Praxis Precision Medicines

Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. [Insert paragraph - high level summary explaining the purpose of the position] Primary Responsibilities - [Include 5-7 KEY job responsibilities in this section] Qualifications - Include key qualifications and success factors Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - Comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Compensation - Annualized Base Salary: $1 - $2 USD - If Praxis were hiring a benefits-eligible employee directly for this position, we would expect the annualized base salary compensation to fit within the range listed above, in addition to company-provided benefits. - Final base salary range may be modified commensurate with job level, education, and experience. - Please ensure you share this information with your candidate so they understand in the event they wish to transition to a full time hire position in the future. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. - Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com . Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.

Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Praxis is seeking a highly organized, detail-oriented, and proactive CMLR Coordinator to drive efficient, compliant review and approval processes for promotional and medical materials across the organization. This role sits at the center of cross-functional collaboration, partnering closely with Commercial, Medical Affairs, Regulatory, Legal, Compliance, and external agencies to ensure materials move quickly, accurately, and responsibly through the Medical, Legal, and Regulatory (MLR) review process. This role is critical to enabling speed without sacrificing quality or compliance. The right person thrives in fast-moving environments, communicates clearly, anticipates obstacles before they become problems, and brings a strong ownership mindset to operational execution. You are not simply managing workflows — you are helping teams operate more effectively and ensuring patients, providers, and stakeholders receive accurate and compliant information. This is an excellent opportunity for someone who enjoys building structure, improving processes, and working cross-functionally in a mission-driven biotech environment. The ideal candidate combines deep knowledge of MLR operations with strong business judgment, systems thinking, and the ability to influence across functions without direct authority. Qualifications - Bachelor’s degree preferred or equivalent relevant experience - 3+ years of experience supporting MLR, promotional review, regulatory operations, commercial operations, or related functions within pharmaceutical, biotech, or healthcare environments - Familiarity with MLR review systems and workflow platforms such as Veeva PromoMats or similar tools - Strong project management and organizational skills with exceptional attention to detail - Ability to manage multiple projects and deadlines simultaneously in fast-paced environments - Strong written and verbal communication skills with confidence interacting across functions and levels - High degree of professionalism, discretion, and accountability - Demonstrated ability to identify operational inefficiencies and drive practical solutions - Comfortable working in ambiguity and adapting quickly as priorities evolve - Embodies a collaborative, ownership-driven mindset aligned with Praxis’s values of Trust, Curiosity, Ownership, and Results Requirements - Coordinate end-to-end MLR review workflows for promotional, educational, and corporate materials across multiple functions and stakeholders - Manage review timelines, approvals, version control, documentation, and routing within MLR systems and platforms - Partner with Commercial, Medical, Regulatory, Legal, and Compliance teams to ensure timely and compliant review processes - Facilitate MLR meetings, capture feedback, track action items, and drive alignment toward final approvals - Identify workflow bottlenecks and recommend process improvements that increase efficiency, transparency, and accountability - Ensure accurate maintenance of review records, archives, and audit-ready documentation in accordance with company policies and regulatory requirements - Support training and onboarding for internal stakeholders and agency partners on MLR processes, systems, and best practices - Serve as a reliable operational partner who proactively communicates risks, status updates, and timeline changes Benefits - 99% of the premium paid for medical, dental and vision plans - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize coverage - Dollar-for-dollar match up to 6% on eligible 401(k) contributions - Long-term stock incentives and ESPP - Discretionary quarterly bonus - Flexible wellness benefit - Generous PTO, paid holidays, and company-wide shutdowns - Join a phenomenal crew of colleagues who are smart, engaged, and inspiring Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. - Core Values: Trust, Ownership, Curiosity, and Results

