AstraZeneca

Role Description Evinova is redefining how digital health accelerates clinical development, using an AI-native platform that already supports hundreds of active studies across more than 54 countries. At this pivotal moment of rapid global growth, the Chief Delivery Officer will build and scale the end-to-end delivery of our AI and SaaS solutions, ensuring that life-changing innovations reach patients faster, safely, and at scale. Reporting directly to the President and sitting on the Evinova Leadership Team, this role leads a global delivery organisation and holds executive accountability for quality, speed, compliance, and customer satisfaction across every deployment and engagement. - Lead the global delivery strategy and execution for Evinova’s AI and SaaS offerings. - Own and evolve a robust delivery framework that spans planning, kick off, deployment, launch, hyper care, continuous improvement, and upgrades. - Build and run a high-velocity “deployment factory” model using automation, AI, templates, and standardised playbooks. - Take full ownership of the professional services P&L, forecasting costs and margins. - Partner closely with Sales and Commercial teams to scope, price, and contract delivery commitments. - Track and report delivery financial performance to the Leadership Team and Board. - Act as the executive point of escalation for critical customer delivery issues. - Build positive relationships with senior customer partners. - Oversee customer success across the full post-sale lifecycle. - Own GxP-compliant delivery of all SaaS implementations and services. - Govern Computer System Validation (CSV), risk-based validation frameworks, and inspection readiness. - Define and enforce documentation standards, SOPs, and quality management practices. - Lead, develop, and encourage a distributed team of delivery professionals. - Drive transformation of delivery processes to increase capacity and reduce cycle times. - Set and manage OKRs, KPIs, and governance rhythms across the delivery organisation. - Partner with Product and Engineering leaders to feed delivery insights into the product roadmap. - Collaborate with People & Culture to define delivery competencies and a global talent acquisition strategy. - Represent Evinova externally as a recognised voice on delivery excellence in digital clinical development. Qualifications - 10+ years of progressive experience in delivery leadership within a global health-tech, eClinical SaaS, or life sciences professional services organisation. - Proven P&L ownership experience: budgeting, forecasting, margin management, and financial reporting. - Deep expertise in GxP-regulated software delivery. - Demonstrated experience leading and scaling a global delivery or professional services organisation of 50+ professionals. - Proven track record to design and operate high-velocity, scalable delivery models. - Strong executive presence and outstanding partner management. - Experience driving operational transformation. - Fluency in English (both written and spoken). - Ability to operate in a fast-paced, global, matrixed environment. - Degree or equivalent experience in related field. Requirements - Direct experience with eClinical platforms is highly valued. - Professional certifications such as PMP (PMI), PRINCE2, MSP or Agile/SAFe credentials. - Knowledge of CDISC standards (CDASH, SDTM) and their implications for clinical data delivery. - Experience applying Lean, Six Sigma or similar operational excellence methodologies. - Exposure to high-growth environments such as venture-backed or corporate spin-out health-tech businesses. Benefits - A purposeful role with real-world impact: improving how life-saving medicines reach patients faster. - A seat on the Evinova Leadership Team with direct influence on company strategy. - Competitive total compensation including base salary, annual performance bonus, and long-term incentive plan. - An inclusive, diverse, and internationally collaborative team environment.

