4D Molecular Therapeutics

• Report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development • Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight • Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations • Serve as medical monitor for assigned studies, ensuring subject safety and data integrity • Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery • Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners • Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts • Lead development and implementation of biomarker strategies for GA and broader retina programs • Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials • Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy • Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses • Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs • Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents • Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input. • Works with the research organization and the portfolio management team to identify and support new project opportunities. • Collaborates to identify program risks, and to create and implement mitigation strategies • Other duties as assigned

• Implement, execute, and oversee clinical trials within a clinical program • Partner with Director of Clinical Operations to develop and manage clinical programs • Provide operational leadership for trial planning, execution, and data collection • Oversee day-to-day activities of Clinical Trial Operations and Clinical Data Management groups • Collaborate on annual budget planning and vendor management • Ensure clinical trials are inspection ready • Coordinate development and review of protocols/amendments and operational execution

• Develop and refine intellectual property strategy for 4DMT products and platforms; present IP strategy updates to executive leadership, as needed. • Responsible for implementing key elements of 4DMT’s intellectual property strategy, and managing its patent, trade secret, and trademark portfolio; implements a strategy for IP lifecycle management. • Directs outside counsel in the preparation and prosecution of applications and responding to office actions; directs outside counsel in evaluating the patentability of invention submissions and registrability of trademarks globally; manages related outside counsel budgets. • Identifies strategic areas for patenting, trade secret protection, and trademarking; collaborates with R&D, CMC, Clinical Science, and other functions to proactively identify and develop patentable intellectual property to prepare, file, and prosecute. • Manages patentability, freedom-to-operate, infringement, validity, and regulatory exclusivity analyses. • Supports and manage IP disputes and administrative proceedings, including oppositions and post-grant challenges. • Identifies and tracks 4DMT trade secrets and provides counsel with respect to 4DMT’s trade secret protection practices. • Provides IP perspective and counseling at 4DMT meetings and presents on IP topics. • Counsels and trains internal clients on intellectual property practices and policies. • Conducts IP due diligence for business development activities and supports IP due diligence related to financing activities. • Drafts, reviews, and negotiates agreements to support R&D and CMC activities, including NDAs, MTAs, MSAs, sponsored research agreements, consulting agreements, and licenses. • Collaborates with Legal colleagues, Business Development, and other key leaders and functions on key strategic agreements, including licenses, collaboration agreements, and other business development efforts. • Assists with other Legal Department matters, including litigation support, SEC reporting (IP-related sections), records management, compliance activities, and template projects. • Other duties as assigned; nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

• Supports the development and execution of Clinical Supply strategies for all 4DMT’s Phase 1/2/3 investigational drug products and ancillaries. • Coordinate and track bulk drug orders to ensure adherence to pre-defined supply and resupply timelines. • Monitor site inventory on a daily basis; coordinate and track drug shipments to ensure uninterrupted supply. • Supports drug product inventory management and distribution in partnership with 4DMT’s clinical partners; evaluates drug utilization versus forecast considering country requirements and logistical timeline. • Maintains study and depot-level accountability and reconciliation documentation to support regulatory compliance and study closeout. • Tracks and resolves study and depot level temperature excursions. Provide routine reporting of drug wastage due to these excursions. • Archives Proof of Delivery (POD) documentation. • Maintain traceable documentation to support GXP activities. • Archives documentation on Trial Master Files as required.

• Provide strategic and operational leadership for global clinical trial execution across the 4DMT lung portfolio. • Responsible for delivering clinical programs aligned with corporate timelines, budget, quality, and regulatory expectations. • Lead internal Clinical Operations teams and external partners/CROs. • Collaborate with external teams to ensure efficient, high-quality, inspection-ready execution of Phase 1–3 clinical studies. • Serve as a key cross-functional leader and Clinical Operations subject matter expert.

• Support 4D‑150, a gene therapy in late-stage development for retinal vascular diseases • Plan, develop, and deliver high-quality clinical and regulatory documents across late-stage development • Collaborate closely with Clinical Science, Clinical Operations, Data Science, Regulatory Affairs, Quality, and external partners • Oversee development, coordination, and execution of key BLA modules • Manage internal and external medical writing resources for timely, high-quality regulatory deliverables. • Author, review, and coordinate key clinical and regulatory documents for the 4D‑150 Phase 3 program as well as for the early-phase lung program.

• Set, communicate and drive strategy for Translational products in alignment with the broader organization of 4DMT • Prioritize and allocate resources, both within Translational and beyond, to meet portfolio needs • Lead the decision-making process with other relevant functional group heads regarding indications, targets and products’ progression from concept, design, preclinical development and Phase 1-2 clinical testing. • Provide input on scientific strategy from the earliest consideration of new targets through development, including risk, scientific challenges, timing of resource investment and development of go/no go decisions • Direct and coordinate the implementation of preclinical study programs for pharmacology studies in support of the lead to candidate optimization process • Design, implement and write-up comprehensive series of pharmacology studies to address preclinical exposure, develop pharmacokinetics and pharmacodynamics profiles and generate GLP toxicology and bio-distribution packages suitable for supporting IND filings • Manage budgets and headcounts • Design, implement and manage externally facing in vivo studies with CROs and academic centers, including drafting proposals, budget oversight and managing deliverables • Resource planning; hiring and mentoring talents; building the team and technical capabilities • Build collaborations with relevant functions at 4DMT; represent own function at the corporate level and externally • Provide direct hands-on responsibility for all Translational interactions as well as grant writing and management with rare disease advocacy groups • Participate on project teams and direct activities to ensure regulatory compliance of pre-clinical and clinical research activities • Support regulatory affairs in their preparation, review and submission of necessary pre-clinical and clinical regulatory information to regulatory agencies worldwide • Contribute to defining of clear human POC study outcome criteria for decision-making on new product candidates • Contribute senior level expertise to alliance, business development, due diligence exercises with external entities and licensing meetings as well as other critical external interfaces such as public health regulatory bodies • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

• Support study execution across start-up, conduct, and close-out phases • Serve as a primary point of contact for assigned clinical sites and CRO field CRAs/monitors • Communicate directly with sites and CRO partners to obtain updates, resolve issues, and support study timelines • Support site initiation, ongoing site management, and site close-out activities • Assist with identification, documentation, tracking, and follow-up of site issues • Support oversight of CRO monitoring activities • Review monitoring visit reports and follow up on action items and unresolved findings • Track monitoring deliverables and escalate issues to the Associate Director, Clinical Operations as appropriate • Support inspection readiness and audit activities • Maintain accurate tracking tools for assigned studies, including: • Site start up and activation status • Subject enrollment and visit status • Essential document collection and TMF status • Vendor reconciliation • Assist with preparation of study status reports and metrics • Collect, review, and track site regulatory documents for completeness, accuracy, and compliance with applicable SOPs and regulatory requirements • Ensure timely filing of documents in the TMF/eTMF in accordance with TMF plans • Perform TMF quality control activities and support TMF audits and study close out • Support organization and coordination of internal team meetings, investigator meetings, and other study related meetings • Prepare meeting materials, take meeting minutes, and maintain action item logs • Support communication of study updates to internal stakeholders

• Provide Quality oversight for multiple 4DMT Clinical Studies, including the following study-specific activities: • Develop and implement Clinical Study Quality Plans for specific 4DMT clinical studies, focused on ensuring subject safety/rights, study data integrity, and GCP compliance. • Provide guidance and support to clinical study teams, including via attendance at Study team meetings and via investigation and management of Clinical Study Quality Events. • Ensure principles of Risk Management are applied to the Clinical Study per ICH E6. • Identify, communicate, and escalate significant incidents of GCP non-compliance and follow to resolution, acting at all times with an appropriate sense of urgency. • Plan, perform, and/or oversee GCP Compliance audits of high-risk clinical vendors/sites, including clinical investigator sites. • Ensure audit findings are communicated to audit stakeholders and collaborate with auditees and vendors to track, review, approve, and assess the adequacy of CAPAs. • Perform Clinical Document reviews, ensuring the quality, accuracy and completeness of various documents, including as applicable Clinical Protocols, IBs, DSURs, Module 2.6 Tabulated and Written Summaries, and Integrated Summaries.

• Manage full-cycle recruitment for assigned roles, including sourcing, screening, interviewing, and offer negotiation • Partner with hiring managers to understand hiring needs, define role requirements, and develop candidate profiles • Proactively source and engage candidates using a variety of channels, including LinkedIn Recruiter and networking • Draft and refine job descriptions in partnership with HR and Total Rewards, ensuring alignment with leveling and compensation frameworks • Coordinate and drive interview processes, including scheduling, debrief facilitation, and delivery of structured feedback • Support offer development and negotiation in alignment with company compensation philosophy • Partner with external search firms and staffing agencies as needed; help ensure quality and cost-effectiveness of vendor support • Track and maintain recruiting data, ensuring accuracy in systems such as Greenhouse and contributing to hiring metrics and reporting • Support execution of hiring plans in alignment with approved headcount and business priorities • Identify opportunities to improve recruiting processes, tools, and candidate experience • Stay informed on industry trends and talent market dynamics within biotech/pharma • Promote inclusive hiring practices and support efforts to mitigate bias in the recruiting process • Participate in special projects and broader Talent Acquisition or HR initiatives as needed