Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity Amylyx is seeking a Senior Medical Director, Clinical Development to provide strategic and scientific leadership for one or more late-stage, pivotal programs with the potential to expand into additional indications and/or programs within the same molecule or across the portfolio. This individual will play a critical role in shaping the overall clinical development strategy and may lead multiple programs or key components of a broader development portfolio. Reporting to the Senior VP of Clinical Development, you will be responsible for leading the design, execution, and interpretation of clinical studies and overseeing the development and implementation of Clinical Development Plans across assigned assets. You will provide strategic input into study design, endpoints, and regulatory strategy, ensuring alignment with the overall program and corporate objectives. The successful candidate will collaborate with cross-functional teams in a matrix environment, influencing stakeholders across Research, Regulatory Affairs, Clinical Operations, and Commercial to ensure that clinical and scientific considerations are fully integrated into development plans. You will proactively identify and mitigate risks, guide decision-making through data-driven insights, and ensure the highest standards of scientific rigor and data integrity. In this role, you will also serve as a key external representative, engaging with global medical experts, investigators, regulatory authorities, and alliance partners. You may lead or mentor a team of clinical scientists and physicians and contribute to broader organizational and portfolio-level initiatives. Responsibilities - Provides strategic medical leadership and oversight for assigned clinical programs, including late-stage and pivotal trials. - Leads development and execution of Clinical Development Plans (CDPs), integrating clinical, scientific, regulatory, and commercial considerations. - Drives study design, protocol development, and interpretation of complex clinical data to inform key program decisions. - Serves as a core member of cross-functional program teams, influencing strategy and ensuring alignment across disciplines. - Provides senior-level medical monitoring and guidance, ensuring patient safety, data integrity, and high-quality trial execution. - Leads interactions with external stakeholders including key opinion leaders, investigators, regulatory agencies, and alliance partners. - Oversees preparation of key program documents including protocols, investigator brochures, clinical study reports, regulatory submissions, and publications. - Mentors and provides scientific guidance to junior team members, including Medical Directors and Clinical Scientists. - Identifies and implements process improvements and best practices within Clinical Development. Required Qualifications - MD required - Significant experience in late-stage clinical development and drug development in biotech/pharmaceutical industry; rare disease experience strongly preferred - Typically 5+ years of experience leading clinical development programs with demonstrated impact on program strategy and execution - Demonstrated ability to collaborate with cross-functional teams and influence without authority in a matrix environment - Strong strategic thinking, problem-solving, and decision-making skills - Proven ability to interpret complex clinical data and translate insights into actionable strategies - Excellent communication and leadership skills, with experience interacting with senior stakeholders and external experts - Experience mentoring or leading team members preferred - Ability to travel internationally and domestically Work Location and Conditions - At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. - You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. - You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $315,000—$354,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Job Title: Field Medical Studies Director, Specialty Care US - Location: Remote, US About the Job Our Team: This field-facing position will report to the National Field Medical Studies Director and will be part of the Specialty Care Medical Innovation team. Medical serves as a valued strategic partner with Development, Clinical, Commercial, Regulatory, and Market Access on therapeutic solutions to support patients’ needs. The US Medical team is proud to support Sanofi’s deep commitment to chasing the miracles of science to improve the lives of patients. Join the team transforming care for people with immune challenges, rare diseases, cancers, and neurological conditions. In Specialty Care, you’ll help deliver breakthrough treatments that bring hope to patients with some of the highest unmet needs. About Sanofi: We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. Main responsibilities: - Serve as the clinical trial subject matter expert for the US Field Medical team, providing scientific guidance on trial design, protocols, amendments, recruitment challenges, site engagement, and pipeline evolution. - Act as a primary liaison between Medical Affairs and R&D, aligning US field medical activities with global research strategy and anticipating evolving field support needs as programs progress. - Establish and maintain strategic relationships with key external stakeholders, including clinical trial KOLs, professional societies, and patient advocacy groups, to support clinical development, evidence generation, and scientific exchange. - Partner cross-functionally and globally across Medical Affairs, R&D, Clinical Operations, Global Medical, RWE, eDev, EDO, CSU, and CSO to ensure alignment on strategy, trial execution, and evidence priorities. - Support insight generation to inform current and future research needs, including exploratory endpoints, biomarkers, novel trial designs, and evolving clinical questions across the product lifecycle. - Collaborate with Home Office Medical Directors, Global Medical, RWE, and R&D to plan, conduct, and execute epidemiological studies, registries, and