The Lupus Research Alliance (LRA) is the world’s leading non-governmental, non-profit funder of lupus research. Over the past 25 years, the LRA has invested over $270 million in lupus research in more than 660 research and clinical studies. This is an exciting professional opportunity to support a critical initiative for the lupus community. Be part of a team of LRA staff, academic and industry experts, and individuals living with lupus who envision and bring to life a unique infrastructure that integrates a patient registry with a linked biorepository and a data analytics platform. This resource, referred to as the Lupus Nexus (LNx), will expedite scientific discovery and clinical development and accelerate precision medicine in lupus, with the goal of transforming lupus care. Candidates for this position may be located anywhere in the United States, but must be able to work on core EST hours with occaisional travel to our NYC office. Position Summary The Lupus Nexus Bioinformatics Scientist will be part of the Lupus Research Alliance’s Research Department and plays an important role in supporting efforts across the Lupus Nexus. This role is responsible for building and managing scientific data pipelines to ensure the quality and integrity of scientific data, from data acquisition and processing through storage and release. This role involves providing guidance on best practices for scientific data analysis, supporting researchers in deriving insights from complex datasets, and maintaining high standards of data accuracy and reproducibility. The ideal candidate will collaborate with data scientists, researchers, and technical teams to establish robust data management protocols, streamline data sharing processes, and enhance data accessibility while safeguarding sensitive information. Responsibilities - Manage scientific data ingestion pipelines. - Manage and oversee scientific data ingestion pipelines, ensuring the accuracy, consistency, and completeness of scientific datasets from vendors and external researchers. - Oversee metadata management and data harmonization efforts to facilitate standardized data sharing. Contribute to the resolution and documentation of data queries as per the established LNx Data Governance and Management Plan. - Engage with key collaborators and business partners to identify data needs, improve data workflows, and enhance the usability of research data for the scientific community. - Contribute to the review and quality control assessments of scientific data by the LNx Scientific Review Committee. - Manage data access for research projects - Manage data access requests and review processes, ensuring compliance with governance policies while promoting responsible data sharing. - Create research project-specific datasets, address and document on-platform data queries and provide on-platform -omics data support for scientific users. - Collaborate with researchers, data scientists, and technical teams to support complex data analysis and visualization efforts. Collaborate on the conceptualization and development of new methodologies associated with these analyses and efforts. - Establish and manage procedures for maintaining scientific data provenance and governance. - Contribute to the development of policies and procedures to support the ethical and effective release of scientific data to researchers and registry participants, including data sharing compliance, data harmonization, and meta-data management. - Work with internal staff and external vendors to ensure the seamless integration and interoperability of clinical and research data across multiple platforms. Requirements: Credentials & Qualifications: - BS degree in immunology, biomedical data analysis, statistics, or a related field - 10+ years of experience in scientific data analysis with extensive experience working with multi-omic/molecular data types. - MS with 8+ years or PhD degree with 3+ years of relevant experience preferred. - Working knowledge of AWS environments, R Studio and Jupyter Notebook is required. Working knowledge of Nextflow, GitHub, and Docker a plus. Skills & Competencies: - Demonstrated ability to think strategically when planning and managing responsibilities. - Hands-on, self-directed, detail-oriented, organized, and conscientious. - Must be able to work independently and prioritize and manage multiple activities within tight timelines. - Team player who can build excellent working relationships both internally and externally. Qualified candidates should submit a cover letter and resume/CV. No phone calls, please. The Lupus Research Alliance and Lupus Therapeutics are an Equal Opportunity Employers, committed to equal opportunity for all regardless of race, ethnicity, color, ancestry, national origin, citizenship, religion, sex, sexual orientation, gender identity/orientation, marital status, age, ability, veteran status, or any other protected characteristic.

