Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Principal Scientist - Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead What you will do Let’s do this. Let’s change the world. In this vital role you will add to our diverse team in Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences (PKDM-BA) to advance our growing siRNA research portfolio. You will lead the strategy and execution of innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetics and pharmacokinetic-pharmacodynamic relationships. In addition to leading teams within PKDM-BA, you will be a project team representative contributing to multidisciplinary teams composed of experts in chemistry, biology, toxicology, clinical pharmacology and the like to drive clinical candidate selection and successfully file regulatory applications. - Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo) - Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates - Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates - PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities - Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications - Mentor and cross-train PKDM-BA scientific colleagues - Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications. Basic Qualifications: Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience Or Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience Or Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience Preferred Qualifications: - Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics; Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules is also highly desirable - Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand - Expertise in antibody-siRNA bioanalytical approaches and considerations - Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms; Experience with respect to RT-qPCR and/or RT-ddPCR is also highly desirable - Exceptional written and verbal communication skills - Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: - A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts - A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan - Stock-based long-term incentives - Award-winning time-off plans - Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. .Salary Range 183,958.00 USD - 204,835.00 USD

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Why Us We are a multi-disciplinary and multinational team focused in using next-generation sequencing technology to transform human health and save patient’s lives. Our team works at the interface of research and clinical practice developing and improving innovative algorithms to call variants and biomarkers that fill gaps in clinical practice, focusing primarily on oncology. We collaborate deeply with internal and external teams, to augment DRAGEN, Illumina’s software platform to analyze high-throughput sequencing data, and remove barriers for its use in clinical settings. Why You We know the importance of your role and offer you a collaborative and supportive environment in which you are actively encouraged to develop your skills and knowledge. Illumina's mission is to improve human health by unlocking the power of the genome - if that inspires you, let's talk. If you are excited as we are about using genomics to transform the practice of medicine, have a proven track record of algorithm development, data analysis, and strong coding ability, this is the role for you. You will be part of a culture fueled by innovation, collaboration, and openness. To be successful as a Sr Bioinformatics Scientist, you will need a background in bioinformatics with a particular focus on algorithm development, biomarkers and oncology. Previous experience with at least two of statistics, common bioinformatics methods, next generation sequencing analysis, and oncology will be key to your success. This role may be performed remotely within the US but the position requires accommodation to meeting times to overlap with Pacific time zone hours. The Role The Sr Bioinformatics Scientist will drive the development of secondary analysis algorithms for variant and biomarker detection to support treatment decisions based on the cancer’s molecular profile. This role will also involve designing R&D studies, to demonstrate the clinical utility of NGS in oncology treatment and prototyping software implementations. Responsibilities: - Assess and improve existing secondary analysis algorithms for variant and biomarker detection - Prototype novel secondary analysis algorithms - In collaboration with external and internal experimental teams, design and analyze experiments to support existing or new Illumina oncology assays. - Provide technical guidance to internal and external collaborators. - Participate in cross functional assay and algorithm R&D teams with minimal oversight. - Effectively communicate plans and results across functions ​ Requirements: - Typically requires a minimum of 5 years of related experience with a Bachelor’s degree; or 3 years and a Master’s degree; or a PhD without experience; or equivalent work experience. - PhD in bioinformatics, computation biology, statistics, math or related field or equivalent work experience preferred - Fluency in at least two of statistics, common bioinformatics methods NGS analysis, and oncology. - Experience developing bioinformatics NGS algorithms beyond leveraging already existing tools. - Fluency in programming languages such as Python. Experience with C++ is desired - Good communication skills to contribute to cross functional project teams and work with stakeholders. #LI-REMOTE The estimated base salary range for the Sr Bioinformatics Scientist role based in the United States of America is: $129,400 - $194,000. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off. We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.

• Tune and optimize ML/DL models for production-scale audio deepfake detection. • Investigate failure cases in the client environment, build custom evaluation frameworks, and implement mitigation strategies for model robustness. • Drive model iteration for performance under a variety of real-world environments, e.g. compression artifacts, noise, telephony, and streaming pipelines. • Present technical findings and model performance insights to internal stakeholders. • Interface with Product and Engineering teams to build a deep understanding of the production environment and incorporate relevant evaluations for performance assessment.

Job Description Summary The role will work in the lab of Dr. Roberta Freitas- Lemos. The Freitas-Lemos lab is focused on investigating health behaviors for cancer prevention and control. The successfully selected candidates will work primarily on projects that are examining the effects of potential tobacco regulatory policies on tobacco/nicotine purchases across different tobacco user types. Postdoctoral Associate responsibilities will focus on the use of the Experimental Tobacco Marketplace to investigate choice behavior from a behavioral economics framework. Other projects may include technology applications to improve smoking cessation. The position is well suited for individuals interested in behavioral economics of tobacco or other substances and health behavior. Moreover, this position will be involved in developing pilot research programs in the areas of addiction, decision-making and other human interactions. The selected candidates will be expected to help develop these additional projects. Entity Medical University of South Carolina (MUSC - Univ) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001039 COM PSYCH Addiction Science CC Pay Rate Type Salary Pay Grade University-00 Pay Range 0.00 - 0.00 - 0.000 Scheduled Weekly Hours 40 Work Shift Job Description 35% Research Conceptualization & Publications - Coordinating with and assisting the PI in the design of experiment and grant proposal methodology as well as methods for analyzing the results of experiments. Preparation of text, tables, and graphical information as appropriate for dissemination in peer-reviewed publications, or presentation at professional conferences or in book chapters. 35% Project Management – Training and supervising research personnel to organize and conduct study sessions. 30% Data Analysis - Analyzing the findings from research methods and transforming the results into formats appropriate for dissemination in peer reviewed publications or conference presentations or in formats that engender further analysis. Additional Job Description Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required. If you like working with energetic enthusiastic individuals, you will enjoy your career with us! The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need. Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees