Karyopharm Therapeutics Inc.

• Lead, manage, coach, and develop a team of field-based Medical Science Liaisons focused on solid tumors • Provide strategic and tactical direction to ensure the MSL team executes against medical priorities • Establish clear performance expectations, goals, metrics, and development plans for direct reports • Active member of GMSA Leadership team • Recruit, interview, hire, onboard, and retain highly qualified field medical talent • Support the professional development and career growth of MSL team members through coaching • Spearhead strategic initiatives • Deliver updates and presentations to senior leadership • Ensure representation of MSL team on select clinical/medical study teams

• Own the U.S. EC brand strategy and multi-year commercial roadmap; deliver an annual Brand Plan/AOP with clear objectives, KPIs, milestones, and investment choices aligned to franchise and corporate priorities. • Define and evolve positioning, message platform, and customer value proposition; translate clinical and real-world evidence into differentiated, compliant claims and communications. • Lead lifecycle planning and strategic scenario work (e.g., competitive response, biomarker-driven opportunities, combination strategies, line-of-therapy expansion opportunities, and treatment sequencing dynamics), partnering with cross-functional leaders to evaluate options and trade-offs. • Drive U.S. EC launch strategy and readiness from pivotal data readout through launch execution, defining launch milestones, critical path, and cross-functional workstreams. • Develop customer segmentation and targeting strategy across key stakeholders, including gynecologic oncologists, medical oncologists, academic cancer centers, community oncology practices, integrated delivery networks, and key accounts.

• Leads the strategy, administration, governance, and continuous improvement of Benefits, HRIS, and related HR operations in alignment with business objectives. • Oversees health and welfare, retirement, leave, disability, wellness, and voluntary benefits programs, including plan design, renewals, benchmarking, open enrollment, and employee communications. • Manages broker, carrier, retirement plan, COBRA, FSA/HSA, leave administration, HRIS, and other vendor relationships, including contracts, service levels, escalations, budgets, purchase orders, and compliance deliverables. • Ensures compliance with applicable benefits and employment requirements, including ERISA, ACA, COBRA, HIPAA, Section 125, FMLA, ADA, required filings, notices, plan documents, Forms 5500, ACA reporting, nondiscrimination testing, audits, SOPs, and documentation retention. • Provides guidance to employees and managers on benefits, leave administration, HR policies and procedures, HRIS, employee data, and HR operational best practices. • Oversees HRIS data integrity, reporting, employee records, workflows, system security, access controls, confidentiality protocols, and audit readiness. • Leads HRIS configuration, enhancements, integrations, testing, release management, and employee self-service tools to support scalable HR processes. • Develops HR metrics and uses AI-enabled tools, people analytics, and workforce data insights to improve operational efficiency, automate processes, support workforce planning, and enhance the employee experience. • Partners with Payroll, Finance, Accounting, IT, Legal, Quality, and external partners on benefits deductions, payroll integrations, budgeting, invoice reconciliation, accruals, cost analysis, and related operational needs. • Supports onboarding, offboarding, Inclusion & Wellness initiatives, and related employee communications through accurate eligibility administration, HRIS updates, planning, and execution. • Leads, coaches, and develops Benefits and HRIS team members while promoting collaboration, responsiveness, confidentiality, data accuracy, and continuous improvement.

• Partnering cross-functionally to provide legal advice related to Marketing and Market Access, including brand strategy, promotional materials, and patient support initiatives • Partnering with Medical Affairs to advise on strategy, scientific exchange, and field medical materials • Fostering a culture of compliance in Karyopharm’s interactions with healthcare professionals, including development of policies and delivery of effective training initiatives • Providing legal advice as a member of cross-functional teams including product development program teams, promotional and medical review committees, and grant and investigator-sponsored trial review committees • Communicating legal advice to business stakeholders in an authentic and understandable way

• Develop and lead the Karyopharm partnership with multiple key contacts across all accounts • Identify opportunities to leverage Karyopharm products across market segments, both directly and indirectly • Plan, initiate, negotiate and manage profitable business relationships and contracts with assigned accounts • Develop and execute account specific business plans and provide ongoing business updates to Market Access team and other internal partners • Manage and maximize internal resources, both financial and human, in meeting planned objectives with each customer • Ensure compliance with all applicable laws, regulations, and guidelines • Work collaboratively with Market Access colleagues and multiple functional areas in developing strategic and tactical plans • Participate and assist in the planning of overall brand and corporate strategies on an ongoing basis and as part of various sub-teams and committees as needed • Be viewed as the subject matter expert on assigned accounts, market segments, and issues that impact our relationship and ability to work with them • Manage administrative and fiduciary duties as appropriate to the CAD role

• Partnering cross-functionally to provide legal advice related to Marketing and Market Access, including brand strategy, promotional materials, and patient support initiatives • Partnering with Medical Affairs to advise on strategy, scientific exchange, and field medical materials • Fostering a culture of compliance in Karyopharm’s interactions with healthcare professionals, including development of policies and delivery of effective training initiatives • Providing legal advice as a member of cross-functional teams including product development program teams, promotional and medical review committees, and grant and investigator-sponsored trial review committees • Communicating legal advice to business stakeholders in an authentic and understandable way

• Provides strategic and operational support within GMP Quality and Quality Systems • Leads training initiatives • Provides vendors management support • Drives process improvement • Partners cross-functionally to support successful Quality operations • Contributes to the continuous evolution of the CSV program, training management program, and strategy for improvement of cross-functional Quality Compliance • Supports day-to-day operational quality oversight for internal batch record review, batch disposition and manufacturing operations across the end-to-end manufacturing processes for the manufacture of clinical and commercial intermediates and drug product batches • Monitors operational activities and assesses continuous improvement within the QA operations • Serves as QA partner on change controls, CAPAs, deviations, OOS, and non-conformances • Facilitates root cause / A3 problem solving and partners with business partners on deviations/CAPAs (close on time, prove effectiveness) • Drafts, revises, reviews, and/or approves controlled documents including Standard Operating Procedures • Represents QA on cross-functional project teams and with external partners • Identifies and anticipates trends in quality issues; collaborates with leadership team to implement quality initiatives • Responsible for managing CSV oversite including planning and scheduling validation activities with external vendors • Ensures business partners assess and approve change controls for commercial processes for assessment of lot disposition processes • Identifies areas of improvement in training system performance, training process and overall training procedures • Manages training KPIs • Ensures business partners implement adequate training modules and learning activities • Contributes to the development, maintenance, and continuous improvement of SOPs, work instructions, and templates

• Write or supervise writing of complex clinical study−related documents, including protocols, protocol amendments, Investigator Brochures and clinical study reports to support Karyopharm clinical development programs • Write or supervise writing of regulatory documents including health authority meeting requests, briefing books, regulatory filings including NDA, IND, and Assessment Aids for submissions, where applicable • Ensure all content is high-quality and consistent with program strategy, and where possible provide recommendations for content enhancements and optimization for team consideration • Adjudicate cross-functional feedback, drive consensus, and reconcile diverse viewpoints via stakeholder management and facilitating comment resolution forums • Serve as mentor to other medical writers and leverage prior experience to help build capabilities and co-develop junior talent • Champion and lead operational workstreams as subject-matter expert to develop new internal guidance and improved practices for other medical writers • Working with the Head of Medical Writing, develop medical writing processes, standards, and innovative initiatives • Solve problems associated with medical writing scope of work, involving ambiguous situations across departments and the need to develop new options to resolve • Coordinate review and approval of oncologic clinical study-related documents • Contribute to creation and maintenance of templates and standard text for clinical documents