Intertwine Associates

• Serve as a senior scientific and technical advisor to the Program Manager, supporting the development and execution of new and existing ARPA‑H R&D programs • Conduct rigorous evaluations of the current scientific and technical landscape across oncology, diagnostics, and medical device development • Identify gaps, risks, and opportunities within research portfolios aligned with ARPA‑H mission objectives • Monitor and assess performer progress against defined technical milestones and quantitative performance metrics • Critically review complex scientific, engineering, and technical data using strong logical and analytical reasoning • Read, synthesize, and distill large volumes of information into concise, executive‑ready briefings for technical and non‑technical audiences • Support program execution through documentation, internal reporting, and coordination across multidisciplinary teams • Perform programmatic support tasks including data collection, analysis, and preparation of internal reports and briefings • Operate effectively both independently and as part of an integrated team supporting ongoing ARPA‑H efforts • Travel within CONUS (~10–35%) to support program reviews, meetings, and stakeholder engagements

• Act as a chief-of-staff–style partner to senior executives, managing day-to-day operations, follow-ups, and priority execution • Maintain and actively manage executive calendars, meeting agendas, decision logs, and action-item tracking • Prepare executives for meetings by coordinating briefings, financial summaries, approvals, and background materials • Track and manage financial actions, including budget requests, funding documents, justifications, and approval packages • Ensure all required documentation is completed, routed, approved, and archived to enable timely next steps • Serve as the coordination hub between leadership, finance, contracting, legal, program teams, and external stakeholders • Monitor deadlines, dependencies, and deliverables to ensure schedules are met and risks are surfaced early • Develop and maintain dashboards, trackers, and reports that provide clear visibility into financial status, actions, and decisions • Support compliance with federal regulations, internal controls, and organizational policies • Anticipate executive needs, resolve bottlenecks, and proactively drive issues to closure • Operate with minimal guidance while balancing multiple priorities in a fast-paced, mission-driven environment

• Work in a dynamic, fast-paced environment as a Business Financial Manager supporting large-scale, high-impact research and development initiatives • Leverage expertise in financial management, program budgeting, and administrative coordination to help shape and execute complex, multi-year programs in science, technology, and healthcare innovation • Collaborate with program managers, scientists, engineers, and operational staff to ensure budgets are developed, tracked, and executed effectively, while maintaining compliance with federal regulations and organizational policies • Provide strategic financial insights, develop forecasts, monitor program performance, and deliver high-quality reports and presentations to support decision-making at all levels • Operate with minimal guidance, balancing multiple priorities while delivering timely, accurate, and actionable results

• Work in a dynamic, fast-paced environment as a scientific and technical advisor supporting advanced research and development in biomedical engineering and life sciences • Leverage a breadth of expertise in medical device design, biomaterials, biosensors, imaging systems, computational modeling, and human–technology integration to evaluate and shape programs that address critical healthcare, public health, and operational challenges • Collaborate with world-class scientists, engineers, and clinicians to assess emerging technologies, identify high-impact opportunities, and drive development in areas such as implantable and wearable devices, regenerative medicine, advanced diagnostics, and integrated biomedical platforms • Provide strategic assessments, create technical reports, develop program plans, track technological progress, and perform related tasks to advance client R&D objectives • Support program management and development, prepare high-quality briefing materials, and engage regularly with stakeholders • Operate with minimal guidance, balancing multiple priorities while delivering high-value results

Key Role: Work in a dynamic, fast-paced environment as a scientific and technical advisor supporting advanced research and development in biomedical engineering and life sciences. Leverage a breadth of expertise in medical device design, biomaterials, biosensors, imaging systems, computational modeling, and human–technology integration to evaluate and shape programs that address critical healthcare, public health, and operational challenges. Collaborate with world-class scientists, engineers, and clinicians to assess emerging technologies, identify high-impact opportunities, and drive development in areas such as implantable and wearable devices, regenerative medicine, advanced diagnostics, and integrated biomedical platforms. Provide strategic assessments, create technical reports, develop program plans, track technological progress, and perform related tasks to advance client R&D objectives. Support program management and development, prepare high-quality briefing materials, and engage regularly with stakeholders. Operate with minimal guidance, balancing multiple priorities while delivering high-value results. Basic Qualifications: - Ideal candidates will have ARPA-H and/or broader-ARPA experience, with at least four (4) years of industry (e.g., biotechnology or biopharmaceutical companies) experience in startups, industry, and have experience with regulatory affairs. - Advanced degree (PhD required) in one of the following or related fields: cancer, medical oncology, clinical oncology, oncological sciences, tumor biomarkers, biology, molecular biology, pharmacology. If PhD is in any field outside of oncology, candidates must have subsequent experience in oncology, oncology clinical trials, oncology biomarkers, and/or oncological sciences. - Demonstrated record of authoring technical papers, reports, or program plans for both technical and non-technical audiences - Ability to develop pitches and present complex engineering and biomedical concepts to multidisciplinary audiences - Must have strong PowerPoint and Excel skills, which include proficiency with keyboard shortcuts and ability to create PPT slides and Excel files on the fly during a meeting in a high-pressure environment. - Must be able to obtain a federal government Public Trust clearance. Core Responsibilities: - Advise on oncology, clinical trials, biomarkers, and oncology treatments. - Conduct market and regulatory analyses, technical due diligence, and literature reviews. - Evaluate technical proposals for scientific merit and innovation; prepare recommendations and briefing materials. - Facilitate collaborations with researchers, clinicians, and technology developers. Additional Qualifications: - In-depth familiarity with the Advanced Research Projects Agency (ARPA) model, such as ARPA-H, DARPA, ARPA-E, or IARPA - Experience with program development, proposal evaluation, and performer oversight in government or industry R&D - Ability to synthesize technical, regulatory, and clinical considerations into actionable strategies - Demonstrated efficiency, adaptability, proficiency, leadership, multidisciplinary skills, and/or high productivity - Mastery of scientific publications and public presentations - Postgraduate experience (e.g., postdoctoral fellowship or industry role) - Experience with clinical trial design, adaptive clinical trials, clinical biomarkers, and oncology treatment - Background in computational modeling, AI/ML for biomedical applications, or systems integration in healthcare environments - Understanding of clinical workflows, interoperability standards, and human factors in medical technology adoption - Experience with program development, proposal evaluation, and performer oversight in government or industry R&D Intertwine Associates LLC – Equal Employment Opportunity Statement Intertwine Associates LLC is an Equal Opportunity Employer. We are committed to fostering a diverse and inclusive workplace where all individuals are treated with respect and dignity. Employment decisions at Intertwine Associates LLC are made without regard to race, color, religion, sex (including pregnancy, sexual orientation, and gender identity), national origin, age, disability, genetic information, marital status, veteran status, citizenship status, or any other characteristic protected by applicable federal, state, or local laws. We comply with all applicable laws governing nondiscrimination in employment and strive to ensure that our workplace reflects the values of fairness, equity, and opportunity. All qualified applicants will receive consideration for employment without regard to any protected status. We also prohibit retaliation against individuals who report discrimination, participate in investigations, or otherwise exercise their rights under equal employment laws. Intertwine Associates LLC is proud to support the mission of our clients, including U.S. Federal Government agencies, by providing exceptional technical talent and services. As such, certain roles may require U.S. citizenship or specific security clearances in accordance with federal contract requirements.