities by change impact level: low, medium, high, and transformational. • Integrate OCM milestones into the broader project plan and phase gate process. • Identify adoption risks early and recommend mitigation actions. • Build stakeholder maps across Quality, Manufacturing, Labs, MSAT/ASAT, Regulatory, Technical Operations, Data, IT, Training, and external partner teams as applicable. • Conduct role-based change impact assessments. • Identify changes to responsibilities, decision rights, review behaviors, escalation paths, data usage, system interactions, and governance. • Group impacted populations by level of change and required OCM support. • Identify where new or updated SOPs/WIs require additional behavior change, training, communications, or manager reinforcement. • Support sponsors and senior leaders in articulating the case for change. • Develop sponsor talking points, leadership messages, and reinforcement actions. • Help leaders understand where visible sponsorship is required to reduce resistance and drive adoption. • Prepare leadership updates for program governance and Steering Committee forums. • Develop targeted communication plans for impacted stakeholder groups. • Create practical messaging that explains what is changing, why it matters, who is impacted, what actions are required, and when. • Support SME briefings, roadshows, office hours, FAQ development, manager toolkits, and readiness sessions. • Ensure communications are aligned with the project timeline, document effective dates, training deployment, and go-live waves. • Partner with Training, Quality Systems, process owners, and SMEs to ensure training is role-based and tied to actual future-state execution. • Identify where training alone is insufficient and where coaching, walkthroughs, job aids, or readiness checks are needed. • Support go-live readiness assessments across people, process, technology, data, documents, and support model. • Define readiness criteria for each go-live wave. • Define 30/60/90-day sustainment plans after go-live. • Establish adoption metrics, feedback loops, issue escalation paths, and business-as-usual ownership. • Monitor adoption risks, behavior drift, workarounds, and inconsistent execution. • Ensure lessons learned are captured and fed into future phases and programs.

Lead the strategy and operational delivery for ELN platforms, develop a team for platform support, and partner with scientists to ensure compliant and scalable solutions for experiment data capture across laboratory environments.

Title: Executive Director, Alliance Management Location: 5000 - Vertex US - Fan Pier Job Description: General Summary: The Alliance Management Executive Director will lead the Alliance Management team in supporting the effective execution of global partnering at Vertex. All alliance managers will report to the Alliance Management Executive Director, who will be responsible for ensuring a consistent Alliance Management user experience across the company and helping to resolve issues across all alliances. In addition, the Alliance Management Executive Director will be a spokesperson for the function within Vertex and be responsible for keeping key stakeholders and senior leaders updated on collaboration status and engaging them in issue resolution and relationship management as appropriate. The Alliance Management Executive Director will continue to build processes and procedures for the Alliance Management function at Vertex as we grow our BD portfolio to ensure risks are appropriately managed, stakeholders are engaged, our relationships are healthy and that Vertex continues to grow its reputation as a world-class partner. In addition to their management and leadership responsibilities, the Alliance Management Executive Director will be directly responsible for the effective management of specific collaborations, overseeing governance, issue resolution and negotiation, financial payments and Vertex’s continued compliance with our agreements. Key Duties and Responsibilities: - Oversee entire Alliance Management team and management of all collaborations across the Vertex portfolio - Develop processes and best practices to enhance Alliance Management function at Vertex and support continued growth of our external partnerships - Develop strong relationships internally and externally to ensure coordination in collaboration activities - Proactively issue spot across all collaborations & drive resolution process; effectively negotiate with partners - Oversee governance for specific collaborations - Ensure consistency across Alliance Management function and project teams Knowledge and Skills: - Ability to lead cross-functional teams; able to manage through ambiguity and influence with and without authority - Strong negotiation skills - Ability to effectively work with senior leaders - Clear, concise written and verbal communication skills - Understanding of drug development and commercialization process - Ability to understand and manage complex legal agreements touching on a range of technologies and differing partnership models - Strong active listening and interpersonal skills - Proactive, organized and comfortable managing shifting priorities in a rapidly changing environment Education and Experience: - Bachelor's degree required - Typically requires 15 years of professional experience, or a equivalent combination of education and experience Pay Range: $264,000 - $396,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Title: Senior Director, Public Policy And Reimbursement Location: Washington, DC Full time job requisition id REQ-29368 Job Description General Summary: Vertex is seeking a highly experienced and strategic Senior Director, US Public Policy and Reimbursement to lead the development and execution of Vertex’s US Public Policy strategy on policy issues related to access to innovative medicines, with a primary focus on Medicare, Medicaid and related issues. This role will serve as a primary subject-matter expert, strategic architect, and external-facing leader within the U.S. Public Policy and Reimbursement team, working to advance favorable public policies that are both aligned with enterprise goals and support product specific reimbursement strategies amid a rapidly evolving legislative, regulatory, and litigation landscape. The Senior Director will be responsible for collaborating closely with our internals teams to understand key barriers and issues affecting our brands, portfolios and business at the State and Federal level; developing and executing strategies that align with Vertex’s core business objectives and ensure patient access to our innovative medicines; and engaging with the Centers for Medicare & Medicaid Services (CMS) and other relevant federal departments and agencies, policy stakeholders, trade associations, and industry peers to advance Vertex’s priorities. The role will not only monitor and analyze policy developments but proactively shape the external environment — cultivating relationships with key policymakers and stakeholders as well as positioning Vertex as a credible and constructive voice in policy discussions. The ideal candidate will have a deep understanding of the US healthcare system, particularly Medicare and Medicaid, and a proven track record of successfully navigating complex policy and reimbursement landscapes. Key Responsibilities: - Develop and execute comprehensive public policy and reimbursement strategies to support Vertex’s business objectives and optimize, mitigate, or enhance policy changes related to access to innovative medicines. - Serve as the primary point of contact with CMS, advocating for policies that support patient access and align with Vertex’s mission, including through rulemaking cycles and ad hoc opportunities. - Build and maintain strong relationships with key policy stakeholders, including government agencies, trade associations, and industry peers. - Monitor, analyze, and interpret federal healthcare policies, regulations, and legislative developments, providing strategic insights and recommendations to internal stakeholders. - Collaborate with cross-functional teams, including Market Access, Legal, and Commercial, to align policy strategies with business priorities, keep them apprised of policy developments, and seek directional input. - Represent Vertex in external forums, including industry coalitions, trade associations, and public policy discussions, to advocate for policies that support innovation and patient access. - Lead the development of policy positions, white papers, and other materials to effectively communicate Vertex’s perspective to policymakers and stakeholders. - Provide strategic guidance to senior leadership on emerging policy trends and their potential impact on Vertex’s business and patients. - Manages certain policy consultants, ensuring that expertise is fully utilized and that deliverables are timely and of high-quality, Qualifications: Required Qualifications: - Bachelor’s degree in public policy, health policy, political science, or a related field. - Minimum of 12-15 years of experience in public policy, government affairs, or a related field, with a strong focus on healthcare policy and reimbursement. - Deep knowledge of the US healthcare landscape (especially Medicare and Medicaid), as well as the biopharmaceutical industry, policy/political landscape, reimbursement/access issues, and regulatory and legislative processes. - Proven experience engaging with CMS, trade associations, and other policy stakeholders. - Strong strategic thinking and analytical skills, with the ability to translate complex policy issues into actionable business strategies. - Excellent communication and interpersonal skills, with the ability to build relationships and influence diverse stakeholders. Preferred Qualifications: - Advanced degree (e.g., JD, MPH, MPP, MBA) is strongly preferred. - Experience working in the biotechnology or pharmaceutical industry. - Demonstrated ability to lead cross-functional teams and manage multiple priorities in a fast-paced environment. - Strong understanding of the broader US healthcare system, including commercial and government payers. Pay Range: $248,000 - $372,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.