Alnylam

Title: Senior Manager, Commercial Training and Development Location: United States Job Description: Overview The Senior Manager, US Commercial Training & Development – TTR Franchise reports to the Associate Director. This role involves developing and implementing capability building strategies, plans and processes that drive measurable field performance and business outcomes within the TTR franchise. The Training Manager will collaborate cross-functionally in a matrix organization with commercial leadership, field force, marketing, access, headquarters teams, medical, legal, and external vendors. This collaboration will involve facilitating group discussions to determine the training needs and deliverables for US commercial team members. Key Responsibilities - Support the design and execution of capability-building strategies that align to TTR Franchise business priorities and drive measurable field performance outcomes - Translate business goals into targeted learning strategies and solutions that enhance field effectiveness across the customer journey - Partner with Commercial Leadership and cross-functional stakeholders (Marketing, Market Access, Medical, Patient Services, and Operations) to identify performance gaps and define capability needs - Act as a trusted advisor, contributing to decisions related to field execution, capability development, and training strategy - Design and deliver high-impact learning experiences (live, virtual, and digital) that prioritize application, practice, and behavior change over knowledge transfer - Ensure learning solutions are scalable, efficient, and minimize time out of territory while maximizing impact - Manage the development and execution of new hire onboarding and continuous learning programs, ensuring readiness, confidence, and sustained performance in role - Contribute to building just-in-time learning approaches that support ongoing development and field application - Support and operationalize the Field Trainer model, enabling Field Trainers to operate as an extension of the CT&D team through strong facilitation, coaching, and in-field execution - Provide guidance, tools, and support to ensure consistent, high-quality delivery of learning initiatives - Leverage data, insights, and field feedback to assess capability gaps, measure training effectiveness, and recommend improvements to learning strategies - Track and report on key performance indicators (KPIs) to demonstrate the impact of training on behavior change and business outcomes - Design, develop, and deploy learning materials and assets, ensuring alignment with brand strategy, clinical accuracy, and compliance requirements - Manage the CRB submission process and ensure all training materials meet legal, regulatory, and medical standards - Apply innovative learning approaches and technologies (e.g., simulations, AI-enabled tools, digital platforms) to enhance engagement, retention, and scalability - Manage multiple learning initiatives and projects simultaneously, ensuring strong execution, clear communication, and alignment across stakeholders - Collaborate with cross-functional teams to support National Sales Meetings (NSM), POA meetings, and other key field engagements, ensuring learning is impactful and aligned to business priorities - Manage vendor relationships and project deliverables, ensuring high-quality, cost-effective execution of learning solutions - Demonstrate a strong understanding of commercial strategy, sales operations, and field tools, ensuring training solutions are practical, relevant, and aligned to how the field operates - Qualifications - Bachelor’s degree required - Must have a minimum of 5 years of experience in the Pharmaceutical Industry, Commercial field sales experience preferred - Preferred to have a minimum of 2 years training experience in a headquarters role or as a field trainer - - Proven ability to translate business strategy into capability-building plans that drive measurable outcomes - Demonstrated experience supporting product launches, complex therapeutic areas, or specialty markets preferred - Strong understanding of clinical data and the ability to translate scientific concepts into clear, compelling learning experiences - Demonstrated ability to influence cross-functional stakeholders and senior leaders in a highly matrixed environment - Strong executive presence with the ability to facilitate both strategic discussions and engaging learning experiences - Experience using data, insights, and performance metrics to identify capability gaps and measure training effectiveness and business impact - Strong foundation in adult learning principles, instructional design, and modern learning approaches, including digital, virtual, and just-in-time learning - Experience leveraging innovative learning solutions (e.g., simulations, AI-enabled tools, scalable learning platforms) preferred - Excellent project management skills with the ability to manage multiple priorities, workstreams, and deadlines in a fast-paced environment - Strong written and verbal communication skills, including presentation and facilitation excellence - Ability to build trusted relationships and collaborate effectively across all levels of the organization - Proficiency in Microsoft Office (PowerPoint, Excel, Word) and virtual learning platforms (e.g., Zoom or similar) - Ability to travel up to 20% - #LI-SS1 #LI-Remote U.S. Pay Range $147,100.00 - $198,900.