• Serve as the clinical pharmacology leader for multiple programs in GondolaBio’s pipeline, defining stage-appropriate PK/PD, exposure–response, and dose-selection strategies to support rapid, high-quality decisions through early proof of concept • Lead clinical pharmacology strategy for first-in-human and early Phase 1/2 studies, including starting dose rationale, dose escalation design, SAD/MAD strategy, and integration of nonclinical and translational data • Design, interpret, and communicate PK/PD, biomarker, and exposure–response analyses to inform dose optimization and go/no-go decisions, in close partnership with Translational and Clinical Development teams • Apply fit-for-purpose pharmacometric and modeling approaches to support early development decisions and regulatory interactions • Partner across functions to support INDs, regulatory interactions, and integrated development plans; clearly communicate clinical pharmacology insights to senior leadership • Oversee external pharmacometrics vendors, CROs, and consultants as needed to ensure timely, high-quality execution

• Design scientifically rigorous, innovative, and cost-effective clinical development programs, integrating preclinical, translational, and biomarker strategies • Direct and oversee the efficient implementation of all clinical projects, including defining initial clinical endpoints, dose-escalation strategies, and patient selection approaches • Lead development and contribute to review of Clinical Study Protocols, Clinical Study Reports, Investigator’s Brochures, and all clinical documentation for regulatory filings • Become an internal expert on all medical features of the disease area, including natural history, patient diagnostic journey, standards of care, and current development programs. • Build, mentor, and scale the clinical development and clinical operations teams, including defining structure, capabilities, and external partnerships appropriate for each stage of the program • Provide leadership and clinical development expertise to the overall organization, including the clinical development, clinical operations, biometrics, toxicology, and translational science teams • Collaborate with Regulatory Affairs to develop strategies and tactical work plans during clinical development and in preparation for the anticipated US and global filings • Lead the preparation and management of clinical information to support timely regulatory submissions, including INDs, briefing documents, and early clinical protocols • Set a high standard and example of urgency, work quality, and effectiveness • Contribute to due diligence and gap analysis on potential new GondolaBio assets • Partner closely with discovery and preclinical teams to ensure clinical readiness for first-in-human studies. • Perform all other duties as assigned

• Interface directly with institutional clients • Run hedge analyses as needed • Contributes to the development and maintenance of valuation models to align with industry best practices and changing client needs • Interfaces with colleagues across multiple teams to explain methodologies and support integration with a high degree of competency and integrity • Oversee work of junior employees • Validate the work of other colleagues for quality assurance • Such other activities as may be assigned by your manager

About the company Deep Origin is a biotech startup building an operating system for science that transforms how life science research is conducted. Led by Michael Antonov, co-founder of Oculus, and backed by Formic Ventures, we are redefining the infrastructure behind modern drug discovery. Our AI-driven platform enables scientists to accelerate discovery, reduce cost, and bring breakthrough innovations to life faster. As we scale, overall excellence is a critical lever in advancing our mission to dramatically reduce disease and extend human healthspan. About the role We are seeking a VP of Product to fully own, define, build, and scale all of our products and services across the enterprise, including software and services designed for early-stage drug discovery. This role owns product strategy and execution end-to-end from vision and roadmap through launch, iteration, and long-term platform evolution. You will work cross-functionally with engineering, AI/ML, scientists, drug discovery experts, and commercial teams to translate complex scientific workflows into an intuitive, scalable, and high-impact platform for biotech and pharmaceutical customers. This role requires both strategic thinking and hands-on execution in a fast-moving startup environment. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.