AstraZeneca, a global biopharmaceutical company led by science, discovers, develops, and commercializes prescription medicines. Since 1999, AstraZeneca has push
Director – Process Design and Optimisation
Location
United Kingdom
Posted
26 days ago
Salary
0
Seniority
Lead
Job Description
Director – Process Design and Optimisation
AstraZeneca
Director – Process Design and Optimisation in Chemical Development locations UK - Macclesfield time type Full time job requisition id R-250536 Job Title: Director – Process Design and Optimisation in Chemical Development Location: Macclesfield, UK Hybrid working model, 3-5 days per week onsite About us: At AstraZeneca, we're united by a bold ambition: to push the boundaries of science and deliver life-changing medicines to patients worldwide. As a global, science-led biopharmaceutical company with an exciting and robust portfolio of nearly 200 investigational therapies at varied stages of clinical development (including >20 at late-stage), we transform pioneering research into breakthrough treatments across oncology, cardiovascular, respiratory, and rare diseases. Here, your talent will contribute to innovations that truly matter—helping us reimagine healthcare and create a healthier future for all! Introduction to role: We are seeking a highly skilled and motivated leader to join the Chemistry function within AstraZeneca’s Chemical Development department as Director – Process Design and Optimisation Are you ready to apply your extensive leadership skills and drug development experience, to guide and inspire our chemists in process design and optimisation, turning bold science into reliable medicines for patients? As Director (senior team manager), you will set the technical direction for modern process design and optimisation, whilst leading your team to deliver high quality, robust sustainable commercial processes, manufacturing campaigns, control strategies and future-proofed regulatory submissions. Through exploiting innovative science, cutting edge technologies and AI / data-driven solutions, you will empower your team to reduce risk and shorten timelines, enabling confident clinical supply and launch Accountabilities: Through leading a process design and optimisation team in Chemistry, you will drive Technical excellence in project delivery: - Applying your experience to successful accountability for drug projects at both Chemistry Section and Chemical Development functional levels - Acting as a source of expert guidance for development of chemical processes, technology transfer and clinical drug substance manufacture both internally and externally. You will facilitate on-time, right quality clinical API supplies and strong data packages, designed to seamlessly support onward process characterisation and finalisation - Delivery of CMC regulatory submissions for clinical and marketing phases – guiding and supporting authorship of drug substance submissions and developing harmonised control strategies at the substance-product interface. Acting as an experienced reviewer, you will reduce risk and seek opportunities to drive the best outcome for the business, via excellence in authorship and response to regulatory questions Senior line-management of a Chemistry technical team, including: - Sophisticated coaching and mentoring to support professional development of ~8-10 highly skilled scientists and scientific leaders, up to and including Principal Scientist level - Advanced performance management – goal setting and regular feed-forward to drive high impact contributions at all levels, generating impactful, meaningful career pathways for each member of your team - Mentorship, coaching and onboarding of first-time team leaders and support and guidance for our wider chemistry team manager community - Driving key elements of SHE and cGxP compliance for our Chemistry section Contributing to key elements of our Chemistry Strategy including: - Identification and execution of improvement programmes to enhance the capability and capacity of the Chemistry function to deliver their contribution to drug substance projects, through strong career pathways for our people - Working across the section to specifically champion integration of innovative route design and process design, with associated support for modern business processes including scale-up assessment and control strategy development. Employing cutting edge AI / data techniques where appropriate, you will drive efficiency across the process design and optimisation area for the business - Understanding the external science and technology landscape to champion innovation and curiosity within process design and optimisation, you will work across interfaces to improve standards and ways of working which impact across the whole project lifecycle Essential Skills/Experience: - Degree, PhD or equivalent experience in Chemistry, plus an additional 8+ years’ experience in synthetic drug substance pharmaceutical development - Proven high-impact people leadership experience, with a track record of delivery at Associate Director (Team Manager) level; effectively managing, coaching and developing scientific teams to deliver complex projects - Expertise in development and scale-up of synthetic chemistry to deliver commercially viable manufacturing processes in mid-to-late phase development, including advanced understanding of process design and optimisation. Proven experience in collaboration with interface groups such as analytical chemistry, chemical engineering, particle science and drug product in order to achieve your goals - Strong understanding and experience of delivery across the drug development process, especially late-stage development to support Phase 3 clinical studies and launch, including