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Title: Director, Field Medical Affairs - Community Cardiology Location: United States Job Description: Requisition ID 3336 Medical Affairs - US TTR - Medical Affairs - US TTR - Medical Affairs Overview: The Director, Field Medical Affairs is a national leadership role responsible for defining and executing the Field Medical strategy for the community segment, aligned to US Medical Affairs and enterprise priorities. This role leads a team of Medical Science Liaisons (MSLs) and is accountable for translating strategy into disciplined execution, measurable outcomes, and sustained scientific impact. This leader demonstrates strong executive presence and leadership credibility, serving as a trusted voice of Field Medical in cross-functional and Medical Affairs leadership forums. The Director ensures medical and scientific priorities are effectively and compliantly integrated into regional and national plans, while influencing senior stakeholders and shaping enterprise decisions. Success in this role requires a balance of strategic thinking and execution rigor, along with the ability to lead through influence, drive alignment across stakeholders, and elevate field medical impact at scale. The Director also plays a critical role in driving performance through KPIs, strengthening coaching and capability development, and building a high-performing national MSL organization. Key Responsibilities: - Lead and develop a national team of MSLs, fostering a high-performance culture grounded in accountability, continuous development, and strong scientific engagement. - Define and execute the Field Medical strategy for the community segment, ensuring alignment to US Medical Affairs priorities and enterprise objectives. - Translate strategy into clear field medical plans, execution frameworks, and measurable outcomes across regions. - Establish and drive KPIs and performance metrics to assess field impact, ensure execution quality, and enable data-driven decision-making. - Ensure consistent, high-quality, and compliant execution of field medical activities across the organization. - Provide ongoing coaching, performance feedback, and leadership development to enhance MSL effectiveness, strategic thinking, and engagement quality. - Represent and lead the Field Medical voice in cross-functional forums, demonstrating executive presence and influencing stakeholders to ensure appropriate and compliant integration of medical priorities into regional and national plans. - Shape cross-functional strategies by incorporating field insights, scientific perspectives, and medical priorities, ensuring alignment with US Medical and enterprise strategy. - Ensure all cross-functional engagement and planning are conducted with strong compliance, scientific integrity, and adherence to Medical Affairs governance standards. - Serve as a strategic liaison across Medical Affairs and cross-functional partners, proactively aligning priorities, removing barriers, and strengthening coordinated execution. - Lead national account planning approaches and field deployment strategies to optimize engagement with key healthcare systems and providers. - Demonstrates resilience, determination, and follow-through in the face of complexity, setbacks, or resistance; maintains focus on strategic priorities; and drives initiatives. - Oversee budget planning and resource allocation, ensuring disciplined investment aligned to strategic priorities. - Represent Field Medical in Medical Affairs leadership discussions, bringing forward field insights and strategic perspectives to influence enterprise decisions. Core Requirements: - Advanced degree (PharmD, PhD, MD, or DO) - 12+ years of Medical Affairs experience, including field medical leadership - Proven ability to lead and develop high-performing MSL teams at scale - Demonstrated strength in executive presence, influencing senior stakeholders, and operating effectively in leadership forums - Strong track record of strategy development, execution, and cross-functional leadership - Experience with KPI-driven performance management, coaching, and organizational leadership - Experience in cardiology, rare disease, or specialty biopharma preferred - Willingness to travel (~50–60%) #LI-ST1 #LI-Remote U.S. Pay Range $214,200.00 - $289,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Title: Sr Director, Executive Sales Lead, TTR - South Location: United States Job Description: Overview: We are seeking a seasoned strategic commercial leader, with strong business acumen, launch experience and executive presence, who is passionate about people development and deeply motivated by the quest of delivering value to patients and their families. The company is preparing for multiple commercial launches and is continuing to build U.S. and global commercial capabilities. Reporting to the VP, US TTR Sales, the successful candidate will be