• Refine Tilt Collective’s US strategy to identify the most critical levers of change, the most effective approaches Tilt should prioritize, and the ecosystem required to achieve it. • Articulate Tilt Collective’s US strategy clearly and concisely, in a way that can be understood by donors and other audiences. • Proactive outreach to different parts of the food systems field – learning from the environment, health, consumer, farmer, and other constituencies to develop an effective strategy. • Work with Tilt Collective's leadership team, other country/region leads, and thematic program leads to identify cross-learning and opportunities that span various markets. • Scope a range of potential US grantees and initiatives across a range of fields (e.g. health, economy, food security, climate, animal advocacy, water). • Manage the process to secure grant approvals. This will require engaging with our Leadership Team and Grants function to ensure grant proposals meet organizational requirements. • Provide ongoing support and strategic guidance to grantees during the grant execution period. • Establish and ensure the execution of directed networks, in which coordination mechanisms are in place to align grantee efforts towards common goals. • Identify gaps in the ecosystem and seek to fill them, potentially through grantmaking. • Engage with philanthropy and grant-making institutions to support fundraising, in coordination with our fundraising team. • Help to build the salience for our US program and for Tilt Collective as a delivery partner among donors.

Director, Patient Services, Market Access Location: Cambridge United States Job Description: Director, Patient Services, Market Access Who we are: At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture - one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion - because our differences shape how we hire, collaborate, and innovate. Our team's proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific - it's deeply personal, grounded in the meaningful connections we have built. To learn more, visit www.agios.com and follow Agios on LinkedIn and X . The impact you will make: Agios Pharmaceuticals is searching for a dynamic Director, Patient Services, to join our growing Market Access team. We want someone who cares about this important work, and who's driven to connect to our mission of helping these patient communities. The Director, Patient Services, is responsible for the strategic leadership and efficient execution of the patient support program for sickle cell at Agios. This leader will oversee the end-to-end operations of patient services, spanning hub services, case management, and specialty pharmacy coordination and ensuring exceptional patient and healthcare provider experiences. The Director drives performance against key business objectives (access, affordability, adherence, and service quality) and spearheads continuous improvement across services. In partnership with cross-functional teams, this role aligns patient services strategy with broader organizational goals, compliance standards, and evolving patient and regulatory needs. What you will do: Operational Leadership: Oversee patient services operations (hub services, case management, specialty pharmacy coordination) with a focus on efficient, compliant, and patient-centric program delivery. Establish and monitor KPIs and performance metrics to drive operational excellence and implement process improvements that enhance the patient and HCP experience. Program Strategy & Execution: Design, implement, and optimize patient support programs (e.g., access, co-pay/affordability, adherence) that align with brand strategy and market access objectives. Drive innovation in service delivery models to improve patient outcomes and scalability while ensuring readiness for new product launches, label expansions, and program growth. Cross-Functional Collaboration: Build strong partnerships with internal stakeholders (e.g., Market Access, Sales, Training, Marketing, Ops and Analytics, Medical, Compliance, IT) and act as the key liaison to external partners (such as hub service providers). Ensure patient services initiatives are integrated with overall corporate strategy and that launch-readiness and ongoing operations are executed seamlessly across teams. Vendor & Partner Management: Oversee third-party vendors and partners (patient support hubs, co-pay vendors, specialty pharmacies), ensuring they meet contractual obligations, compliance requirements, and performance expectations. Conduct regular business reviews, address gaps through corrective action plans, and foster a collaborative environment with partners to achieve service excellence. Team Leadership & Development: Lead and mentor a high-performing patient services team-including two senior manager direct reports-fostering a culture of accountability, collaboration, and continuous improvement. Provide coaching, performance management, and professional development for staff to drive engagement and results. Empathy-Driven Patient Support: Champion a culture of empathy and respect across the patient services team and vendor partners, recognizing the lived experience and complexity of sickle cell disease. Ensure patient interactions, program design, and issue resolution reflect a high-touch, patient-first approach. Governance & Financial Oversight: Manage patient services budgets and resource allocation to ensure cost-effective operations. Establish robust governance processes and quality controls for patient support programs to maintain high standards, compliance, risk mitigation, and audit readiness. Data-Driven Improvement: Leverage data and analytics to inform decision-making and optimize program performance. Develop dashboards and reporting tools to monitor patient journey metrics, identify trends, and guide strategic enhancements for more effective patient services delivery. What you bring: Education & Experience: Bachelor's degree required (advanced degree such as MBA/MPH or related field preferred). 