Role Description As a Platform Engineer (m/f/d), you will be part of a talented team of developers at all levels and play a central role in building and operating the next generation of our infrastructure. We are actively migrating from an Ansible-based VM deployment model to a Kubernetes-based platform managed via GitOps. You will help design, build, and run this platform — from multi-cluster operations to developer-facing deployment pipelines — while ensuring the reliability and security our healthcare customers depend on. - Design, build, and operate our Kubernetes platform across multiple clusters - Develop and maintain our GitOps workflows with Argo CD (app-of-apps model, Helm-based deployments) - Operate and evolve core platform services such as Harbor, OpenBao, Zitadel - Build and improve observability across the platform (Grafana, Mimir, Loki, Tempo, Alloy) and contribute to actionable alerting - Manage secrets, backups, and data services (e.g. CNPG/PostgreSQL, VolSync, S3 storage) - Partner with product engineering teams to migrate services from Ansible/VM-based deployments to Kubernetes and define reusable deployment standards - Improve developer experience through documentation, templates, golden paths, and self-service platform capabilities - Troubleshoot platform issues across infrastructure, networking, and application layers (2nd-level support) - Participate in on-call duties to ensure stable platform operations - Contribute to platform architecture decisions, runbooks, and operational documentation Qualifications - Several years of experience in infrastructure engineering, platform engineering or DevOps - Solid hands-on experience operating Kubernetes in production (multi-cluster experience is a plus) - Experience with GitOps and declarative infrastructure (e.g. Argo CD, Helm) - Good knowledge of networking, TLS/certificates, DNS, firewalls, and container technologies - Experience with monitoring and observability for distributed systems (e.g. Grafana, Prometheus/Mimir, Loki) - Scripting and automation skills (e.g. Nix, Bash, OpenTofu/Terraform) - Familiarity with CI/CD workflows and production deployment practices (progressive rollouts, rollbacks, health checks) - Strong problem-solving skills, clear communication, and a proactive ownership mindset - Very good English skills, written and spoken Requirements - Ideally a completed IT apprenticeship or degree — or equivalent qualifications through professional experience - Experience with service mesh (Istio), Gateway API, and policy engines (e.g. Kyverno) - Experience with secrets management (e.g. OpenBao/Vault, External Secrets Operator) - Experience with PostgreSQL operators (e.g. CNPG) and backup/restore workflows - Prior involvement in large-scale infrastructure migrations - Experience in regulated or security-sensitive environments (e.g. healthcare) Benefits - Work at a fast-growing startup in an exciting phase - Your perfect work-life balance with remote work and flexible hours - Attractive conditions with a permanent contract and competitive compensation (range between 60-70k € gross/year depending on your experience) - Flexible Benefits with Probonio – a monthly wellbeing budget for various vouchers or discounted memberships - Opportunities to contribute to open-source projects - Autonomy & room to shape company structures and internal processes - A diverse and international team valuing an open mindset and inclusive culture - Regular team events such as workshops, team-building activities, and company events

Role Description The Senior Engineer/Manager, Process Validation will lead and manage various process validation activities for drug substance (DS) and drug product (DP) manufacturing, label and secondary packaging, and shipping validation processes at Contract Manufacturing Organizations (CMOs). This role involves executing and overseeing process validation and related lifecycle activities to ensure compliance with Good Manufacturing Practices (GMP) and global regulatory requirements. This role requires collaboration across various departments, including Manufacturing, Supply Chain, Quality Assurance (QA), and Contract Manufacturing Organizations (CMOs), to ensure successful development and execution of all validation activities. This position will report to the Director of Manufacturing Validation. Key Responsibilities - Lead and execute complex validation projects, including process, labeling/packaging, and shipping validation. - Develop and implement process validation master plans (PVMPs), risk assessments, and validation strategies aligned with lifecycle and quality-by-design (QbD) principles. - Coordinate with CMOs and internal teams to plan, execute, and review validation and qualification activities, ensuring consistent documentation and adherence to standards. - Define acceptance criteria, sampling plans, and load configurations, and perform thermal mapping to assess environmental impacts on product stability and CQAs across all shipping conditions. - Collaborate with internal and external partners to review, approve, and execute validation documentation, including qualification and requalification protocols. - Collaborate with internal and external partners to develop and define key product lifecycle documentation, including quality attribute and process risk assessments (FMEAs), process control strategy documents, continued process verification control plans, etc. - Provide expert input during deviation investigations, Corrective and Preventive Actions (CAPAs), and regulatory audits to ensure compliance with ICH, FDA, and global validation guidelines. - Lead gap assessments and recommend improvements to maintain the validated state throughout the product lifecycle. - Author, review, and approve validation protocols and reports in accordance with GMP and internal quality systems. - Support FDA Pre-Approval Inspection (PAI) preparations and address validation-related queries regarding shipping and combination product programs. - Participate in cross-functional meetings with Quality, Manufacturing, and Regulatory Affairs to align on validation priorities and strategies. Qualifications - Bachelor’s degree in engineering, Life Sciences, or a related field with 8+ years or Master’s and 6+ years of experience. - Experience in pharmaceutical or biotechnology with significant expertise in process validation of drug substances and drug products is preferred. - Prior experience leading labeling/packaging and shipping validation is preferred. - Expertise in oligonucleotide manufacturing is highly desirable. - Demonstrated experience leading validation activities with external CMOs and internal manufacturing partners. - Prior experience in leading process design and validation of combination drug-device products (e.g. pre-filled syringes, autoinjectors, etc) is a plus. - Strong working knowledge of current Good Manufacturing Practices (cGMP), ICH Q8-Q11, and FDA Process Validation Guidance using a lifecycle approach. - Understanding of combination products (drug-device) and regulatory expectations under 21 CFR Part 4, FDA Guidance for Combination Products, and ISO 13485. - Knowledge of applicable standards and regulations, including ISTA 2A/3A, Good Distribution Practice guidelines. - Familiar with statistical methods applied to manufacturing controls such as Design of Experiments (DOE) and Statistical Process Control (SPC) and associated software packages such as JMP. - Level of hire (Senior Engineer or Manager) will be commensurate with the selected candidate's qualifications, scope of prior responsibility, and years of relevant experience. Location(s) - Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. - This position is eligible for either remote or hybrid work arrangements. Travel - This position will require approximately 10-20% travel. Compensation & Benefits - The anticipated salary range for this role is $140,000 - $161,000. - The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. - In addition to base salary, Stoke offers an annual bonus and equity participation. - Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values - At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. - We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. - Our values guide our work to deliver meaningful medicines for people who need them. - We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. - We embrace diversity within a unique culture that is defined by our values. - Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. Interested candidates Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center: https://www.stoketherapeutics.com/careers/ For more information, visit https://www.stoketherapeutics.com/ . All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify.