part of the U.S. sales leadership team responsible for the driving performance with AMVUTTRA® (vutrisiran) for the treatment of polyneuropathy of hATTR and the recently expanded indication in cardiomyopathy in ATTR. The successful candidate will play a key role in the U.S. leading the sales organization to deliver against the AMVUTTRA territory, area and national goals. They will be responsible for TTR product commercialization through diligent talent selection, leadership and oversight of our field based TTR Regional Business Directors with appropriate coordination across Alnylam Assist® (our in-house Patient Support Services team), Field Reimbursement, Training, Business Operations, Legal and Compliance. They will partner closely with the U.S. Marketing team across all activities and coordinate appropriately with Medical Affairs. They will foster a culture of accountability and lead the sales team to meet or exceed targets. The achievement of objectives will be based on Alnylam values: our Commitment to People, Purposeful Urgency, Passion for Excellence, Open Culture, and Fiercely Innovative as well as our unwavering commitment to integrity. Key Responsibilities: The Senior Director, Executive Sales Lead (East), will support development of the field structure and customer facing strategies to deliver against the TTR Franchise goals with AMVUTTRA to treat the polyneuropathy of hATTR and the expanded indication in cardiomyopathy in ATTR, ensuring market leading and compliant coordination across Commercial, Medical Affairs and all additional supporting teams. As a key member of the U.S. TTR Leadership Team, they will: - Contribute to the future direction of the U.S. TTR Franchise supporting the strategic direction and development of in field executional plans in partnership with the core functional leads. - Lead a team of approximately 5-6 Regional Business Directors (RBDs), tasked with building their teams and delivering patient and business value. - Ensure team meets or exceeds targets following all compliance expectations. - Develop a zone strategic plan to outline zone and regional objectives including competencies and capabilities. - Lead the sales organization pre-launch and launch planning to support maximum uptake at approval. - Provide input to design the incentive compensation plan in partnership with the Central and West Executive Sales Leads and the VP, US TTR Sales and partner with the Field Operations team to establish the call plan, targets, expectations and tracking to effectively measure performance. - Partner with Sales training leadership to develop coaching frameworks and capability to successfully engage in the field. - Collaborate with IDN team, U.S. Marketing, Market Access, Patient Support Services, Business Operations, U.S. Medical Affairs, Legal, Compliance and other internal stakeholders to support the field with appropriate materials and programs; monitor progress and drive course correction where necessary. - Establish appropriate U.S. targets and objectives, support definition of key performance indicators (KPIs) and proactively monitor and adjust incentives and metrics to drive success. - Conduct field visits, regional and national team meetings to align teams, monitor execution, identify issues/opportunities and define new actions. - Be deeply involved in the recruitment and onboarding of the Business Account Executives (BAEs) in conjunction with RBDs to hire and retain talent. Qualifications and Key Competencies: - Seasoned commercial leader with 13+ years U.S. leadership experience in sales, marketing, commercial operations, and/or account management in commercial healthcare organizations. - BA/BS Required - MBA and/or other advanced scientific degree preferred (i.e., M.D., PhD or PharmD). - Previous second line management and U.S. Specialty product Launch experience preferred. - Previous experience in additional functions beyond sales (marketing, market access, patient services) is strongly preferred - Working knowledge of Buy/Bill and expertise of Part B & D preferred; knowledge of how to compliantly work with a case management and field reimbursement team required. - Must be familiar with relevant legal and regulatory environment in biotech/pharmaceutical industry. - Demonstrated leadership working in network operating model environment. - Proven track record in driving culture of accountability. - Effective planning, prioritization, management, and organizational skills. - Ability to clearly communicate complex messages, accurately. To understand specific needs of intended audience and tailor communication accordingly, detail oriented with ability to understand big picture impact. - Works collaboratively across expertise areas and functions; seeks to advance higher goals; highly regarded across stakeholders both at senior and junior levels; inspires trust at all levels; patient-centric, and passionate for innovation and discovery. - Must be comfortable spending 50% of time traveling to visit customers, attend conferences and attend meetings in the Cambridge (MA) office. - Candidate must have a valid U.S. driver’s license to be considered. - Demonstrated commitment to ethics and