Role Description We are seeking an exceptional Executive Support Lead & Business Operations professional who thrives in a dynamic environment and is motivated by the opportunity to contribute across multiple areas of the business. This role is instrumental in enabling the CEO and Leadership Team to operate effectively, ensuring priorities are well-coordinated and execution runs smoothly across the organization. The position will begin with a focused scope centered on executive support, with a clear path to expand into broader operational responsibilities as the individual builds context, trust, and readiness. What You’ll Do - Executive Support & Prioritization - Manage the CEO’s complex calendar, ensuring strategic prioritization of time, alignment with organizational goals, and coordination of meetings with other top industry executives. - Oversee all travel logistics and expense management for the CEO with efficiency and discretion. - Proactively manage the CEO’s inbox and correspondence, ensuring timely responses and appropriate escalation and closure of critical matters. - Anticipate the CEO’s needs and emerging needs of the team and stakeholders, identify potential conflicts or risks, and proactively develop action and contingency plans. - Track and manage CEO’s and your own critical and urgent tasks to ensure triage, escalation, and closure on a timely basis, ranked on urgency and impact. - Board & Executive Governance - Coordinate and facilitate all Board of Directors engagements, including scheduling, logistics, and preparation of high-quality, engaging materials. - Partner with the CEO to lead and manage end-to-end execution of monthly Executive Committee meetings and quarterly Board meetings, ensuring alignment on priorities, progress, and outcomes. - Drive the development of high-quality materials—including polished pre-reads—delivered in advance of Board and executive sessions. - Coordinate content inputs from across the Leadership Team and individual contributors ensuring adequate lead time and review time to avoid last-minute delivery. - Strategic & Operational Enablement - Prepare and synthesize information and prepare agendas focused on key decisions, creating space for discussion and decisions for executive discussions. - Capture key insights, decisions, and action items from high-impact meetings, ensuring disciplined follow-up and timely execution across the organization. - Provide strategic support to the CEO and leadership team on operational priorities, helping drive execution timelines and organizational alignment. - Co-own Leadership Team agendas, ensuring focus on critical priorities and effective use of executive time in weekly and quarterly forums. - Stay ahead of events calendar, identifying, scoping, directing, and delivering work products needed to support upcoming engagements and events. - Cross-Functional Collaboration - Partner closely with HR, Finance, and Delivery teams to spot improvement opportunities and streamline workflows to improve operational efficiency. - Support executive leadership with preparation of reports, presentations, and key documents for internal and external audiences. - Confidentiality & Judgment - Handle highly sensitive and confidential information with the utmost discretion and professionalism. - Apply sound judgment and deep understanding of company operations, policies, and leadership priorities to support decision-making and execution. Qualifications - 5+ years of progressively responsible experience supporting senior executives, ideally in a high-growth or dynamic environment. - Strong understanding of business operations and administrative functions. - Advanced proficiency with Microsoft Office and collaboration tools (Outlook, PowerPoint, Excel, Word). - Knowledge and experience leveraging GenAI tools like Microsoft Copilot 365. - Exceptional organizational and time management skills. - Meticulous attention to detail paired with a proactive, solutions-oriented mindset. - Excellent written and verbal communication skills. - Demonstrated initiative and sound judgment. - Continuous improvement mindset. - High level of discretion and integrity. - Collaborative and adaptable work style. Requirements - Full-Time - 5-10% Travel expected