• Contributes to the selection of potential investigators • In some countries, as required, CRAs are accountable for study start-up and regulatory maintenance • Tasks may include Site Qualification Visits, collection, preparation, review and tracking of documents for the application process; submission of proper application/documents to EC/IRB and to Regulatory Authorities for start-up and for the duration of the study • Trains, supports and advises Investigators and site staff in study-related matters, including Risk Based Quality Management (RbQM) principles • Confirms that site staff have completed and documented the required trainings appropriately, including ICH-GCP training, prior to and for the duration of the study • Ensures the sites are inspection ready at all times • Actively participates in Local Study Team (LST) meetings • Contributes to National Investigators meetings, as applicable • Initiates, monitors and closes study sites in compliance with AZ Procedural Documents • Shares information on patient recruitment and study site progress (site quality/performance) within the LST • Drives performance at the sites • Proactively identifies and ensures timely resolution to study-related issues and escalates them as appropriate • Updates CTMS and other systems with data from study sites as per required timelines • Manages study supplies (ISF, etc), drug supplies and drug accountability at study site • Prepares study drug for destruction, if applicable • Performs monitoring visits (remote and onsite), as well as remote data checks, in accordance with the timelines specified in the study-specific Monitoring Plan • If required, determines and discusses with LSAD the correct timing and type of visits • Performs Source Data Review (SDR), Case Report Form (CRF) review and Source Data Verification (SDV), in accordance with the Monitoring Plan • Performs regular Site Quality Risk Assessments and adapts monitoring intensity accordingly during the study • Ensures data query resolution in a timely manner • Works with data management to ensure robust quality of the collected study data • Ensures accurate and timely reporting of Serious Adverse Events and their follow-ups • Prepares and finalises monitoring visit reports in CTMS and provides timely feedback to the Principal Investigator, including follow-up letter, within required timelines and in line with AZ SOP • Follows up on outstanding actions with study sites to ensure resolution in a timely manner • Follows quality issue processes by escalating systematic or serious quality issues, data privacy breaches, CSP or ICH-GCP compliance issues to Local Management and/or CQM as required • Assists site in maintaining inspection-ready ISF • Prepares for and collaborates with activities associated with audits and regulatory inspections in liaison with LSAD and CQAD • Ensures timely collection/uploading of essential documents into the eTMF in accordance with ICH-GCP, AZ SOPs and local requirements • Supports/participates in regular QC checks performed by LSAD or delegate • Ensures that all study documents under their responsibility (i.e., site documents, relevant communications, etc.) are available and ready for final archiving and completion of local part of the eTMF • Provides feedback on any research-related information including sites/investigators/competing studies that might be useful for the local market • Ensures compliance with AstraZeneca’s Code of Ethics, company policies and procedures relating to people, finance, technology, security and SHE (Safety, Health and Environment) • Ensures compliance with local, national and regional legislation, as applicable • Collaborates with local MSLs as directed by LSAD or line manager

Role Description This is a fully remote role based in the United States. The hours for this role may vary depending on business coverage needed, however hours will default to 8:30 AM EST-5:00 PM EST. Role may require up to 10% travel. Travel needs may be higher for periodic trainings and/or as business needs. The Alexion Patient Services C5 OSS role is a key patient-facing role that supports OneSource Support Specialist responsibilities when there are gaps or other needs in territory coverage. This role will be responsible for executing on C5 task/activities spanning from patient welcome and enrollment to onboarding tasks, providing educational, logistical, and emotional support to patients through long-term adherence care plan tasks, to supporting onboarding and precepting of new OSS team members. The OSS may need to pivot daily between onboarding or adherence activities and/or be asked to work in a different territory day to day as determined by the current operational needs of the team or may be asked to support longer term coverage in a given territory. Strong prioritization skills, working with urgency and flexibility are key to success in this role. You will be responsible for: - Providing exceptional initial onboarding experience and long-term adherence support to patients - Sharing materials on the disease, diagnosis, community resources and treatment support - Maintaining and communicating up-to-date knowledge of the resources available as needed, including approved external resources - Placing the required welcome calls to patients to introduce the OneSource program and confirm required/requested support - Communicating