Role Description Reporting to the Senior Medical Director, Pharmacovigilance, the Associate Medical Director, Drug Safety and Pharmacovigilance is responsible for the medical assessment of Individual Case Safety Reports (ICSRs) and other drug safety information. The individual will be responsible for assessing and interpreting safety data from multiple sources, including clinical trials, spontaneous and solicited reports, aggregate, and literature reports. This individual is expected to provide interpretation and summaries of drug safety information and provide input in the generation of safety reports (e.g., DSURs, PSUR and clinical safety assessments). The individual will be an integral part of a group of safety professionals within Nuvalent and will closely collaborate with safety teams in Contract Research Organizations (CROs) and partners. He/she will need to maintain medical knowledge as required by the role, strong and current knowledge of drug safety and pharmacovigilance regulations, pharmacovigilance practices, safety surveillance and risk-management practices. Responsibilities - Provide medical expertise in the assessment of ICSRs - Contribute to the generation of aggregate safety reports including development safety update reports, periodic benefit risk evaluation reports, and provide medical input in review of new or existing safety documents to ensure compliance with relevant regulatory requirements, such as protocols, safety summaries and regulatory reports - Contribute to signaling and safety surveillance process, including the identification of safety observations, emergent safety concerns and new safety signals, ensure prompt assessment and communication of confirmed safety signals - Serve as a medical resource for the generation and review clinical trial protocols, informed consent forms (ICFs) and investigator brochures (IBs) and the development of Reference Safety Information - Contribute to creation or and updates to Risk Management Plans (RMPs) and/or Risk Evaluation and Mitigation Strategies (REMS) and the maintenance of these documents - Contribute to the development of Standard Operating Procedures, Working Instructions and other guidance documents - Provide safety and pharmacovigilance training programs as required - Collaborate cross functionally (e.g. Reg Affairs, Clin Ops, Clin Science) to ensure pharmacovigilance input - Support other pharmacovigilance and drug safety responsibilities as assigned Competencies Include - Strong written/verbal communication skills - Ability to work in a collaborative environment and build effective working relationships across the organization, and with external stakeholders/vendors - Detail and process orientated, with excellent project management, problem solving, and organization skills - Ability to think critically with strong attention to detail - Demonstrated project management and prioritization capabilities Qualifications - 4+ years’ experience in Drug Safety / Pharmacovigilance in a Biotech / Pharma company - 8+ years of industry (Biotech / Pharma) experience - Healthcare degree required / Medical Degree (MD) from recognized medical school preferred - Good working knowledge of US and EU drug safety regulations, CIOMS and ICH guidelines - Demonstrated experience with medical drug safety assessments, drug safety surveillance and monitoring activities - Proficiency with medical review of ICSRs, including expectedness assessments, causality assessments, narrative review and generation, generation of Analysis of Similar Event and company comment statements, including benefit-risk assessment - Experience with safety data collection and interpretation originating from clinical trials and other sources (such as literature, solicited and post-marketing environment) - Experience with the medical review and preparation of aggregate reports (DSUR, PSUR/PBRER, PADER) - Experience with preparation of responses to Regulatory Authorities, preferred experience with IND/NDA submissions and negotiations with Regulatory Authorities as part of marketing approval - Experience with the development and updates to Reference Safety Information, including IB, Company Core Data Sheet (CCDS) and local labels - Ability to build relationships, collaborate and influence across disciplines within Nuvalent and with outside stakeholders - Experience with MedDRA coding, Points to Consider, AoSE, and SMQs - Excellent verbal, written and presentation skills Benefits - Medical, dental, and vision insurance - 401(k) retirement savings plan - Generous paid time off (including a summer and winter company shutdown) - Comprehensive benefit package to support employees at each stage of their career, financial, health, and well-being journey Annual Salary Range $210,000 — $235,000 USD

• Lead and execute clinical trials for oncology products in development • Participate in the design/planning of clinical studies • Establish and approve scientific methods for design and implementation of clinical protocols • Support project teams with therapeutic area specific information • Collaborate with internal safety group in analyzing and reporting safety data from clinical trials • Interact with key opinion leaders and investigators in relevant disease specific area • Ensure consistency of scientific and development strategies for oncology products in development

Title: OFFICE MEDICAL DIRECTOR - Home Based Practice Location: Baltimore, MD Job Description: Requisition ID 654728 - Physicians - Johns Hopkins Community Physicians - Day Shift - Full Time - Baltimore, MD - On-site: 90-100% of hours worked on-site Johns Hopkins Community Physicians (JHCP) is looking for an Office Medical Director to join our Home-Based Primary Care Program in Baltimore, Howard County, and Anne Arundel County in Maryland. This growing program focuses on high needs geriatric home-limited patients and provides high-touch, comprehensive primary care. The Office Medical Director (OMD) will be a practicing physician who is also responsible for oversight of all provider clinical and patient care activities in an office practice. This includes participation in provider recruitment and retention, provider staffing, provider performance evaluation, provider discipline and corrective action plans and provider scheduling. The OMD and Practice Administrator (PA) work together collaboratively and effectively to manage the responsibilities and duties inherent in the office practice. OMD Specific Duties and Responsibilities include Budget Responsibility. Participates in the development of annual operating and capital budgets while monitoring actual expenditures against the budget. Coordinates procurement of supplies and equipment and maintains appropriate inventory management and budgetary controls. Complies with JHCP financial policies and procedures. Recognizes and encourages efforts in cost effectiveness and works to implement cost effective initiatives. Professional Licensures/Certifications: Licensed to practice medicine in the state of Maryland. Board certified in Internal Medicine, Family Practice or Med Ped. Preferred Education Requirement: Graduate of accredited Medical School or School of Osteopathy. Preferred Years of Experience and/or Skills: 3 years physician experience preferred. Excellent interpersonal and demonstrated written and verbal communications skills necessary to interact with JHCP providers, staff and a diverse patient population. Effective organizational and time management skills. Ability to analyze data to synthesize and summarize information, and make judgments regarding patient care. Ability to document legibly using a writing instrument. Ability to use a computer keyboard to input and obtain data. Machines, Tools, Equipment: Must operate standard office machines and equipment such as calculators, typewriters, word processing, photocopiers, PC, general office and communications equipment. Benefits: - Full-time – which will be a mix of clinical and admin - Additional protected time provided for director duties - Night call once per month - CME allowance - Protected time off - Malpractice insurance - Productivity model includes bonus eligibility - Dedicated medial assistant support Our Physicians and leaders are highly engaged and committed to teamwork. At JHCP you will work beside the unequaled talent of Johns Hopkins nurses and staff and enjoy extensive benefits and opportunities for personal and professional growth. Our Medical Leadership team are all practicing in our clinics. Through the diverse backgrounds and experiences of our employees, we are able to deliver on the promise to improve the health of the communities we serve! Put your passion to care towards our role as a Hopkins Physician, where you’ll be responsible for providing the exceptional quality of primary care that our patients expect. You’ll ­­­­­­­­­­­­­enjoy regular hours with night call less than once per month, allowing you ample time to enjoy all the activities that the area has to offer. Requirements: - MD License in the State of Maryland required - CPR Certification required - 3 years of experience required We offer a competitive salary, signing bonuses, excellent benefits and the opportunity to practice high-quality medicine as part of the Johns Hopkins Health System. Together we will deliver the Promise of Medicine! Salary Range: Minimum 0.00/hour - Maximum 0.00/hour. In cases where the range is displayed as a $0 amount, salary discussions will occur during candidate screening calls, before any subsequent compensation discussion is held between the candidate and any hiring authority. We are committed to creating a welcoming and inclusive environment, where we embrace and celebrate our differences, where all employees feel valued, contribute to our mission of serving the community, and engage in equitable healthcare delivery and workforce practices. Johns Hopkins Health System and its affiliates are an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity and expression, age, national origin, mental or physical disability, genetic information, veteran status, or any other status protected by federal, state, or local law. Johns Hopkins Health System and its affiliates are drug-free workplace employers.

