Job Closed

This listing is no longer active.

Senior Clinical Data Manager

Location

United States

Posted

47 days ago

Salary

$130K - $170K / year

Seniority

Lead

Job Description

Senior Clinical Data Manager

Pharming Group N.V.

Role Description The Senior Clinical Data Manager (Sr. CDM) serves as the primary in‑house data management expert within a near-to-fully outsourced clinical execution model. This role provides strategic oversight and hands‑on leadership of all data management activities across the development programs in the Pharming portfolio. The goal of this role will be to ensure timely, accurate, and compliant data delivery across the Pharming portfolio. - Building fit for purpose data capture systems - Database cleaning - Coordination of third-party data transfers to facilitate trial reporting - Ensuring end‑to‑end data quality, SDTM/ADaM traceability, and accuracy of all statistical outputs Responsibilities - Provide expert guidance on data implications for protocol design, endpoints, and operational feasibility. - Act as the primary liaison between Pharming and vendor data management and biostatistics teams. - Review and approve CRO plans, including Data Management Plans, CRF completion guidelines, edit check specifications, and data review plans. - Oversee CRO and vendor performance, ensuring adherence to timelines, data quality standards, and contractual deliverables. - Partner closely with Clinical team members, Safety and Regulatory to ensure cross-functional alignment on data strategy. - Support the development of study-specific database builds using study protocol and configuration specifications, including performance of the User Acceptance Testing (UAT). - Review SAPs and TLF mock shells for feasibility, completeness, and alignment with collected data, ensuring complete end-to-end traceability: CRF → SDTM → ADaM → TLF outputs. - Periodically conduct targeted QC of key listings (e.g., AEs, SAEs, ConMeds, labs, vitals, exposure, efficacy assessments) to identify outliers, missing data, unexpected patterns, and data inconsistencies; drive their resolution with CROs. - Manage clinical data cleaning and delivery activities, including (soft) database lock, for interim analyses, DMC/DSMB reviews, and final CSR. - Ensure all data cut and database lock criteria are met and documented. - Ensure alignment between data management findings and statistical programming outputs. - Ensure AE/SAE data quality, including reconciliation with safety narratives and coding consistency (e.g., MedDRA). - Validate treatment-emergent flags, exposure metrics, and safety population definitions produced by CRO partners. - Lead TFL review workshops and data review meetings with Medical, Safety, and Clinical Ops. - Manage ad-hoc biostatistics and data requests from Health Authorities (e.g., FDA, EMA) during NDA/BLA review and coordinate rapid turnaround analyses and data outputs with CRO Biostats/Programming. - Support data output and review for medical and scientific presentations/publications. - Collaborate with Regulatory Affairs to track requests, ensure timely responses, and document resolutions. - Drive both strategy and delivery of all data management related items. - Other duties as assigned. Qualifications - At least 6 years of clinical data management experience in the pharmaceutical/biotech industry, preferably in a small biotech. - Bachelor’s or Master’s degree in a scientific or technical discipline. - Expertise with EDC systems (e.g., Rave, Veeva, Inform) and vendor data pipelines. - Solid understanding of SAS outputs, derivations, and dataset structures (SAS programming experience a plus but not required). - Proficiency with CDISC standards, Pinnacle 21, and submission metadata tools. - Experience using AI tools to enhance work product and increase efficiency. - Proven experience overseeing outsourced DM/Biostats activities. - Experience supporting regulatory submissions (NDA/BLA) preferred. - Commitment and alignment to Pharming’s mission, core values and behaviors. Salary Range The base salary range for this job is from $130,000 to $170,000 per year. Pharming takes into consideration a combination of candidate’s work experience, training, and education, as well as the scope of the role, complexity, and external market and internal value when determining a salary level. Benefits - A fully remote work schedule - Competitive compensation package including annual target bonus - Long-term incentive program - 401(k) plan with company match - Paid Time Off (PTO) - 13 Company Holidays per year - Excellent benefit plans including medical, dental, and vision - Flexible spending accounts - Company-provided life insurance, short-term disability, and long-term disability plans - Optional accident, hospital indemnity, critical illness, and pet insurance plans - Tuition reimbursement program - Health and wellness program - Choice of company provided mobile phone or cell phone stipend

