Title: Senior Clinical Trial Manager - Job ID: 1955 Location: Palo Alto CA US Full time Remote The Sr. Clinical Trial Manager (Sr CTM) is responsible for effective conduct of Ascendis’ global and regional clinical trials. As a key member of the cross-functional team driving one or more Ascendis’ clinical trials to completion according to agreed timelines and quality, the Sr. CTM contributes directly to Ascendis’ focus on making a meaningful difference in patients’ lives and is part of a global organization with locations in US, Germany and Denmark. The role will be based in Palo Alto, CA or be remote and reports to the Director, Clinical Operations. Key Responsibilities - Foster and maintain favorable clinical site and investigator relationships. Including conducting and/or supporting informational calls for sites and investigators. - Support in planning and conducting investigator meetings, if applicable. - Review and/or approve of IP release packages. - Review monitoring reports for compliance to study protocols, regulations and ICH/GCP. Track and manage monitoring report metrics. If applicable, serve as a backup monitor to the monitoring team. - Generate and utilize metric reporting (e.g. CTMS, DM Query Trends, Outstanding Monitoring Reports) to ensure that the study is conducted per plans and communicates issues to Director and CRAs as appropriate. - Ensure accurate reporting of Protocol Deviations and follows up with monitoring team of any subsequent re-SDV and close out of PDs if applicable. - Provides any assistance with findings from Protocol Deviation Review Team meetings and disseminates any applicable information to the CRA team. - Conducts monitoring meetings, creating agendas and meeting minutes which may include but is not limited to: monitoring team training and tracking, report quality issues, site level issues/trends in data and EDC metrics reporting. - Assist in coordinating study specific training or re-training for the internal study team, internal monitoring team and site staff as appropriate. - Responsible for the ongoing development and maintenance of Trial Master File and Investigator Site Files in Veeva Vault which includes quarterly eTMF reviews. Assists CRAs in ensuring eTMF completeness, eTMF audit findings and resolutions. - Manages and/or supports vendor management for central laboratory, central IRB, central imaging, patient concierge services, and site payment systems including but not limited to: portal access management for sites and internal teams, report review, sample tracking, metrics review, document reviews and meeting participation - Facilitate EDC and IRT access requests for site teams. - Facilitate CRA team access to internal Ascendis systems such as TMF, EDC and vendor systems (e.g. IRT). - Assist and manage CRA transition meetings which may include creating and/or reviewing transition documentation - Run Study Team Meetings including providing agendas and meeting minutes. - Reviews site information/informed consents and completes associated checklists as per Ascendis SOPs. - Support central and site IRB/IEC and regulatory submissions, as needed. - Accountable to assist sites, internal staff and CRAs with the preparation for GCP audits - Maintains CTMS including but not limited to: site and site staff contact information, study level and site level milestones, regulatory submissions and approvals on both study and site level. - Escalate pertinent CRA performance and site compliance issues when necessary. - Collaborate with Director of Clinical Operations, data management and CRAs to ensure data quality and compliance with data cleaning timelines. - Assist CRAs and sites with supply shipment/tracking, sample tracking and IMP shipment tracking and management. - May review and approve Vendor Data Clarification Forms. - Prioritize and escalate issues, as needed. - May develop or assist in developing study related clinical documents (e.g. clinical plans, Informed Consent Form templates, study specific forms and manuals, CRF completion guidelines, study trackers, PSV/SIV slides and other training materials). - May be responsible for management of clinical vendors (e.g. labs, IP, patient diary, home health care) in conjunction with Associate Director. - May be responsible for development, review and/or implementation of vendor documentation. - May perform clinical data review of patient profiles, data listings and summary tables, including query generation - May meet with Associate Director, Clinical Operations on a regular basis to report deliverables, timelines and employee development. Requirements - Bachelor’s degree or master’s degree in natural or health sciences (biology, pharmacology, pharmaceutical sciences or equivalent) - Demonstrates mastery knowledge of ICH-GCP, relevant Ascendis SOPs and Work Instructions and regulatory guidance, as well as the ability to implement - Working knowledge of clinical management techniques and tools - Direct work experience in a cross-functional environment - 7+ years of combined experience in managing/monitoring Phase 1, 2, or 3 clinical trials. · High proficiency