Summit Therapeutics, Inc.

• Lead design and execution of HUB, copay, and patient assistance programs • Support oncology launch planning and execution • Manage vendors and performance • Coordinate with outsourced Field Reimbursement Managers (FRMs) to align patient services with field reimbursement support and provider needs • Partner across Market Access, Commercial, Medical, Trade, and Compliance, Finance • Track KPIs (time to therapy, approvals, adherence) • Identify insights from the field and translate them into actionable strategies to enhance patient access and support • Partner with Market Access Strategy to develop appropriate tools and resources for service offerings • Ensure compliance with legal and regulatory requirements • Continuously improve patient experience • All other duties as assigned

• Partner with the Talent Acquisition team to best organize and effectively manage the day-to-day administrative operations of the Talent Acquisition department from the initial job opening through new hire onboarding • Work extensively within the Applicant Tracking System (ATS) to communicate coordinate monitor and manage candidates requisitions templates and communications • Coordinate interview schedules with candidates and internal interview teams taking into account the dynamics of the organization/team/individuals as well as priorities • Manage any necessary travel arrangements including correspondence with travel partners and ensure all parties are informed and related expenses are submitted promptly • Evaluate and identify opportunities to drive process improvements that positively impact the candidate and hiring manager experience • Generate initiate and monitor pre-employment screenings (i.e. background drug screen credentialing etc.) and keep recruiter updated • Maintain strong open timely communication and coordination with the candidates hiring managers and recruiters as well as any other key stakeholders • Support TA projects and deliverables for various initiatives • Understanding of internal and external compliance standards and requirements including HR procedures training requirements for new and continuing associates and applicable federal and international requirements as outlined in the Quality system procedures • Other duties as assigned

• The Senior Manager, Clinical Operations Site Partner (CSP) is responsible for providing leadership and operational expertise in the execution of one or more Phase I–III clinical trials across the European region. • As a key member of the Global Clinical Operations (GCO) group and reporting to the Senior Director, Clinical Operations (Europe), the Senior Manager CSP plays a pivotal role in ensuring operational excellence in trial conduct and site performance. • This position serves as the primary Summit operational point of contact for assigned clinical trial sites, with full accountability for the end-to-end lifecycle of studies. • The role drives site selection, site start-up efficiency, accelerates site activation, recruitment, and maintains high standards of performance and quality throughout the study lifecycle. • The Senior Manager CSP acts as a strategic partner to sites and study teams—helping Summit achieve its vision of becoming a Sponsor of Choice by delivering a concierge-level experience to our clinical trial sites.

• We are seeking a physician to serve as a Senior Medical Director to oversee global Phase 3 clinical trials and BLA (Biologic Licensing Application) filings. • The incumbent will be primarily responsible for developing and executing an integrated clinical trial programs including protocol design and medical oversight of new or ongoing studies. • They will be responsible for obtaining scientific advisory input, work with biostatisticians for phase 3 design and analyses, support regulatory interactions for product advancement, and work closely with clinical operations to provide advice and decision making regarding medical input to achieve operational excellence. • This position will provide medical insight across a myriad of functions from discovery to manufacturing are expected. • Additionally, the Medical Director will play a pivotal role in leading investigator engagements including travel to support face-to-face interaction and protocol training. • Prior experience in a mid-sized, fast-growing pharmaceutical environment is preferred, as this role will be working on product development in an extremely fast-paced and intense environment. • The Medical Director will serve as a leader on one multiple potentially pivotal programs.

• We are seeking a physician to serve as a Medical Director to oversee global Phase 3 clinical trials and BLA (Biologic Licensing Application) filings. • The incumbent will be primarily responsible for developing and executing an integrated clinical trial programs including protocol design and medical oversight of new or ongoing studies. • He/she will be responsible for obtaining scientific advisory input, work with biostatisticians for Phase 3 design and analyses, support regulatory interactions for product advancement, and work closely with clinical operations to provide advice and decision making regarding medical input to achieve operational excellence. • The candidate must have demonstrated effective collaborative skills to work across various phases of clinical development and serve as a key medical expert for multiple cross functional teams. • Investigator engagement including travel to support face to face interaction and protocol training is a vital component of this role.

• Manage multiple programs or a therapeutic portfolio to maximize pipeline • Partner with executive leadership on program, indication, and portfolio strategy, including prioritization and sequencing • Define and oversee major milestones, decision points, objectives, and inflection points across programs • Lead scenario planning, trade-off analyses, and decision frameworks to support executive decision-making • Ensure alignment across Development, Regulatory, Manufacturing, and Corporate Strategy • Lead and integrate complex cross-functional workstreams across Research, Development, Regulatory, and Manufacturing • Facilitate effective decision-making and accountability across global teams and external partners • Present clear insights, recommendations, and program status to C-suite and senior leadership • Mentor and develop Program Management leaders and strengthen organizational capability • Oversee end-to-end program execution, including activation of new indications post–Go decision • Ensure consistent application of program management standards, dashboards, and governance models • Chair timely, efficient, and action-oriented team meetings to coordinate operations and communications. • Review and validate integrated program plans, timelines, and metrics for accuracy and strategic alignment • Represent Program Management on senior governance forums and key internal or external teams • Oversee integrated, cross-program timelines aligned with enterprise goals • Partner with functional leaders on budgets and forecast planning • Lead portfolio-level scenario and contingency planning to support strategic agility • Ensure data integrity and transparency in executive reporting • Identify and manage program- and portfolio-level risks and mitigation strategies • Communicate risks, opportunities, and trade-offs clearly to executive leadership • Drive continuous improvement of program management processes, tools, and operating models • Lead strategic initiatives to mature the Program Management function as the company grows • All other duties as assigned