Benefit Investigation (BI) results with patients and HCP and help interpret them, as needed - Informing patients of financial support eligibility based on available programs - Enrolling patients in Alexion financial assistance programs as eligible or refer to external support programs as appropriate - Proactively conducting routine and/or year-end reverification of coverage outreach by working with patients and caregivers, healthcare providers, insurance companies, and Alexion colleagues - Connecting patients to the Alexion patient community and inform them about available advocacy groups for their disease - Assisting patients in receiving required vaccinations either through Alexion or other vaccination locations - Efficiently navigating CRM documentation and other required record keeping during all patient interactions as to maintain high visibility into patient case status - Properly and immediately reporting Adverse Events during any customer interactions in the PV Event Reporting Tool - Acting as the primary coordinator of all HCP needs across onboarding from case creation to product delivery and ongoing support through lifetime of product use - Coordinating with other appropriate HCP facing roles and cross functional partners to respond to questions from physicians and office staff and address any issues - Communicating with HCPs to confirm required/requested support or obtain missing information - Proactively and effectively consulting with and engaging the appropriate internal cross functional partners to resolve barriers quickly - Maintain working understanding of the reimbursement process, and leverage knowledge to communicate with internal and external stakeholders while insurance approval is being obtained and work with appropriate field specialists for denial/appeal support - Triggering initiation of adherence program on conclusion of onboarding and connecting with patients through defined channels for the determined touchpoints based on product-specific programs - Educating prescribed patients and their caregivers regarding how to prepare for and what to expect during the long-term adherence of the Alexion product or switching from one Alexion product to another - Providing emotional support for patients and caregivers on continued administration of Alexion products Will also be crucial to: - Develop compliant and collaborative professional relationships with all relevant internal and external customers including but not limited to Patient Education Managers, Field Reimbursement Managers, Regional Account Managers, Customer Operations Representatives, Medical Accounts, Access Specialists, Specialty Pharmacies, Site of Care staff, and office coordinators - Effectively escalate access issues by informing the right stakeholders of actions to be taken to resolve any pending items in a timely manner - Collaboratively work with and share responsibilities with other Alexion members and external members for pull through of the target patient and HCP experience - Participate in project related work based on operational needs - Participate in any role appropriate cross functional collaboration work including but not limited to, acting as a liaison to other depts, facilitating and scheduling meetings and planning and preparing presentations - Support the orientation needs of new OneSource Support Specialists Qualifications - Associates Degree is required - Minimum of 1 year in Patient Services - Well-developed, effective communication, collaboration and problem-solving skills, as well as data entry/computer literacy skills - Ability to work independently, be goal-directed and have strong organizational skills - Must be flexible as well as easily adapt to a changing work environment which will require ongoing maintenance/training of job-related skills/activities - Must be willing to adjust work schedules in response to department needs Requirements - The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation, to: use a computer; engage in communications via phone, email, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. Benefits - The annual base salary for this position ranges from $86,663 - $129,950. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. - In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Company Description Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Medical Director, Acute Lymphoblastic Leukemia (ALL) Location: Gaithersburg, MD (US) - This is a hybrid role, with an onsite requirement Job Description: Job Title: Medical Director, Acute Lymphoblastic Leukemia (ALL) Are you passionate about Medical Affairs in Oncology and in making a difference for patients? Do you have the expertise to make a significant impact in the role of Medical Director for US Oncology Medical Affairs? If so, AstraZeneca could be the perfect fit for you! As a Medical Director, you will play a crucial role within the US Oncology Medical Affairs organization, reporting directly to the Medical Head or Group Medical Lead. Your responsibility will be the execution of medical plans for specific or multiple indications within a specified disease area. Accountabilities: As the Medical Director, you will support Medical Affairs activities in Hematology Oncology Franchise coordinating the development and the implementation of the integrated medical plans (iMAP), leading key projects, and