Role Description This is a remote position. We are seeking a detail-oriented and self-motivated Plumbing Estimator to manage our end-to-end bidding process for US-based construction projects. This is a remote role, aligned to US working hours, and well suited for experienced estimators based in South Africa who are interested in the US construction market. In this role, you will take ownership of plumbing estimates from opportunity identification through bid submission. You’ll work closely with US general contractors (GCs), analyze full construction plan sets, and deliver accurate, competitive estimates that help secure new work across commercial and residential projects. This position can be performed fully remotely, with estimating, takeoffs, GC communication, and bid management all handled online. Key Responsibilities - Identify and pursue new bid opportunities via GC portals, plan rooms, and direct outreach - Attend virtual pre-bid meetings and coordinate bid requirements - Review architectural, mechanical, and plumbing drawings; perform detailed takeoffs - Prepare accurate plumbing estimates using Excel and/or estimating software - Solicit pricing from suppliers and subcontractors; manage bid deadlines - Follow up with GCs, negotiate scope and pricing, and support bid closeout - Maintain a bid log and manage an active pipeline of opportunities Qualifications - Minimum 3+ years of plumbing estimating experience (commercial experience preferred) - Strong ability to read and interpret full construction plan sets - Proficiency with takeoff/estimating tools such as Bluebeam, OST, or similar - Understanding of US plumbing systems (DWV, water service, gas, underground) - Willingness to work US hours and collaborate with US-based stakeholders - Self-starter with strong organization and time management skills - Familiarity with US plumbing codes and standards Nice to Have - Prior experience estimating US-based projects Benefits - Competitive Salary - Completely Remote Position

• Develop scientific relationships with hematology thought leaders, investigators, and treatment centers focused on multiple myeloma and related hematologic malignancies. • Serve as Karyopharm’s scientific representative and facilitate balanced, compliant scientific exchange. • Gather and communicate medical insights, treatment trends, competitive intelligence, and unmet needs. • Support clinical trial awareness, site identification, and investigator engagement activities in partnership with Clinical Development. • Support investigator-sponsored research and scientific collaboration opportunities. • Participate in advisory boards, congresses, steering committees, and medical education initiatives. • Partner closely with Medical Affairs, Clinical Development, Commercial, Market Access, and HEOR teams. • Mentor less experienced MSLs and contribute to special projects as assigned.

• Validate documentation accuracy and ensure financial and funding readiness. • Create Sales Orders (SO) in LN. • Perform final accuracy checks on all received documentation. • Identify financial or system issues prior to installation execution. • Review all received documentation for completeness and accuracy. • Escalate documentation accuracy concerns as necessary. • Maintain system integrity by following established ERP entry standards. • Validate funding method, payment status, and financing details for completeness. • Ensure consistency between upstream systems and LN. • Manage assigned ERP entry queue to meet SLA expectations. • Maintain detailed system notes and documentation to support audits or corrections.

• Collaborate with project sponsors/stakeholder groups to understand scope of a project • Utilize pre-existing parametric estimating tool to generate parametric estimates in accordance with AACE estimate class requirements for substation and transmission projects based on conceptual scope of work for the project • Utilize existing estimating templates to generate assembly-level cost estimates for projects based on detailed scope of work and 30-50% engineering design • Facilitate the identification of changes to the parametric estimating tool to provide data in a more usable format for subsequent use in the project schedule and cost management • Utilize estimates vs actuals cost comparisons from projects to refresh & update cost data in parametric estimating tool • Revision of existing cost data in parametric estimating tool, to assist with structuring of the enterprise estimating system and work with developers for implementation • Improve coordination of estimates to avoid duplication of estimates, improve ownership, and avoid overlaps in estimate scope • Train estimators on revised tools, especially for contracted estimators and assist with development of standard work instructions to standardize project scoping and estimating • Ability to use estimating software to generate cost estimates and to go through the QAQC process • Have the flexibility to attend client and company meetings as needed