Role Description The Senior Director of Quality Excellence (Systems & Technology) is a strategic quality leader responsible for shaping, executing, and continuously advancing the enterprise Quality Management System (QMS) and Quality systems operating model across Praxis Precision Medicines. This individual provides vision and direction for all Quality Systems functions including: - Veeva QMS governance - Document control - GxP training administration - Validation and inspection readiness - Supplier oversight for Quality Systems and GxP computerized system providers This role ensures a compliant, efficient, and scalable quality infrastructure that supports the company’s global clinical, manufacturing, and commercial operations. The Senior Director serves as the organization’s subject matter expert on GxP system compliance, regulatory readiness, and quality systems excellence. This role is accountable for: - Strategy, oversight, and continuous improvement of Praxis’s QMS and validation programs - Ensuring all GxP systems are fit for intended use and maintained in a controlled state - Aligning with current industry expectations (e.g., CSA concepts and GAMP 5) Partnering closely with senior leadership across Quality, Clinical, Technical Operations, and IT, the Senior Director drives a culture of proactive quality, operational discipline, and continuous improvement. Primary Responsibilities - Lead the strategy, governance, and continuous improvement of Praxis’s enterprise QMS to ensure compliance with global GxP regulations. - Serve as the process owner for QMS elements including document control, deviation/CAPA management, change control, training, and risk management. - Provide leadership and oversight for computerized lifecycle controls (CSV/CSA) for GxP computerized systems. - Partner with IT, Clinical Operations, Technical Operations, and Commercial teams to establish risk-based lifecycle standards. - Evaluate and qualify vendors, CROs, and CMOs supporting Praxis systems. - Maintain oversight of electronic systems, including Veeva QMS. - Lead the global GxP training administration program. - Establish and oversee QMS governance mechanisms. - Ensure ongoing inspection readiness across all GxP functions. - Monitor evolving regulatory expectations and implement timely updates. - Define, monitor, and report key QMS and validation metrics. - Lead, mentor, and develop a high-performing team of QMS and validation professionals. - Represent Quality leadership in enterprise governance and initiatives. - Drive sustained inspection readiness and execution support. Qualifications - BS/BA in a relevant scientific discipline, or ASQ or equivalent professional certification; equivalent experience considered. - Minimum 15 years of progressive experience in the pharmaceutical or biotechnology industry, with direct Quality Systems and Quality Assurance experience; at least five years in a leadership role. - Demonstrated expertise in developing, implementing, and managing enterprise QMS across clinical, manufacturing, and commercial functions. - Proven success governing QMS processes such as document control, training, deviation/CAPA, change management, and risk management. - Hands-on experience validating GxP and enterprise systems. - Demonstrated leadership experience supporting both clinical-stage and commercial operations environments. - Documented history supporting regulatory inspections and partner audits. - Strong working knowledge of FDA, EMA, and global GxP regulations. - Demonstrated ability to analyze and optimize quality processes. - Strategic, solutions-driven quality leader with excellent collaboration, communication, and influencing skills. - Proficient in Veeva Vault applications, DocuSign, and SharePoint. Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - Comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental, and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans. - 401(k) contributions matched dollar-for-dollar up to 6%. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Flexible wellness benefit. - Generous PTO, paid holidays, and company-wide shutdowns. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. Our core values of Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business. At Praxis, we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Reporting to the Head of Pharmacovigilance, the Associate Medical Director, PV Scientist supports the medical oversight, analysis, coding, interpretation, and reporting of pharmacovigilance data at Praxis. This role contributes to high-quality safety surveillance, signal detection, benefit-risk evaluation, and regulatory compliance across clinical development programs. As Praxis advances its pipeline and prepares for regulatory submissions, this position plays a critical role in strengthening U.S.