supervising budget spend. You will influence the Field Engagement plan by synthesizing field insights into actionable tactics and modifying plans as vital. You will also complete all Medical Affairs Leadership Team (MALT) directives, support quarterly iMAP reviews at the Core Medical Team (CMT) in collaboration with the Medical Lead, and provide cross-functional coverage by supporting the Medical Lead on the CMT and leading WGs as appropriate. Essential Skills/Experience: - Master's degree in science-related field, such as Pharmacology, Pharmacy, Medicine, or equivalent - 3+ years of Medical Affairs experience, with strong knowledge of medical strategy, clinical development, and understanding of field medical science liaison functions - Expert technical depth in disease area – Hematology/Oncology - Experience in relationship and partner management (3P’S-Payer, Provider and Patients) - Project and relationship management experience with track record of strategic influencing skills - Experience with clinical trial methodology and evidence generation (especially RWE) - Business Insight, financial and project management skills - Demonstrated ability work effectively in a cross-functional team environment and to manage a diverse group of responsibilities - Highly developed written / verbal communication and presentation skills Desirable Skills/Experience: - Doctorate degree, PharmD (MD or equivalent) with Oncology specialization or PhD in Sciences preferred - Hemato-oncology HQ Medical Affairs experience within the pharmaceutical industry with experience with the clinical management of leukemia disease areas such as Acute Lymphoblastic Leukemia (ALL) - Working knowledge of FDA requirements - Excellent computer skills (Excel, Word, Power Point, etc.) - Budget management experience - Experience delivering country or global medical affairs plans When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca? At AstraZeneca, we change the practice of medicine and improve the patient experience by generating and communicating compelling medical evidence. We translate our wealth of medical and scientific expertise to ensure that our data helps physicians better treat patients at every point in their journey. We are a high-performing team within a global, growing organization. Our culture is one of openness and transparency, fused with ambition and drive. We work hard to not just meet but go beyond the needs of patients and the wider healthcare industry. We are brave thinkers, bold innovators, encouraged and empowered to try out new and innovative ideas. We have the opportunity to impact every point in the patient journey and reach beyond the interventions that AstraZeneca can influence. By partnering with experts, we gather information and influence across the whole experience. Ready to make a difference? Apply today! The annual base pay (or hourly rate of compensation) for this position ranges $193,281.60 - 289,922.40 USD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Title: Medical Director - Chronic Lymphocytic Leukemia (CLL) Location: US - Gaithersburg - MD Job Description: Job Title: Medical Director,Chronic Lymphocytic Leukemia (CLL) Location: Gaithersburg, MD (US) - This is a hybrid role, onsite requirement Are you passionate about Medical Affairs in Oncologyand in making a difference for patients? Do you have theexpertiseto make a significant impactinthe role of Medical Director for US Oncology Medical Affairs? If so, AstraZeneca could be the perfect fit for you! As a Medical Director, you will play a crucial role within the US Oncology Medical Affairs organization, reporting directly to the Medical Head orMedicalGroupMedicalLead. Your responsibility will be the execution of medical plans for specific or multiple indications within a specified disease area. Accountabilities: As the Medical Director, you will supportMedical Affairs activities in Hematology Oncology Franchisecoordinating the developmentandthe implementationof theintegratedmedical plans (iMAP),leadingkey projects, and supervising budget spend. You will influence the Field Engagement plan by synthesizing field insights into actionable tactics andmodifyingplans as vital. You will also complete allMedical Affairs Leadership Team (MALT)directives, support quarterlyiMAPreviews at theCore Medical Team (CMT)in collaboration with the Medical Lead, and provide cross-functional coverage by supporting the Medical Lead on the CMT and leading WGs asappropriate. Essential Skills/Experience: - Master's degree in science-related field, such as Pharmacology, Pharmacy, Medicine, or equivalent - 3+ years of Medical Affairs experience, withstrong knowledge of medical strategy, clinical development, and understanding of field medical science liaison functions - Expert technical depth in disease area – Hematology/Oncology - Experience in relationship and partner management (3P’S-Payer, Provider and Patients) - Project and relationship managementexperiencewithtrack recordofstrategic influencing skills - Experience with clinical trialmethodologyand evidence generation (especially RWE) - Business Insight,financialand project management skills - Demonstrated abilitywork effectively in a cross-functional team environmentandto manage a diverse group of responsibilities - Highly developed written/verbal communicationand presentationskills Desirable Skills/Experience: - Doctorate degree, PharmD (MD or equivalent) with Oncology specialization or PhD in Sciences preferred - Hemato-oncologyHQ Medical Affairs experience within the pharmaceutical industrywith experience with the clinical management of leukemia disease areas such as chronic lymphocytic leukemia (CLL) - Working knowledge of FDA requirements - Excellent computer skills (Excel, Word, Power Point, etc.) - Budget management experience - Experience delivering countryor globalmedical affairs plans When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work atpaceand challenge perceptions.That’swhy we work, on average, a minimum of three days per week from the office. But thatdoesn'tmeanwe’renot flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca? At AstraZeneca, we change the practice of medicine and improvethe patientexperience by generating and communicating compelling medical evidence. We translate our wealth of medical and scientificexpertiseto ensure that our data helps physicians better treat patients at every point in their journey. We are a high-performing team within a global, growing organization. Our culture is one of openness and transparency, fused with ambition and drive. We work hard to not just meet but go beyond the needs of patients and the wider healthcare industry.We are brave thinkers, bold innovators, encouraged and empowered to try out new and innovative ideas.Wehave the opportunity toimpactevery point in the patient journey and reach beyond the interventions that AstraZeneca can influence. By partnering withexperts,we gather information and influence across the whole experience. Ready to make a difference? Apply today! The annual base pay (or hourly rate of compensation) for this position ranges $193,281.60 - 289,922.40 USD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 13-May-2026 Closing Date 01-Jun-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

• Develop and implement your sales management plan to meet or exceed sales targets for your territory • Promote our range of primary care products and educate our valued customers to deliver positive outcomes for patients • Communicate product information to healthcare professionals • Identify unmet needs and develop solutions to address them • Collaborate with the sales team and colleagues at headquarters

• Successfully complete all training requirements, including product examinations. • Engage primary care healthcare professionals in dialogue about approved indications and product efficacy/safety profiles. • Work with Sales Manager to develop a local strategy and business plan to meet or exceed sales and call execution goals in territory. • Drive sales performance and ensure sales forecasts and assigned budgets meet or exceed therapeutic and territory expectations. • Develop and maintain in-depth knowledge of market, demographic, and managed markets information relative to assigned sales territory. • Comply with all regulations regarding interactions with healthcare professionals.

Title: Associate Principal AI Scientist Location: Durham United States Job Description: Full time job requisition id R-250533 Are you a driven Data Scientist with a robust foundation in traditional data science methods and a passion for Agentic AI, and human-in-the-loop (HITL) multi-agent systems? If so, an exciting opportunity awaits you at AstraZeneca! We are looking for Associate Principal AI Data Scientists eager to utilize their expertise in these advanced technologies to revolutionize our drug development processes. In the Pharmaceutical Technology and Development (PT&D) department, you will be a key player in transforming molecules into groundbreaking medical treatments. PT&D leads the charge in developing cutting-edge synthetic routes, drug formulations and delivery technologies, ensuring our products are effective, safe, and of the highest quality. Your role involves contributing data science expertise into cross functional global pharmaceutical development projects in support of transforming the way we deliver medicines to patients. You'll play a pivotal role in shaping our AI strategy and driving the co-development of sophisticated HITL multi-agent systems. We are hiring two candidates for this position, and the roles will be based at our dynamic site in Durham (USA). Work Modality: Hybrid (3 days office and 2 remote) Accountabilities: - Drive innovation in agentic AI, multi-agent systems, and digital twins, exploring new methodologies and applications. - Design, implement, and optimize algorithms for autonomous decision-making, coordination, and policy learning among agents and digital twins using techniques like Markov Decision Processes (MDPs), Partially Observable MDPs (POMDPs), and multi-agent reinforcement learning (MARL). - Evaluate agent performance in the context of decision making, collaboration, competition, uncertainty. - Collaborate with cross-functional teams ensuring knowledge transfer to IT engineering teams for IT solution builds and deployment. - Keep pace with industry advancements by reviewing academic papers and attending conferences. Publish findings in peer-reviewed journals and represent the company at scientific forums. - Communicate technical concepts and results to technical and non-technical audiences. Essential skills/Experience: - Min Bachelor´s degree in computer science, data science, artificial