• Serve as a strategic leader for the HEOR and RWE strategy • Define global HEOR and RWE strategy integrating advanced analytics, digital health • Drive U.S. market access priorities and support optimal reimbursement • Oversee design and delivery of real-world studies and economic models • Collaborate with internal and external stakeholders to align evidence generation with clinical strategy

• Lead the end-to-end YieldMax brand strategy, positioning the firm as the premier income-focused ETF brand for retail investors • Build and scale an influencer-first brand engine, owning strategy, relationships, contracts, performance measurement, and long-term partnership development • Serve as the senior steward of YieldMax’s reputation across social platforms, retail investor communities, media, and digital channels • Translate complex, options-based investment strategies into clear, compelling, and compliant retail investor messaging • Own brand and marketing communications governance under the Investment Company Act of 1940, ensuring all public-facing content, influencer activity, and social communications meet SEC regulatory and disclosure requirements • Partner closely with legal and compliance leadership to design scalable, influencer-compatible communication frameworks that protect the firm while preserving authenticity and speed • Develop and lead a high-performance brand team across content, social, influencer marketing, creative, and communications • Establish a rigorous, data-driven brand operating model with clear KPIs tied to awareness, trust, engagement, and investor growth • Partner closely with executive leadership, product, legal/compliance, and distribution teams to ensure alignment and execution excellence • Anticipate shifts in retail investor behavior, social platforms, creator dynamics, and regulatory expectations to keep YieldMax ahead of the market

Role Description The Vice President of Portfolio & Program Management will provide strategic leadership and operational excellence for a growing biotech company focused on developing new therapies for NI&I. A successful candidate will have a foundational expertise in project management, with an established track record in managing all phases of clinical-stage programs, with required experience in early stage through Phase 2, and a proven ability to lead cross-functional teams. This individual must be a strategic thinker with excellent communication and organizational skills to drive our therapeutic candidates toward regulatory approval and commercialization. The Vice President will oversee all aspects of project management, ensuring that our clinical trials are completed on time, within budget, and in compliance with regulatory standards. The individual (and/or the individual’s team) will work closely with cross-functional teams, including Clinical Research, Clinical Operations, Regulatory Affairs, CMC, and Research, to ensure seamless coordination and communication across the organization. In this role, the VP will drive the coordinated cross-functional execution of programs from early research through clinical development, oversee portfolio strategy, and lead key preclinical and clinical initiatives. The VP will also establish and implement governance structures tailored to the scientific and operational challenges inherent in advancing a varied and high-impact portfolio. While this role can be remote, it is preferred that the candidate be based on the west coast of the United States. Qualifications - Advanced degree in a scientific or medical discipline relevant to inflammation, immunology, and/or fibrosis or to drug development (PhD, MD, PharmD strongly preferred) - 15+ years of experience in biotech/pharma, including significant time leading development programs in inflammation, fibrosis, immunology, and/or neurosciences – experience specific to pulmonary fibrosis is viewed positively - Demonstrated success managing programs from Pre-IND, through Phase 2 and Phase 3 registrational trials; experience in early through or mid to late-stage clinical development is required - Excellent leadership, communication, and organizational skills, with the ability to operate effectively in a small, fast-paced biotech environment Requirements - Develop and maintain an integrated, data-driven portfolio strategy aligned with corporate vision and scientific priorities - Lead portfolio review processes, ensuring timely, evidence-based decision-making and clear resource allocation across programs - Evaluate and prioritize internal programs and external opportunities, including partnerships, licensing deals, and platform extensions - Conduct scenario planning, risk assessments, and investment trade-off analyses to guide strategic direction - Oversee or directly lead key development programs spanning discovery, preclinical, and clinical stages - Drive creation and execution of integrated, cross-functional program plans encompassing research, translational, clinical, regulatory, CMC, and commercial considerations - Ensure programs meet timelines, budgets, and milestones; actively identify risks, dependencies, and mitigation strategies - Maintain transparent reporting systems and dashboards for executive leadership, governance committees, and the board - Partner with Research, across Clinical Development functions, and with other internal teams to ensure alignment and operational excellence - Facilitate clear communication and decision-making across all program teams - Support readiness for key milestones such as IND submissions, clinical trial initiations, regulatory interactions, and strategic partnerships - Together with the CMO, establish and refine clinical development team and governance frameworks that enable efficient and high-quality development activities, clear decision-making structures, that facilitate clear communication and a documented alignment in R&D strategy - Build and mentor a high-performing PPM function tailored to the needs of a small, rapidly growing biotech - Implement best practices in project planning, resource management, and cross-functional communication - Champion a culture of accountability, transparency, and collaboration across the organization Benefits - 90% employer-covered benefits - Flexible PTO - A very generous holiday schedule that includes a week off in August and time off around the winter holidays - A well-stocked kitchen with snacks and beverages - Additional benefits include the opportunity for annual bonuses, stock options, an Employee Stock Purchase Program, and a 401(k) with an employer match - The comprehensive wellness program includes medical, dental, vision, and LTD coverage

• Set and own the enterprise integration strategy and multi-year roadmap across file-based, SSO, and API integrations, ensuring alignment with business growth and partner expansion goals. • Develop and evolve a modern, scalable integrations platform, including reusable patterns, standards, governance frameworks, and architectural best practices. • Drive self-service integration capabilities that enable internal teams and external partners to configure, validate, onboard, and manage integrations with minimal engineering dependency. • Lead build-versus-buy assessments for integration tools and platforms, guiding investment decisions to maximize efficiency, scalability, and ROI. • Oversee execution and operational performance across all integration types, including high-volume file workflows, EDI transactions, identity and access protocols (SAML, OAuth), and real-time APIs. • Establish and maintain security, compliance, performance, and resiliency standards across the integrations ecosystem, including SLAs, KPIs, observability, and incident management processes. • Influence and align cross-functional stakeholders by partnering closely with Product, Engineering, Client Services, Sales, and external partners to ensure integration outcomes meet business and customer needs. • Build, develop, and lead high-performing teams, fostering a culture of accountability, technical excellence, and continuous improvement. • Provide executive-level communication and reporting on portfolio health, delivery progress, risks, and measurable business impact.