clinical trials in the US. - Contribute to the development, execution, and external validation of the global integrated Evidence Generation Plan (iEGP), including engagement with external experts and research partners. - Support and guide MSL trial site engagement strategy and execution, including site identification, recommendation processes, Site Initiation Visit engagement, and ongoing support throughout trial conduct. - Ensure appropriate site and patient participation in registries to meet both regulatory and Medical Affairs objectives, in partnership with MSLs. - Provide rapid scientific support to MSLs responding to field inquiries and external stakeholder questions related to clinical trials and pipeline programs. - Maintain deep therapeutic area expertise through continuous review of scientific literature, technology advancements, and participation in relevant scientific meetings and congresses. - Contribute scientific input to R&D and clinical content development for trial-related materials, advisory boards, and HCP education initiatives. - Participate in publications and authorship activities in accordance with established criteria and governance. - Develop, track, and report R&D field KPIs, demonstrating impact and progress through regular leadership updates and global dashboards. About You Education: MD, PhD, DNP, PharmD, or equivalent preferred. Work Experience: - Medical, pharmacy or post graduate level science degree required. Previous pharmaceutical industry experience with relevant Specialty Care expertise preferred. - Clinical research experience and/or basic science research. Skills / knowledge: - Strong and versatile clinical development experience in specialty care, immunology and/or neurology preferred. - Knowledge of pharmaceutical product development, product lifecycle, and commercialization processes. - Experience with developing study concepts for clinical development and clinical trial designs with cross-functional input, including biostatistics, observational research and patient-reported outcomes in Phase 2b and/or 3 clinical trials. - Leadership experience/potential as a medical expert in a complex matrix environment. - Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication. - Strong interpersonal skills and problem-solving abilities while exhibiting superior judgment and a balanced, realistic understanding of issues and resolution path. Why Choose Us - Bring the miracles of science to life alongside a supportive, future-focused team. - Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. - Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. - Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SG #LI-GZ #LI-Remote #vhd Pursue progress, discover extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com! US and Puerto Rico Residents Only Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. North America Applicants Only The salary range for this position is: $206,250.00 - $297,916.66 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK.

• Develop and execute clinical strategies that support organizational growth, enhance workflows, and strengthen clinical operations and staffing models across IME, Review Services, Case Management, and managed care service lines. • Design, implement, and evaluate new clinical programs that improve outcomes and maximize value for clients across diverse markets and specialties. • Provide clinical guidance to ensure the delivery of high-quality, evidence-based services and compliance with clinical standards and regulatory requirements. • Identify areas of client or employee dissatisfaction and implement targeted solutions to elevate the customer and workforce experience. • Partner closely with operations, business development, and cross-functional teams to streamline processes, improve efficiency, and support revenue objectives. • Identify and support collaborative selling opportunities to expand service utilization and client engagement. • Lead, mentor, train and inspire nursing and clinical teams to achieve high performance and professional growth. • Oversee clinical recruitment strategies, including interviewing, hiring, onboarding, and performance development planning. • Establish, monitor, and ensure compliance with quality initiatives, clinical standards, and regulatory requirements. • Leverage data and analytics to identify trends, educate clients, and drive continuous improvement in program outcomes. • Conduct regular performance reviews, coaching sessions, and leadership development activities for clinical staff.

ROLE SUMMARY This position will assume a global role within the RSV adult vaccines asset, with a focus and direct responsibility for RSV adult vaccine program medical evidence strategy, including RSV vaccine effectiveness and burden studies. This position has a worldwide focus and will include supporting work in Asia. The work will have as its first priority the adult indication of Pfizer's RSV vaccine, RSVpreF. RSVpreF/Abrysvo is licensed in numerous countries globally in adults. The most urgent need will be coordinating evidence generation work across Pfizer to ensure RSV adult studies are conducted appropriately in context of latest information on RSV disease, strategic goals of the vaccine program, and best practices in epidemiological methods. The role also oversees regulatory interactions related to Abrysvo vaccine effectiveness studies in adults. ROLE RESPONSIBILITIES Under the supervision of the Team Lead, Medical Affairs, Adult RSV Vaccine Program, take the primary lead for oversight of medical evidence strategy, including RSV vaccine effectiveness and burden studies: - Ensure RSV adult studies are conducted appropriately in context of latest information on RSV disease, strategic goals of the program, and best practices in epidemiological methods. - Design post-authorization epidemiology studies for RSV adult indication including assessments of post-licensure adult RSV vaccine effectiveness. - Ensure methods and outcomes are harmonized across RSV adult evidence generation portfolio. - Ensure all regulatory feedback on RSV adult VE studies is considered in future regulatory interactions. - Execution of studies is done by another group within Pfizer, but role will provide technical oversight and coordination for those executing the studies to ensure design and strategic consistency across portfolio and be member of key study teams. - Provide input on RSV adult study design and execution based on deep expertise in RSV disease and epidemiologic methods. - Oversee the development of common strategies across studies and study sites, including common protocols, case report forms, and databases, as indicated. - Identify, establish, and maintain relationships with external partners that can collaborate with high priority global studies. - Oversee aspects of study design (e.g., methodology, protocols, analytic plans) for high priority epidemiologic and other scientific studies. - Provide expertise on vaccine safety concerns within context of RSV adult vaccine studies. - Provide expertise in RSV diagnostics. - Assist with trouble shooting major scientific/epidemiology issues during study implementation, including through travel to study sites when appropriate. - Work with internal and external experts in statistics and data analysis to analyze and interpret data from key RSV vaccine and burden studies. - Work with internal and external experts to publish data in peer-reviewed manuscripts, including taking the lead for writing the first draft of these manuscripts if needed. - Work with internal and external experts to develop abstracts and present data for scientific congresses, including taking the lead for writing and presenting in some cases. - Develop strategy regarding the collection of epidemiologic and other scientific data in target regions necessary for enhancing RSV vaccine product labels. - Take the lead in writing original manuscripts each year (such as conceptual manuscripts, position manuscripts, systematic reviews, or where appropriate manuscripts based on original data). BASIC QUALIFICATIONS - MD degree with expertise in vaccinology and field-based and analytic epidemiology - At least 10 years of experience in vaccine-related or vaccine-preventable disease related medical/scientific activities including research, clinical development, epidemiological, and immunization programs. - Recognized expert in vaccines and viral respiratory disease to be credible both internally and externally as evidenced by one or more of the following: - Lead or senior author of at least 5 peer-reviewed publications or book chapters. - Principal or lead investigator for at least two major projects. - Presenting author for at least 5 abstracts at international scientific congresses - Specific expertise in adult RSV epidemiology and vaccine effectiveness studies - Demonstrated experience with participating in a matrixed team. - Demonstrated ability to lead across diverse cultures and geographies. - Significant cross-functional leadership experience. - Previous work experience on RSV disease considered a major plus but not required. - Documented ability to manage projects to completion. - Documented ability to take a relevant vaccine or vaccine-preventable disease epidemiology project from start to end including conception, design, protocol, analytic plan, implementation, analysis, and reporting and interpretation of results. - Ability to understand subtle issues related to RSV vaccinology and epidemiology. - Able to review, evaluate, interpret, and present complex data; understand the emerging safety and efficacy profile of Pfizer RSV vaccines. - Understand the critical data elements related to assessing the public health value of RSV vaccines, ability to oversee or conduct public health analyses of RSV vaccine impact, and ability to interpret data and data limitations for both Pfizer and competitor RSV vaccines. - Proficiency with MS-Office software (Word, Excel, PowerPoint) - Excellent verbal and written communication skills including scientific writing skills as evidence by lead authorship in at least 5 peer-reviewed publications in English. - Strong interpersonal skills. - Proven ability to influence and succeed through others and to form excellent relationships with key cross-functional stakeholders. - Demonstrated strong work ethic, and proven track record of delivering high quality within timelines. - Willingness to travel (approximately 15% may be required) • Fluent in English writing, reading, speaking. Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. PREFERRED QUALIFICATIONS - Direct experience overseeing post-authorization efficacy studies - Experience with adverse events assessments as part of vaccine effectiveness studies ORGANIZATIONAL RELATIONSHIPS • Managerially, reports directly to the Team Lead, Medical Affairs, Adult RSV Vaccine Program; technically coordinates with RSV evidence generation staff scientific affairs. • Participates at the global level with other colleagues in RSV vaccine program on issues of importance to global RSV epidemiology and vaccinology, with an emphasis on issues of relevance to RSV vaccine licensure, recommendations, and use. • Coordinates activities with others working on RSV adult evidence generation including clinical scientists and medical evidence generation lead. • Works closely with Pfizer country medical staff globally to ensure that studies are aligned with scientific, public health, and medical goals for adult RSV vaccines. • Works with RSV KOLs globally Define data gaps globally that will impede decision-making related to RSV vaccine use, (including pre- and post-licensure), prioritizing these gaps, and developing and implementing solutions to close these gaps. No direct supervisory responsibility PHYSICAL/MENTAL REQUIREMENTS No specific physical or mental requirements NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Travel approximately 15% (up to 20%) Work Location Assignment: This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week or more as needed. The annual base salary for this position ranges from $254,100.00 to $423,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Medical