Deciphera Pharmaceuticals

• Provide clinical development leadership to one or more programs. • Contribute to clinical development strategy in alignment with enterprise goals and management. • Serve as medical monitor for one or more studies. • Perform ongoing clinical trial data review and cleaning in collaboration with clinical science and pharmacovigilance. • Attend and contribute to study team meetings. • Present clinical trial findings to management. • Author clinical documents (protocol, investigator brochure). • Author clinical portions of regulatory documents (IND, CTA, NDA, MAA or equivalent). • Develop and manage relationships with key opinion leaders for clinical programs. • Organize, manage and lead Steering Committees and contribute to Strategic or Clinical Advisory Boards. • Contribute to writing of manuscripts, publications, or other documents intended for external audiences. • Contribute in an active and ongoing manner to the scientific, clinical, and commercial development of current and future product candidates. • Contribute to company culture and growth. • Foster communication, collaboration and coordination with other functions. • Contribute to maximizing synergistic collaboration between Ono and Deciphera. • Contribute to assessment of new internal or external targets by outlining clinical challenges and opportunities. • Support Medical Affairs activities as needed. • Participate in and/or coordinate cross-functional continuous improvement projects. • Act as an internal resource for functions requiring clinical input on select drug(s) including primary point of contact for clinical trial staff at study sites for clinical issues as well as regulatory, safety and other functions.

• Develop and execute a strategic territory business plan • Build strong relationships with hematology/oncology healthcare professionals • Communicate the clinical profile of tirabrutinib • Build, maintain, and apply deep clinical and business expertise related to PCNSL • Identify territory opportunities and barriers to patient access • Develop account and prescriber action plans with clear objectives • Collaborate effectively with internal partners • Use CRM and other available tools to support effective territory planning • Execute all activities in a compliant, ethical, and patient-focused manner

• Develop and execute a strategic territory business plan aligned to brand objectives and tailored to the needs of customers, accounts, and treatment centers within the assigned geography. • Build strong relationships with hematology/oncology healthcare professionals, key accounts, and other appropriate stakeholders to support disease state education, product readiness, and access for patients who may benefit from tirabrutinib. • Communicate the clinical profile of tirabrutinib, present pivotal trial data clearly and credibly, and address clinical and non-clinical barriers in a meaningful way with customers involved in hematology patient care. • Identify territory opportunities and barriers to patient access, synthesize market insights, and use those insights to inform territory execution and cross-functional collaboration. • Collaborate effectively with internal partners including Marketing, Market Access, Medical Affairs, Commercial Operations, and other field-based colleagues to support coordinated execution, launch readiness, and a seamless experience for providers and patients.

• Develop and execute a strategic territory business plan aligned to brand objectives and tailored to the needs of customers, accounts, and treatment centers within the assigned geography. • Build strong relationships with hematology/oncology healthcare professionals, key accounts, and other appropriate stakeholders to support disease state education, product readiness, and access for patients who may benefit from tirabrutinib. • Communicate the clinical profile of tirabrutinib, present pivotal trial data clearly and credibly, and address clinical and non-clinical barriers in a meaningful way with customers involved in hematology patient care. • Build, maintain, and apply deep clinical and business expertise related to PCNSL, the treatment landscape, competitive dynamics, customer segment needs, local market access, and the broader marketplace. • Identify territory opportunities and barriers to patient access, synthesize market insights, and use those insights to inform territory execution and cross-functional collaboration. • Develop account and prescriber action plans with clear objectives, use data and analytics to assess trends and progress, and adjust plans as needed to address evolving market conditions and business dynamics. • Collaborate effectively with internal partners including Marketing, Market Access, Medical Affairs, Commercial Operations, and other field-based colleagues to support coordinated execution, launch readiness, and a seamless experience for providers and patients. • Provide field feedback and contribute to the development of resources, tools, and processes that support launch execution, field effectiveness, and customer engagement. • Demonstrate strong understanding of the patient journey, treatment landscape, access and reimbursement considerations, and distribution dynamics relevant to the assigned territory. • Use CRM and other available tools to support effective territory planning, customer engagement, and execution of business priorities. • Execute all activities in a compliant, ethical, and patient-focused manner consistent with company values and policies.

• Develop and execute a strategic territory business plan aligned to brand objectives and tailored to the needs of customers, accounts, and treatment centers within the assigned geography. • Build strong relationships with hematology/oncology healthcare professionals, key accounts, and other appropriate stakeholders to support disease state education, product readiness, and access for patients who may benefit from tirabrutinib. • Communicate the clinical profile of tirabrutinib, present pivotal trial data clearly and credibly, and address clinical and non-clinical barriers in a meaningful way with customers involved in hematology patient care. • Build, maintain, and apply deep clinical and business expertise related to PCNSL, the treatment landscape, competitive dynamics, customer segment needs, local market access, and the broader marketplace. • Identify territory opportunities and barriers to patient access, synthesize market insights, and use those insights to inform territory execution and cross-functional collaboration. • Develop account and prescriber action plans with clear objectives, use data and analytics to assess trends and progress, and adjust plans as needed to address evolving market conditions and business dynamics. • Collaborate effectively with internal partners including Marketing, Market Access, Medical Affairs, Commercial Operations, and other field-based colleagues to support coordinated execution, launch readiness, and a seamless experience for providers and patients. • Provide field feedback and contribute to the development of resources, tools, and processes that support launch execution, field effectiveness, and customer engagement. • Demonstrate strong understanding of the patient journey, treatment landscape, access and reimbursement considerations, and distribution dynamics relevant to the assigned territory. • Use CRM and other available tools to support effective territory planning, customer engagement, and execution of business priorities. • Execute all activities in a compliant, ethical, and patient-focused manner consistent with company values and policies.

• The Associate Director Clinical Scientist contributes to the execution of the clinical development plan for candidate drug products in collaboration with Project Leaders and Medical Directors. • The clinical scientist will be involved in operationalizing studies, monitoring data in real time to ensure the integrity of the study and proactively identifying issues in the conduct of trials. • Responsible for medical review and data analysis for the purposes of both data cleaning and interpretation for regulatory documents and publications. • Monitoring of clinical data: Perform high level clinical data review for quality and patient safety on an ongoing basis and escalate issues to the medical director as appropriate. • Work collaboratively with data management, clinical operations, and medical monitors to ensure clinical data review is performed efficiently and in alignment with the needs of the trial. • Generate and review clinical documents including concept sheets/decks, clinical study protocols, investigator brochures, and regulatory documents. • Organize and present data, study designs, and other information to advisory boards, investigator meetings, site interactions, study committees, and other internal and external settings.

• Lead the development and management of study-level risk assessments, including Risk Assessment Categorization Tools (RACTs) and integrated Quality Risk Management Plans (iQRMPs) • Maintain risk logs and ensure accurate, real-time tracking of study risks • Facilitate periodic risk review meetings and drive proactive risk identification and mitigation • Provide expert guidance on site risk levels, study health, and performance trends • Define and implement study-specific monitoring strategies, including risk-based monitoring approaches such as targeted SDV or centralized monitoring • Document, communicate, and escalate risks to leadership as appropriate • Track, trend, and report Key Risk Indicators (KRIs) to support data-driven decision-making • Partner with internal teams and external vendors to manage risks, mitigations, and issue resolution timelines • Ensure CROs and service providers adhere to RBQM processes and expectations

• Lead a team of experienced and highly competent, knowledgeable, and motivated sales professionals with a track record of performance and a passion for making a difference for patients. • Partner with cross-functional commercial partners to become a true subject matter expert on the key factors that will impact launch success. • Lead the development of regional business plans in close coordination with cross-functional partners that clearly articulate specific actions, timing, and metrics for achieving established goals. • Identify customer needs and marshal the company’s resources to meet those needs. • Partner effectively across field and home office teams to create a seamless experience for providers and their patients within the geography. • Provide feedback on commercial strategy and contribute to the development of resources, tools, and processes critical to field readiness, account execution, and identification of appropriate patients. • Establish a culture of accountability and achievement for the regional team; set clear expectations for performance including meeting business goals and deploying tools and resources appropriately and in line with strategic direction. • Track progress against goals, refine when necessary and celebrate success. • Meet and exceed business objectives through thoughtful planning, collaboration with partners and utilization of tools and resources for flawless execution of strategic direction. • Invest in people development and continual improvement through strong leadership, on-going coaching, and consistent performance management for direct reports.

• Lead batch release activities, including review/approval of batch records and material disposition • Provide GMP oversight for manufacturing and distribution partners (DS, DP, and supply chain) • Ensure compliance with global regulations (FDA, EMA, ICH) • Manage investigations, deviations, CAPA, and change controls • Support audits, inspections, and annual product reviews • Drive quality system improvements and track key quality metrics • Partner with CMOs and suppliers on validation, tech transfer, and qualification activities • Mentor and develop junior QA staff

• Lead day-to-day oversight of commercial manufacturing operations, process engineering activities, and continuous improvement initiatives. • Drive process optimization, troubleshooting, scale-up, PPQ, validation, and lifecycle management activities for commercial products. • Support regulatory CMC strategy, including development and review of Module 3 CTD submissions and health authority responses. • Oversee CDMO/CMO relationships, ensuring strong technical, operational, quality, and regulatory performance across the supply chain. • Partner cross-functionally to support successful product launches, technology transfers, supply chain expansion, and post-approval improvements. • Lead operational improvement initiatives utilizing Lean/Six Sigma methodologies to improve efficiency, reduce costs, and enhance manufacturing performance. • Manage project timelines, deliverables, and budgets while ensuring alignment with overall business and technical operations strategy.