Kyverna Therapeutics

• Develop and execute strategic account plans across health systems, IDNs, and treatment centers. • Lead treatment center activation, onboarding, contracting, operational readiness, and site certification. • Serve as the primary customer contact for CAR-T/cell therapy operations, logistics, and order management. • Partner cross-functionally with Sales, Marketing, Medical Affairs, Market Access, Patient Services, Supply Chain, Manufacturing, Quality, Finance, Legal, and Commercial Operations to resolve issues and deliver key performance indicators. • Support reimbursement strategies, and contracting initiatives. • Drive expansion initiatives including satellite apheresis, outpatient treatment models, and multi-site frameworks. • Analyze and monitor account performance, identify operational gaps, and implement continuous improvements. • Represent customer insights, site performance and launch readiness in senior level meetings. • Build executive relationships and lead strategic business reviews.

• Provide sponsor oversight of CMO QC labs in support of clinical manufacturing. • Establish internal QC processes and maintain control strategy for investigational products. • Support analytical control strategies for Kyverna’s clinical products including ownership of product specifications. • Develop and maintain Kyverna’s stability program, including establishment of trend monitoring and statistical evaluation practices. • Manage Validation/Qualification of Analytical methods as needed, to support multi-phase clinical trials. • Provide subject matter expertise in the investigation of laboratory deviations, out of trend (OOT) and out of specification (OOS) events. • Maintain Kyverna’s internal Quality Control data management and review process, and Certificate of Analysis (COA) generation. • Support Manufacturing to develop and monitor key performance indicators and risk registry to ensure effective oversight of contract/external laboratories. • Ensure QC issues are identified and managed through to resolution in a timely manner and deliverables are met as required. • Work with functional leadership to design, implement and maintain Risk Based Quality Management strategies in support of Kyverna’s clinical programs. • Support business development due diligence projects as needed to support analysis and assessment of internal/external laboratory capabilities. • Other duties as assigned.

• Develop and execute the U.S. sales strategy supporting the commercialization of CAR-T for autoimmune diseases. • Build and lead a best-in-class specialty sales organization capable of supporting current and future product launches. • Establish commercial objectives, territory design, targeting strategies, and deployment models aligned with corporate goals. • Drive revenue growth while ensuring compliance with all regulatory, legal, and company requirements. • Partner with executive leadership to shape long-term commercial strategy and portfolio planning. • Lead commercialization efforts across the CAR-T ecosystem, including treatment centers, referring physicians, infusion centers, and hospital systems. • Develop strategies to optimize treatment center activation, patient identification, referral pathways, and patient access. • Collaborate closely with Market Access, Cell Therapy Operations, Patient Services, and Medical Affairs to ensure seamless therapy adoption. • Understand and address the complexities associated with cell collection, manufacturing, logistics, reimbursement, and site readiness. • Monitor evolving CAR-T market dynamics, competitive intelligence, and emerging treatment paradigms. • Establish and expand relationships with key neurology stakeholders, including academic centers, comprehensive neuroscience programs, and community neurologists. • Drive customer engagement strategies supporting therapies for autoimmune neurological disorders, neurodegenerative diseases, and other complex neurological conditions. • Develop disease-state education and value-based customer engagement approaches. • Partner with Medical Affairs to ensure effective scientific exchange and customer education initiatives. • Recruit, develop, and retain top-performing regional sales leaders and field sales professionals. • Foster a high-performance culture focused on accountability, collaboration, innovation, and patient impact. • Establish performance expectations, coaching programs, succession planning, and talent development initiatives. • Lead ongoing training efforts focused on disease state expertise, clinical data, reimbursement, and customer engagement excellence. • Partner closely with Market Access, Medical Affairs, Marketing, Commercial Operations, Patient Services, Legal, Compliance, and Finance. • Ensure alignment between field execution and broader commercial strategies. • Support forecasting, business planning, resource allocation, and launch readiness activities. • Provide field insights to inform brand strategy, lifecycle planning, and evidence generation priorities. • Establish and monitor KPIs related to sales performance, account engagement, treatment center activation, patient referrals, and market penetration. • Utilize data analytics to optimize territory performance and resource deployment. • Deliver regular business reviews and strategic recommendations to executive leadership. • Identify opportunities to improve commercial effectiveness and customer experience.

