• Oversee an indirect team of approximately 50 full-time employees • Managing staff, including all HR-related matters across the employee lifecycle • Ensuring governance, control, and SLA performance for transaction accuracy, quality, and timeliness • Supervising financial activities, including monthly, interim, and year-end closures • Driving cost efficiencies, improved working capital, and cash flow management • Functioning as the end-to-end finance and accounting delivery partner • Continuously reviewing operations to ensure process maturity • Preparing and presenting monthly and executive change management business reviews on operational performance • Identifying new business opportunities and revenue streams • Managing contracts to ensure compliance, mitigate risks, and optimise vendor relationships • Leading best practice adoption, process optimisation, and efficiency enhancements through insight analytics • Implementing robotic process automation to enable teams to focus on higher-value tasks

• Represents the department and serves as the liaison between Systems Development, Process Improvement, and business end-users from all functional areas • Determines operational objectives within the department • Reviews, analyses, and proposes modifications to business systems to support departmental business needs • Communicates departmental business technology priorities to Systems Development and Process Improvement • Manages internal department business technology projects • Writes and maintains user documentation, provides training to end-users • Provides support and communicates potential business impact to end-users from all functional areas, acting as an escalation point and subject matter expert for departmental business technology systems • Participates in department initiatives related to new and existing business applications

• Serve as the primary operational interface between clients and offshore BIM/VDC teams • Lead client onboarding, governance meetings, technical alignment, and delivery reviews • Translate project requirements and design intent into clear direction for production teams • Oversee BIM/VDC coordination activities across architectural, structural, and MEP disciplines • Develop and maintain BIM standards, templates, workflows, content libraries, and execution procedures • Support clash detection, coordination issue tracking, constructability reviews, and installation planning • Manage Autodesk Construction Cloud (ACC/BIM 360) collaboration environments and workflows • Support scan-to-BIM and point cloud coordination workflows • Ensure project quality, schedule adherence, and operational performance expectations are met • Provide technical leadership, training, and best practice guidance to internal and client teams • Collaborate with Client Services and executive leadership to support account growth and strategic initiatives

• Define and lead Ionis’ channel operations strategy across Specialty Pharmacies, Specialty Distributors, and other key distribution channel accounts in support of current brands, launches, and future portfolio growth. • Own the design, governance, and continuous improvement of the end-to-end distribution channel operating model, including forecasting, inventory management, allocation, reporting, partner management, and issue escalation with assigned accounts. • Serve as the senior Trade & Distribution lead for U.S Commercial Distribution operations in S&OP/IBP, launch readiness, and cross-functional business planning forums, ensuring channel considerations are incorporated into enterprise decisions. • Own short-, mid-, and long-range distribution channel demand forecasting and support product and account level forecasting through integration of channel data, launch assumptions, access dynamics, and commercial insights. • Establish distribution channel inventory strategies, targets, and guardrails, and lead recommendations on allocation decisions by balancing patient need, contractual commitments, service expectations, and commercial priorities. • Provide strategic oversight of distribution channel inventory, ordering patterns, service performance, and other operational KPIs, and lead cross-functional action plans to address emerging risks and performance gaps. • Develop and maintain executive-level reporting, dashboards, and business reviews that translate distribution channel performance, demand signals, and market developments into clear, actionable recommendations. • Build and sustain senior-level relationships with external distribution channel partners and key accounts, representing Ionis as a strategic and effective manufacturer partner. • Lead governance with distribution channel partners, including business reviews, performance management, service issue resolution, and expectations related to data, reporting, and operational execution. • Influence channel-related contracting strategy by providing operational, service-level, inventory, and reporting perspectives during contract discussions and renewals. • Partner closely with Supply Chain, I&A, Finance, FP&A, Brand, Market Access, Sales, Marketing, and Patient Services leaders to align distribution channel strategy with commercial objectives and business plans. • Define policies, standards, and decision frameworks for channel operations that improve consistency, control, scalability, and readiness across products and channels. • Apply deep understanding of the operational implications associated with pharmacy benefit and medical benefit products, including specialty pharmacy, buy-and-bill, site-of-care, and patient journey considerations. • Lead the ongoing development of Distribution Channel Operations as a capability, including organizational structure, process design, talent strategy, and succession planning. • Lead through direct and matrix influence to strengthen accountability, execution, and collaboration across internal stakeholders and external partners. • Ensure distribution channel operations decisions and actions support compliance expectations, operational rigor, and Ionis’ commitment to patient access and business continuity. • Manage work and decisions with a longer-term view, recognizing the impact of channel strategy on launches, product performance, patient experience, and enterprise results.