Vir Biotechnology

Title: Senior Manager, Quality Control Location: San Francisco, California, United States Job Description: Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company. We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best. THE OPPORTUNITY The Senior Manager, Technical Operations Quality Control, is responsible for executing and operationalizing QC strategy across assigned programs and external testing partners (e.g., CDMOs/CTLs) from Phase 1 through commercialization. This role ensures the timely and compliant delivery of QC activities, including release and stability testing, method lifecycle management, and vendor oversight. The Senior Manager partners cross-functionally with Quality, Technical Operations, Regulatory, and Analytical Development to deliver program milestones, maintain inspection readiness, and support global regulatory submissions. This individual contributes to the development of QC strategy and drives continuous improvement in QC processes, systems, and external network performance. This role is located in our San Francisco headquarters with an expectation of 3 days per week in office. WHAT YOU'LL DO - Execute and operationalize QC strategy for assigned programs and external testing networks in alignment with QC and Quality organization strategy. - Lead QC activities across the product lifecycle (Phase 1 through commercial) for designated programs, ensuring effective implementation of phase-appropriate control strategies. - Support development and refinement of QC strategies, including methods, specifications, and testing approaches, in collaboration with Analytical Development and QC leadership. - Drive consistent execution and harmonization of QC methods, specifications, and practices across programs and external partners. - Identify, assess, and escalate risks to QC performance, supply continuity, and compliance, and implement mitigation plans with cross-functional stakeholders. - Represent QC on program teams and sub-teams, ensuring alignment of analytical deliverables, timelines, and QC readiness for key CMC milestones. - Manage day-to-day execution of QC operations to ensure timely, compliant testing for clinical and commercial programs. - Coordinate and oversee release and stability testing (including CDMOs/CTLs), including review of analytical data, batch records, and supporting documentation; support CoA generation. - Lead execution of QC GMP processes (deviations, OOS/OOT, change controls, investigations) in collaboration with QA. - Coordinate QC documentation and logistics at external labs, including sampling plans, shipments, and reagent/inventory management. - Manage vendor performance and execution, including CTL/CDMO oversight and routine operational interactions. - Execute method lifecycle activities (qualification, transfer, validation, implementation, and monitoring) across internal and external labs. WHO YOU ARE AND WHAT YOU BRING - BA/BS with 10 + years experience, MA/MS/MBA with 8+ years experience in Biochemistry, Chemistry, Biology, Virology, Chemical Engineering or a related discipline is preferred - Technical expertise in a wide range of analytical methods for release and stability testing of monoclonal antibodies - Strong scientific background in Quality Control and/or assay development in biotech industry with strong knowledge of cGMP/ICH/FDA/EMA regulations - Expertise with analytical test method optimization, validation, and transfer as well as working with contract organizations #LI-AS1 WHO WE ARE AND WHAT WE OFFER The expected salary range for this position is $142,500 to $199,000 per year. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors. Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office. Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time. All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics. This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment. Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees. For hires based in the United States, Vir Biotechnology, participates in E-Verify. Candidate Privacy Notice