integrity. - Clear Alignment with Alnylam Core Values: Commitment to People, Purposeful Urgency, Passion for Excellence, Open Culture, and Fiercely Innovative #LI-ST1 #LI-Remote U.S. Pay Range $242,300.00 - $327,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Title: Business Account Executive, TTR - Central CA Location: United States Job Description: TTR Sales - US - Commercial - US TTR - Sales Overview: We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA™. Patients with TTR amyloidosis often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market’s knowledge of TTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders Achievement of targets will be grounded in Alnylam’s core values—our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture—while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities: - Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption. - Continuously assesses sales opportunities and challenges within territory and accounts to grow their business. - Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential. - Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach. - Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people’s emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals. - Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care. - Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results. - Collaborates with key accounts and physicians to drive patient identification through market development and physician education; aligns with cross functional team on strategy to retain customers. - Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results. - Demonstrates and upholds the highest standards of integrity and compliance. - Additional responsibilities as required to support business needs and organizational priorities. Qualifications: - 4-year degree from an accredited college or university required. - B2B sales experience required. - 1-2 years of progressive and successful business experience in biotech or the specialty pharmaceutical industry preferred; individuals with B2B experience in all industries encouraged to apply - Strong interpersonal skills with the ability to build relationships and rapport with internal teams and stakeholders. - Basic understanding of data analysis tools and ability to interpret simple datasets. - Willingness to learn and adapt to changing environments and new methodologies under supervision. - A growth mindset with the ability to treat challenges as learning opportunities. - Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times. - Excellent communication and listening skills. - Collaboration: Builds foundational relationships, seeks feedback, and adapts to new methods with guidance. - Customer Focus: Engages customers with empathy, delivers approved messaging based on customer needs, and starts building trust with stakeholders. - Execution: Completes tasks on time, tracks performance, and begins aligning business plans with team goals and emerging trends in their territory. - Critical Thinking: Learns basic data analysis, identifies opportunities, and makes small decisions with support. - Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories. - Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable. - Must live within assigned territory. #LI-ST1 #LI-Remote U.S. Pay Range $119,000.00 - $161,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Title: Business Account Executive, TTR - Jacksonville, FL Location: United States Requisition ID 3390 TTR Sales - US - Commercial - US TTR - Sales Job Description: Overview: We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA™. Patients with TTR amyloidosis often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market’s knowledge of TTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering & collaborating very closely with internal and external stakeholders Achievement of targets will be grounded in Alnylam’s core values—our unwavering commitment to people, a sense of urgency, passion for excellence, innovation and discovery, and an open culture—while upholding the highest standards of integrity. This position reports to the Regional Business Director within its respective area. Key Responsibilities: - Identify and/or target healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption. - Continuously assesses sales opportunities and challenges within territory and accounts to grow their business. - Effectively prioritizes and manages time, activities, and resources to optimize access to and development of accounts with the most sales potential. - Builds and maintains relationships with physicians by maximizing their time through pre-call planning, leveraging insights to tailor a call plan, and conducting post-call analysis to continually refine and enhance their approach. - Proactively builds effective working relationships with internal/external stakeholders; can drive agreement/decisions from multiple stakeholders; can read people’s emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals. - Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care. - Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results. - Collaborates with key accounts and physicians to drive patient