-based pharmacovigilance footprint, enhancing vendor oversight, supporting implementation of evolving safety infrastructure, and ensuring inspection readiness. The Associate Medical Director, PV Scientist enables the PV Lead to focus on clinical safety strategy, regulatory submission activities, and labeling development by providing both strategic and operational support across safety activities. Primary Responsibilities - Serve as the U.S. facing PV leader, ensuring timely follow-up on safety actions across global teams and time zones. - Proactively identify and resolve operational gaps before they become compliance risks. - Own oversight of end-to-end PV service providers, including governance meetings, KPI monitoring, TMF documentation, and continuous process improvement. - Ensure quality, timeliness, and regulatory compliance at all times. - Contribute to the development and evolution of PV SOPs, safety management plans, and database migrations. - Lead or support implementation of new safety tools (e.g., signal detection platforms, monitoring systems) to strengthen proactive surveillance. - Support signal detection activities, literature review, aggregate report preparation, and safety governance meetings. - Author signal assessments, benefit-risk evaluations, and health hazard evaluations with scientific rigor and clarity. - Prepare and/or QC safety narratives, regulatory safety responses, IND/NDA/MAA components, and DSMB materials. - Ensure TMF documentation is complete, accurate, and inspection ready. - Maintain compliance with global safety reporting requirements. - Collaborate with Clinical Operations, Regulatory, Medical Affairs, Commercial, and Quality to ensure aligned safety processes. - Ensure safety data exchange complies with partner agreements. - Author searches for strategies for regulatory queries and internal requests. - Maintain rigorous documentation standards to support inspections and audits. Qualifications - Nurse, Nurse Practitioner, Pharmacist, or Allied Health Professional. - Minimum 3-5 years of experience in pharmacovigilance within the pharmaceutical/biotechnology industry. - At least 1 year of clinical trial experience highly desirable. - Experience with regulatory filings (INDs, NDAs, MAAs). - Strong knowledge of FDA, EMA, ICH, and GVP pharmacovigilance regulations. - Experience in individual case safety reporting (clinical and post-marketing), aggregate reporting, signal detection, risk management planning, regulatory inspections, and PV SOP development. - Experience implementing safety databases and signal detection tools preferred. - Familiarity with MedDRA and WHO-Drug coding. - Excellent written and verbal communication skills. Key Success Factors at Praxis - Ownership mindset: You act like the safety infrastructure is yours. You don’t wait for direction to solve problems. - Operational rigor: You create clarity in ambiguity and ensure documentation withstands inspection scrutiny. - Scientific judgment: You understand the difference between noise and signal and contribute meaningfully to benefit-risk discussions. - Speed with precision: You move quickly without sacrificing quality. - Cross-functional credibility: You build trust across Clinical, Regulatory, Medical Affairs, Commercial, and external partners. - Builder mentality: You enjoy scaling systems, not just operating within them. - Candid communicator: You raise risks early, directly, and constructively. Compensation & Benefits - 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays, and company-wide shutdowns. - Joining a phenomenal crew of colleagues who are smart, engaged, and inspiring. Company Overview Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis, we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. As Director of Process Chemistry, you will take the lead on drug substance activities for one or more projects within Praxis’ portfolio of small molecule and ASO programs to drive forward both clinical and commercial readiness. You’ll design products & processes that support clinical phase testing and then mature those processes through development to Commercial supply. Working intimately within the CMC and project teams under Agile management, you’ll identify requirements and constraints of our product to define a workplan that will lead to the successful manufacturing and creation of a data package to support commercial regulatory submissions. This role is ideal for someone who thrives in a fast-moving, collaborative environment, where science meets ownership. You’ll help define product requirements, anticipate challenges, and co-create practical, creative solutions that accelerate progress for patients in urgent need. Primary Responsibilities - Leads the Process Chemistry Research and Development for one or more projects from early to late phase within Praxis. - Designs both early phase and late-phase/commercial drug substance process and then leads their demonstration from lab to pilot plant. - Provides chemistry and technical leadership throughout the lifecycle. - Participates/leads activities to identify final API forms for pharmaceutical development. - Working closely with formulations, analytical, operations, engineering and quality, expectation to be integrated into the overall CMC team responsible for delivery of clinical and commercial drug substance to Praxis programs. - Identify, collaborate and lead external CRO, and CDMO organization(s) to achieve deliverables. - Analyze external experimental data to drive synthetic experimental plans at CROs and CDMO. - Authoring or co-authoring of regulatory submissions. - Define manufacturing strategy and execution, including GMP requirements and issue resolution. - Assessment and application of new trends and concerns in process development, quality and manufacturing