Role Description The Vice President, Operations and Analytics will serve as the organization's principal architect and steward of data-driven execution and technology. Reporting to the Chief Strategy Officer, this leader will transform organizational data, systems, and technology into actionable insight and high-impact operations — while ensuring that our performance story is told compellingly to funders, partners, boards, and the communities we serve. This role exists to ensure that strategy is consistently and effectively executed through disciplined implementation and rigorous analysis. The VP will build and lead a team of analytics and operations professionals, managing at least one direct report to start, and will serve as a cross-functional leader across the organization. Qualifications - 10+ years of relevant leadership experience, including at least 3 years managing cross-functional teams or direct reports in a fast-paced, mission-driven environment - Deep analytics expertise: demonstrated ability to design and manage integrated data systems, performance frameworks, and impact measurement infrastructure - AI and technology fluency: proven experience applying AI-enabled analytics, automation tools, and enterprise systems to advance organizational goals - Track record of external communication: experience presenting data and impact findings to boards, funders, government agencies, or public audiences with clarity and confidence - Equity-centered practice: demonstrated experience using disaggregated data to identify disparities and partnering with program or policy teams to drive more equitable outcomes - Strong alignment with Leading Edge’s mission and values, particularly regarding sector-wide talent, leadership, and workplace culture advancement. Requirements - Exceptional systems thinking — the ability to see how strategy, data, technology, and people connect and to design solutions that hold together over time - Strong execution orientation with a track record of translating complex plans into operational reality - Collaborative, cross-functional leadership style that builds trust and alignment across teams with diverse expertise - Excellent written and verbal communication skills, including the ability to distill complex analysis into clear, actionable narratives for varied audiences - Deep commitment to the organization’s mission and the communities it serves - U.S.-based and authorized to work in the United States Benefits - 100% coverage for employees and 50% coverage for spouses and dependents for medical, dental, and vision - Retirement matching, wellness benefits, ample flex time, and a three-month paid parental leave - Generous professional development stipend

• Supports the identification and prioritization of deliverables across clinical departments (i.e., Medical Writing, Biostatistics, Drug Safety, Clinical Science), organizes cross-functional teams and tracks progress against goals and timelines • Understands and advises on functional priorities within the context of enabling larger organizational success. • Supports business planning, such as budget review, resource forecasting, goals review, etc. • Supports business data collection and analysis, helps track delivery against corporate and department goals and collaborates with Department Heads on Quarterly Business Reviews • Problem solves by leveraging understanding of business and functional relationships to activate right people and solutions. • Spends time connecting individuals and teams within function, across functions and across the organization. • Serves as a thought partner for vision and goal setting and partner with teams to drive functional short-to-long-term business planning and execution. • Keeps Department meetings on track with focused agendas and objectives. Takes minutes and tracks deliverables as appropriate, follows up on deliverables as needed. • Anticipates needs of CMO and Department Heads and prompts actions and conversations that enhances team success. • Helps the CMO and Department Heads balance needs of the function and needs of the overall organization. • Advises on new approaches to address organizational needs and complex challenges within Departments and broader organization • Identifies opportunities to leverage synergies and eliminate redundancies, drives operational excellence, helps control spend • Collaborates with PMO team to align on priorities, processes and tools • Represents Clinical Organization in appropriate meetings and committees • Must adhere to Iovance Biotherapeutics’ core values, policies, procedures, and business ethics. • Perform miscellaneous duties as assigned.

• Serve as a strategic partner to executive leadership, shaping long-term direction and contributing to enterprise-level decision making • Own the analytical foundation and narrative for board-facing decisions, ensuring strategies are supported by rigorous analysis and sound business logic • Evaluate key drivers including unit economics, portfolio performance, and operational trade-offs, and provide actionable recommendations • Partner with Finance on forecasting, scenario analysis, and financial planning for strategic initiatives • Design, implement, and continuously improve the company’s operating model, including business reviews, quarterly planning, and executive reporting • Manage prioritization processes to ensure alignment with business objectives as the organization scales • Develop and enhance reporting frameworks, dashboards, KPIs, and scorecards to provide a consistent view of performance • Lead company-wide initiatives that span multiple functions, including Operations, Finance, Compliance, and Technology • Translate executive priorities into structured plans with clear scope, ownership, timelines, and success metrics • Ensure alignment between business requirements and technical execution by connecting strategy with delivery • Leverage data and analytics to inform decision making, build insights, and support leadership priorities • Identify trends and emerging risks across the business and proactively highlight areas requiring attention • Build strong relationships across leadership and functions, acting as a trusted partner in solving complex challenges • Operate with a high degree of autonomy while maintaining close alignment with PMO leadership