control strategy development - Strong project management skills developed through personal leadership and delivery of drug projects, as well as the capability to support multiple projects simultaneously within the team - Proven CMC-wide experience and an appreciation of how to generate the best impact for patients. Demonstrated application of this experience to high quality regulatory delivery through authoring and reviewing module 3.2 regulatory submissions and/or response to health authority questions - Demonstrated experience of managing change through continuous improvement, increasing efficiency and with measurable impact inside and outside of a Chemical Development setting - Track record of driving the introduction of digital approaches and new synthetic / manufacturing platforms or technologies, and examples of publicising these achievements to the outside world - Extensive experience of leading senior scientific staff / peers to deliver high impact improvements to ways of working, as well as projects in both an internal and external development and manufacturing setting When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world! ***Please note: we operate a rolling recruitment process and may close this vacancy early if a strong candidate is identified. Early applications are strongly encouraged. Competitive salary and benefits package on offer. The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, a performance recognition scheme and a competitive, generous remuneration package Why AstraZeneca: Here, your leadership turns complex science into dependable supply for patients worldwide. You will work with pioneering chemistry, digital technologies, and lean principles, side by side with colleagues who put unexpected teams in the same room to crack tough problems. With a truly global network and strong investment in people and modern facilities, you will grow your impact and your career—learning from diverse teams, shaping standards across sites, and contributing to a more sustainable future. We value kindness alongside ambition, and we back decisive leaders who take ownership and deliver outcomes that matter. Call to Action: Step forward to lead the chemistry that scales breakthrough molecules into life-changing medicines—and shape what’s next! Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Related Guides
Related Categories
Related Job Pages
More Director Jobs
Structural Director - Water Infrastructure
AECOMWe are the world’s trusted infrastructure consulting firm.
Title: Structural Director - Water Infrastructure Location: Newcastle, Sydney, Australia Company Description “Business and technical acumen are valued attributes, where people are given the freedom and encouragement to work in areas that they are not only their strengths but explore other areas of interest” – Dominique Keirens, Technical Director – Water Gold Coast, QLD Work with Us. Change the World. At AECOM, we're delivering a better world. Whether improving your commute, keeping the lights on, providing access to clean water, or transforming skylines, our work helps people and communities thrive. We are the world's trusted infrastructure consulting firm, partnering with clients to solve the world’s most complex challenges and build legacies for future generations. Become part of our dynamic Water business which boasts around 600 experts across Australia and New Zealand and 6000 globally. Collaborate with top-tier civil, mechanical, electrical, and process engineers to deliver a variety of captivating projects, from small initiatives to large-scale ventures, all the way from concept to completion. At AECOM, you’ll thrive in an inclusive and forward-thinking environment where your contributions are valued. Everyone belongs at AECOM We’re committed to diversity, equity, inclusion, and belonging - because great ideas come from diverse perspectives. AECOM is proud to be a Fortune 500 Most Admired Company, a WGEA Employer of Choice for Gender Equality, Work180 Equitable Workplace Awards 2025 Winner an AWEI Bronze Tier LGBTQ+ Inclusive Employer. Job Description This role can be based in either Melbourne, Canberra, Sydney, Newcastle, Gold Coast, Sunshine Coast or Brisbane offices. As the Structural Director for our Water Infrastructure team, you will provide technical leadership and governance for structural scopes across major water programs. Your role will involve leading the structural design process from concept through detailed design and delivery support, ensuring compliance with Australian standards and client requirements. You will champion digital delivery and quality, advancing model-based coordination and analysis workflows to enhance productivity. In addition to managing scope, risk, and program delivery, you will mentor and develop talent within the team, fostering a culture of excellence and continuous improvement. By partnering with clients and delivery teams, you will shape bids and execution plans, maintaining strong, long-term relationships that drive successful project outcomes. Your expertise will be pivotal in delivering resilient and sustainable water infrastructure solutions across Australia. How you’ll make a difference • Lead structural engineering for major water infrastructure programs from concept to delivery. • Set design strategies and ensure compliance with Australian codes and client standards. • Conduct design reviews and inspections, providing construction phase support. • Champion structural excellence for water retaining/process structures (e.g., tanks, pump stations). • Drive digital delivery and quality through model-based coordination and automation. • Mentor and grow talent, providing technical guidance and development pathways. • Collaborate across regions to enhance