to Praxis’ products. - Manage quarterly budgeting of drug substance relevant activities. - Contributor to inventions that add value to Praxis and its patients while strengthening our intellectual property position. Qualifications - Advanced degree or commensurate experience equivalent in Chemistry, Pharmaceutical Sciences, Engineering or related discipline. - Minimum of 12 years of industry experience in CMC specifically for small molecule drug substance. - A scientific track record or working knowledge in continuous processing, biocatalysis, catalysis, and/or high throughput experimentation desirable. - Strong knowledge of US and EU cGMP requirements and best practices relating to drug substances and drug products. - Strong knowledge of CMC development across all phases of drug development from initial regulatory filings through registration, validation and launch. - Experience in working with third-party CRO / CMO partners and associated service providers to develop and manufacturing pharmaceutical products. - Experience with salt/crystalline form selection preferred. - Experience with oligonucleotide chemistry is a plus. - Demonstrates a high level of intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit; can thrive in an agile environment. - Excellent interpersonal and communication skills, with the ability to develop important relationships that include trust and encourage diversity in all its forms. - Highly organized and detail-oriented with a passion to deliver quality results. - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays, and company-wide shutdowns. - A collaborative and inspiring work environment. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. At Praxis, we turn neuroscience discoveries into treatments to improve patients’ lives. As our Monitoring Oversight Lead, you’ll play a key role in making sure our studies are conducted to the highest standards. You’ll develop and manage strategies that keep trial data accurate, compliant, and inspection-ready, while helping our sites and partners perform at their best. - Lead oversight of onsite, remote, and centralized monitoring across our clinical programs. - Review monitoring reports, assess site and CRA performance, and identify trends or issues early. - Collaborate closely with Clinical Operations, Data Sciences, QA, and CRO partners, if applicable, to drive excellence in trial execution. - Perform risk assessments and develop proactive strategies for issue detection and prevention. - Prepare clear, actionable monitoring oversight reports and CAPA plans. - Support ongoing training and mentoring of CRAs, oversight staff, and vendor teams. - Ensure inspection and audit readiness for all monitoring activities. The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Qualifications - Lead oversight of onsite, remote, and centralized monitoring across our clinical programs. - Review monitoring reports, assess site and CRA performance, and identify trends or issues early. - Collaborate closely with Clinical Operations, Data Sciences, QA, and CRO partners, if applicable, to drive excellence in trial execution. - Perform risk assessments and develop proactive strategies for issue detection and prevention. - Prepare clear, actionable monitoring oversight reports and CAPA plans. - Support ongoing training and mentoring of CRAs, oversight staff, and vendor teams. - Ensure inspection and audit readiness for all monitoring activities. Benefits - 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays, and company-wide shutdowns. - Joining a phenomenal crew of colleagues who are smart, engaged, and inspiring. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. - Core Values: Trust, Ownership, Curiosity, and Results. - Guided by our core values, we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion. - Equal opportunity employer committed to providing opportunities to all qualified applicants.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Praxis is seeking a skilled and hands-on Process Engineer to serve as Praxis’s lead point of contact with our Contract Manufacturing Organizations (CMOs). You’ll work onsite at partner facilities to validate small molecule API manufacturing processes, ensure successful tech transfer, and support commercial readiness. You’ll also play a key role in maintaining reliable supply by overseeing future production. The ideal candidate combines strong technical fundamentals with clear, proactive communication, and thrives in a fast-moving, cross-functional environment. Primary Responsibilities - Ability to understand written chemical synthesis processes from lab partners and help translate those to instructions for industrialized execution by authoring scale up spreadsheets and process manuals. - Efficient use of technologies and applications to gather, analyze and archive large data packages that can support regulatory filings. - Review relevant documentation from CMOs and lab partners including instructions, procedures, batch records, non-conformances, in-process controls, bulletin of analysis, developmental reports. - Work alongside Quality Assurance to ensure all proper regulations and standards are followed in all our processes being executed by