in English with strong communication and presentation skills - Experience managing and overseeing vendors - Experience in performing clinical site monitoring visits, including remote visits - Ability to prioritize and to work independently on assigned tasks, manage timelines, and to present ideas to sites / stakeholders clearly and effectively - High proficiency with Veeva Systems (Clinical Vault eTMF, Veeva EDC), CTMS, Endpoint IRT and Microsoft Office (Outlook, Word, Excel, PowerPoint). - Possibility to travel up to 20% of the time domestically for investigator meetings, meetings with remote employees, co-monitoring, if needed. The estimated salary range for this position is $160-170K DOE. Actual salary determination is dependent on a variety of factors some of which include: experience, qualifications, and geographic location. This position may be eligible for a discretionary annual bonus or an incentive compensation plan (eligibility varies based on role and position level), discretionary stock-based long-term incentives, paid time off, and a comprehensive benefits package. Benefits - 401(k) plan with company match - Medical, dental, and vision plans - Company-offered Life and Accidental Death & Dismemberment (AD&D) insurance - Company-provided short and long-term disability benefits - Unique offerings of Pet Insurance and Legal Insurance - Employee Assistance Program - Employee Discounts - Professional Development - Health Saving Account (HSA) - Flexible Spending Accounts - Various incentive compensation plans - Accident, Critical Illness, and Hospital Indemnity Insurance - Mental Health resources - Paid leave benefits for new parents

Measurement Science Manager II Canada - Remote (ON, AB, BC, or NS Only) We're transforming the grocery industry At Instacart, we invite the world to share love through food because we believe everyone should have access to the food they love and more time to enjoy it together. Where others see a simple need for grocery delivery, we see exciting complexity and endless opportunity to serve the varied needs of our community. We work to deliver an essential service that customers rely on to get their groceries and household goods, while also offering safe and flexible earnings opportunities to Instacart Personal Shoppers. Instacart has become a lifeline for millions of people, and we’re building the team to help push our shopping cart forward. If you’re ready to do the best work of your life, come join our table. Instacart is a Flex First team There’s no one-size fits all approach to how we do our best work. Our employees have the flexibility to choose where they do their best work—whether it’s from home, an office, or your favorite coffee shop—while staying connected and building community through regular in-person events. Learn more about our flexible approach to where we work. Overview About the Role - We are looking for an experienced analytics professional specialized in advanced experimentation and attribution modeling to join our Measurement Science Team in Media Analytics. As an analytics expert, you’ll develop sophisticated measurement solutions that demonstrate the effectiveness of advertising on the Instacart platform. This role offers a unique opportunity to work with multi-retailer 1st party deterministic data to provide causal understanding of advertising impact on consumer behavior. You’ll represent Instacart’s measurement capabilities both internally and externally to leading CPG brands and agency partners. Success in this position requires not only analytical expertise but also the ability to build strategic partnerships with advertisers and crossed-functional partners through data-driven and recommendations. About the Team - The Measurement Science Team is our advertiser-facing team that uses experimentation and custom analytics to help our advertisers understand the effectiveness of their advertising spend. Measurement Science is one part of our broader Media Analytics organization, whose mission is to leverage data to identify opportunities, prove value, and improve performance of Ads through impactful insights, strategic partnership and operational efficiency. About the Job - Design and execute advanced experiments that prove advertising value and optimize campaigns, delivering actionable insights that drive business decisions - Analyze experiment data to produce nuanced recommendations for improving ad performance and measurement outcomes - Tailor measurement approaches to meet stakeholder needs, by developing innovative metrics and data visualizations that reveal deeper business insights - Proactively partner with stakeholders to shape media measurement strategies and address complex challenges, navigating through ambiguous measurement questions - Present experimental findings and other data-driven insights with an executive presence to senior clients, educating them on methodologies and ensuring alignment on actionable insights - Lead discussions, trainings, and Q&A sessions as a thought leader on ad measurement and experimentation to inspire confidence in measurement outcomes with