identification through market development and physician education; aligns with cross functional team on strategy to retain customers. - Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results. - Demonstrates and upholds the highest standards of integrity and compliance. - Additional responsibilities as required to support business needs and organizational priorities. Qualifications: - 4-year degree from an accredited college or university required. - B2B sales experience required. - 1-2 years of progressive and successful business experience in biotech or the specialty pharmaceutical industry preferred; individuals with B2B experience in all industries encouraged to apply - Strong interpersonal skills with the ability to build relationships and rapport with internal teams and stakeholders. - Basic understanding of data analysis tools and ability to interpret simple datasets. - Willingness to learn and adapt to changing environments and new methodologies under supervision. - A growth mindset with the ability to treat challenges as learning opportunities. - Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times. - Excellent communication and listening skills. - Collaboration: Builds foundational relationships, seeks feedback, and adapts to new methods with guidance. - Customer Focus: Engages customers with empathy, delivers approved messaging based on customer needs, and starts building trust with stakeholders. - Execution: Completes tasks on time, tracks performance, and begins aligning business plans with team goals and emerging trends in their territory. - Critical Thinking: Learns basic data analysis, identifies opportunities, and makes small decisions with support. - Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories. - Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable. - Must live within assigned territory. #LI-ST1 #LI-Remote U.S. Pay Range $119,000.00 - $161,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Title: Sr Mgr, Medical Science Liaison, Community - River Valley (MI, OH, KY, TN) Location: United States Job Description: Overview: The Medical Science Liaison (MSL) is a field-based scientific expert who serves as a strategic bridge between Alnylam and the external medical community, with a particular focus on community-based care settings. The MSL builds and sustains peer-to-peer relationships with emerging opinion leaders (EOLs), healthcare professionals (HCPs), and community, regional and local health systems to advance evidence-based scientific exchange, gather critical field insights, and drive optimal patient outcomes. Success in this role requires tenacity and persistence to navigate complex community dynamics, sustain engagement over time, and advance meaningful outcomes for patients and providers. Key Responsibilities: - Identify, engage, and cultivate long-term relationships with EOLs, thought leaders, and HCPs across community and health system settings within a defined territory. - Deliver accurate, balanced, and scientifically rigorous information on Alnylam's therapies and therapeutic areas through peer-to-peer scientific exchange. - Engage HCPs in community practice settings in evidence-based scientific dialogue, drawing on relevant clinical and outcomes data to support awareness of diagnostic and treatment considerations across the disease area. - Support medical education initiatives, advisory boards, speaker programs, and clinical research activities, including those that address the needs of community-based providers and care teams. - Gather, synthesize, and communicate medical and scientific insights from the field to internal stakeholders (e.g., Medical Affairs, Commercial, Market Access, Strategic Account Management). - Respond to unsolicited medical information requests from HCPs in a compliant and timely manner (within 2 business days). - Collaborate cross-functionally with Medical Affairs, Commercial, Market Access, and Strategic Account Management teams to align on scientific strategy and messaging. - Represent Alnylam at national, regional and local medical conferences, symposia, and scientific meetings. - Maintain current knowledge of relevant disease areas, clinical data, competitive landscape, and evolving evidence. - Ensure all activities comply with applicable regulations, company policies, and PhRMA guidelines. - Apply business acumen to understand territory dynamics and prioritize engagements that drive scientific and organizational impact. - With guidance, builds foundational skills in strategic thinking, scientific expertise, engagement excellence, integrity-driven conduct, and cross-functional collaboration - developing the independence and confidence to execute field medical responsibilities with increasing consistency. Qualifications: - Required: PharmD, PhD, MD, or DO in a relevant life science discipline, pharmaceutical industry fellowship preferred - 1-3 years’ prior MSL experience within the pharma/biotech industry - Scientific acumen with ability to critically evaluate and communicate complex clinical data. - Excellent interpersonal, communication, and presentation skills; ability to engage credibly in peer-to-peer scientific dialogue. - Proficiency