Title: Senior Director, Total Rewards and Analytics Location: San Francisco, California, United States Job Description: Vir Biotechnology is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best. THE OPPORTUNITY Reporting to the Head of Human Resources, the Sr Director of Total Rewards and Analytics will lead the design, delivery, and governance of Vir Bio's global compensation and benefits programs. You will also be responsible for the strategy and implementation of HR analytics initiatives and HRIS oversight across the HR function and broader organization. In this role you will partner with senior business leaders and the HR leadership team to translate business strategy into total rewards strategies that attract, reward, and retain key talent. You will ensure programs are competitive, equitable, and aligned with organizational objectives. The ideal candidate will be a hands-on leader with deep compensation and benefits expertise, strong analytical capabilities, and a track record of developing successful strategies. This position requires the ability to balance strategic thinking with tactical execution-conceptualizing innovative solutions while driving day-to-day program administration and continuous improvement. This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office. WHAT YOU'LL DO - Lead the strategic design, implementation, and administration of global compensation and benefits programs, including base pay structures, short-term and long-term incentive plans (including commercial sales incentive plans), recurring compensation cycles, and program targets - Design and implement benefits programs through needs analysis, competitive benchmarking, and cost-effectiveness evaluation - Manage annual benefit enrollment, plan changes, wellness initiatives, and compensation planning cycles - Conduct competitive market analysis to ensure programs remain competitive, equitable, and aligned with business objectives - Ensure compliance with federal, state, and international compensation and benefits regulations - Serve as the hands-on lead for executive compensation, including program design and benchmarking - Prepare and present analyses and recommendations to senior leadership, the Board of Directors, and the Compensation Committee - Strategically lead all aspects of management and coordination with the Compensation Committee including meeting planning, deliverable preparation, meeting facilitation, and tracking of follow up actions. - Align compensation programs with performance management processes to drive accountability and reward performance - Oversee global mobility programs including immigration and relocation - Develop and implement HR analytics strategy and provide HRIS oversight to ensure data integrity - Execute total rewards communication strategies to ensure employees understand and value their compensation and benefits - Manage a high-performing team across compensation, benefits, and analytics functions WHO YOU ARE AND WHAT YOU BRING - BA/BS and 12+ years or MS/MBA and 10+ years of relevant experience - Ideally experience includes work within a commercial life science company - Proven track record leading compensation and benefits teams at a public company - Deep expertise in executive compensation programs, including presenting to Board of Directors, Compensation Committees, and external stakeholders - Comprehensive knowledge of compensation regulatory, compliance, and legislative requirements - Strong analytical capabilities with experience performing complex reporting and analysis - Superior executive presence and communication skills with ability to present credibly at all organizational levels - Proven ability to build trust with stakeholders through strong organizational skills and proactive problem-solving - Strong people management skills with a track record of developing high-performing teams - Experience managing vendor relationships with benefits brokers, consultants, and external partners - Exceptional project and program management skills - Collaborative leadership style with a hands-on approach - Collaborative leadership style with a hands-on approach to problem-solving and stakeholder engagement #LI-AS1 #LI-Hybrid WHO WE ARE AND WHAT WE OFFER The expected salary range for this position is $227,500 to $318,000 per year. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors. Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office. Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time. All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics. This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment. Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

• Chair cross-functional Safety Risk Management Team (SRMT) to review safety data from all sources to detect, evaluate, monitor, and minimize safety signals/risks • Contribute to safety related sections of clinical study documents including Study Protocols, Informed Consent Forms, IB Reference Safety Information, Publications, and other relevant documents • Provide expert guidance and leadership both internally and externally based on in-depth knowledge of development and post-marketing global regulations • Support inspection readiness and provide expertise in audits, inspections, and CAPAs • Perform medical review of Individual Case Safety Reports • Perform medical review and analysis for aggregate safety reports and responses to ad-hoc requests for safety information • Provide leadership in regulatory authority interactions regarding safety and risk management • Support the negotiation of safety data exchange/pharmacovigilance agreements with license partners and distributors for drug safety and risk management related activities • Assist in the maintenance of Global PVRM related cross-functional SOPs in compliance with global safety regulations and guidelines and lead corporate initiatives and inspection readiness

• Lead the development of clear, accurate, and compliant regulatory documents for global health authorities (FDA, EMA, PMDA), serving as the author for complex submissions • Author and oversee critical regulatory documents including: Clinical trial protocols and amendments, Investigator Brochures (IBs), Clinical Study Reports (CSRs), briefing packages, regulatory submission dossiers (e.g., NDA, IND, MAA) and summary documents, such as summaries of safety and efficacy. • Serve as the regulatory writing lead for high-priority programs, managing end-to-end document development from strategy through submission, including coordination of cross-functional input and review cycles • Analyze complex scientific and medical information, including clinical trial data, and translating it into clear, concise, and accurate language understandable by both technical and non-technical audiences. • Work closely with cross-functional teams (e.g., clinical, biostatistics, regulatory affairs, pharmacology, safety) to gather data and ensure comprehensive and accurate documentation. • Drive continuous improvement in regulatory writing processes, templates, and standards, implementing best practices and innovative approaches to enhance efficiency and quality • Analyze and synthesize complex scientific, clinical, and nonclinical data from multiple sources to create compelling, scientifically rigorous regulatory narratives that address anticipated health authority questions