• Act as primary local company contact for assigned sites for specific trials. • Actively participate in site feasibility and/or Site Qualification Visits (SQVs). • Attend/participate in investigator meetings as needed. • May be expected to help prepare meeting materials and may be required to present at the investigator meeting. • Execute activities within site initiation and start-up, preparation and conduct of site monitoring (including remote monitoring), site management (by study specific systems and other reports/dashboards) and site/study close-out according to SOPs, Work Instructions (WIs) and policies. • Implementation of analytical risk-based monitoring model at the site level and work with the site to ensure timely resolution of issues found during monitoring visits. • Implement and execute all tasks independently with little or limited supervision. • Ensure site staff are trained, and the corresponding training records are complete and accurate at any point during all trial phases. • Collaborate closely with LTM and central study team for the activities during site activation phase in order to speed up the process and activate the site in shortest possible timeframe. • May be required to help provide solutions to challenges faced in other sites in the country. • Contribute to site level recruitment strategy and contingency planning and implementation in partnership with other functional areas. • Ensure site study supplies (such as Non-Investigational Product (IP), lab kits, etc.) are adequate for trial conduct. • Ensure that clinical drug supplies are appropriately used, handled and stored and returns are accurately inventoried and documented. • Arrange for the appropriate destruction of clinical supplies. • Ensure site staff complete data entry and resolve queries within expected timelines. • Ensure accuracy, validity and completeness of data collected at trial sites. • Proactively ensure that all Adverse Events (AE)/Serious Adverse Events (SAEs)/Product Quality Complaints (PQCs) are reported within the required reporting timelines and documented as appropriate. • For AEs/SAEs, ensure that they are consistent with all data collected and with the information in the source documents. • Maintain complete, accurate and timely data and essential documents in relevant systems utilized for trial management. • Fully document trial related activities, in particular monitoring. • Write visit reports and follow-up letters in accordance with the SOPs. • Promptly communicate relevant status information and issues to appropriate stakeholders. • Reviews study files for completeness and ensure archiving retention requirements are met, including storage in a secure area at all times. • Collaborate with LTM for documenting and communicating site/study progress and issues to trial central team. • Attend regularly scheduled team meetings and trainings. • Comply with relevant training requirements. • Act as local expert in assigned protocols. • Possess proficient therapeutic knowledge sufficient to support role and responsibilities. • Work closely with LTM to ensure Corrective Action Preventative Action (CAPA) is completed for Quality Assurance (QA) site audits and for quality issues identified at the site during routine monitoring and other visit types (e.g., Compliance Monitoring Visit (CMV)). • May be required to oversee audit and inspection preparation by Associate SM. • Prepare trial sites for close out and conduct final close out visit. • Track costs at site level and ensure payments are made, if applicable. • Establish and maintain good working relationships with internal and external stakeholders, in particular investigators, trial coordinators and other site staff. • May participate in the Health Authority (HA) and Independent Ethics Committee (IEC)/Institutional Review Board (IRB) submission and notification processes as required/appropriate. • Act as a point of contact in site management practices. • Provide credible and useful insights and input. • May be assigned as a coach and mentor to a less experienced site manager. • May be required to contribute to process improvement and training. • Occasionally lead and/or participate in special initiatives as assigned. • May assume additional responsibilities or special initiatives such as “Champion” or Subject Matter Expert.”