with CRM systems and digital engagement platforms. - Ability to travel up to 60–70% within assigned territory; must reside within territory. - Valid driver's license required. #LI-ST1 #LI-Remote U.S. Pay Range $162,800.00 - $220,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Title: Regional Business Director, TTR - Northeast (MA, ME, NH, VT, RI, CT) Location: United States Job Description: TTR Sales - US - Commercial - US TTR - Sales Overview: We are looking for an experienced Regional Business Director (RBDs to support the promotion of AMVUTTRA® (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA® (vutrisiran). The approval expands the indication for AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults. The RBD will be principally responsible for leading and managing a high-performing team of Business Account Executives, focusing on disease awareness and product education among healthcare professionals managing hATTR amyloidosis patients. This is an incredible opportunity to build a team and shape a market in support of patients, caregivers, and the hATTR amyloidosis community. The RBD will provide coaching to help ensure every BAE meets or exceeds target. He/she will be critical in the assessment and improvement of field and selling processes. RBDs will also need to provide insights to inform commercial strategy, given their proximity to the market, and ultimately meet and exceed performance targets. The RBD will also need to embody Alnylam values: our commitment to people, sense of purposeful urgency, passion for excellence, innovation & discovery, and open culture as well as our unwavering commitment to integrity. Additionally, an RBD will be responsible for the creation of a customer-oriented climate that focuses on an understanding of patient and customer needs, value-added services, and seamless execution. Through the building of best-in-class teams, talent development, and regular monitoring and coaching, the RBD will foster a culture of accountability. The position reports to the Executive Sales Lead role. Key Responsibilities: - Lead and manage a high-performing team of Business Account Executives, focusing on disease awareness, product education among healthcare professionals managing hATTR amyloidosis patients - Utilize strong sales management, strategic planning skills, financial acumen, and analytical capabilities to align sales execution with overarching product strategies and market needs. - Analyze market and proactively develop a forward-thinking action plan, rather than solely reacting to past events. Capable of clearly conveying the current market situation and proposed plan of action to leadership, while also ensuring the team is aligned to future objectives and expectations. - Coach and develop team members to exceed performance targets, emphasizing compliance and effective local business management through strategic business planning and cross-functional alignment. - Leverage proximity and familiarity of their market to provide insights that help inform the commercial strategy. - Attract, manage, and retain top sales talent with a demonstrated experience in diverse specialties. - Hold the team accountable to sustaining a customer-oriented culture that prioritizes understanding and meeting patient needs, delivering seamless execution and value-added services. - Allocate and manage regional resources effectively that support targeted strategic and operational excellence. - Align people, processes, structure, information, and communication systems within a complex ecosystem – both within and across functions. - Inspire and motivate the team by clearly articulating the strategy and vision for the future. Qualifications: - Bachelor’s degree required: science focus strongly preferred; MBA/PhD is a plus. - 7+ years in sales, marketing, commercial operations, and/or account management experience in commercial healthcare organizations (i.e., Biotech, Med Device or Specialty Pharmaceuticals). - 3+ years of experience in leading teams, experience building out field sales teams preferred - Rare/orphan disease experience preferred. - Experience training and managing BAEs to effectively promote multiple specialties. - US product launch experience is helpful. - In-depth reimbursement knowledge of Buy/Bill and expertise of Part B & D, working with in-house patient support services team required. - Hospital / Institution knowledge and expertise with the P&T process. - Deep experience in Neurology and Cardiology is preferred. - Knowledge and experience with “site-of-care” development. - Experience in working in various departments, managing multiple teams (sales, marketing, market access, patient services). - Demonstrated leadership in working in a matrix environment and influencing management decisions. - Effective planning, prioritization, management, and organizational skills. - Must be familiar with relevant legal and regulatory environments in biotech/pharmaceutical industry. - Significant domestic/regional travel is required (approximately 60 – 70%). - Valid Driver’s license required. - Demonstrated commitment to ethics and integrity. #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.