clients and internal teams - Identify strategic opportunities, including client upsell potential or internal operational improvement needs, informed by data-driven insights - Develop customized analytical solutions, including code, dashboards, and self-service tools with data-driven enhancements either through client works and/or project initiatives About You Minimum Qualifications - Bachelor’s Degree in a quantitative field such as Engineering, Mathematics/Statistics, Finance, Economics, Business - 6+ years of experience in data and measurement or consulting fields with demonstrated expertise in statistical data analytics - 3+ years of relevant experience within advertising efficacy, media/marketing measurement, and experimentation - Advanced expertise in experimentation techniques, including A/B testing, holdout designs, and incrementality measurement - Strong data storytelling and advanced visualization skills using tools like Tableau or Mode - Experience developing self-service tools and dashboards for stakeholders - Strong SQL skills and proficiency in statistical programming (Python/R) to create and validate custom analytical solutions - Track record of turning analytics insights into strategic recommendations that drive business outcomes - Track record of operating independently, demonstrating curiosity, active listening skills, creativity, and delivering results in a highly organized manner Preferred Qualifications - 4+ years of conducting and presenting lift measurement studies to clients - Experience directing sales teams in an analytic/quantitative capacity - Advanced knowledge of statistical techniques including marketing mix modeling, Bayesian analysis, and causal inference - Ability to automate processes using AI-driven tools and workflows - Technical expertise in advanced experimental methodologies including A/A testing, SRM detection, and statistical techniques that ensure measurement validity and reliability - Comprehensive knowledge of ad auction mechanics, targeting algorithms, and attribution models #LI-Remote

• Build and manage alliances with other strategic technology partners • Drive growth and sales opportunities through strategic partnerships • Negotiate partnership agreements and contracts • Manage and nurture existing partner relationships • Stay updated with industry trends and technology partnership developments • Perform competitive analysis reviews of the market • Collaborate with leadership, product, sales, and marketing teams on technology partnership initiatives • Understand the needs of all stakeholders and manage expectations

Senior SOX Manager – IT Location: United States - Remote We're transforming the grocery industry At Instacart, we invite the world to share love through food because we believe everyone should have access to the food they love and more time to enjoy it together. Where others see a simple need for grocery delivery, we see exciting complexity and endless opportunity to serve the varied needs of our community. We work to deliver an essential service that customers rely on to get their groceries and household goods, while also offering safe and flexible earnings opportunities to Instacart Personal Shoppers. Instacart has become a lifeline for millions of people, and we’re building the team to help push our shopping cart forward. If you’re ready to do the best work of your life, come join our table. Instacart is a Flex First team There’s no one-size fits all approach to how we do our best work. Our employees have the flexibility to choose where they do their best work—whether it’s from home, an office, or your favorite coffee shop—while staying connected and building community through regular in-person events. Learn more about our flexible approach to where we work. Overview We are looking for a highly skilled and detail-oriented Senior SOX Manager – IT, to lead and manage the execution of our IT General Controls (ITGC) and IT Automated Controls (ITAC) compliance activities as part of the company's SOX program. In this role, you will ensure the company's IT control environment supports an efficient and effective internal control framework to comply with Section 404 of the Sarbanes-Oxley Act (SOX). This is a leadership role ideal for an experienced IT compliance professional who thrives in a fast-paced, highly collaborative engineering environment. This is not a traditional audit role. It requires genuine curiosity about how engineering teams build and operate, and the ability to translate between two very different worlds. You are equally comfortable in a compliance conversation and an engineering standup — someone who can earn the trust of both auditors and engineers, challenge outdated control assumptions, and drive toward a more efficient and sustainable SOX program. About the Team: You will be part of the broader SOX Compliance and Controls team and work alongside professionals from accounting, finance, and IT, as well as external auditors. This collaborative and innovative team is focused on building a resilient compliance program to address operational, financial, and system-level risks