intelligence, machine learning or related fields. - At least 3 years of experience in Deep Learning and ML - Excellent coding skills in languages such as Python, R. - Hands-on industrial experience designing multi-agent patterns, digital twins and experience with agentic AI design patterns, reinforcement learning. - Extensive industrial experience with AI and ML frameworks like TensorFlow, PyTorch, - Hands-on experience with GenAI orchestration frameworks such as LangGraph, CrewAI - Hands-on experience with reinforcement learning libraries such as OpenAI Gym, Ray RLlib, or Stable Baselines. - Hands-on industrial experience with applied machine learning domains such as deep learning, NLP, GenAI. Desirable skills/experience: - Contributions to open-source projects. If you meet these criteria, please highlight merged GitHub PRs in your application. - Strong publication record in the field of AI. - Experience designing multi-agent systems in the pharmaceutical sector. - Experience delivering machine learning projects with applications in pharmaceutical development, chemical engineering or chemistry. - Experience with one or more of the following applied machine learning domains such as transfer learning, federated learning, few/zero shot learning, meta learning, explainable AI. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca is a place where change is embraced, and new solutions are trialed with patients and business in mind. Here, technology is a key lever for delivering medicines quickly, affordably, and sustainably. Our diverse workforce is united by curiosity, sharing learnings to scale fast. Be part of a digitally-enabled environment that impacts all parts of the business—from robotic process automation to machine learning for quality batches—while contributing to society and the planet. Ready to make a difference? Apply now to join our team! Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Director – Process Design and Optimisation in Chemical Development locations UK - Macclesfield time type Full time job requisition id R-250536 Job Title: Director – Process Design and Optimisation in Chemical Development  Location: Macclesfield, UK  Hybrid working model, 3-5 days per week onsite    About us:   At AstraZeneca, we're united by a bold ambition: to push the boundaries of science and deliver life-changing medicines to patients worldwide. As a global, science-led biopharmaceutical company with an exciting and robust portfolio of nearly 200 investigational therapies at varied stages of clinical development (including >20 at late-stage), we transform pioneering research into breakthrough treatments across oncology, cardiovascular, respiratory, and rare diseases. Here, your talent will contribute to innovations that truly matter—helping us reimagine healthcare and create a healthier future for all!    Introduction to role:  We are seeking a highly skilled and motivated leader to join the Chemistry function within AstraZeneca’s Chemical Development department as Director – Process Design and Optimisation   Are you ready to apply your extensive leadership skills and drug development experience, to guide and inspire our chemists in process design and optimisation, turning bold science into reliable medicines for patients? As Director (senior team manager), you will set the technical direction for modern process design and optimisation, whilst leading your team to deliver high quality, robust sustainable commercial processes, manufacturing campaigns, control strategies and future-proofed regulatory submissions. Through exploiting innovative science, cutting edge technologies and AI / data-driven solutions, you will empower your team to reduce risk and shorten timelines, enabling confident clinical supply and launch    Accountabilities:  Through leading a process design and optimisation team in Chemistry, you will drive    Technical excellence in project delivery:  - Applying your experience to successful accountability for drug projects at both Chemistry Section and Chemical Development functional levels  - Acting as a source of expert guidance for development of chemical processes, technology transfer and clinical drug substance manufacture both internally and externally. You will facilitate on-time, right quality clinical API supplies and strong data packages, designed to seamlessly support onward process characterisation and finalisation   - Delivery of CMC regulatory submissions for clinical and marketing phases – guiding and supporting authorship of drug substance submissions and developing harmonised control strategies at the substance-product interface. Acting as an experienced reviewer, you will reduce risk and seek opportunities to drive the best outcome for the business, via excellence in authorship and response to regulatory questions     Senior line-management of a Chemistry technical team, including:  - Sophisticated coaching and mentoring to support professional development of ~8-10 highly skilled scientists and scientific leaders, up to and including Principal Scientist level   - Advanced performance management – goal setting and regular feed-forward to drive high impact contributions at all levels, generating impactful, meaningful career pathways for each member of your team  - Mentorship, coaching and onboarding of first-time team leaders and support and guidance for our wider