structural capability and client outcomes. • Manage scope, risk, and budgets to deliver on-time, sustainable results. Qualifications The qualities that help you thrive • Tertiary qualifications in Civil/Structural Engineering; RPEQ and/or CPEng preferred. • Experience in structural design for water retaining/process structures to Australian standards. • Proven leadership of project/technical teams with strong communication skills. • Proficient in FEA and structural design software for complex analysis. • Passion for mentoring and developing others in a collaborative environment. • Expertise in Australian Standards (e.g., AS 3600, AS 5100) and digital delivery methods. If you don’t tick every box, we still want to hear from you — your potential and mindset matter. All applications will be considered. Additional Information • By joining us, you’ll collaborate with teams across Australia, New Zealand and our global network, accessing diverse projects and professional growth opportunities. • We welcome flexible working arrangements and strive to accommodate individual needs and preferences. • We are an equal opportunity employer and encourage applications from all backgrounds. Why you’ll love working with us • Flexible work arrangements, including alternative start/finish times, part‑time, job‑sharing and hybrid options • Purchase up to 6 weeks’ additional annual leave per year • Volunteer and representation leave • Flex public holidays – swap Easter or other public holidays for those that suit you better Join us in shaping the future of water infrastructure in Australia — where your expertise will drive sustainable solutions and make a lasting impact on communities. AECOM acknowledges the Traditional Owners and Custodians of the lands on which we, our clients and our communities live and work around Australia. We pay our respects to their cultures and to their Elders — past, present, and emerging. We are committed to connecting to Country in our work through meaningful engagement with First Nations peoples and businesses. About AECOM AECOM is the world’s trusted infrastructure consulting firm, delivering professional services throughout the project lifecycle – from advisory, planning, design and engineering to program and construction management. On projects spanning transportation, buildings, water, new energy and the environment, our public- and private-sector clients trust us to solve their most complex challenges. Our teams are driven by a common purpose to deliver a better world through our unrivaled technical and digital expertise, a culture of equity, diversity and inclusion, and a commitment to environmental, social and governance priorities. Freedom to Grow in a World of Opportunity You will have the flexibility you need to do your best work with hybrid work options. Whether you’re working from an AECOM office, remote location or at a client site, you will be working in a dynamic environment where your integrity, entrepreneurial spirit and pioneering mindset are championed. You will help us foster a culture of equity, diversity and inclusion – a safe and respectful workplace, where we invite everyone to bring their whole selves to work using their unique talents, backgrounds and expertise to create transformational outcomes for our clients. AECOM provides a wide array of compensation and benefits programs to meet the diverse needs of our employees and their families. We also provide a robust global well-being program. We’re the world’s trusted global infrastructure firm, and we’re in this together – your growth and success are ours too. Join us, and you’ll get all the benefits of being a part of a global, publicly traded firm – access to industry-leading technology and thinking and transformational work with big impact and work flexibility. As an Equal Opportunity Employer, we believe in each person’s potential, and we’ll help you reach yours.
Director of Engineering
Scout SpaceScout Space is a defense and space manufacturing company working to make sure operations in space are safe and sustainable amidst increasing congestion and uncertainty. According t
Title: Director of Engineering Location: Reston, VA - Remote Job Description: Scout is building a new way to see and operate in space: with a new paradigm of data empowering every satellite to make space safer. We are a rapidly growing team; we are deploying real solutions to orbit over the next 2 years; and our work will transform the face of spaceflight. We are looking for people who bring excitement and energy to our organization, are curious and eager to learn, and want to help drive our programs forward. Scout Space is seeking a mission-driven Director of Engineering to lead the execution, growth, and technical direction of our engineering organization. This leader will be responsible for scaling a multidisciplinary team across hardware, software, and autonomy while delivering high-performance space-based sensing systems to government and commercial customers. The role sits at the intersection of technical excellence, operational execution, and team leadership, ensuring that Scout’s payloads, flight software, and data products are delivered on time, meet mission requirements, and push the boundaries of on-orbit capability. Responsibilities - Lead and scale a multidisciplinary engineering organization spanning optical, mechanical, electrical, firmware, flight software, autonomy, and mission systems engineering - Drive execution of complex space payload programs and architecture decisions from concept through design, integration, test, launch, and on-orbit operations - Coordinate closely with the executive team on product, program management, and business development to align the engineering team and execution with customer