Overview The Manager, Clinical Operations is responsible for the execution of study-level activities including but not limited to creating and updating trial-specific documents, vendor oversight & delivery, compound training and country and regional oversight of CRO operational delivery. This includes alignment on the feasibility strategy, target setting, risk reviews, and country challenges that could impact overall study delivery. Summary of Key Responsibilities - Manage integration of project team activities, leveraging internal and external resources, expertise and knowledge, along with optimizing CRO resources, expertise and knowledge. - Provide input on trial level operational strategies for clinical trials from protocol design to the final clinical study report for specified studies - Provide input into global subject/patient recruitment plans. - Relationship management between study sites and vendors - Manage aspects of CRO/vendor identification and the day to day operational management activities of CROs & other vendors including set up, statement of work creation and budget oversight. - Manage strategic study operations including: study sites and tracking systems for regulatory submissions, drug supply and use, enrollment of subjects, regulatory document flow, study timelines, all budgetary and financial information, performance metrics, data flow, etc. - Create and update critical trial-specific documents (for example country specific ICF) and plans - Support development of compound and protocol level training materials - Review and provide input into budgets, timelines, and forecasts for assigned clinical studies - Interface with internal key stakeholders including, but not limited to; Finance, Program Management, Vendor Management, Safety, Accounting, Clinical Supply, Quality Assurance, Data Management, Statistics, Clinical Research, Commercial, Regulatory, Bio Analytical, Medical Affairs; which may include acting as a liaison between groups. - Provide support for inspection readiness activities and on identification of risks and mitigation plans at the trial level - Participate in process improvement activities at a trial and department level as needed - Support onboarding of new team members - Attend CTWG and provide input and updates on operational activities and progress - Ability to travel (approximately10% but flexibility to go over or below as per business need. Qualifications - BS/ BA Degree is required. - 5+ years of clinical research experience gained with a CRO, Biotech, or Pharmaceutical Company working on Phase 1-4 global clinical trials. - 2-3+ years leading aspects of global clinical trials - Experience working with a CRO - Strong regulatory knowledge, including Good Clinical Practices (GCPs) - Strong decision-making, analytical and financial management skills are essential to this position - Proven ability to foster team productivity and cohesiveness and the ability to operate and execute with limited supervision - Experience in leading without authority and in multifunctional matrixed and global environments - Experience mentoring/ coaching others - Exceptional organizational skills and ability to deal with competing priorities, also strong reasoning and problem-solving ability. - Strong project planning/ management, communication (written and verbal) and presentation skills - Experience with protocol, ICF, CRF, CSR development and review. - Proficient with MS Office Suite (Excel, Word and PowerPoint) #LI-AL1 #LI-Remote U.S. Pay Range $126,700.00 - $171,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

• Responsible for clinical trial management of multiple studies • Oversee/leads study-specific study management resources • Mentor other Clinical Project Managers • Serve as the project lead for multiple studies of high complexity • Prepare and/or review study-related or essential study start-up documents • Ensure that the Study Management team meets or exceeds the timelines and deliverables assigned to the study team • Develops and manages group of studies for an entire business unit or large development program • Handle relationships with sites/PIs and vendors, including CROs • Define, track and report schedule attributes such as durations, interdependencies, and key deliverables • Proactively identify and manage risks and issues to ensure cost-effective and timely delivery of the project

• Collaborate with cross-functional teams to design and implement effective clinical trial enrollment • Collaborating with cross-functional teams to develop and implement comprehensive clinical trial protocols. • Overseeing and managing the day-to-day operations of clinical trials, ensuring compliance with regulatory standards. • Analyzing and interpreting clinical trial data, identifying trends, and providing insights to optimize study outcomes. • Proactively addressing challenges and implementing effective solutions to ensure the successful execution of clinical trials. • Communicating effectively with internal and external stakeholders to foster strong partnerships and facilitate smooth trial processes.

Clinical Operations Manager About Avail Health Avail Health is a Nurse Practitioner–founded organization dedicated to removing barriers to care, access, and meaningful clinical work for Medicare-age individuals. We combine thoughtful technology, strong operational infrastructure, and deep respect for the patient–provider relationship to enable nurse-led virtual and mobile care. By empowering nurses, reducing administrative burden, and supporting consistent, high-integrity clinical practices, we deliver compassionate, high-quality care through scalable, team-based, and data-driven care models that improve access, quality, and patient outcomes in the communities we serve. Program Overview Avail Health partners with Medicare Advantage health plans to support Institutional Special Needs Plan (I-SNP) members through nurse-led programs focused on accurate risk adjustment and proactive risk management. Care is delivered by a hybrid team of Nurse Practitioners and mobile nurses, with nurses supporting NP-led telehealth visits through in-person member engagement, clinical data collection, and coordination. The team conducts structured in-person and virtual assessments to identify and document chronic and complex conditions in alignment with CMS requirements, producing actionable insights for the health plan and care teams. In select programs, NPs also provide limited, plan-directed clinical support to address identified risks and close care gaps, improving member experience and health plan performance without serving as the primary care provider. Role Summary The Manager, Clinical Operations – Risk Performance leads the day-to-day operations and overall performance of Avail Health’s Risk Performance programs. This role is accountable for operational execution, workflow standardization, and team performance, serving as a hands-on leader and first-line operational resource for frontline clinical teams. The position supports an interdisciplinary clinical team and reports directly to the Vice President of Operations, with matrixed accountability to the Vice President of Care Delivery. The Manager, Clinical Operations partners closely with clinical leadership, peer Clinical Operations Managers, and cross-functional teams—including Technology, Product, Quality, Analytics, and Revenue Cycle—to identify operational challenges, implement workflows and tools, and drive continuous improvement. This role supports program scalability by creating structure, standardizing processes, and ensuring consistent execution as the program evolves. This is a primarily remote, work-from-home role requiring a reliable high-speed internet connection and a dedicated, HIPAA-compliant workspace to support confidential patient information and secure communications. Minimal travel may be required for team meetings, occasional site visits within and around the Ohio region, or other operational priorities. Preference given to candidates residing in or near Ohio and in the Eastern Standard Time Zone. While the role primarily supports clients in the Ohio region, there may be periodic travel to other states and time zones periodically to support other operational initiatives. Standard business hours are Monday–Friday, 8 a.m. to 5 p.m. Eastern Time. Flexibility is required to accommodate occasional early or late meetings across multiple time zones. Position Overview This is a hands-on, “player-coach” operations role responsible that drives day-to-day execution building operational structure for Avail Health’s Risk Performance program. The Clinical Operations Manager serves as the internal operations lead, partnering with clinical leadership to define, standardize, and improve workflows. This role is responsible for documenting current-state processes, developing SOPs, and identifying opportunities to improve efficiency, consistency, and performance. This individual also supports frontline clinical teams by addressing day-to-day operational needs, including scheduling coordination, workflow troubleshooting, and field support. In addition, the role leads onboarding and training for new hires and ensures teams have clear processes and expectations. The Clinical Operations Manager tracks and manages key performance metrics and partners with analytics and technology teams to improve reporting and support data-driven decisions. This role requires a highly adaptable, tech-savvy operator who can build structure in a fast-paced, evolving environment. Key Responsibilities 1. Program Operations, Workflow Design & Execution Own day-to-day operational execution across the program, ensuring reliable and efficient care delivery for mobile and virtual clinical teams. Document current-state workflows and translate them into standardized, scalable SOPs across core functions, including scheduling, patient engagement, clinical team support, and care coordination. Identify operational gaps and implement process improvements to enhance efficiency, consistency, and quality across markets. 2. Frontline Operations Support & Clinical Team Enablement Serve as the primary operational resource for frontline clinical teams, providing real-time support to address day-to-day needs, remove barriers, and maintain continuity of care. Coordinate scheduling and field support for mobile teams, and ensure workflows, tools, and processes enable clinicians to operate effectively. Partner closely with clinical leadership to reinforce expectations, improve throughput, and support high-quality, compliant care delivery. 3. Training, Onboarding & Team Readiness Lead onboarding for new clinical hires by developing and delivering structured training programs, materials, and workflows. Ensure all team members are equipped with clear guidance on operational processes, documentation requirements, and tools. Continuously refine training content and onboarding approaches based on field feedback, performance trends, and program evolution. 4. Performance Management, Metrics & Continuous Improvement Track and manage key operational and clinical performance metrics, including access, productivity, documentation quality, patient engagement, and program outcomes. Partner with analytics and technology teams to define reporting needs, improve data visibility, and close gaps in performance tracking. Use data-driven insights to identify trends, inform workflow improvements, and drive ongoing program optimization. 5. Cross-Functional Collaboration and Standardization Partner cross-functionally with Product, Technology, Analytics, Quality/Compliance, and Revenue Cycle teams to support program evolution and scaling across markets. Translate new initiatives and enhancements into clear, actionable workflows and standardized SOPs that align with the care model and regulatory requirements. Establish operational structure by documenting best practices, driving consistency across teams, and supporting change management in a rapidly evolving environment. Provide feedback to inform product and technology development, particularly to improve workflow efficiency, reporting capabilities, and overall program performance. Required Qualifications - Bachelor’s degree in healthcare administration, business administration, public administration, nursing, or a related field; or equivalent combination of education and experience - 5+ years of progressive experience in healthcare operations or clinical practice management, ideally in virtual, mobile, or hybrid care settings - Demonstrated experience developing and implementing SOPs, workflows, training materials, and process improvement initiatives - Experience supporting clinical or care delivery teams, with the ability to troubleshoot operational and workflow challenges in real time - Familiarity with value-based care, managed care, or integrated delivery models - Proven ability to influence, coach, and support distributed or remote teams, driving accountability and performance across cross-functional environments - Strong technology aptitude, including experience with EHRs, telehealth platforms, and data/reporting tools - Experience defining, tracking, and improving key operational performance metrics (KPIs) - Authorization to work in the United States - Ability to work on an Eastern Time Zone schedule Preferred Qualifications - Experience in Medicare Advantage, including familiarity with risk adjustment and quality (e.g., HEDIS/STARS) - Familiarity with revenue cycle workflows and billing processes - Experience building dashboards, reports, or operational performance tracking tools - Experience in a startup or high-growth environment, building structure and processes from the ground up - Residence in Ohio, Indiana, or West Virginia preferred What Success Looks Like - Operational workflows are clearly documented, standardized, and consistently executed across teams - Frontline clinical teams are well-supported, with minimal operational friction and clear, reliable processes - Scheduling, coordination, and communication run smoothly, with low error rates and strong continuity across care teams and patient support networks - Key performance metrics (e.g., access, productivity, documentation quality, patient engagement) are consistently tracked, understood, and improving over time - Operational gaps are proactively identified and addressed, with continuous refinement of workflows and SOPs - Strong cross-functional coordination enables efficient execution and ongoing program improvement - Effective use of technology and reporting tools supports visibility, decision-making, and scalability - Ability to operate independently in a fast-paced, evolving environment with a high degree of ownership and accountability - A collaborative, accountable team culture that supports performance, engagement, and alignment with organizational goals Compensation & Benefits - Benefits Package: Medical, dental, and vision insurance, in accordance with company benefit plans and eligibility requirements. - Paid time off: 3 weeks annually (accrued per pay period) - Holidays: 8 paid holidays plus 1 floating holiday - Retirement: 401(k) plan with 2% employer match - Base salary: $90,000 – $105,000, commensurate with experience - Performance bonus: Quarterly bonus of up to 2.5% of annual salary. Performance bonuses are tied to operational KPIs, including access, documentation quality, productivity, and program execution milestones. - Annual salary increase: Up to 5% of base salary, subject to performance review Additional Information - Our company is growing! We welcome candidates with leadership and management experience as the role may evolve quickly.