Title: Senior Manager, PV Operations Location: London England GB\ Full time Job Description: Location: London, UK / Hybrid Orchard Therapeutics is a global biotechnology gene therapy company dedicated to transforming the lives of people affected by rare diseases through the development of innovative, potentially curative cell and gene therapies. Orchard has its global headquarters in London and is a wholly owned subsidiary of Kyowa Kirin, a Japan-based Global Specialty Pharmaceutical Company. Job Summary: The Senior Manager, PV Operations is a key operational leader responsible for the execution and management of global pharmacovigilance operations. This role on a day to day basis ensures the seamless delivery of case management, regulatory reporting, and operational compliance across clinical and post-marketing portfolios. This role serves as the primary operational interface for PV vendors and cross‑functional study teams. The Senior Manager, PV Operations is an emerging expert who translates the functional strategy into actionable operational plans, manages complex technical issues with limited guidance, and ensures that the "hands‑on" elements of the PV system are robust, scalable, and inspection‑ready. Key Elements and Responsibilities: - Lead and continuously improve global safety operations processes, including case intake, processing, and submissions, ensuring alignment with global PV regulations and company policies with close oversight of the pharmacovigilance vendors. - Oversee timely and compliant case processing and regulatory reporting of Individual Case Safety Reports (ICSRs) from all sources. Act as database business administrator for the Orchard safety database (Veeva Safety). - Ensure robust operational oversight of internal and external safety case management, including performance monitoring and quality metrics. - Provide strategic leadership for the selection, configuration, validation, and life-cycle management of safety systems and tools, in partnership with IT and Vendor Safety Systems teams. - Lead the design, implementation, and maintenance of standard operating procedures (SOPs), work instructions, and training for safety operations. - Act as key technical SME supporting inspection readiness and support internal audits, Health Authority inspections, and partner audits related to PV operations, coordinating responses and remediation plans. - Liaise with Orchard Quality Assurance colleagues to ensure audit programme of internal and external components of the pharmacovigilance system and partners run smoothly - Collaborate with safety physician, safety scientist and cross-functional teams to ensure efficient processes and systems for production of high-quality data for signal detection, aggregate safety reporting, benefit–risk assessments, and Risk Management Plans (RMPs). - Provide senior operational input into Safety Management Teams and cross-functional project teams, managing operational feasibility, timelines, and compliance risks. - Lead operational aspects of safety data exchange agreements (SDEAs) with partners and licensees and oversee literature surveillance workflows. Requirements Education, Experience & Knowledge Education - Bachelor's degree or equivalent in a life science, pharmacy, nursing, or a related health field. - Relevant certifications in pharmacovigilance or drug safety are highly desirable. Experience - Extensive experience in pharmacovigilance operations, with significant leadership in global ICSR management and regulatory reporting. - Experience with safety databases (Veeva Safety preferred but not required) - In-depth knowledge of global PV regulations (GVP, ICH, FDA, MHRA, EMA) and proven ability to implement them operationally. - Strong experience with safety databases and PV systems, including configuration, validation, and maintenance. - Demonstrated ability to lead and oversee PV vendors/CROs. - Experience with clinical studies, postmarketing safety, risk management plans and aggregate report preparation. - Proven track record in preparing for and supporting Health Authority inspections and audits, alongside strong project management skills. Desirable - Advanced degree in a relevant scientific or health-related field. - Experience with safety data exchange agreements (SDEAs) and literature surveillance. - Demonstrated ability to drive continuous improvement, process