while maintaining high standards for internal controls and governance. About the Job As the Senior SOX Manager – IT, you will own all IT related controls processes, including defining and optimizing IT controls over financial reporting (ICFR). You will take charge of maintaining compliance while proactively identifying risks and partnering with IT stakeholders to strengthen the control environment. Your contributions will directly impact the reliability of financial data and the compliance posture of the company. A defining feature of this role is close day-to-day partnership with Engineering- an aligned associate embedded within Engineering teams. You will work alongside this embedded team — leveraging their systems knowledge and Engineering relationships to design controls that are rigorous, right-sized, and operationally sustainable. You bring the compliance expertise; they bring the Engineering context. Together you bridge the gap between audit requirements and engineering reality. Key Responsibilities include: - IT Controls Ownership: - Lead the IT controls component of the SOX program, including managing the identification and evaluation of IT processes and risks. - Design and assess IT controls to support ICFR, such as access management, change management, and IT operations controls. - SOX Compliance: - Ensure IT controls comply with SOX requirements while staying aligned with COSO and PCAOB standards. - Work with IT and finance stakeholders to resolve control deficiencies and drive remediation efforts in a timely and efficient manner. - Collaboration with IT and Audit Partners: - Partner with IT teams to implement, document, and maintain effective IT controls. - Collaborate with internal and external auditors to coordinate audit schedules, provide evidence, and address IT audit findings. - Risk Management and Process Improvement: - Perform periodic risk assessments related to IT processes and evaluate the impacts of system implementations or changes on the control environment. - Identify opportunities to automate IT controls and improve process efficiency. - Testing and Reporting: - Oversee testing efforts for IT controls and collaborate on reporting outcomes to SOX leadership, executive management, and the Audit Committee. - Provide recommendations to address identified issues and ensure robust controls are in place. - Influence and Partnership: - Operate as a subject matter expert and trusted compliance partner to Engineering-aligned associates, providing SOX guidance and coaching without direct management authority. - Influence without authority — driving alignment, building trust, and moving the program forward across teams that do not report to you. - Bring structure and rigor to a complex, cross-functional program — maintaining clear plans, owners, and timelines across Engineering, Finance, and external audit partners. About You Minimum Qualifications - Bachelor's degree in Information Technology, Accounting, or a related field; relevant certifications such as CISA, CISSP, or CPA preferred. - 10+ years of experience in IT audit, SOX compliance, or risk management with a focus on IT controls, preferably in a publicly traded company or Big Four public accounting firm. - Demonstrated expertise in identifying, designing, and testing IT controls to support compliance standards. - Deep knowledge of SOX 404, COSO framework, COBIT principles, IT security, and risk management practices. - Hands-on experience with IT controls domains including access management, change management, and disaster recovery. - Proven ability to earn the trust of engineering teams and communicate technical risks and control concepts in plain language — to engineers, senior executives, and audit committees alike. - Experience working in or alongside high-velocity engineering organizations at a technology company. Preferred Qualifications - Advanced degree (MBA, MIS, or equivalent) is a plus. - Experience managing IT SOX efforts for ERP systems such as Oracle, SAP, or Workday. - Familiarity with cloud-based environments (AWS, Azure, GCP) and related control implications. - Prior experience in an embedded or liaison role between compliance and engineering functions. - Strong project management and organizational skills with a results-oriented approach. #LI-Remote Instacart provides highly market-competitive compensation and benefits in each location where our employees work. This role is remote and the base pay range for a successful candidate is dependent on their permanent work location. Please review our Flex First remote work policy here. Offers may vary based on many factors, such as candidate experience and skills required for the role. Additionally, this role is eligible for a new hire equity grant as well as annual refresh grants. Please read more about our benefits offerings here. For US-based candidates, the base pay ranges for a successful candidate are listed below. CA, NY, CT, NJ $185,000 - $195,500 USD WA $177,000 - $187,000 USD OR, DE, ME, MA, MD, NH, RI, VT, DC, PA, VA, CO, TX, IL, HI $170,000 - $179,500 USD All other states $155,000 - $163,500 USD