• Act as primary local company contact for assigned sites for specific trials. • Actively participate in site feasibility and/or Site Qualification Visits (SQVs). • Attend/participate in investigator meetings as needed. • Execute activities within site initiation and start-up, preparation and conduct of site monitoring (including remote monitoring), site management (by study specific systems and other reports/dashboards) and site/study close-out according to SOPs, Work Instructions (WIs) and policies. • Implementation of analytical risk-based monitoring model at the site level and work with the site to ensure timely resolution of issues found during monitoring visits. • Occasionally may require assistance or oversight from Lead SM or LTM. • Ensure site staff are trained, and the corresponding training records are complete and accurate at any point during all trial phases. • Collaborate closely with LTM and central study team for the activities during site activation phase in order to speed up the process and activate the site in shortest possible timeframe. • Contribute to site level recruitment strategy and contingency planning and implementation in partnership with other functional areas. • Ensure site study supplies (such as Non-Investigational Product (IP), lab kits, etc.) are adequate for trial conduct. • Ensure that clinical drug supplies are appropriately used, handled and stored and returns are accurately inventoried and documented. • Arrange for the appropriate destruction of clinical supplies. • Ensure site staff complete data entry and resolve queries within expected timelines. • Ensure accuracy, validity and completeness of data collected at trial sites. • Ensure that all Adverse Events (AE)/Serious Adverse Events (SAEs)/Product Quality Complaints (PQCs) are reported within the required reporting timelines and documented as appropriate. • For AEs/SAEs, ensure that they are consistent with all data collected and with the information in the source documents. • Maintain complete, accurate and timely data and essential documents in relevant systems utilized for trial management. • Fully document trial related activities, in particular monitoring. • Write visit reports and follow-up letters in accordance with the SOPs. • Promptly communicate relevant status information and issues to appropriate stakeholders. • Review study files for completeness and ensure archiving retention requirements are met, including storage in a secure area at all times. • Collaborate with LTM for documenting and communicating site/study progress and issues to trial central team. • Active participation in regularly scheduled team meetings and trainings. • Provide feedback as appropriate. • May be asked to lead/provide leadership at these meetings. • Comply with relevant training requirements. • Act as local expert in assigned protocols. • Develop therapeutic knowledge sufficient to support role and responsibilities. • Works closely with LTM to ensure Corrective Action Preventative Action (CAPA) is completed for Quality Assurance (QA) site audits and for quality issues identified at the site during routine monitoring and other visit types, e.g. Compliance Monitoring Visit (CMV). • Prepare trial sites for close out, conduct final close out visit. • Track costs at site level and ensure payments are made, if applicable. • Establish and maintain good working relationships with internal and external stakeholders, in particular investigators, trial coordinators and other site staff. • May participate in the Health Authority (HA) and Independent Ethics Committee (IEC)/Institutional Review Board (IRB) submission and notification processes as required/appropriate. • Act as a point of contact in site management practices. • May contribute to process improvement and training.

• Reporting to the Associate Director, Technology Enablement, perform the day-to-day execution of the organization’s digital product and service enablement strategy • Ensure staff have the knowledge, resources, and support needed to effectively adopt and utilize enterprise systems • Contribute to training delivery, enablement content, and user support operations • Manage the intake, prioritization, and execution of enablement-related initiatives • Translate system and process changes into clear, user-centered experiences that drive adoption and reduce friction • Lead the planning, coordination, and delivery of training sessions and learning experiences across systems and tools • Partner with subject-matter experts to translate technical and process changes into clear, user-ready materials • Define and track training success metrics (adoption, engagement, proficiency) and continuously refine approaches based on insights • Establish and enforce standards for documentation, training materials, and user-facing content to ensure consistency and quality • Oversee the lifecycle of SOPs, guides, and enablement assets, ensuring content remains accurate, accessible, and streamlined • Coordinate updates across platforms (e.g., knowledge bases, intranet, tools like Spekit) to create a seamless user experience • Develop and manage project plans, timelines, and deliverables for system rollouts, process changes, and training initiatives • Track progress, manage risks, and proactively communicate updates to stakeholders to ensure successful delivery • Capture user support trends and analyze request data to identify systemic issues, training gaps, and opportunities for proactive enablement • Implement scalable solutions (training, documentation, process improvements) to reduce support volume and improve user experience • Act as a feedback loop between end users and system owners to inform ongoing enhancements • Support other Data & Technology efforts as needed such as imports, reporting, and other data quality initiatives.

• Support the execution of federal and state advocacy strategies and policy campaigns under the direction of the Director of Advocacy Engagement and Mobilization. • Draft advocacy materials including action alerts, fact sheets, blog posts, talking points, and social media content to advance the Association’s legislative and regulatory priorities. • Coordinate day-to-day advocacy communications, including updating the Advocacy Action Center and monitoring engagement metrics. • Drive the creation and execution of compelling public affairs messaging and materials that elevate and reinforce the Association’s government affairs objectives. • Assist in managing logistics for advocacy events, including briefings, webinars, and Hill or state-level meetings. • Track and analyze policy developments, hearings, and legislation relevant to ALS and related health policy issues. • Support grassroots engagement, including recruitment, training, and mobilization of advocates. • Assist with the development of advocacy reports, presentations, and dashboards to evaluate campaign effectiveness. • Provide administrative and project management support to the Advocacy & Public Policy team. • Represent The ALS Association at meetings, coalition convenings, and advocacy events as assigned. • Perform other duties as required to support the team’s mission and objectives.