Related Categories

Related Job Pages

More Data Scientist Jobs

Whatnot logo

Data Scientist, Finance

Whatnot

Whatnot is an online community marketplace where people can work to “turn their passion into a business.” In past hiring for flexible roles, the venture-bac

Data Scientist47 days ago

• Partner closely across the business to find improvements/opportunities and influence decisions using data analytics methodologies and tools. • Act as the data owner for Finance functions, including but not limited to accounting, tax, strategic finance, profitability, and the executive office. • Build production-quality data products, dashboards, notebooks, and actionable KPIs to convey critical financial insights. • Drive incremental improvements in contribution margin by deeply understanding business drivers and analyzing cross-functional initiatives. • Collaborate on data and analytics engineering work to ensure financial datasets are enriched, reliable, and scalable.

California
$194K - $215K / year
Twilio logo

Staff Data Scientist

Twilio

Build the future of communications.

Data Scientist47 days ago
Full TimeRemoteTeam 5,001-10,000H1B Sponsor

• Translate business objectives into a data science roadmap that prioritizes high-LTV (Lifetime Value) growth • Dig into the science of our self-service funnel and graduation to Sales to uncover optimization opportunities, diagnose issues, and provide actionable recommendations through data products • Identify leading indicators of revenue and build data science models that surface high potential opportunities • Serve as a key technical advisor to GTM leadership across Sales and Marketing • Build extensive knowledge of user behavior, the customer purchase and usage experience, and our lead funnel to inform data science solutions • Develop sophisticated recommendation engines that identify "next-best-action" opportunities within our existing customer base, ensuring sales and marketing engagement the right person at the right time • Build robust frameworks to measure the incremental impact of your data products, moving beyond simple correlation to prove true ROI • Leverage machine learning and generative AI capabilities to support Product-led-growth (PLG) initiatives • Partner with Data Engineering to define the long-term roadmap for GTM data architecture, ensuring high-fidelity 'source of truth' data for signals like product-qualified leads (PQLs) • Oversee the seamless integration of data products into the daily workflows of stakeholders, ensuring insights are delivered where they work (Slack, CRM, Wiki/Docs, Tableau, email, etc.) • Create documentation, dashboards, reports, and executive summaries for your data products • Partner with Sales, Marketing, Enterprise Technology, Product, and Ops teams to bring relevant data science products to life

California + 5 moreAll locations: California | Connecticut | New Jersey | New York | Pennsylvania | Washington
$155.5K - $228.7K / year

Senior Data Scientist - Optimization

NTT DATA Services

NTT DATA is a $30 billion business and technology services leader, serving 75% of the Fortune Global 100. We are committed to accelerating client success and positively impacting society through responsible innovation. We are one of the world's leading AI and digital infrastructure providers, with unmatched capabilities in enterprise-scale AI, cloud, security, connectivity, data centers, and application services. Our consulting and Industry solutions help organizations and society move confidently and sustainably into the digital future. As a Global Top Employer, we have experts in more than 50 countries. We also offer clients access to a robust ecosystem of innovation centers as well as established and start-up partners. NTT DATA is a part of NTT Group, which invests over $3 billion each year in R&D.