Role Description The MSL role embodies our medical mission to be recognized as the trusted partner for internal stakeholders and the healthcare community, driving scientific exchange to enhance medical education, data generation, insight generation, and patients’ access to medicine. The Medical Science Liaison (MSL) is responsible for identifying disease and product related medical needs in a defined geography. - The Regional Oncology MSL role is field-based, and it is anticipated that the majority of their time will be spent in the field with external customers. - Serves as an educational resource for external Oncology stakeholders in the Community. - Primary responsibility is to communicate scientific and medical information supporting Multiple Myeloma and future Oncology pipeline assets. - Support the safe, effective, and appropriate use of BMS medicines. - Scientific dialogue focuses on: - scientific/clinical/safety information around Multiple Myeloma disease management and BMS products in a fair and balanced way - appropriate clinical value-based discussions. - Demonstrate strong medical and cross-functional or matrix collaboration. - Develop and maintain relationships with community-based thought leaders, appropriate community HCPs, and access stakeholders, within a given geography to answer specific clinical and/or scientific, unsolicited product and adverse event management related questions. - Use various channels for interactions (face to face 1:1 or group presentation; virtual). - Demonstrate proficiency in using available scientific resources and presentations. - Effectively present information to HCPs and be able to respond to questions, ensuring medical accuracy and compliance with local procedures, ethical and legal guidelines and directives. - Exceptional presentation skills. - Actively assess the medical and healthcare landscape by meeting with TLs/HCPs to understand their needs and expertise. - Continuously update knowledge in treatment strategies, products, unmet medical needs, clinical trials, and scientific activities. - Understand the competitive landscape and actively prepare to address the informational needs of customers. - Collect and provide meaningful medical insights back to the medical and commercial organizations to be actioned in support of strategy development. - Adapt to change in objectives and territory with continuing focus on Community HCPs and institutional or health system needs. - Demonstrate understanding of relevant HEOR and access resources as required. - Field execution of established Medical Plans. - Adopt institution/account planning approach and contribute to cross-functional institution/account plans. - Contribute to the development and delivery of scientifically meaningful medical programs/projects in line with the local Medical and Field Medical plan. - Support the initial and ongoing medical/scientific area and product specific training and provide key scientific updates to internal stakeholders (e.g. Commercial, Pharmacovigilance, Legal, HEOR, Market Access, Portfolio marketing). Qualifications - MD, PharmD, PhD, APP, PA, NP with experience in a specific Disease Area or with a broad medical background and relevant pharmaceutical experience. - Disease area knowledge and an understanding of scientific publications. - Knowledge of a scientific or clinical area, competitive landscape, and patient treatment trends. - Knowledge of clinical trial design and process. - Knowledge of the national healthcare and access environment. - Knowledge of HEOR core concepts. - Excellent English language skills, spoken and written. Requirements - A minimum of 2 years working in a pharmaceutical environment. - Prior MSL experience. - Ability to work independently and act as a team player. - Translating scientific or clinical data into an understandable and valuable form to help physicians best serve their patients. - Good communication and presentation skills to present scientific and/or clinical data to research or healthcare professionals. - Developing peer-to-peer relationships with TLs, scientists, and other healthcare professionals. - Ability to quickly and comprehensively learn about new subject areas and environments. - Demonstration of the BMS Values (innovation, urgency, accountability, Inclusion, Integrity, and Passion). - Ability to drive a company-provided car is an essential qualification of this position. - Candidates must be able to drive a BMS-provided vehicle between locations (often great distances apart) and arrive at each location ready and able to enthusiastically and efficiently demonstrate an applied knowledge of pertinent health care industry trends. - Candidates must possess a high level of ethics, integrity, and a responsible and safe driving history. - Act with an enterprise mindset. - Practice authentic leadership by cultivating honest relationships, seeking to understand blind spots, and staying true to own values and those of BMS, even in the face of challenge. - Possess a positive attitude and change agility during times of transition. - Demonstrate a growth mindset and is open to innovation and process improvements. - Contribute to talent development by providing timely feedback, understanding what will enable team success, and maintaining a strong network. - Actively engage in live meetings and teleconferences. - Completion of all administrative aspects of the job. Benefits - Health Coverage: - Medical, pharmacy, dental, and vision care. - Wellbeing Support: - Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). - Financial Well-being and Protection: - 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. - Work-life benefits include: - Paid Time Off: - US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays). - Phoenix, AZ, Puerto Rico, and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays. - Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown between Christmas and New Year's Day.