• Lead a matrix team comprised of global and/or local subject matter experts, business process owners, and key stakeholders, with minimal assistance, in the development, revision, process mapping, process enhancements, implementation and maintenance of process quality standards and procedural documentation (policies, SOPs and associated documents) for approximately 10,000 colleagues across client clinical, medical, safety, regulatory and enterprise quality management system global processes. • Function as a key subject matter expert in the document management model, quality management system, and quality standards. • Providing advice and recommendations to global and local colleagues on process enhancement and continuous improvement project teams. • Provide strategic recommendations regarding process design, documentation development, change management and supporting systems by understanding the business, organization and associated responsible roles. • Plan and manage process development projects to address the full life cycle: requirements and policy setting; process design, documentation and training development and delivery; change management planning and deployment; and transition to an oversight system that incorporates performance monitoring and continuous improvement once the new/revised process is fully operational. • Applies knowledge and understanding of global regulations in a GxP environment and produces processes and related documentation that meets regulatory requirements, supports corporate compliance, is inspection ready and is designed with operational effectiveness in mind and contains measurable controls where applicable. • Identifies areas of training focus and collaborate closely with training developers on training strategies and plans. • Contribute to compliance and audit/inspection readiness strategies and plans. • Participate in regulatory inspections, external PV license partner audits, and other internal audits by being the liaison for documentation requests and responding to findings. • Participate in integration activities for process and documentation analysis of the acquiree's process documentation. • Evaluate global procedural documentation against evolving industry/regulatory requirements and expectations, audit/inspection findings, business needs, higher level corporate policies, changes in industry standards and client feedback and trends, and make recommendations for changes when necessary. • Manage queries and exceptions from the organization related to assigned policies/SOPs. • Understand relational database functionality and serve as a subject matter expert in regard to process design.

• Liderar un equipo matricial constituido por expertos en la materia, propietarios del proceso empresarial y partes interesadas clave • Funcionar como experto en el modelo de gestión documental, el sistema de gestión de calidad y los estándares de calidad • Planificar y gestionar proyectos de desarrollo de procesos que abordan todo el ciclo de vida: desarrollo de requisitos y políticas, diseño de procesos, distribución de capacitación, gestión de cambios y planificación de despliegue

Overview Microsoft’s Cloud Infrastructure and Operations (MCIO) is the engine that powers Microsoft’s cloud services. Our global datacenter infrastructure enables more than 200 online businesses—including Azure, Office 365, Xbox, OneDrive, and Bing—and supports over one billion customers and 20 million businesses worldwide. We are looking for a Regional Critical Environment (CE) Program Director - Americas to help provide strategic and operational leadership for Critical Environments across Microsoft’s Americas datacenter portfolio. This role is accountable for availability, safety, compliance, and operational excellence across a diverse, large‑scale footprint of datacenters while partnering closely with global teams to drive standardized processes, tooling, and governance. Microsoft’s datacenter portfolio spans more than 200 facilities across 30+ countries, supported by highly specialized Mechanical, Electrical, and Controls professionals. This role focuses on regional program leadership, enabling local site teams to execute consistently while ensuring alignment to global CE strategy, standards, and transformation initiatives. Rooted in Microsoft’s mission to empower every person and organization on the planet to achieve more, this role embodies a growth mindset, inclusive leadership, and accountability—fostering a culture where safety, reliability, and innovation thrive at scale. Responsibilities Regional CE Leadership & Governance - Provide regional leadership for Critical Environments across all Americas datacenters, ensuring alignment with global CE strategy, standards, and operating models(insource vs vendor). - Own regional CE program execution, translating global standards and initiatives into scalable, repeatable regional practices. - Serve as a key regional voice into global CE governance forums, influencing strategy, prioritization, and roadmap decisions. Availability, Safety, and Risk Management - Champion a culture of safety, security, and compliance across all CE operations in the Americas region. - Drive sustained improvements in Critical Environment availability, resilience, and operational readiness. - Lead efforts to reduce high‑impact and human‑error‑driven CE incidents year‑over‑year through standardization, learning, and systemic improvement. - Oversee regional risk posture, ensuring proactive identification, communication, and mitigation of CE risks impacting service availability. Standards, Process, and Tooling - Partner with Global CE teams and strategic partners to develop, mature, and deploy standardized CE processes, procedures, and operational tooling. - Ensure consistent regional adoption of Lease CE standards, best practices, and governance models. - Sponsor continuous improvement initiatives that simplify operations, improve compliance, and enable data‑driven decision‑making. Partner & Stakeholder Engagement - Establish and maintain strong executive‑level relationships with strategic partners and suppliers, ensuring alignment to performance, safety, and cost expectations. - Collaborate closely with regional and global stakeholders across CE, IT, Operations, Logistics, and Engineering to deliver integrated outcomes. - Develop and execute regional communication strategies to effectively engage site teams, regional leaders, and global stakeholders. Financial & Portfolio Management - Lead region‑wide CE programs and cross‑site initiatives, including lifecycle investments, risk remediation, and operational optimization projects. - Develop and manage regional CE OPEX budgets, ensuring financial discipline while supporting availability and efficiency objectives. - Drive cost and energy efficiency initiatives aligned to Microsoft’s sustainability commitments. People & Capability Development - Lead and develop regional CE program leaders and subject matter experts, fostering technical excellence, accountability, and inclusive leadership. - Enable local site teams by providing clarity, priorities, tools, and support—without direct site‑level micromanagement. - Promote knowledge sharing and best‑practice exchange across the Americas and global CE communities. Qualifications Required/minimum qualifications - High School Qualification or equivalent AND 10+ years experience of mission-critical service management (e.g., providing IT services, manufacturing, warehouse, retail, military, or managing physical operations in an IT and/or critical environment infrastructure) - OR equivalent experience - 3+ years people management experience. Background Check Requirements: Ability to meet Microsoft, customer and/or government security screening requirements are required for this role. These requirements include, but are not limited to the following specialized security screenings: - Microsoft Cloud Background Check: This position will be required to pass the Microsoft Cloud background check upon hire/transfer and every two years thereafter. Additional or preferred qualifications - Bachelor's or Technical College Degree in Computer Science, Math, Telecommunications, Electrical/Mechanical Engineering, Supply Chain Management or related field AND 15+ years experience in enterprise-level experience managing large scale and complex projects/programs, or critical environment infrastructures (e.g., UPS, Generator, AHU), or working in physical IT infrastructures (e.g., Servers, SANs, Networking, Capacity, DC Rack/Enclosures, structured cabling) - OR High School Qualification or equivalent AND 17+ years experience in enterprise-level experience managing large scale and complex projects/programs, or critical environment infrastructures (e.g., UPS, Generator, AHU), or working in physical IT infrastructures (e.g., Servers, SANs, Networking, Capacity, DC Rack/Enclosures, structured cabling) - OR equivalent experience. - 5+ years people management experience. - Applicable certifications: APICS/Inventory Control, CompTIA, Microsoft, Network Certifications, CCNA Certifications, ITIL v3 Foundation, Microsoft Operations Framework (MOF) Certifications, Leadership Development Certifications, PMP, CDCMP. - 7+ years enterprise-level experience managing large scale and complex projects/programs AND 7+ years’ experience in Critical Environment infrastructures (e.g., UPS, Generator, AHU). - Experience working on large scale CE projects   - Experience with the operation of IT infrastructure (Servers, SANs, Networking, etc.)  Data Center Operations Management M6 - The typical base pay range for this role across the U.S. is USD $140,200 - $277,200 per year. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $185,600 - $306,000 per year. Certain roles may be eligible for benefits and other compensation. Find additional benefits and pay information here: https://careers.microsoft.com/us/en/us-corporate-pay This position will be open for a minimum of 5 days, with applications accepted on an ongoing basis until the position is filled. Microsoft is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance with religious accommodations and/or a reasonable accommodation due to a disability during the application process, read more about requesting accommodations.

Overview We are seeking an experienced Regional Business Director (RBD) to support the promotion of OXLUMO® (lumasiran) for Primary Hyperoxaluria Type 1 and GIVLAARI® (givosiran) for Acute Hepatic Porphyria. This is an exceptional opportunity to build a meaningful legacy of support for patients, caregivers, and the PH1 and AHP communities. The RBD will lead and develop a high-performing team of Business Account Executives (BAEs), driving disease awareness and product education among healthcare professionals. In addition to coaching and performance management, the RBD will provide market insights to inform commercial strategy, champion a customer-oriented culture, and foster a team environment grounded in accountability and excellence. The RBD will embody Alnylam's core values: commitment to people, purposeful urgency, passion for excellence, innovation and discovery, open culture, and an unwavering commitment to integrity. The position reports to the Head of Rare Sales. Key Responsibilities - Lead, coach, and develop a high-performing BAE team focused on disease awareness and product education across PH1 and AHP patient communities. - Apply strong sales management, strategic planning, financial acumen, and analytical capabilities to align field execution with broader commercial strategy. - Proactively analyze market dynamics and develop forward-looking action plans; clearly communicate market context and proposed direction to both leadership and the field team. - Coach team members to meet and exceed performance targets, with an emphasis on compliance, business planning, and cross-functional alignment. - Leverage deep market knowledge to provide insights that shape and refine commercial strategy. - Build best-in class team culture by attracting, developing, and retaining top sales talent. - Cultivate a customer-oriented culture that prioritizes patient needs, value-added services, and seamless execution. - Allocate and manage regional resources to support strategic and operational excellence. - Align people, processes, and communication systems effectively across a complex, matrixed organization. - Inspire and motivate the team by clearly articulating strategy, vision, and future objectives. Qualifications - Bachelor’s degree required; science focus is strongly preferred. MBA or PhD is a plus. - 5+ years of experience leading commercial teams; 7+ years in sales, marketing, commercial operations, or account management within biotech, medical device, or specialty pharma. - Rare/orphan disease experience preferred. - Proven experience training and managing BAEs across multiple specialties and working cross-functionally across sales, marketing, market access, and patient services. - In-depth reimbursement knowledge of Buy/Bill and Part B & D, including experience with in-house patient support services and site-of-care development. - Strong familiarity with hospital/institutional environments and the P&T committee process. - Demonstrated ability to lead and influence a matrixed organization across multiple teams and functions. - Strong planning, prioritization, and organizational skills with the ability to manage competing priorities effectively. - Working knowledge of relevant legal and regulatory requirements within the biotech/pharmaceutical industry. - Demonstrated commitment to ethics and integrity in all aspects of work. - Valid driver's license required; regional travel approximately 60–70%. #LI-KB2 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.