8-12+ years of progressive experience in patient services, healthcare operations, or a related function within the pharmaceutical/biotech industry, including significant leadership roles managing teams and complex support programs. Industry & Technical Knowledge: In-depth understanding of patient support program models, including patient hubs, reimbursement processes, specialty pharmacy distribution, and case management services. Experience with reimbursement landscape and patient access challenges is essential. Strategic & Operational Expertise: Proven track record of designing, scaling, and improving patient services or market access programs. Experience in supporting product launch readiness, program expansion, and implementing best practices for scalability. Familiarity with risk management strategies and REMS program requirements is a plus. Leadership & Communication: Demonstrated ability to lead and develop high-performing teams. Excellent communication, collaboration, and stakeholder management skills, with the ability to influence across functions and engage with senior leadership and external partners. Analytical & Financial Acumen: Strong analytical and problem-solving capabilities. Experience using data-driven insights to guide decisions and optimize performance. Financial acumen, including experience managing budgets and vendor contracts, is highly valued. Compliance Orientation: Solid knowledge of healthcare compliance, privacy (e.g., HIPAA), and relevant regulatory requirements for patient support programs. Commitment to maintaining the highest ethical and compliance standards. Strategic thinking with a strong execution focus Leadership skills, including talent development and team empowerment Operational excellence mindset and continuous process optimization Ability to collaborate cross-functionally and influence without authority Deep patient-centric focus and commitment to service quality Adaptability and resilience in a fast-paced, evolving environment Concerned that you don't check off every box in the requirements listed above? Please apply anyway! At Agios, we value each other's differences and recognize that teams thrive when everyone brings their unique experiences to the table. We are dedicated to building an inclusive, diverse, equitable, and accessible environment where all employees can bring their whole selves to work. If you're excited about this role but your previous experience doesn't align perfectly with the job description, we still encourage you to apply. You may be just the right candidate for this role or another opening! Work Location: Location Agnostic: Work location for this role is based on employee's individual preference. This role has the ability to be either remote in the US or hybrid in our Cambridge Headquarters. Hybrid schedules vary but are generally less than 3 days per week onsite and hybrid employees are expected to live within commutable distance to our Cambridge Headquarters. Remote employees work entirely from home except for attending Company sponsored events/ meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate to the above job description.. What we will give you: Deliberate Development. Your professional growth as one of our top priorities. Flexibility. We're all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you're at your best, we're at our best. Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website. Competitive and equitable performance-based compensation. This includes base salary and both short- and long-term incentives that are connected to our business strategy and vary based on individual and company performance. The current base salary range for this position is expected to be between $183,549 and $275,324 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries. Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We're continuously looking to improve the inclusivity of our workforce. Commitment to community. We're an active participant in the communities that surround us - the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked. Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.

Title: Associate Director, Global Safety Lead Primary Work Location; Remote - US Job Code; 2410 # of openings; 1 Job Description: Who we are: At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture – one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion – because our differences shape how we hire, collaborate, and innovate. Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific – it’s deeply personal, grounded in the meaningful connections we have built. To learn more, visit www.agios.com and follow Agios on LinkedIn and X. The impact you will make: Agios Pharmaceuticals is searching for a dynamic AD, Global Safety Lead to join our growing Medical Safety and Risk Management team. We want someone who cares about this important work, and who’s driven to connect to our mission of helping these patient communities. The Global Safety Lead is an exciting opportunity within the Medical Safety and Risk Management (MSRM) function at Agios to drive and develop safety and risk management strategy in our rare genetic disease program. The Global Safety Lead will have an important role in implementing best-in-class safety and risk management processes and working with multiple functions across the company. What you will do: • Responsible for safety strategy for one or more clinical protocols and/or products • Proactively assesses and evaluates the clinical implications of safety data from all sources in order to understand and communicate the benefit-risk profile of assigned drugs in development and in the post-marketing settings as appropriate • Ensures that important safety issues are addressed in a timely fashion; ensures a deep understanding of the potential issue and high quality data presentations • Represents medical safety at the Clinical Trial Working Group(s) for each assigned protocol • Responsible for driving collaborative and timely safety discussions at Safety Management Team(s) • Contributes to key clinical and regulatory documents including safety sections of protocols, investigator brochures and informed consent forms, and regulatory submissions including IND, NDA and PIP/PSP documents. • Contributes to scientific publications (abstracts, posters, papers) for scientific meetings and approves the submissions from a safety perspective • Strategically contributes to the development of key safety messages for internal communications and reviews all communication to the public from a safety point of view • Contributes to safety documents including periodic safety reports (including DSURs, PADERs and PBRERs) • Contributes to the writing and/or review of the RMP/REMS documents and their maintenance, in collaboration with the safety sciences function • Prepares and participates in independent data monitoring committee (IDMC) meetings • With support from safety scientists, conducts/supports routine and ad hoc signal detection and evaluations according to SOPs and guidelines • Contributes to continuing improvement of MSRM processes and systems • Provides support to ICSR medical review as needed • Supports product Therapeutic Area head in other activities as appropriate What you bring: • MD/DO with a minimum of 3 years of industry experience in safety or clinical development and relevant clinical