Support Engineer Remote UK Full-time Permanent employee 30,000 - 40,000 £ per year About us Cronofy is a high-growth technology company headquartered in Nottingham, UK. Our mission is to be the go-to scheduling infrastructure for high performance companies globally. Over the past 11 years, we’ve grown a self-sustaining, profitable business serving businesses around the world. From market leaders like GoDaddy, Houzz and Indeed through to the smallest tech start-ups. We're truly international, with over half of our customers in the US with the remainder across EMEA and APAC. Our Customer Support team provides first-class service, with a Customer Satisfaction rating of >97%. It’s an incredibly exciting time to join us, following recent funding we are in a strong position to enhance our core offering and expand into growing international markets. We are now looking for someone to help support the growth of the unparalleled Scheduling products that Cronofy offer. We actively support and encourage people to grow in their careers, and this role comes with real, proven progression. Previous support team members have moved into other areas of the business, such as engineering or infrastructure - or focus on Support to become an expert in what you do. We provide the time and tools to learn, improve, and develop, and we'll support you in finding the right path. The role As part of the Technical Support team, the role of Support Engineer is to resolve technical issues and queries for Cronofy's customers while delivering first-class support. The Support Engineer is responsible for fielding questions from the Cronofy customer base, taking ownership of customer issues, and seeing them through to resolution. Alongside ticket resolution, the Support Engineer regularly reviews and updates our documentation pages. This person genuinely cares about doing right by the customer and works closely with other teams across the business to ensure that customers have positive experiences with Cronofy. They naturally look for a better way forward, using initiative to find improvement opportunities and act on them. They're curious by nature and keen to deepen their understanding, building expertise in Cronofy's API and Scheduler tool. This role will also work alongside our Engineering team on product development projects, building the technical grounding needed to support increasingly complex, product-related issues. This role reports to Rachael, Support Team Lead. Key Responsibilities: - Helping customers use Cronofy effectively - Building an in-depth understanding of Cronofy’s API, Scheduler tool, and the problems our customers face; becoming a Scheduling Expert - Managing, investigating, and resolving customer support tickets. Taking ownership from first response through to resolution - Troubleshooting technical issues, identifying root causes, and problem solving across a range of customer use cases - Providing exceptional customer service by offering advice, resolving confusion, and identifying possible bugs for our customers - Writing clear and helpful documentation for existing and upcoming features - Searching for opportunities to improve processes and support continuous improvement within the department - Working with Success, Product, Engineering, and Sales teams to understand and help customers Requirements: - Clear understanding of API concepts and how they operate - Experience with an API or SaaS based business supporting a product - Technical customer support experience - Development experience with APIs, NodeJS, Ruby on Rails, C#, PHP or Go is preferred but not essential - Sysadmin experience with MS Exchange and/or Office 365 is preferred but not essential How we work We can support a predominantly remote, office-based or hybrid working model. We really do value face to face time and, under normal circumstances, encourage teams to spend regular time together at our offices or suitable locations. Our Support team currently covers the UK and Amsterdam. We meet in a mixture of Nottingham (HQ), London, and Amsterdam offices. For this reason we are open to considering applicants in either the UK or Netherlands. We work hard but insist that everyone considers the balance between this alongside life and responsibilities outside of work. We use our principles to guide our behaviour as people and form the basis for our day-to-day decision making. We are direct with our dealings with each other. We continuously work to build mutual trust so that we can give each other feedback without fear of it being taken personally. Hiring process The goal is to discover what you will bring to Cronofy and what Cronofy will bring to you. It's as important for you to determine whether this is the right move for your career as much as anything else, so don't be afraid to ask questions. We value transparency and so are happy to answer (virtually) any questions you may have. What we offer - £30,000 - 40,000 per annum according to your experience - Pension scheme matched at 5% - 25 days holiday in addition to flexible national holidays. National holidays are added to your holiday allowance and you're not required to take them on the corresponding day. - 6 personal development days per year to use for L&D, charitable causes or similar - Private medical care with Bupa - Medicash Proactive cash plan for dental, optical etc. - EAP - Employee Assistance Programme providing 24/7 mental health support - Extended maternity and paternity leave for new parents and adoption - Pleo card for work expenses, hardware, travel etc. - A flexible approach to working; remote, office or hybrid - A principles driven culture that provides the framework for autonomous decision making and personal development. Cronofy exists to schedule everything for everyone. We can only achieve this goal when we strive to foster an inclusive working environment that inspires innovative thinking. We believe everyone at Cronofy should have equal opportunity to learn, create their best work, and grow in their careers.

• Work across changing projects and settings • Build LLM integrations, agents, and RAG pipelines • Treat prompt engineering as a code discipline • Help rethink how agency work is done