Madrigal Pharmaceuticals

• Directing, monitoring, and enhancing specialty pharmacy operations within Madrigal’s Market Access and Trade team • Managing dispensing operations across the channel to drive continuous improvement in patient access and adherence • Collaborating with internal stakeholders including MPS, Marketing, Data Analytics, Medical Affairs, Finance, Pricing & Contracting, Regulatory, Legal, and Market Access field team • Engaging external stakeholders in day-to-day program operations and analysis of key data and KPIs • Developing and implementing operational structures to support Madrigal’s specialty pharmacy network strategy • Overseeing brand planning initiatives, operational plans, project budgets, expenses, and timelines • Ensuring timely and accurate reporting of Adverse Events received through SP network

Role Description The Patient Access Manager serves as the primary point of contact for patients, compliantly guiding them through the medication coverage and reimbursement process to foster timely, affordable therapy access while delivering a supportive and personalized experience. This role provides education, coordination, and problem-solving to address patient and provider needs, secure insurance approvals, and proactively remove barriers to coverage. Patient Access Managers collaborate within a matrix environment, partnering with Field Access, Operations, and other support functions to deliver a seamless, patient-centered experience. Key Responsibilities - Act as the main point of contact for patients and caregivers, offering education, guidance, and ongoing support throughout the access and reimbursement journey. - Lead the case management process with urgency and accountability to achieve prompt and compliant access to therapy. - Conduct benefit investigations, verify coverage, and facilitate prior authorization, denial, and appeal processes. - Facilitate enrollment in financial assistance programs and coordinate with patients, payers, and partners to maintain continuity of care. - Collaborate with healthcare offices, specialty pharmacies, payers, and internal partners to resolve complex reimbursement or fulfillment challenges. - Maintain expertise in payer policies, reimbursement pathways, and product distribution channels to anticipate and address access barriers. - Communicate clearly, compliantly, and compassionately with patients, families, and HCP offices about case progress and available support. - Accurately document all case activity in real time within CRM systems to ensure data quality and case continuity. - Share insights, identify trends, and contribute to process and quality improvement initiatives. - Demonstrate professionalism, empathy, and proactive problem-solving in all interactions while adhering to company policies, privacy standards, and regulations. Qualifications - Bachelor’s degree preferred; advanced degree (MSW, MHA, MBA) preferred. - 7+ years in healthcare or pharmaceutical industry, and 5 years of patient access, reimbursement, case management, direct patient-facing high-touch experience required. - Deep understanding of health insurance benefits, payer policies, and reimbursement processes. - Proven ability to coordinate across healthcare stakeholders, including providers, specialty pharmacies, and financial assistance programs. - Skilled in resolving complex access issues such as benefit verification, prior authorization, and appeals. - Excellent communication, empathy, and critical thinking skills. - Strong organizational and documentation abilities with sharp attention to detail. - Effective collaborator within a matrixed environment. - Up to 15% domestic travel may be required. Preferred - Experience in pharmaceutical or biotech patient services. - Familiarity with multiple drug distribution channels. - Proficiency in Salesforce CRM. Benefits - Base salary range for this position is $136,000 - $167,000 per year. - All full-time employees receive equity, reinforcing our ownership culture. - Comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings. - Additional voluntary benefits like supplemental life insurance, legal services, and other offerings. - Mental health benefits through our Employee Assistance Program for employees and their family.

• Leads GCP quality oversight for global clinical program(s) to ensure sustained compliance, inspection readiness across internal teams. • Implements standards for risk-based oversight, issue management rigor, translating quality signals into cross-functional actions that protect participants and data integrity. • Oversees quality performance across a portfolio of programs and studies, ensuring measurable recurrence reduction. • Provides executive-ready reporting on quality risks, trends, and readiness. • May lead/mentor GCP quality staff.

