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Creating new and meaningful medicines for patients with genetic diseases
VP, Clinical Pharmacology
Location
California
Posted
98 days ago
Salary
$302K - $360K / year
Seniority
Lead
Job Description
VP, Clinical Pharmacology
GondolaBio
• Serve as the clinical pharmacology leader for multiple programs in GondolaBio’s pipeline, defining stage-appropriate PK/PD, exposure–response, and dose-selection strategies to support rapid, high-quality decisions through early proof of concept • Lead clinical pharmacology strategy for first-in-human and early Phase 1/2 studies, including starting dose rationale, dose escalation design, SAD/MAD strategy, and integration of nonclinical and translational data • Design, interpret, and communicate PK/PD, biomarker, and exposure–response analyses to inform dose optimization and go/no-go decisions, in close partnership with Translational and Clinical Development teams • Apply fit-for-purpose pharmacometric and modeling approaches to support early development decisions and regulatory interactions • Partner across functions to support INDs, regulatory interactions, and integrated development plans; clearly communicate clinical pharmacology insights to senior leadership • Oversee external pharmacometrics vendors, CROs, and consultants as needed to ensure timely, high-quality execution
Job Requirements
- Ph.D., Pharm.D., M.D., or equivalent advanced degree in pharmacology, pharmaceutical sciences, or a related discipline
- 15+ years of experience in clinical pharmacology and/or pharmacometrics, including leadership at the program or portfolio level
- Demonstrated record of supporting IND-stage programs through first-in-human and early clinical proof of concept
- Strong expertise in dose selection, PK/PD integration, exposure–response, and early safety margin assessment
- Experience working across multiple modalities (experience with oligonucleotides and small molecules is a plus)
- Experience operating in small or mid-sized biotech environments where leaders are both strategic and hands-on
- Experience applying model-informed drug development in regulatory interactions
- Familiarity with rare diseases or development programs with slow or indirect clinical endpoints
- Prior experience serving as a senior clinical pharmacology voice with executive leadership or boards
- Comfort making decisions with limited data while maintaining scientific rigor
Benefits
- Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
- A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
- An unyielding commitment to always putting patients first.
- A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
- A place where you own the vision – both for your program and your own career path
- A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
- Access to learning and development resources to help you get in the best professional shape of your life
- Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
- Flexible PTO
- Rapid career advancement for strong performers
- Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time
- Partnerships with leading institutions
- Commitment to Diversity, Equity & Inclusion
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