third parties. - Adhere to industry guidelines, standards and laws including being well-versed in cGMPs. - Travel required - PIP at CMOs (US and worldwide). Qualifications - Advanced degree in chemical engineering or other relevant engineering field; MS or equivalent a plus. - Pharmaceutical or fine chemical industry experience required. - 8 years’ with a BS degree or 6 years’ with an MS degree of applied experience in CMO management, chemical manufacturing, or comparable positions that handle diverse chemical syntheses in laboratory and manufacturing environments, reviewing Manufacturing and Executed Batch records, operating procedures, non-conformances, change controls, and fostering business partner relationships. - Excellent written and visual communication skills with an ability to build relationships internally and externally. - Self-motivated and able to contribute to a productive and collaborative team environment. - Highly organized and detail-oriented with a passion to deliver quality results. - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays and company-wide shutdowns. - Joining a phenomenal crew of colleagues who are smart, engaged and inspiring. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Praxis is seeking a Service Desk Manager to lead our IT Support Team and ensure excellent technical service delivery across the company. This role is vital to keeping our IT support experience fast, clear, and reliable. As the first line of escalation from our Service Desk Specialists, you’ll triage tickets, optimize routing, and partner across the business to resolve issues quickly. You’ll also drive process improvements, support ongoing maintenance work with our Tier II team, and proactively manage hardware and licensing needs. This is a hands-on leadership role, ideal for someone who’s energized by problem-solving, team coaching, and delivering high-integrity support in a dynamic environment. Primary Responsibilities - Manage day-to-day ticket intake performance and ensure SLAs are met or exceeded - Serve as the primary point of escalation for Tier I tickets, resolving issues or coordinating handoff to Tier II as needed - Support the Tier II team on ongoing IT maintenance and infrastructure projects - Identify and escalate trends in hardware and licensing needs before they impact the business - Coach, mentor, and develop a small team (3–4) of Tier I Service Desk Specialists - Partner cross-functionally with internal teams and external vendors to ensure seamless service - Develop documentation, workflows, and training to improve consistency and efficiency Qualifications - 4+ years of hands-on experience with Microsoft enterprise environments, including Entra ID (Azure AD), Microsoft 365, Defender for Endpoint, and related tools - 3+ years of experience managing a service desk or IT support team - Proven ability to lead, coach, and develop Tier I support staff - Strong troubleshooting skills across hardware, software, and systems in a corporate environment - Demonstrated customer service orientation — responsive, clear, and empathetic in every interaction - Able to triage effectively, prioritize under pressure, and manage workload in a fast-paced setting - Experience with ITSM tools, endpoint management platforms, and remote support technologies - Detail-oriented, proactive, and highly accountable — you take ownership and follow through Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - Comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental and vision plans - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage - Dollar-for-dollar match up to 6% on eligible 401(k) contributions - Long-term stock incentives and ESPP - Discretionary quarterly bonus - Extremely flexible wellness benefit - Generous PTO, paid holidays, and company-wide shutdowns - Joining a phenomenal crew of colleagues who are smart, engaged, and inspiring Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description We’re looking for a knowledgeable and detail-oriented Manager or Senior Manager of Clinical Supply Chain to ensure our clinical trials are always ready to run - without delay, disruption, or waste. You'll be responsible for the end-to-end planning, execution, and oversight of clinical supply activities for assigned clinical programs and studies. You'll manage across the full study lifecycle, from protocol development and study startup through closeout, ensuring uninterrupted supply, regulatory compliance, and operational excellence. This role calls for an experienced clinical supply pro who can manage complexity, proactively identify and mitigate risk, and partner across teams to support Praxis’s clinical development objectives. Primary Responsibilities - Supply strategy development for assigned clinical programs or studies, including forecasting and demand planning as well as packaging, labeling, and distribution oversight. - Depot and site supply management. - Returns, reconciliation, and destruction. - Develop and maintain integrated supply plans aligned with protocol requirements and study timelines. - Support study startup activities, including IRT design input, pharmacy manual development, and vendor onboarding. - Monitor supply performance throughout