Role Description We are seeking a highly motivated and experienced professional to join our team as the Senior Director, Access and Reimbursement Manager. In this role, you will lead a team of Access and Reimbursement Managers (ARMs) focused on supporting Healthcare Providers offices in optimizing patient access to a large pharmacy benefit specialty product. This role emphasizes leadership, strategic coaching, and operational excellence to deliver outstanding results in patient access and reimbursement. Position Responsibilities - Leadership and Team Management: - Oversee a regional team of Access and Reimbursement Managers (ARMs), ensuring alignment with organizational goals and strategies. - Provide ongoing coaching and development to ARMs to enhance their performance, with a focus on building strong customer relationships and delivering patient-centric solutions. - Foster a culture of accountability, collaboration, and continuous improvement within the team. - Strategic Planning, Collaboration and Execution: - Develop and execute strategies to optimize access and reimbursement for the specialty product across endocrinology practices. - Monitor regional and national trends in access and reimbursement to proactively address barriers. - Drive implementation of innovative solutions relevant to the market. - Partner with internal stakeholders, including Trade, Market Access, Thought Leader Liaisons, Sales, and Analytics, to ensure alignment on access strategies. - Customer Engagement: - Serve as a key point of contact for escalated issues related to patient access and reimbursement, working collaboratively with ARMs and other stakeholders to resolve challenges. - Build strong relationships with endocrinology offices to understand their unique needs and deliver tailored solutions. - Operational Excellence: - Ensure compliance with company policies and industry regulations in all access and reimbursement activities. - Track and report on team performance metrics, identifying areas for improvement and implementing corrective actions where necessary. - Oversee the development of tools and resources to support ARMs in their day-to-day responsibilities. Qualifications - Bachelor’s degree required; advanced degree preferred (MBA, MHA, or related field). - Minimum of 10 years of experience in access and reimbursement, patient support services, or related roles within the pharmaceutical or healthcare industry. - Proven experience leading and coaching high-performing teams. - In-depth knowledge of pharmacy benefit structures, specialty products, and endocrinology practices is a strong plus. - Exceptional communication, interpersonal, and leadership skills. - Willingness to travel 50-70% in the assigned region. Key Competencies - Strong coaching and mentoring abilities, with a passion for developing team members. - Strategic thinker with the ability to execute effectively in a fast-paced environment. - Exceptional problem-solving skills and a customer-focused mindset. - Ability to navigate complex access and reimbursement landscapes to deliver results. - Cross-functional collaboration. Benefits - Base salary range for this position is $247,000 - $302,000 per year. - Comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings. - Additional voluntary benefits like supplemental life insurance, legal services, and other offerings. - Mental health benefits through our Employee Assistance Program for employees and their family.

Role Description We are seeking an experienced Associate Director, GLP Quality to provide phase-appropriate quality oversight for non-clinical development activities across a growing portfolio of programs. This role requires strong knowledge of US and EU regulatory expectations, risk-based vendor oversight, and the ability to operate effectively in a virtual biotech environment with a global network of CROs, laboratories, consultants, and development partners. The Senior Manager will lead GLP quality oversight for regulated non-clinical studies and external partners, ensuring compliance, documentation integrity, and inspection readiness. This individual will drive audit strategy, issue management, CAPA effectiveness, and continuous improvement while partnering cross-functionally with Development, Regulatory, CMC, Technical Operations, Clinical, and external vendors to support progression of key programs (e.g., Investigational New Drug (IND) submissions). Key Responsibilities - GLP Oversight & Vendor Governance - Lead quality oversight of non-clinical studies conducted at CROs, contract laboratories, bioanalytical laboratories, toxicology sites, and other external partners supporting development programs. - Develop and maintain a risk-based vendor oversight model, including qualification, onboarding, performance monitoring, audits, issue escalation, and periodic review. - Plan, conduct, and manage GxP audits; drive timely closure of findings and CAPAs with effectiveness verification. - Review study- and vendor-related quality documentation, including protocols, reports, deviations, CAPAs, change controls, quality agreements, and data integrity concerns, as applicable. - Issue Management, Inspection Readiness & QMS Support - Lead investigations, root cause analysis, and CAPA activities associated with non-clinical quality events and vendor performance issues, including trending and recurrence prevention. - Maintain inspection readiness for non-clinical activities through controlled documentation, evidence packages, and support for regulatory inspections, partner audits, and due diligence reviews. - Provide guidance and training to internal teams and external partners to reinforce GLP expectations, documentation discipline, and quality standards. - Contribute to the design, implementation, and continuous improvement of phase-appropriate QMS processes relevant to non-clinical development in a virtual company model. - Cross-Functional Partnership - Provide quality input to governance forums, program teams, and functional leadership on compliance risks, mitigation strategies, and business impact. - Partner with Regulatory Affairs to support quality aspects of IND, CTA, IMPD, NDA/BLA/MAA, or related submissions. - Collaborate across Development, CMC, Technical Operations, and Clinical to ensure quality interfaces are managed effectively across development programs. - Support the build-out of scalable quality infrastructure and mentor junior team members as needed. Qualifications - BS in Life Sciences or related discipline; advanced degree preferred. - 10+ years of GLP QA or non-clinical quality experience, including audit and vendor oversight responsibilities. - Strong knowledge of applicable US and EU regulatory requirements for non-clinical development and GLP-regulated activities. - Demonstrated experience overseeing outsourced activities in a virtual or highly outsourced biotech or pharmaceutical environment. - Strong risk-based judgment, documentation integrity, and issue management capability. Preferred Qualifications - Experience supporting regulatory submissions and health authority inspections related to development programs. - Hands-on experience auditing and managing CROs, contract laboratories, and other GxP vendors supporting non-clinical programs. - Familiarity with Veeva and other electronic quality systems, audit management tools, and document management platforms used in virtual organizations. - Experience supporting cross-functional quality interfaces spanning non-clinical, CMC, and clinical development. - Experience in a mid-sized biotech with both commercial and development-stage assets. Key Competencies - Deep knowledge of non-clinical quality, GLP oversight, and vendor governance. - Strong risk assessment, decision-making, and problem-solving capability. - Inspection readiness and audit leadership with a focus on pragmatic, compliant execution. - Clear, concise communication and the ability to influence across internal teams and external partners. - Ability to thrive in a fast-paced, cross-functional, remote environment with high integrity and accountability. Benefits - Competitive Total Rewards strategy including base pay, bonus, equity, and a generous benefits package. - Base salary range: $163,000 - $200,000 per year. - Equity opportunities to reinforce ownership culture. - Comprehensive benefits including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings. - Voluntary benefits like supplemental life insurance, legal services, and mental health benefits through the Employee Assistance Program.

Role Description In this role, the Regional Sales Director will develop the regional business strategy, and hire and lead a team of high-performing Area Business Managers to achieve/exceed business and sales goals. You will work closely with commercial leadership and collaborate with other senior leaders across the organization to develop and execute strategies and initiatives that contribute to the overall performance, culture and success of the organization. The Regional Sales Director will be a working leader with a player/coach mentality. The successful candidate will participate in field-based activities, including but not limited to shared ownership of high value regional accounts and relationships with local thought leaders. The Regional Sales Director will be adept at understanding analytics, market research and local geographic trends to identify business opportunities and create comprehensive and detailed business plans for execution at launch. It is expected that the RSD will display a high level of collaboration with colleagues/stakeholders to develop materials and customer-focused initiatives targeted for a diverse range of healthcare professionals. Qualifications - Bachelor’s degree required. - 5+ years of first-line management experience. - 10+ years of pharmaceutical/biopharmaceutical, medical or related sales experience. - GI/Hepatology experience strongly preferred. - Prior launch experience is required. - Local experience, track record of success, and access to relevant regional thought leaders within assigned region strongly preferred. - Ability to utilize performance and market data to create actionable business plans to drive sales results. - Demonstrated track record of leading successful sales leaders and teams in an environment requiring a high level of initiative, accountability and ethical and compliant actions. - Ability to learn complex scientific and technical information and effectively communicate to a broad audience of healthcare professionals. - Strong communication skills, including proven ability to successfully influence in the virtual setting. - Collaborative, working leader mindset. - Proficiency with Microsoft Office Suite. - A valid driver’s license and ability to travel as needed (including overnights and/or weekends) is required. - Overnight travel up to 50-65% is expected, depending on regional boundaries. - Frequent travel between meeting sites, requiring the ability to sit for extended periods of time. - Frequent use of a computer, telephone, printer or other office equipment. - Ability to lift up to 20 pounds. Requirements - Source, recruit and hire a team of Area Business Managers who are responsible for driving sales results while effectively and compliantly promoting company’s product(s) to targeted HCPs and other healthcare professionals. - Drive performance of region and lead by example as a working leader, meeting with top regional accounts and HCPs/staff. - Work collaboratively and compliantly with cross-functional field facing partners to develop internal and external customer focused initiatives and deliver a positive customer experience and engagement. - Review and analyze district performance and market data in order to develop sales strategies to meet or exceed sales objectives. - Drive performance while developing individual contributors on teams through an established coaching and development plan. - Manage performance issues with parity and a sense of urgency. - Ability to create culture that attracts and retains top talent while driving sales results. - Lead by example to master and display high level of clinical acumen; accountability for self and team to demonstrate mastery level of clinical knowledge, including assessments. - Demonstrate patient centric mindset. - Monitor and ensure utilization of sales and marketing tools and other resources provided to educate healthcare professionals on company’s product(s). - Establish and cultivate strategic relationships with physicians and other healthcare professionals within designated geography (working leader). - Attend all company-sponsored sales and medical meetings as directed by management; attend live conferences and/or programs as necessary as a Madrigal representative. - Comply with all legal, regulatory and compliance policies and demonstrate a high level of integrity and professionalism at all times. - Spearhead cross-functional collaboration and serve as an advocate for customer engagement model. - Additional duties as required. Benefits - Comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match). - Equity offers meaningful opportunity allowing employees to share in the success they help create. - Mental health benefits through our Employee Assistance Program for employees and their family. - Additional voluntary benefits like supplemental life insurance, legal services, and other offerings.

• Partner with Compliance and Legal team members to maintain and enhance infrastructure that supports a culture of compliance • Project management tied to legal and compliance operational excellence • Collaborate cross-functionally to identify policy and guidance needs; develop and refine policies, procedures, and documentation • Lead design, implementation, and continuous improvement of risk-based compliance training programs • Support the annual compliance risk assessment process • Provide practical compliance guidance to business stakeholders • Drive continuous improvement initiatives

• Lead analytics for national payer and PBM accounts, including coverage quality, utilization management, approval rates, time to therapy, abandonment, and pull-through • Monitor performance against contracts, forecasts, and access objectives; identify gaps, risks, and opportunities • Oversee rebate validation, contract performance, and downstream analytics to ensure alignment with financial and contractual terms • Partner with Pricing & Contracting on accruals, forecasting, reconciliation, and gross-to-net performance; resolve discrepancies with clear recommendations • Develop and maintain dashboards, QBRs, executive updates, formulary trackers, and standardized reporting tools • Conduct root-cause analyses of access challenges across payer, provider, field, patient support, specialty pharmacy, and claims data • Collaborate with Field Reimbursement, Specialty Pharmacy, Trade, RADs, KADs, and Sales to convert payer wins into real-world access • Support pre-deal analytics and scenario modeling to ensure future contracts align with access, operational, and financial goals • Translate complex data into clear, actionable insights for leadership and cross-functional teams • Support payer, PBM, and GPO engagements with performance insights and business reviews • May directly manage a select payer account

Role Description The Madrigal MSL will build scientific partnerships with Healthcare Professionals and decision makers using evidence-based science and non-promotional scientific exchange across Northwest Italy (Piedmont, Liguria, Lombardy, Valle d'Aosta and Sardinia). The MSL will serve as a point of contact for the latest scientific and clinical information regarding Madrigal’s novel NASH research program to thought leaders, academic centers, community group practices and regional professional organizations. The MSL will report external insights to better understand MASH diagnosis and treatment landscape. Strategically support the development and utilization of disease state educational materials in the field as needed through disease education, scientific collaboration, clinical trial support, and scientific exchange. Key Responsibilities - Identify, develop and maintain relationships with leading influential experts, key thought leaders (TLs) and health care professionals (HCPs) in fields of medicine or research relevant to the NAFLD/NASH. - Build peer to peer relationships with TLs and HCPs. - Identify and engage key TLs, HCPs, and investigators in proactive scientific exchange on disease landscape and reactive exchange on mode-of-action and clinical data. - Represent the company at selected scientific congresses and professional society meetings. - Deeply understand the fatty liver therapeutic area (NAFLD/NASH), key stakeholders, and healthcare landscape (i.e. reimbursement/access, diagnostic, testing) in your region. - Help execution of medical plans by representing the medical expertise in NAFLD/NASH and through scientific engagement with medical community in Hepatology and Gastroenterology. - Attend relevant scientific meetings and conferences and support development of summaries of key data, presentations or symposium. - Collaborate with other internal team members (i.e., commercial, payer/access, clinical development) to share regional insights/learnings and contribute to respective strategies. - Assist in the scientific training for Commercial and other internal colleagues regarding products and the conditions they treat utilizing approved materials. - Provide scientific expertise and support for speaker training and advisory boards as requested. - Respond to external inquiries and deliver appropriate clinical and scientific information. - Develop and deliver scientific trainings. - Gather careful information from TLs/HCPs and report back to help develop clinical, as well as commercial strategy. - Operate in a highly ethical manner and comply with all laws, regulations and policies. - Complete mandatory training in assigned timelines upon hire as well as when new policies, SOP’s, guidance are issued. - Adhere to internal standard processes and comply with regulatory and compliance. - Working knowledge of relevant research procedures as well as EMA and other ethical guidelines relevant to the pharmaceutical industry. Qualifications - 3+ years medical field experience (MSL or similar). - Advanced degree in healthcare or science-related area of study (e.g., MD/DO, PharmD, PhD, DNP, PA-C) or other life sciences or equivalent with solid medical/technical background. - Hepatology / Gastroenterology and/or Fatty Liver experience strongly preferred. - Working knowledge of regulatory, health technology assessment and disease management for NAFLD/NASH strongly preferred. - Ability to function well, both independently and within a team setting, in a dynamic, fast paced environment. - Team oriented and ability to work collaboratively towards common goals. - Ability to exhibit an entrepreneurial mindset and proactive approach, demonstrating ownership, adaptability to change, and effectiveness within a rapidly growing organizational environment. - Ability to deeply understand and convey emergent scientific information. - Good interpersonal skills, including communication, presentation, persuasion, and influence. - Proficiency with technology – computers, video conferencing, key software (e.g., Microsoft Office, CRM tools). - Willing to travel internationally. - Fluent in English & local language. Benefits

• Lead and mature our global PV Quality function • Provide strategic direction and operational Quality leadership in pharmacovigilance activities • Partner closely with Pharmacovigilance, Regulatory Affairs, Manufacturing, and Commercial teams • Shape risk-based PV QA systems, and mentor a team committed to patient safety practices • Establish product-specific quality strategies and maintain inspection readiness • Support rapid response to product quality concerns