• Lead system design and architecture reviews for scaled data warehouses and engineer and designing and deploying web scale applications • Deep experience in SRE and deploying application at scale to clouds. Strong foundation in SRE principles and practices • Create and maintain architectural documentation, including authoring and reviewing ADRs (Architecture Decision Records), to ensure alignment with overall software architecture • Data lakehouse design, data modeling, and integration patterns for deploy databases and data as a service, at scale • Provide technical direction for scaling complex features and initiatives involving data storage, processing and deployments • Familiarity with machine learning infrastructure and MLOps • Monitor and improve technical debt across all engineering teams, related to data storage, processing and site reliability • Partner with Engineering Managers to define key technical health metrics and streamline technical onboarding processes • Drive reliability, performance, and security best practices for data storage, processing and SRE • Break down complex technical tasks into clear, manageable deliverables for the team • Ensure sustainable engineering practices and code quality standards • Serve as a technical guide for team members, helping them understand data access and storage and deployment architecture, and development practices • Ensure teams are delivering solutions to satisfy requirements while aligning to current and future architectural designs • Coach and mentor engineers on data storage, warehouse, processing, and SRE systems architecture, and best practices • Lead by example through high-quality code contributions to critical or complex components • Share knowledge of hyperscale data warehouse/lakehouses, data models, and emerging technologies with the team • Assist SRE teams with improving stability, automation, and scalability • Conduct code reviews with focus on architectural alignment and quality • Support hiring processes and technical assessments for engineering candidates • Partner with Engineering Managers through regular 1:1s and team planning sessions • Collaborate with product management, UX, and other architects to design and deliver new software solutions • Work with other Technical Architects to identify and resolve cross-team dependencies and technical challenges • Ensure technical roadmap alignment with product and business priorities • Participate in and contribute to platform-wide architectural initiatives • Take ownership of the entire lifecycle and toolchain of all data components from design through deployment • Contribute to critical technical implementations, balancing hands-on coding with architectural responsibilities • Work collaboratively in a fast-paced environment touching a variety of projects and products • Build software that will meaningfully impact how people approach data privacy

• Define and maintain product success metrics and KPI frameworks for reputation and trust-related product areas. • Build and evolve measurement strategies that connect product changes to user behavior, engagement, and business outcomes. • Design, execute, and analyze experiments (A/B tests and quasi-experiments), applying causal inference methods where appropriate. • Develop and maintain dashboards and reporting to monitor product health, leading indicators, and strategic goals. • Partner with cross-functional teams to improve data instrumentation, ensuring high-quality and reliable datasets. • Conduct deep-dive analyses to uncover user behavior insights, friction points, and growth opportunities. • Translate complex analyses into clear, actionable recommendations and narratives for stakeholders. • Establish analytics best practices and operating rhythms, including reporting cadences and measurement plans. • Support survey data governance, including sampling strategies and interpretation of response trends.

COG Research Foundation, LLC is a California 501(c)(3) entity that was founded in 2024 and designed to become the federal grantee organization for the Children's Oncology Group (COG). The COG, a member of the National Cancer Institute (NCI) National Clinical Trials Network (NCTN), is the world’s largest organization devoted exclusively to childhood and adolescent cancer research. COG unites over 12,000 experts in childhood cancer at more than 220 leading children’s hospitals, universities, and cancer centers across the United States, Canada, Australia, New Zealand, and Saudi Arabia in the fight against childhood cancer. COG conducts more than 100 active clinical trials, with approximately 12,000 patients registered on COG trials each year. These trials include front-line treatment for many types of childhood cancers, studies aimed at determining the underlying biology of these diseases, and trials involving new and emerging treatments, supportive care, and survivorship. Position Summary The Statistician I supports research efforts in the study of new treatments and cures for childhood cancer within the Children’s Oncology Group (COG). The responsibilities of the Statistician include computerized data screening, computer report generation, statistical data analysis, report writing, statistical study design and tasks related to selected research topics in clinical trials methodology. The COG Research Foundation, LLC is a 100% remote employer, though some travel may be required. Employee must reside within the United States. Full salary range for this position: $ 91,910 to $ 137,348 per year. The typical hiring range for this position is from $91,910 (minimum) to $114,629 (midpoint), based on 100% FTE. The starting salary is determined based on the candidate’s knowledge, skills, experience, as well as budget availability. Essential Duties and Responsibilities - Computerized Data Management - Manipulate data records from a database management system, using appropriate data management computer software, to produce abstracted data files which will be used for routine and special statistical analysis and data reporting tasks. - Data Screening - Produce computer programs using appropriate data management computer software to identify any internal inconsistencies or errors in study data and collaborate in resolving these errors prior to formal statistical analysis and computer report generation. - Computer Report Generation - Produce computer programs as needed which will present and summarize study data in ways understandable and useful to COG clinical investigators and senior statisticians. - Statistical Data Analysis - Perform, as directed by and under minimal supervision of the senior statistician, the appropriate statistical analyses required for interim study monitoring, routine study reporting, and manuscript preparation, as required by the research objectives of COG. - Report Writing - Produce written reports of statistical analyses which describe the patient population, statistical methods used, and results and conclusions from these analyses. Contents of the reports will be tailored to and will be understandable by the target audience of COG clinical scientists or senior statisticians, as appropriate. - Statistical Study Design - Perform statistical analyses, patient accrual estimates, and power and sample size computation necessary for the planning and design of COG clinical trials, as directed by the senior statistician. - Study Committee Support - Participate in study committee discussions of study design and status and provide data and other information in support of these discussions. - Support of Selected Research Topics in Clinical Trials Methodology - Perform computer programming, manuscript review, and methodological investigations, as directed by the senior statistician, in support of statistical research projects which address methodological problems of vital interest to COG's ongoing research effort. - Travel - travel may be required for up to 2 working weeks per year. - Perform other duties as assigned. Qualifications To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Minimum Qualifications - Four years of experience in Public Health, Biostatistics, Epidemiology, or Clinical Research fields - Master's degree or substitute with 2 additional years of experience in statistics or a related discipline. Other Qualifications - Experience with extensive application to the analysis of research data. - Experience using a high level of proficiency with computing and computerized statistical analysis (such as SAS, R, Stata) and strong knowledge of statistical methodology of clinical trials. - Training or experience with survival analysis. - Training or experience in biological or medical sciences. - Excellent oral and written communication skills. - Strong ability to work independently under minimal supervision by a Ph.D. level senior statistician in a collaborative environment with COG research coordinators, information services staff, statisticians, and clinical scientists in support of COG's ongoing research efforts. Fair Labor Standards Act (FLSA) Status This position is classified as exempt based on the job duties. However, based on the FTE, salary level of the employee, or federal/state/local laws, the employee may be classified as nonexempt. Why Join Us This is a unique opportunity to be on the ground floor of a critical role within a mission-driven organization. This position will play a vital part in shaping the function of the Children’s Oncology Group, contributing to lasting change and making a difference in the lives of children and families impacted by cancer. Benefits Comprehensive benefit options include medical, dental, vision, 401(k), accrued Paid Time Off (PTO), Employee Assistance Program (EAP), Flexible Spending Account (FSA), cell phone and internet stipends, wellness stipend, paid holidays, and more. Employees who work 20 hours or more per week are eligible for these benefit options. These benefits are provided for informational purposes only and are subject to change in accordance with applicable policies and plan documents. Equal Employment Opportunity Statement COG Research Foundation, LLC is an Equal Employment Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants and employees without regard to race, color, religion, creed, sex, pregnancy, national origin, age, ancestry, physical or mental disability or medical condition, genetic information, marital status, sexual orientation, gender identity or expression, military or veteran status, or any other characteristic protected by applicable federal, state, or local law. COG Research Foundation, LLC seeks to recruit, develop, and retain the most talented people from a diverse candidate pool. Employment at COG Research Foundation, LLC is based on merit, competence, and qualifications, and we are committed to providing equal opportunities for training and advancement for all employees. COG Research Foundation, LLC is also committed to making our application process accessible to individuals with disabilities and will provide reasonable accommodation upon request. For further information regarding Equal Employment Opportunity, please feel free to access it here. ADA/Application Accommodation Statement COG Research Foundation, LLC is committed to providing reasonable accommodation to individuals with disabilities in the application and employment process, consistent with applicable law. Applicants who require accommodation are encouraged to make their request at the earliest opportunity to allow COG Research Foundation, LLC sufficient time to evaluate and respond to the request. Accommodation requests may be directed to the Recruitment Team at career@evolvehr.com. This position falls under a contract with the Federal Government and is subject to the provisions in OMB Circular A-76 which prohibit contractors from performing inherently governmental functions. Specifically, employees placed in agency positions will not perform inherently governmental functions, nor supervise any personnel other than the contractor’s own staff, nor make final decisions or sign documents that commit the U.S. Government.

Job Description Our Small Molecule API Chemical Technical Operations Unit is seeking a highly motivated individual to fill an open Technical Lead position to support drug substance tech transfer and commercial manufacture within our External Manufacturing Network. This is an exciting opportunity to work with key strategic external partners, grow technical experience in API manufacturing, and work on high visibility network initiatives. Our team strives to provide technical excellence in our work and be strong partners, collaborators, and leaders within the small molecule line of business at our company. This position reports to the Director, Chemical Technical Operations, Small Molecule API External Manufacturing. The Technical Lead will be responsible for the management of the technical interface between our company and External Partners (EP). The technical lead will provide process support to External Partners for existing supply products to resolve production issues, evaluate and manage process change requests, proactively assess, and manage process/technical risks, and provide guidance on process improvement and capacity optimization. The technical lead will also provide oversight of External Partners during New Product Introductions and Technical Transfers, proactively identifying process/technical risks as part of pre-execution activities, providing on-site support during execution, and supporting post-execution activities. Key Responsibilities: - Operate independently on priorities established with assigned External Partners. - Foster proactive partnerships with External Partners to meet business goals, identify and mitigate risks, and continuously enhance performance. - Maintain a strong focus on compliance and Environmental Health and Safety (EHS) to drive supply excellence. - Serve as the primary technical contact for assigned External Partners while coordinating with impacted company sites and External Partners. - Collaborate with internal teams to ensure seamless product supply with an end-to-end mindset. - Initiate and drive change controls to completion. - Provide rapid support to External Partners to resolve manufacturing challenges and minimize supply disruptions. - Collaborate with Research Laboratories groups during New Product Introductions/Technical Transfers and new technology development. - Offer on-site support at External Partners as required, proactively identifying risks and supporting all phases of execution. - Conduct technical due diligence assessments and provide expert consultation on chemical manufacturing matters. - Review process change requests and deviation reports while ensuring regulatory compliance. Education and Minimum Requirements: - Bachelor’s degree in engineering, chemistry sciences or related discipline with a minimum of 7 years of relevant work experience in manufacturing or development, in the areas of process start up, technology introduction, manufacturing and/or technical transfer - A minimum of 7 years of experience in manufacturing, specifically in Small Molecule API process production, development, optimization, and technical transfer. - GMP experience in pharmaceutical manufacturing, ensuring compliance with quality and regulatory standards. What You Bring: - Exceptional organizational skills and the ability to work independently. - Proven leadership attributes including a global mindset, an end-to-end supply chain perspective, and strong collaborative abilities across functions and geographies. - Demonstrated capacity to solve complex technical challenges, lead project teams, and influence stakeholders effectively. - A solid understanding of small molecule pharmaceutical manufacturing processes. - Fluency in Italian & English is essential - Ability to travel up to ~50% Required Skills: Adaptability, Automation Systems, Capital Project Management, Change Management, Clinical Manufacturing, Data Analysis, Decision Making, Drug Product Manufacturing, Interpersonal Relationships, Lean Manufacturing, Manufacturing Scale-Up, Regulatory Compliance, Root Cause Analysis (RCA), Strategic Thinking, Technical Transfer Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: VISA Sponsorship: Travel Requirements: Flexible Work Arrangements: Remote Shift: Valid Driving License: Hazardous Material(s): Job Posting End Date: 04/30/2026*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.