• Identify, establish, and maintain high‑quality scientific relationships with key opinion leaders (KOLs), investigators, academic medical centers, community physicians, pharmacists, nurses, and treatment centers within the assigned territory. • Serve as a trusted scientific partner by providing fair‑balanced, accurate, and compliant scientific exchange related to disease state, treatment landscape, Kyverna’s CAR‑T programs, and emerging clinical data. • Act as a primary scientific liaison to investigators interested in clinical research collaborations and investigator‑initiated research discussions, in alignment with company policies. • Develop and execute geography‑specific Medical Affairs and KOL engagement plans aligned with therapeutic area objectives, investigator needs, and Kyverna’s medical strategy. • Demonstrate ownership of the assigned territory through stakeholder mapping, prioritization, and proactive planning to influence the patient journey and support optimal therapeutic decision‑making. • Partner with other Kyverna field medical colleagues to share insights and coordinate external engagement approaches where appropriate. • Collaborate with Clinical Development and Clinical Operations colleagues to support Kyverna‑sponsored clinical trials, including: Identification of potential trial sites, Engagement with participating investigators, Support of trial awareness and scientific dialogue, Contribute to efforts aimed at enhancing trial feasibility and enrollment through appropriate scientific engagement with investigators and treatment centers. • Capture and communicate timely, high‑quality medical insights related to the autoimmune and cell therapy landscape to internal stakeholders to support strategy and evidence planning. • Translate external scientific perspectives into actionable insights that inform medical, clinical, and development decision‑making. • Collaborate cross‑functionally with Clinical Development, Clinical Operations, Regulatory Affairs, Commercial, Market Access, and Patient Services teams while maintaining strict non‑promotional boundaries. • Provide scientific support at national, regional, and local congresses, advisory boards, investigator meetings, and medical education forums. • Respond compliantly to unsolicited medical information requests and serve as an internal and external scientific resource. • Maintain current knowledge of therapeutic areas, treatment guidelines, clinical research processes, and cell therapy operational considerations, including treatment center workflows where applicable. • Ensure timely completion of CRM documentation, administrative tasks, required training, and pharmacovigilance responsibilities, including adverse event and product complaint reporting. • Conduct all activities in full compliance with applicable laws, regulations, and company policies.

• Serve as a field-based scientific expert supporting external engagement with healthcare professionals, investigators, treatment centers, and KOLs focused on autoimmune diseases and cell therapy. • Identify, establish, and maintain high‑quality scientific relationships with KOLs, investigators, academic medical centers, community physicians, pharmacists, nurses, and treatment centers within the assigned territory. • Serve as a trusted scientific partner by providing fair‑balanced, accurate, and compliant scientific exchange related to disease state, treatment landscape, Kyverna’s CAR‑T programs, and emerging clinical data. • Act as a primary scientific liaison to investigators interested in clinical research collaborations and investigator‑initiated research discussions. • Develop and execute geography‑specific Medical Affairs and KOL engagement plans aligned with therapeutic area objectives, investigator needs, and Kyverna’s medical strategy. • Demonstrate ownership of the assigned territory through stakeholder mapping, prioritization, and proactive planning. • Collaborate with Clinical Development and Clinical Operations to support Kyverna‑sponsored clinical trials. • Capture and communicate timely, high‑quality medical insights related to the autoimmune and cell therapy landscape to internal stakeholders to support strategy and evidence planning. • Provide scientific support at national, regional, and local congresses, advisory boards, investigator meetings, and medical education forums.