practice experience. Complete residency program in hematology is a plus. • Previous experience in drug safety pre-approval (ranging from early to late-stage) and/or in the post-marketing setting • Demonstrated knowledge and tangible experience in pharmacovigilance and risk management • Solid knowledge and understanding of global pharmacovigilance regulatory requirements and general regulatory expectations • Fluent in verbal and written English. • Excellent written/verbal communication and interpersonal skills • Demonstrated persuasion, influencing and negotiation skills to effectively drive discussions and decisions toward desired end-results. • Ability to interact effectively and collaboratively in cross-functional teams Concerned that you don’t check off every box in the requirements listed above? Please apply anyway! At Agios, we value each other’s differences and recognize that teams thrive when everyone brings their unique experiences to the table. We are dedicated to building an inclusive, diverse, equitable, and accessible environment where all employees can bring their whole selves to work. If you’re excited about this role but your previous experience doesn’t align perfectly with the job description, we still encourage you to apply. You may be just the right candidate for this role or another opening! Work Location: Location Agnostic: Work location for this role is based on employee's individual preference. This role has the ability to be either remote in the US or hybrid in our Cambridge Headquarters. Hybrid schedules vary but are generally less than 3 days per week onsite and hybrid employees are expected to live within commutable distance to our Cambridge Headquarters. Remote employees work entirely from home except for attending Company sponsored events/ meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate to the above job description.. What we will give you: • Deliberate Development. Your professional growth as one of our top priorities. • Flexibility. We’re all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you’re at your best, we’re at our best. • Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website. • Competitive and equitable performance-based compensation. This includes base salary and both short- and long-term incentives that are connected to our business strategy and vary based on individual and company performance. o The current base salary range for this position is expected to be between $185,369 and $308,948 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. • Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries. • Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We’re continuously looking to improve the inclusivity of our workforce. • Commitment to community. We’re an active participant in the communities that surround us – the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Role Description The Client Director (Strategic Accounts) is the owner of Complexio's most important enterprise relationships post signature. Your primary mandate is customer success — accountable for value realisation, adoption, retention, and long-term partnership growth, with every renewal earned by outcomes already delivered. You also serve as the technical translator and feedback loop between the customer and Complexio's Product and Engineering teams, and when the situation requires it, you can run a full commercial cycle independently — but this is a supporting capability, not the centre of the role. You will shadow both Co-CEOs in strategic customer meetings and represent Complexio at C-suite level with full authority and credibility. - Senior owner of a portfolio of strategic enterprise accounts — multi-threaded relationships from day-to-day users through to C-suite, accountable for retention, health, and long-term partnership growth - Drive value realisation with the customer — co-define success metrics, drive adoption of the full Complexio platform (Event Knowledge Graph, Context Broker, Stevie, Enterprise Automator) against clear use cases, and maintain a customer-signed value narrative refreshed every QBR - Own account health and on-time renewals — track leading indicators, run structured recovery plans on at-risk accounts, and treat every renewal as earned by outcomes delivered - Own account revenue across renewal, upsell, and cross-sell — accountable for retained ARR and Net Revenue Retention; capable of running renewal and expansion cycles end to end, including procurement, legal, and contracting - Act as the technical translator between customer and Complexio Product/Engineering — hold credible architecture, integration, and security conversations with customer CTOs and IT teams without escalating every question, and convert operational requirements into structured Product input - Voice of the customer inside Complexio — feed prioritised, actionable feedback into Product Management on what works, what's friction, and what's missing - Lead executive engagement at C-suite level — represent Complexio independently, shadow Co-CEOs in strategic meetings, and orchestrate internal teams (Solution Engineering, Delivery, Product, Support) around shared account priorities Qualifications - 7+ years in a senior post-sale role — Customer Success, Account Management, Client Partner, or equivalent — managing strategic enterprise accounts in B2B SaaS or enterprise software, with a track record of driving Net Revenue Retention through documented value delivery - Executive presence and commercial capability — credible at C-suite level (alongside or in place of Co-CEO leadership), able to run renewal and expansion cycles independently including procurement and contracting - Technically fluent without being an engineer — able to translate between customer and Complexio Product/Engineering, hold credible architecture and security conversations, and convert operational requirements into structured Product input - Highly organised and proactive — disciplined enough to manage multiple high-complexity accounts simultaneously, calm under pressure, and energised by scale-up environments Requirements - Sector background in maritime, shipping, energy, or industrial; experience with AI, data platforms, or knowledge graphs; enterprise accounts in the $500k–$5M+ ACV range; ability to step into a hunter role when situations have called for it Benefits - Senior individual contributor role with strategic influence over Complexio's most important customer relationships - Competitive base + performance component tied to retention, value realisation, and expansion outcomes - Direct access to the Co-CEO and senior leadership team - Opportunity to shape Complexio's customer success frameworks as the company scales