• Design the Future of Ads Identity: Develop/employ probabilistic models for identity resolution. Design the methodology that links on-platform and off-platform actions to maximize addressability while honoring privacy. • Advance Lift Methodologies & Experimentation: Own the statistical rigor behind Reddit’s Brand and Conversion Lift products. Innovate experimental design and develop infrastructure that supports large-scale, high-velocity, low-bias testing for advertisers. • Maximize Signal for Predictive Performance: Define the strategy for new signal sources. You will mathematically quantify the value of these signals and work with modeling teams to incorporate them into predictive models, directly improving bidding efficiency and ROAS. • Define Ground Truth & Evaluation Frameworks: Solve the industry-wide challenge of validating identity and measurement. Design the objective functions and truth sets used to train our models and measure the incremental impact of our identity graph. • Lead Through Cross-Functional and Technical Influence: Collaborate deeply with engineering, product, and sales to align on strategic goals, translate insights into action, and drive execution. Set a high technical bar by mentoring others and championing best practices across modeling, experimentation, and measurement.

• Design the Future of Ads Identity: Develop/employ probabilistic models for identity resolution. Design the methodology that links on-platform and off-platform actions to maximize addressability while honoring privacy. • Advance Lift Methodologies & Experimentation: Own the statistical rigor behind Reddit’s Brand and Conversion Lift products. Innovate experimental design and develop infrastructure that supports large-scale, high-velocity, low-bias testing for advertisers. • Maximize Signal for Predictive Performance: Define the strategy for new signal sources. You will mathematically quantify the value of these signals and work with modeling teams to incorporate them into predictive models, directly improving bidding efficiency and ROAS. • Define Ground Truth & Evaluation Frameworks: Solve the industry-wide challenge of validating identity and measurement. Design the objective functions and truth sets used to train our models and measure the incremental impact of our identity graph. • Lead Through Cross-Functional and Technical Influence: Collaborate deeply with engineering, product, and sales to align on strategic goals, translate insights into action, and drive execution. Set a high technical bar by mentoring others and championing best practices across modeling, experimentation, and measurement.

Principal Statistical Programmer (Multiple Openings), IQVIA RDS Inc., Durham, NC. May telecommute (work from home) from anywhere in the US and report to Durham, NC company location. Conduct statistical analysis for client reports and publications. Perform advanced statistical programming and biostatistical analyses. Utilize the findings and insights for practical application to further business operations and come across innovative findings and discoveries for solution and product development. Plan and coordinate the development of integrated programming solutions serving the full spectrum of statistical programming needs. Provide technical expertise and leadership to the department and provide internal consulting services, including specifications and user needs analysis for complex project or client requirements. Perform all responsibilities associated with the Senior Programmer role. Assist all the Sr. Programmers and Programmers in their day-to-day activities. Act as escalation point for Sr. Programmer and Programmer. Communicate regularly with the sponsor on the progress of programming aspects of the project and proactively anticipate issues and work with the sponsor on resolution of the problems. Provide input and/or write the programming specifications. Serve as subject matter expert on all aspects of SAS programming. Understand pharmaceutical industry standards and trends and proactively plan, develop, and implement. Develop consistent practices of clinical and statistical review of output and mentor programming staff. Check for consistency across therapeutic areas. Identify, plan, and oversee the implementation and success measures of all process improvement initiatives. Maintain expertise in the use of SAS Macros and determine macro development priorities. Perform other responsibilities as defined on ad-hoc basis by senior management. Work, M-F, 40 hours/week. Salary Range: $152,091 - $227,700/year. Requires a bachelor’s degree in Statistics, Pharmaceutical Sciences or related field or foreign equivalent. Requires five (5) years of statistical programming experience in the life sciences or pharmaceutical industry to include five (5) years with the following: overseeing and guiding programming activities for regulatory submissions with the NDA or BLA; utilizing knowledge of CDISC standards, including SDTM and ADaM, to create and review mapping specifications; preparing and validating submission deliverables such as define.xml, SDRG, and ADRG; performing data analysis and pooling analyses (ISS or ISE); working as a liaison between regulatory agencies (such as FDA or PMDA) and representing programming in cross-functional meetings; utilizing knowledge of clinical trial data and regulatory requirements. Apply: reference id #118694. IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at https://jobs.iqvia.com IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism. The potential base pay range for this role is US $152,091 - $227,700 annually. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.