needs, mission objectives, and company roadmap - Establish and enforce engineering processes, standards, and best practices to ensure high-quality, flight-ready systems - Build and mentor high-performing engineering teams, fostering a culture of collaboration, accountability, innovation, and continuous improvement - Support proposal efforts, including technical strategy, architecture definition, and programmatic inputs - Qualifications: - Bachelor’s degree in Aerospace Engineering, Electrical Engineering, Mechanical Engineering, Computer Science, or related technical field - 10+ years of experience in aerospace, defense, or related high-reliability engineering environments - 5+ years of experience leading engineering teams and delivering complex hardware/software systems - Demonstrated experience delivering space systems (payloads, spacecraft, or related subsystems) from concept to operations - Strong understanding of spacecraft systems engineering, including integration across hardware, software, and operations - Experience with space-based sensing systems, optical payloads, or autonomy/AI-driven systems is highly preferred - Proven ability to manage technical risk, schedules, and cross-functional dependencies in fast-paced environments - Experience working with U.S. Government customers and programs - Ability to obtain and maintain a TS/SCI clearance - Preferred Qualifications: - Master’s degree in Aerospace Engineering, Electrical Engineering, Mechanical Engineering, Computer Science, or related technical field - Experience scaling engineering teams in a startup or high-growth environment - Background in space domain awareness (SDA), remote sensing, or on-orbit autonomy - Familiarity with flight software architecture (e.g., modular frameworks, onboard autonomy systems) - Experience with production and manufacturing of space hardware, including supply chain and vendor management - Strong track record of leading teams through design reviews (SRR, PDR, CDR) and flight qualification - Experience supporting or leading capture/proposal efforts for government programs - Benefits - Open Time Off - Paid Parental Leave - Medical, Dental, Vision Insurance - 401k Matching - Health Savings Account, Flexible Spending Accounts, Dependent Care FSA - Wellness Stipend - Work From Home Stipend - Life Insurance - Long-term Disability plans - Commuter Benefit - Education Reimbursement - Don't fulfill all the qualifications listed above? If you still feel like you might be a good fit, please feel free to APPLY ANYWAY. We believe in a well-rounded team, and this sometimes means that someone with out-of-context knowledge can contribute just as well as someone with very explicit alignment with our capabilities needs stated. Our positions are based in Reston, Virginia, with much of our team operating in a hybrid or remote fashion. Our preference is for candidates in or around this area (or willing to relocate) as we scale our facilities and engineering team to provide more opportunities to work and collaborate in-person. This position involves access to technology that is subject to U.S. export controls. Any job offer made will be contingent upon the applicant’s capacity to serve in compliance with U.S. export controls. Scout Space Inc. does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy and gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service, or other non-merit factor. To conform to US Government space technology export regulations, applicants must be a US citizen, lawful permanent resident of the US, a protected individual as defined by 8 USC 1324b(a)(3), or eligible to obtain the required authorization from the US Department of State. We’re Proud to Prioritize Mental Health. Scout Space has been recognized with the Bell Seal for Workplace Mental Health by Mental Health America. This certification reflects our ongoing commitment to creating a supportive environment where mental well-being is valued, protected, and openly talked about. We know that when people feel seen and supported, great work happens, and that is the kind of culture we are building here at Scout Space. Compensation is based upon candidate experience and qualifications, as well as market and business considerations. Summary pay range: $175,000-230,000.
• Cultivate and maintain strong relationships with healthcare stakeholders within hospitals and other assigned accounts to identify qualified leads, grow market share and increase revenue, and reduce customer attrition. • Deliver on quarterly & annual orders and revenue sales targets; maximize profit margin on equipment and service contract sales. • Leverage knowledge of customers’ strategic goals, market position, and budget to develop offerings that deliver greater value to the customer, driving funnel growth for the region. • Demonstrate expertise in customers’ installed base and develop technology & capital plans that map with their annual budget process. • Lead the account community team and orchestrate deals and long-term plans that align with a mutually beneficial strategy that contributes to increased market share, revenue, and profitability. • Reduce cycle time by leveraging Salesforce.com (CRM tool) to track customer and account activity, to map visibility and drive market share, and to prioritize sales funnel.
Associate Director, Biostatistics
Bristol-Myers SquibbHeadquartered in New York, New York, Bristol-Myers Squibb is a global biopharmaceutical company that works to develop and deliver medicines to help treat a broa
Collaborate in designing clinical trials, author and review statistical documents, and present data analyses clearly. Provide statistical leadership and manage multiple studies to ensure adherence to standards within therapeutic areas.