optimization, and automation in PV operations. - Demonstrated understanding of clinical development processes. - Experience with global product launches and implementation/assessment of complex risk minimisation measures. - Evidence of scientific contributions to the field (e.g., peer reviewed publications, invited presentations, guideline development, or recognised subject matter expertise in biologic safety). Skills & Abilities · Self-motivated, with initiative and ability to take ownership of, and follow through with, specific tasks · Working knowledge of available information sources and ability to navigate multiple channels to secure required information · Works effectively with cross-functional teams to address complex issues and recommend actions with potentially significance impact · Effective time management and organization skills · Ability to multi-task and shift priorities quickly while working under tight deadlines · Excellent verbal and written communication skills · Strong PC experience and demonstrated proficiency in MS Office (Outlook, Word, Excel and Powerpoint)

Role Description The Sales Operations Business Partner supports the sales organization through data analysis, Salesforce optimization, reporting, and process improvement. This role partners closely with Sales, Revenue Operations, Marketing, and other cross-functional teams to improve pipeline visibility, maintain data accuracy, and deliver insights that drive better business decisions. The ideal candidate is curious, detail-oriented, and motivated to continuously improve business processes while building trusted relationships across the organization. They thrive in a fast-paced, collaborative environment and are passionate about leveraging data to drive operational excellence. What You’ll Get to Do - Improve sales processes to increase pipeline efficiency and conversion. - Maintain Salesforce data accuracy across accounts, opportunities, and pipeline. - Build and manage Salesforce reports and dashboards to track pipeline health, sales performance, and key business metrics. - Support forecasting activities by ensuring clean and accurate pipeline data. - Deliver insights and analysis to support sales leadership decision-making. - Assist with territory alignment, account ownership, and data management activities. - Support the adoption and effective use of sales tools such as Salesforce, Gong, Outreach, and other sales technologies. - Partner cross-functionally with Sales, Revenue Operations, Marketing, and Channel/Alliance teams to support business initiatives and operational improvements. Qualifications - Bachelor’s degree in Information Technology, Business, Analytics, or a related field, or equivalent experience. - 3–5 years of experience in Sales Operations, Revenue Operations, Analytics, or a related role. - Strong proficiency with Microsoft Excel. - Experience working with Salesforce reporting, dashboards, and pipeline data. - Experience supporting forecasting and pipeline management processes. - Exposure to territory planning or quota setting. - Strong analytical and problem-solving skills with exceptional attention to detail. - Ability to translate data into clear, actionable business insights. - Experience using AI tools or data-driven automation technologies such as ChatGPT or Microsoft Copilot. - Familiarity with tools such as Gong and Power BI. - Experience working within a SaaS or other data-driven business environment preferred. What Would Make You Stand Out - Experience partnering directly with sales leadership to drive operational improvements. - Strong understanding of sales processes, pipeline management, and revenue operations best practices. - Experience building scalable reporting and dashboard solutions. - Passion for continuous improvement through data, automation, and emerging technologies. - Proven ability to influence cross-functional stakeholders and support strategic business initiatives. Benefits - Medical, dental, vision, and life insurance. - 401k plan (plus match) and a Global Employee Stock Purchase Plan. - Unlimited Time Away From Work (in lieu of accrued vacation time). - 10 paid US holidays. - Up to 80 hours of paid sick time. - 17 weeks of paid parental leave, subject to the terms of the applicable policy or program. - Opportunities for community impact, including volunteer days and Dayforce Cares charity.