• Develop, execute and maintain high impact territory plans, including HCP and Investigator engagement plans in alignment with therapeutic area medical and scientific objectives with a focus on quality. • Support clinical development and research initiatives across development at the request of R&D. • Identify, gain access to, and develop professional customer centric based relationships with external experts in Immuno-Oncology within assigned geography. • Provide education relative to disease state, therapeutic landscape and Summit Therapeutics products across the product lifecycle to healthcare providers and researchers. • Participate, monitor, and provide insights to Summit from relevant scientific meetings in relevant geography. • Continuously maintain self-education on market issues/trends, product knowledge, and new therapeutic areas of interest as it pertains to specific business responsibilities. • Actively participate in relevant team meetings, organizational activities, and Country-driven medical affairs activities (e.g. advisory boards, masterclasses, roundtables). • Create, maintain, and collaborate in relationships with Cross-Functional partnerships to develop and execute Account plans.

• Independently cultivate and manage relationships with PBDMs, acting as primary point of contact and collaborating closely with other field roles to ensure an aligned approach to stakeholder engagement • Collaborate with internal HEOR team and market access team, to execute on scientific engagement strategy for appropriate stakeholders (e.g., Payers, PBMs, GPOs, IDNs and Oncology Pathways) within a territory or customer base • Serve as a conduit and resource for providing clinical and healthcare economic information (HCEI) to payers and formulary decision-makers • Maintaining required knowledge of ivonescimab, to proactively and reactively communicate clinical and economic information related to ivonescimab to advance formulary decision-making and improve patient outcomes • Capture and communicate internally key stakeholder insights and evidence gaps/needs including potential opportunities for collaboration • Understand the medical affairs priorities to contribute to content strategy development and execute aligned field tactics • Work with stakeholders to ensure inclusion of ivonescimab in clinical/payer pathways, and treatment order sets, while optimizing budget assessments. • Collaborate effectively with medical affairs, HEOR, market access and other colleagues as appropriate in support of developing and implementing account engagement plan, providing input on scientific and value topics • Understanding of principles of study design, methodology, data analysis, and interpretation to successfully communicate data to stakeholders • Utilize and effectively present clinical, humanistic, and economic evidence as well as the value proposition in a clear and compelling manner to the payer audience • Maintain understanding of market and payer needs in an increasingly complex and dynamic environment to drive actionable recommendations to inform medical and market access strategy • All other duties as assigned

• Act independently to lead global regulatory strategies for assigned products/indications through all phases of development to include regulatory approvals/product launches, and post-marketing efforts, with little to no oversight. • Will represent Regulatory Affairs as relates to development collaborations and/or partnerships, to include leading due diligence as required supporting BD activities • For new indications assigned, will lead effort on behalf of regulatory cross-functionally with colleagues from clinical, biostatistics, commercial, medical affairs, clinical pharmacology, safety, and others. Expected to provide material (content) input into potential study synopses and corresponding global regulatory briefing documents. • Continually expands TA knowledge and ensures strategic messaging and content of global regulatory dossiers, to include development of tumor landscape assessment to inform evolving development strategy. • Advises management and cross-functional team members of the effect of current or proposed relevant laws, regulations, guidelines, and standards, etc. • Key internal leader and driver of regulatory policy and strategy for assigned products • Lead regulatory team in the preparation and maintenance of risk assessment and mitigation strategy development for assigned products • Lead labeling strategy for given product(s)/indication(s), in support of initial license applications through post-marketing • Demonstrates excellent understanding of drug development and leadership behaviors consistent with the level • Accountable for ensuring that corporate goals are met with respect to assigned projects • Based on experience and scientific strengths, expands TA knowledge of TA; provides coaching and mentoring for other regulatory members and extra-departmental colleagues • Will have direct reports and contributes to the performance management for other RA team members • May advance the organization's goals by participating and taking leadership roles in professional associations, industry, and trade groups as appropriate • Follows budget allocations

• Provide leadership and operational expertise in the execution of one or more Phase I–III clinical trials across the European region. • Ensure operational excellence in trial conduct and site performance. • Serve as the primary Summit operational point of contact for assigned clinical trial sites. • Drive study start-up efficiency and maintain high standards of performance and quality throughout the study lifecycle. • Act as a strategic partner to sites and study teams to deliver a concierge-level experience to our clinical trial sites. • Track key performance metrics to assess site progress, mitigate potential risks, and implement corrective actions.