• Identify, establish, and maintain high‑quality scientific relationships with key opinion leaders (KOLs), investigators, academic medical centers, community physicians, pharmacists, nurses, and treatment centers within the assigned territory. • Serve as a trusted scientific partner by providing fair‑balanced, accurate, and compliant scientific exchange related to disease state, treatment landscape, Kyverna’s CAR‑T programs, and emerging clinical data. • Act as a primary scientific liaison to investigators interested in clinical research collaborations and investigator‑initiated research discussions, in alignment with company policies. • Develop and execute geography‑specific Medical Affairs and KOL engagement plans aligned with therapeutic area objectives, investigator needs, and Kyverna’s medical strategy. • Demonstrate ownership of the assigned territory through stakeholder mapping, prioritization, and proactive planning to influence the patient journey and support optimal therapeutic decision‑making. • Partner with other Kyverna field medical colleagues to share insights and coordinate external engagement approaches where appropriate. • Collaborate with Clinical Development and Clinical Operations colleagues to support Kyverna‑sponsored clinical trials, including: Identification of potential trial sites, Engagement with participating investigators, Support of trial awareness and scientific dialogue, Contribute to efforts aimed at enhancing trial feasibility and enrollment through appropriate scientific engagement with investigators and treatment centers. • Capture and communicate timely, high‑quality medical insights related to the autoimmune and cell therapy landscape to internal stakeholders to support strategy and evidence planning. • Translate external scientific perspectives into actionable insights that inform medical, clinical, and development decision‑making. • Collaborate cross‑functionally with Clinical Development, Clinical Operations, Regulatory Affairs, Commercial, Market Access, and Patient Services teams while maintaining strict non‑promotional boundaries. • Provide scientific support at national, regional, and local congresses, advisory boards, investigator meetings, and medical education forums. • Respond compliantly to unsolicited medical information requests and serve as an internal and external scientific resource. • Maintain current knowledge of therapeutic areas, treatment guidelines, clinical research processes, and cell therapy operational considerations, including treatment center workflows where applicable. • Ensure timely completion of CRM documentation, administrative tasks, required training, and pharmacovigilance responsibilities, including adverse event and product complaint reporting. • Conduct all activities in full compliance with applicable laws, regulations, and company policies.

• Plan and execute strategic external communications activities to support Kyverna’s business goals; this includes priorities such as targeted, proactive media relations. • Develop a pipeline communications strategy and related activities to manage key company data milestones. • Lead stiff person syndrome (SPS) pre-launch communications plan and supported activities, in partnership with Corporate Communications team. • Shape and implement the Company’s social and digital media strategy including managing and updating Kyverna’s corporate digital channels (website, social media feeds, etc.) and driving a social media calendar to maintain stakeholder engagement. • Write press materials (press releases, Q&As, key message documents, etc.) and maintain a corporate news flow calendar. • Support the development of a corporate narrative that can be used to create content for Kyverna’s internal and external corporate channels. • Maintain and update Kyverna’s core corporate communication tools (corporate deck, corporate ads, style guidelines, branding, etc.). • Support crisis communications and issues management when needed. • Build strong working relationships with the Investor Relations team and respective subject matter experts across pipeline programs. • Manage agency partners. • Plan and execute internal communications activities to drive employee education and engagement around the business strategy. • Develop and write internal communications (internal announcements, change management communications, etc.). • Partner with functional leaders to understand their strategies and how best to communicate internally. • Closely partner with the Human Resources team on related employee engagement plans.

