Role Description The Senior Staff Software Engineer is responsible for designing, developing, and delivering business-critical instrument control software for next-generation sequencing platforms. This is a highly visible, cross-functional role that works closely with mechanical, electrical, firmware, and systems engineering teams at PacBio. This role is ideal for a deeply technical engineer who thrives on solving complex system-level challenges and driving high-impact software solutions at the intersection of hardware and software. - Own and deliver business-critical instrument control software spanning multiple subsystems, directly impacting instrument performance, reliability, and customer experience. - Drive technical design and implementation for complex, high-risk areas, independently defining approach and managing technical risk. - Collaborate cross-functionally with mechanical, electrical, firmware, and systems teams to ensure robust hardware-software integration and clear requirements. - Identify and resolve systemic issues in performance, reliability, and scalability, including proactively addressing technical debt. - Lead design and code reviews while contributing hands-on development in C#/.NET, ensuring high-quality, maintainable software. - Influence system architecture and technical direction, and mentor engineers to elevate team-wide engineering standards. Qualifications - Bachelor’s degree in Computer Science, Engineering, or a related discipline. - 10+ years of software engineering experience. - Deep expertise in C#/.NET and proficiency in Python. - Strong experience with real-time or embedded systems and hardware-software integration. - Experience working with hardware systems such as robotics, optical systems, environmental sensors, or motion control. - Strong proficiency with Linux environments. - Solid understanding of software architecture, design principles, and best practices. - Experience developing instrument control software, user interfaces, and system-level integrations. - Experience designing and implementing APIs (e.g., RESTful services). - Demonstrated ability to independently drive complex technical projects from concept to production. - Excellent interpersonal, written, and verbal communication skills. Requirements - Experience developing scientific instrumentation. - Master’s degree or higher in a technical field. - Experience working with firmware and low-level system interactions (e.g., FPGA interfaces). - Experience with Agile software development methodologies. - Experience with DevOps practices, CI/CD pipelines, and automated testing frameworks. - Experience in life sciences, biotech, medical devices, or other regulated environments. - Candidates must have current authorization to work in the United States without the need for present or future sponsorship. Benefits - Salary Range: $144,500.00 - $253,600.00.