Role Description Globe Life is seeking a highly organized and detail-oriented Benefit Coordinator to join our dynamic team. In this role, you will be responsible for guiding our union and association members through the process of selecting the right benefits program for their families' specific situation through a needs analysis and completing any necessary paperwork. - Strong communication skills - Excellent problem-solving abilities - Passion for helping families - 100% remote work from home opportunity - No experience required; however, experienced individuals are encouraged to apply - Basic computer knowledge highly recommended Qualifications - Strong communication skills - Excellent problem-solving abilities - Passion for helping families Requirements - No experience required; however, experienced individuals are encouraged to apply - Basic computer knowledge highly recommended Benefits - Paid weekly - Competitive pay - Benefits after 90 days - Opportunities for professional growth and development Company Description Globe Life is a global leader in providing innovative and comprehensive employee benefits solutions. We are committed to creating a positive and supportive work environment where employees can grow, develop, and thrive. - Values collaboration, excellence, and the well-being of our employees - Opportunity to make a real impact on the lives of our union and association members

Role Description Lead and manage the Enterprise Project/Portfolio Management Office (GTPMO) Operations. Develop and facilitate enterprise Project and Portfolio Management processes and reporting. Monitor compliance to the standards. Serve as the overall subject-matter expert in Project and Portfolio Management Operations knowledge areas. Provide leadership and insights on company-priority programs and projects. - Leads and manages a team of professionals responsible for enterprise project portfolio management operations. - Lead multiple projects and/or EPMO services and apply efficient and innovative solutions to supporting systems, hardware, software, networking, programming, and/or applications problems. - Partner with IT Shared Services and Finance to lead the annual portfolio funding process and maintain funding standards. - Enhance portfolio prioritization, reporting, and operational processes to improve decision-making and transparency. - Manage staff through hiring, training, evaluating, coaching, and disciplining of direct reports. - Provide mentoring and coaching to team members through performance evaluation and identifying development opportunities; continually developing project team competencies. - Establish and promote industry-recognized project management best practices and standards. - Responsible for the central repository for Projects, PM tools, templates, and historical data. - Establish and maintain a process for monitoring and reporting on compliance to adopted PMO policies, processes, and procedures. - Perform strategic planning and maintain alignment of projects with RGA’s strategic direction. - Responsible for providing the Project Portfolio Management reporting tools, metrics, and dashboards to the Governance Committees and the IT Balanced Scorecard construct including Quarterly Performance Packages. - Ensure that projects provide the necessary project metrics to the portfolio management reporting process. - Provide a program to ensure continued utilization and maturation of best practice project management operations standards and methodologies. - Provide the RGA Project Management methodology onboarding orientation for all Project Managers. - Develop and maintain effective business relationships, coordinating service delivery in line with negotiated Service Commitments. - Take ownership of the relationship, ensure that business partner’s objectives are met, and gain mutual understanding when the objectives are not feasible. - Manage the business partner’s application portfolio by understanding and communicating needs to internal IT project teams and external vendors. - Ensure properly defined and communicated project requests. - Support business partners, Technology Partners, and Product Teams in developing business requirements and business cases ensuring IT requests are understood and properly supported by all stakeholders; ensuring the integrity of the RGA IT Project Initiation process. Qualifications - Bachelor’s Degree in Arts/Sciences (BA/BS) or equivalent experience required. - Master’s degree in Arts/Sciences (MA/MS) and/or LOMA certification preferred. - 10+ Years experience in project management, portfolio management, and resource management required. - 5+ Years management experience required. - Direct experience in leading a PMO build out and managing/running a PMO required. - 10+ Years running or operating within PMO function as well as operations and support of an enterprise application/platform preferred. - Application Portfolio management experience preferred. - Previous experience managing large international, global projects. - Effective management of projects with virtual teams preferred. - Six Sigma / Lean Process Evaluation / Improvement Preferred. - Microsoft Certification Preferred. - PeopleSoft Certification Preferred. Skills & Abilities - Highly advanced project management and systems analysis skills. - Advanced oral and written communication skills. - Highly advanced people management skills. - Advanced interpersonal skills. - Advanced analytical and problem-solving skills. - Advanced knowledge of broad business and finance related practices. - Advanced ability to work well within and manage a team. - Ability to manage multiple projects and/or sub-teams simultaneously. - Proficient in systems operations and project management methodologies. - Excellent planning and organizational skills. - Insurance and/or reinsurance industry knowledge preferred. Benefits - Gain valuable knowledge from and experience with diverse, caring colleagues around the world. - Enjoy a respectful, welcoming environment that fosters individuality and encourages pioneering thought. - Join the bright and creative minds of RGA, and experience vast, endless career potential. - Compensation Range: $126,710.00 - $188,840.00 Annual. - Annual bonus plan and eligibility for participation in long-term equity incentive plan. - Full range of health, retirement, and other employee benefits.