• Evaluate, source and manage the network of contract manufacturers, cell collection centers, and contract development organizations. • Evaluate, negotiate and implement major contracts related to manufacturing, procurement and logistics management for autologous and allogeneic CAR T therapies globally. • Build and lead the manufacturing function and supply chain function, including relationship, technical management, contract negotiation and oversight of our external manufacturing and supply organizations. • Build and lead the organization to provide and manage clinical supply, materials management, sourcing and strategic sourcing for the pipeline of cell therapies (both autologous and allogeneic) for Kyverna. • Recruit, hire, and develop employees, and assess, recommend, and implement the structure and capabilities needed to grow the function in step with Kyverna’s strategic growth. • Source and lead the evaluation of qualified organizations to provide critical services, materials, or products to Kyverna. Provide strategic input, including capital planning and capacity management, and information supporting the expansion of the Kyverna footprint globally. Assist teams in building the full business case with risks, opportunities and recommendations that support the growth of Kyverna. • Lead the Supply and Ops planning for all products at Kyverna. Aggregate demand and ensure robust and agile supply strategies to meet demand. • Participate as Member/Leader for Kyverna on JSCs with external members of the supply chain. • Develop and lead the Business Operational reviews for manufacturing and supply of all Kyverna products. Assess and communicate the performance heatmap of the components of the entire supply chain. Escalate conditions of high risk and actively intervene to mitigate risks. • Ensure network readiness for pivotal/registrational studies and launch/commercial supply activities. • Develop and manage manufacturing and supply chain operational budget(s) • Provide scientific and technical guidance and serve as SME for manufacturing processes and technology adoption. • Establish and build the process for process monitoring and performance management of products produced in multiple supply points. Set the expectations for performance of this capability and manage the team to communicate and respond to signals indicating out-of-alignment conditions. • Implement and operate the supply orchestrations systems for Kyverna to track, trace, and adjust the end-to-end patient journey, meeting scheduling requirements and optimizing patient experience. • Support CMC and product development teams through collaboration on development of product history files, master files, site master plans and validation plans. • Maintain current awareness of GMP/GTP and other regulations, guidance documents, advisory committees, industry standards and trends applicable to current and future cell therapy development operations and products. • Provide key strategic Compliance best business practices to projects and cross-functional teams, including process development, manufacturing implementation, IMPD and IND preparation, and discussions with regulators.

• Develop and execute channel strategies that balance customer experience, operational efficiency, compliance requirements, and gross-to-net (GTN) optimization. • Serve as business owner for third-party logistics (3PL) partnerships and distribution operations supporting CAR T commercialization. • Lead specialty pharmacy and distribution strategy development to support current and future portfolio needs. • Partner with Market Access, Finance, Commercial, and Legal teams to evaluate channel design alternatives and their impact on GTN performance. • Assess channel economics and recommend strategies that optimize reimbursement, contracting, distribution costs, and commercial profitability while maintaining customer satisfaction. • Oversee state licensing strategy, renewals, compliance requirements, and regulatory readiness. • Support government pricing activities through cross-functional coordination, process governance, and operational oversight. • Lead distribution governance, service-level management, and operational performance reviews across external partners. • Support launch planning, market expansion, and new product introductions through scalable channel infrastructure. • Develop reporting, analytics, and performance metrics that provide visibility into channel effectiveness and operational health. • Identify and mitigate operational, regulatory, and commercial risks across the distribution network.

• Serve as the executive lifecycle lead for future indications and is accountable for the integrated asset strategy across clinical development, regulatory strategy, manufacturing readiness, and commercialization planning. • Define and maintain the integrated development plan and lifecycle strategy, aligned with the Target Product Profile and long-term commercial value drivers. • Drive strategic planning for key development milestones including Phase transitions, pivotal trial strategy, regulatory interactions, and launch readiness. • Ensure program execution is aligned with corporate strategy, timelines, regulatory requirements, and budget targets. • Lead and develop the Lifecycle Leaders organization, providing strategic oversight and mentorship to lifecycle leads across Kyverna’s development portfolio. • Establish best-in-class lifecycle governance, decision frameworks, and cross-program coordination processes. • Partner with the Executive Leadership Team to ensure portfolio prioritization and investment decisions align with corporate strategy and value creation. • Standardize lifecycle strategy development, program governance, and cross-functional planning across programs. • Serve as a primary strategic advisor to executive leadership on program strategy, portfolio risk, and lifecycle opportunities. • Lead preparation and presentation of program updates, strategic options, and decision packages to governance committees and the Board. • Ensure robust risk assessment, scenario planning, and mitigation strategies are in place across the program. • Define go/no-go decision points and guide governance discussions around program investment and strategic direction. • Represent Kyverna externally with key scientific, regulatory, and industry stakeholders. • Support strategic partnerships, collaborations, and licensing discussions where appropriate. • Engage with key opinion leaders and external experts to inform program strategy. • Ensure coordinated execution across all functional areas including: • Oversee the development and execution of key program deliverables including: