• Own and operate clinical systems as system owner, including access control, configuration, validation, and lifecycle management. • Ensure systems remain compliant with GxP regulations and internal SOPs, preserving data integrity and inspection readiness. • Lead requirements definition, solution design, and implementation planning with cross-functional stakeholders. • Provide Level-2 application support and vendor coordination for incident resolution and system enhancements. • Maintain and continuously improve system documentation, including validation deliverables, SOPs, and operational records. • Partner with Clinical Data Management to support data quality, flow, and operational needs. • Execute core system governance activities, including performance monitoring, upgrades, disaster recovery testing, access reviews, and license and vendor management. • Drive system adoption through training, documentation, and user enablement. • Support audits and regulatory inspections, including inspection responses, remediation, and CAPA closure. • Contribute to product roadmaps and release planning, balancing business value, regulatory risk, and technical feasibility. • Manage and maintain collaborative relationships with core business partners.

• Act as an escalation point beyond Tier 1 and own complex incidents end-to-end • Troubleshoot advanced Windows 11, mobile device, and virtual machine performance issues • Support Azure infrastructure, including VMs, Development, and virtual desktop environments • Administer Microsoft 365 (Exchange Online, Teams, SharePoint, licensing) • Manage Entra ID (user lifecycle, group management, MFA, access control issues) • Deploy and enforce Intune device policies and compliance standards • Diagnose and remediate endpoint security posture issues • Own patch validation, vulnerability remediation, and system hardening • Document thoroughly and follow structured operational practices • Maintain strong alignment with HIPAA/HITRUST security controls

Description About the Role We are seeking a highly skilled Senior Enterprise Architect to join our Enterprise & Federal team. This role is responsible for tackling the most challenging technical and product barriers in large, complex customer environments. Acting as a bridge between Sales Engineering, Support, Professional Services, and Product, you will create and scale the technical content, tools, and frameworks that enable NinjaOne to succeed in enterprise and federal markets. This is a hands-on, customer-facing role for someone who thrives in ambiguity, excels at creative problem solving, and can build rapid prototypes, integrations, and reusable technical assets-often leveraging PowerShell , Python, APIs, and automation frameworks to produce scalable, repeatable solutions that accelerate deal cycles and elevate customer outcomes. Location - We are flexible on remote working from home, if you are located in the USA and reside in one of the following states - CA, CO, CT, FL, GA, *IL, KS, ME, MA, MD, NJ, NC, NY, OR, TN, TX, VA, & WA. Travel: Up to 35% required What You'll be Doing Enterprise/Federal Deal Enablement Partner with SEs and AEs to identify and solve deeply technical problems that block large opportunities Rapidly prototype and iterate on new NinjaOne content, dashboards, and API-based integrations Advanced Technical Escalations Triage and resolve complex support tickets beyond the scope of frontline SEs and support staff Diagnose and mitigate customer-side factors impacting NinjaOne performance (e.g., firewalls, load-balancers, storage systems, endpoint agents, OS tuning) Tooling & Migration Support Collaborate with Professional Services and Product teams to design and deliver tools that reduce effort for customers, partners, and NinjaOne staff Build solutions to accelerate migrations from competitive platforms onto NinjaOne Cross-Functional Technical Voice of Authority Serve as a technical advisor and problem-solver across Sales, Product, Pro Serve, and Support Contribute to internal knowledge sharing, helping create repeatable playbooks and tools for future enterprise deployments Provide hands-on technical leadership in ad hoc or emergent areas critical to advancing enterprise accounts Other duties as assigned About You Technical Expertise Strong background in systems engineering, IT operations, or enterprise endpoint management required Deep familiarity with enterprise IT environments, networking, storage, OS tuning and troubleshooting Experience with API development/integration, scripting, and automation tools Proficiency in MULTIPLE operating systems ( Windows, macOS, Linux , iOS, Android) and exposure to "irregular" or legacy OS/device environments Proficient in MULTIPLE common scripting languages with demonstrable proficiency in PowerShell and/or Python (preference for PowerShell) Proficient with MULTIPLE troubleshooting and analysis tools using advanced network and OS tools (e.g. sysmon, procmon, WPR/T/A, sysinternals, strace/ltrace, WireShark, nmap, tcpdump, gbd, lsof, sysdiagnose, etc.) Problem-Solving Mindset Track record of building creative gap-fills, prototypes, and integrations to unblock deals Ability to diagnose complex, multi-system performance issues Enterprise Experience Previous work with large-scale, complex IT organizations, preferably in Federal or regulated industries required Strong understanding of enterprise procurement and implementation cycles Collaboration Skills Comfortable working cross-functionally with Sales, Support, Product, and Professional Services Excellent communication skills, with the ability to translate deep technical details into customer-ready solutions Operate with urgency and flexibility, applying structured thinking to ambiguous situations and excelling in dynamic, high-growth environments where priorities evolve quickly Embody NinjaOne's values of Curiosity, Integrity, Kindness, Humility, Builders and foster an environment where these values thrive About Us NinjaOne automates the hardest parts of IT to deliver visibility, security, and control over all endpoints for more than 30,000 customers. The NinjaOne automated endpoint management platform is proven to increase productivity, reduce security risk, and lower costs for IT teams and managed service providers. NinjaOne is obsessed with customer success and provides free and unlimited onboarding, training, and support. NinjaOne is #1 on G2 in endpoint management, patch management, remote monitoring and management, and mobile device management. What You'll Love We are a collaborative, kind, and curious community. We honor your flexibility needs with full-time work that is hybrid remote. We have you covered with our comprehensive benefits package, which includes medical, dental, and vision insurance. We help you prepare for your financial future with our 401(k) plan. We prioritize your work-life balance with our unlimited PTO. We reward your work with opportunity for growth and advancement. Additional Information This position is NOT eligible for Visa sponsorship. *Due to operational policies, NinjaOne is unable to hire for this role within the city limits of Chicago. We will consider all qualified candidates who reside outside of the city proper or are willing to self-relocate. Starting pay for the successful applicant depends on a variety of job-related factors, including but not limited to location, market demands, experience, job-related knowledge, and skills. The benefits available for this position include medical, dental, vision, 401(k) plan, life insurance coverage and PTO. For roles based in California, Colorado, Maryland, New Jersey or Washington the base salary hiring range for this position is $150,000 to $200,000 per year with On Target Earnings of $180,000 to $240,000 per year. For roles based in New York, the base salary hiring range for this position is $150,000 to $200,000 per year with On Target Earnings of $180,000 to $240,000 per year. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic information, marital status, veteran status, or any other status protected by applicable law. We are committed to providing an inclusive and diverse work environment. #LI-KG1 #LI-Remote #BI-Remote

• Serve as the main escalation point for the helpdesk team and handle advanced troubleshooting. • Troubleshoot and resolve end-user issues across different environments, including RDS users, office PCs, CAD workstations, and SaaS/cloud applications. • Troubleshoot Windows Server issues such as logins, permissions, Group Policy, DNS, printing, and performance. • Provide support for issues related to Microsoft 365 (email, permissions, MFA, Teams/OneDrive). • Respond to security alerts from Huntress and Blumira, investigate, isolate affected devices/users, apply fixes, and document the outcome. • Work on both proactive system maintenance and reactive incident resolution. • Use ConnectWise Manage for ticket management and client communication, and Datto RMM for remote troubleshooting and system maintenance. • Document solutions and troubleshooting procedures in UseWhale, ensuring other technicians can replicate fixes. • Coach junior technicians, providing guidance and repeatable troubleshooting steps for complex issues, such as RDP/RDS and VPN problems. • Diagnose and resolve VPN and network connectivity issues. • Perform and verify restores when needed using tools such as Acronis, Veeam, or client-specific backup tools. • Review recurring issues and implement preventive measures (GPO fixes, PowerShell automation, standard settings, and documentation).