Data Scientist47 days ago

Role Description We are currently seeking a Senior Data Scientist - Optimization to join our team in Remote, Texas (US-TX), United States. NTT DATA is seeking a client-facing senior level Data Scientist with deep expertise in Optimization and Operations Research (OR) to lead high-impact consulting engagements. This role blends advanced quantitative modeling, data science leadership, and executive-level client interaction. You will partner closely with clients to solve complex operational and strategic problems using optimization, analytics, and AI-driven decisioning. - Lead and deliver client-facing data science and optimization engagements, ensuring high satisfaction and measurable business outcomes. - Define project objectives, scope, timelines, and success metrics in collaboration with client stakeholders and internal teams. - Establish and maintain strong executive-level client relationships, gaining a deep understanding of business challenges and operational constraints. - Communicate complex mathematical, optimization, and technical concepts clearly and credibly to non-technical and senior audiences. - Prepare and deliver executive-ready updates, insights, and recommendations, including sensitivity analyses and scenario-based findings. - Conduct market research, develop informed perspectives, and communicate thought leadership to clients and internal stakeholders. - Lead the design, formulation, and delivery of operations research and optimization models for large, complex enterprises. - Translate ambiguous business problems into rigorous mathematical formulations and scalable optimization solutions. - Develop and refine models across domains such as: - Resource allocation - Scheduling and workforce optimization - Cost and network optimization - Vehicle routing - Strategic planning (e.g., facility opening/closing, multi-period network modeling) - Apply deep expertise in optimization solvers (e.g., Gurobi preferred, CPLEX or similar) to deliver robust, production-ready solutions. - Scrutinize model outputs, perform sensitivity and trade-off analyses, and clearly articulate implications and recommendations to stakeholders. - Handle data sets of varying complexity, including large-scale, distributed, and streaming data environments. - Assemble, process, and validate large, complex data sets that meet both functional and non-functional requirements. - Implement batch and real-time model scoring to support operational and strategic decision-making. - Apply strong business acumen to analyze data, produce insights, and develop impactful reports and analyses. - Perform ad hoc and exploratory analyses in response to evolving client and business needs. - Collaborate with data engineers, architects, and business stakeholders to resolve data quality, availability, and information flow issues. Qualifications - 7+ years of experience supporting data science projects in a consulting or professional services environment. - 7+ years of experience across one or more of the following areas: Predictive Analytics, Data Design, Statistics, AI / Machine Learning, MLOps. - 2+ years of hands-on experience in Operations Research, Optimization, and Mathematical Modeling. - 3+ years of experience using Python, R, and/or C# to analyze disparate datasets and develop analytical solutions. - Ability to travel up to 25%. Preferred Qualifications & Skills - Master’s degree in Operations Research, Industrial Engineering, Applied Mathematics, Data Science, or a related field preferred. - Demonstrated ability to work independently with minimal guidance while engaging practice leadership as needed. - Strong consulting mindset with exceptional problem decomposition, prioritization, and solutioning skills. - Excellent verbal and written communication skills, with the ability to influence senior and executive stakeholders. - Consistently demonstrates strong teamwork, professionalism, and a results-driven work ethic. - Maintains a flexible, "can-do" attitude and commitment to client and team success. Location & Work Arrangement - United States, with a preference for Atlanta, GA; Louisville, KY; or New Jersey. - Primary work location is remote, with occasional travel to client sites for key workshops, working sessions, and executive presentations. Compensation Where required by law, NTT DATA provides a reasonable range of compensation for specific roles. The starting pay range for this remote role is $144,975.00 - $241,265.00. This range reflects the minimum and maximum target compensation for the position across all US locations. Actual compensation will depend on a number of factors, including the candidate’s actual work location, relevant experience, technical skills, and other qualifications.

United States
$145.0K - $241.3K / year
Job Closed
HERE Technologies logo

Senior Data Scientist

HERE Technologies

The world's leading location platform company

Data Scientist47 days ago
Full TimeRemoteTeam 5,001-10,000Since 1985H1B No Sponsor

• Design, develop, and deploy computer vision and machine learning models to automatically extract map‑observable features from satellite imagery • Leverage and adapt vision foundation models and modern deep learning techniques for geospatial feature extraction at global scale • Build scalable, production‑ready ML pipelines that process large volumes of satellite imagery with high accuracy and efficiency • Integrate ML outputs into HERE’s mapmaking systems, ensuring alignment with cartographic quality, consistency, and accuracy standards • Address real‑world geospatial challenges such as variable imagery resolution, diverse sensors, regional differences, and environmental conditions • Define evaluation metrics, conduct experiments, and drive continuous improvement of model performance and map data quality • Collaborate cross‑functionally with data engineering, mapping, and product teams to translate business needs into ML solutions

United States
$140K - $160K / year
Job Closed