study execution and proactively resolve issues related to supply shortages, excursions, and distribution challenges. - Manage relationships with clinical supply vendors (e.g., depots, packaging/labeling vendors, couriers, IRT providers). - Lead vendor forecasting discussions, review performance metrics, and manage issue resolution. - Author, review, and approve clinical supply-related documents, including pharmacy manuals, supply plans, shipping documentation, vendor specifications, and work orders. - Ensure all activities are conducted in compliance with GxP requirements, internal SOPs, and applicable regulations. - Support inspection readiness activities and participate in audits and inspections as needed. - Identify clinical supply risks and implement mitigation strategies to protect study timelines and patient safety. - Support quality events, deviations, CAPAs, and change management activities. Qualifications - Bachelor’s degree in a scientific, clinical, or supply chain–related discipline (or equivalent experience) with a minimum of 5 to 8 years of experience in Clinical Supply management in a pharmaceutical or biotechnology environment – small or mid-sized biotech environment preferred. - Experience supporting Phase 2 and/or Phase 3 clinical trials strongly preferred. - Preferred hands-on experience with DTP/DFP models, IRT systems, and global clinical supply distribution. - Demonstrated experience managing end-to-end clinical supply activities for clinical trials. - Proven ability to independently manage multiple studies simultaneously. - Strong working knowledge of GxP requirements and clinical trial operations. - Preferred experience supporting audits and regulatory inspections. - Strong organizational and project management skills. - Proactive problem-solving and risk-based decision-making. - Ability to operate independently with minimal supervision. - Effective cross-functional communication and stakeholder management. - Comfort operating in a fast-paced, evolving environment. Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - You'll need comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental, and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays, and company-wide shutdowns. - Join a phenomenal crew of colleagues who are smart, engaged, and inspiring. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis, we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high-impact medicines for patients and families affected by and living with complex brain disorders. Our core values of Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Praxis Medicines is seeking a Commercial FP&A leader to serve as a strategic finance partner to our Commercial organization as we prepare for launch and scale toward a multi-billion-dollar revenue organization. This role will support near-term launch readiness while also building the financial capabilities, discipline and insights required to operate at commercial scale over time. This role sits within Finance but works in close, real-time partnership with Commercial, CMC and other cross-functional teams. The successful candidate will be deeply embedded in ongoing commercial workstreams, enabling forward-looking decision-making through continuous engagement rather than periodic reporting. Primary Responsibilities - Act as the primary FP&A partner to Commercial leadership, supporting brand strategy, launch planning and revenue forecasting from pre-launch through scale. - Perform revenue modeling, scenario and sensitivity analyses and key commercial assumptions as the business grows to multi-billion-dollar revenue levels. - Partner closely with CMC and Supply Chain teams on inventory assumptions, demand planning and working capital considerations. - Collaborate cross-functionally on pricing, gross-to-net, market access and demand dynamics. - Lead Commercial and CMC input into budgets, ongoing forecasts and long-range plans. - Evaluate investment decisions through ROI analysis and financial modeling to support prioritization and resource allocation. - Develop executive-ready materials that clearly communicate risks, opportunities and trade-offs. - Continuously improve forecasting tools, processes and analytical rigor to support a scaling commercial organization. Qualifications - 12–15+ years of experience in FP&A or strategic finance, with strong commercial exposure. - Biopharma experience required, including experience supporting a commercial-stage company. - Experience supporting product launch and operating in a scaled commercial environment preferred. - Advanced financial modeling and analytical skills. - Proven ability to influence and partner with senior stakeholders across Finance, Commercial and CMC. - Strong business judgment and executive communication skills. - Comfortable operating in a fast-paced, evolving environment with ambiguity. Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - You'll need comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays and company-wide shutdowns. - Joining a phenomenal crew of colleagues who are smart, engaged and inspiring. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. - Core Values: Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business.