chemistry team manager community  - Driving key elements of SHE and cGxP compliance for our Chemistry section     Contributing to key elements of our Chemistry Strategy including:  - Identification and execution of improvement programmes to enhance the capability and capacity of the Chemistry function to deliver their contribution to drug substance projects, through strong career pathways for our people  - Working across the section to specifically champion integration of innovative route design and process design, with associated support for modern business processes including scale-up assessment and control strategy development. Employing cutting edge AI / data techniques where appropriate, you will drive efficiency across the process design and optimisation area for the business  - Understanding the external science and technology landscape to champion innovation and curiosity within process design and optimisation, you will work across interfaces to improve standards and ways of working which impact across the whole project lifecycle  Essential Skills/Experience:  - Degree, PhD or equivalent experience in Chemistry, plus an additional 8+ years’ experience in synthetic drug substance pharmaceutical development  - Proven high-impact people leadership experience, with a track record of delivery at Associate Director (Team Manager) level; effectively managing, coaching and developing scientific teams to deliver complex projects   - Expertise in development and scale-up of synthetic chemistry to deliver commercially viable manufacturing processes in mid-to-late phase development, including advanced understanding of process design and optimisation. Proven experience in collaboration with interface groups such as analytical chemistry, chemical engineering, particle science and drug product in order to achieve your goals  - Strong understanding and experience of delivery across the drug development process, especially late-stage development to support Phase 3 clinical studies and launch, including control strategy development  - Strong project management skills developed through personal leadership and delivery of drug projects, as well as the capability to support multiple projects simultaneously within the team  - Proven CMC-wide experience and an appreciation of how to generate the best impact for patients. Demonstrated application of this experience to high quality regulatory delivery through authoring and reviewing module 3.2 regulatory submissions and/or response to health authority questions  - Demonstrated experience of managing change through continuous improvement, increasing efficiency and with measurable impact inside and outside of a Chemical Development setting  - Track record of driving the introduction of digital approaches and new synthetic / manufacturing platforms or technologies, and examples of publicising these achievements to the outside world   - Extensive experience of leading senior scientific staff / peers to deliver high impact improvements to ways of working, as well as projects in both an internal and external development and manufacturing setting    When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world!    ***Please note: we operate a rolling recruitment process and may close this vacancy early if a strong candidate is identified. Early applications are strongly encouraged.   Competitive salary and benefits package on offer. The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, a performance recognition scheme and a competitive, generous remuneration package   Why AstraZeneca:  Here, your leadership turns complex science into dependable supply for patients worldwide. You will work with pioneering chemistry, digital technologies, and lean principles, side by side with colleagues who put unexpected teams in the same room to crack tough problems. With a truly global network and strong investment in people and modern facilities, you will grow your impact and your career—learning from diverse teams, shaping standards across sites, and contributing to a more sustainable future. We value kindness alongside ambition, and we back decisive leaders who take ownership and deliver outcomes that matter.    Call to Action:  Step forward to lead the chemistry that scales breakthrough molecules into life-changing medicines—and shape what’s next!   Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Director, Immunology Cell Therapy Discovery locations US - Waltham - MA time type Full time job requisition id R-250709 Job Title: Director, Immunology Cell Therapy Discovery  Location: Waltham, MA  Hybrid Working: 3 days per week in the office   About the Position  AstraZeneca, a global leader in biopharmaceuticals, is committed to discovering and delivering innovative therapies that transform patient outcomes. We are seeking an experienced and visionary Director to join our Immunology Cell Therapy Discovery team. The role focuses on leading both ex vivo and in vivo cell therapy discovery efforts, underpinned by an in-depth understanding of immunological disease biology and expertise in cell therapy (e.g., CAR-T) discovery.    Key responsibilities  - Strategic leadership: Develop and execute strategy to advance cell therapy discovery, leveraging state‑of‑the‑art ex vivo and in vivo cell therapy technologies to help build a robust pipeline.  - Scientific domain expertise: Maintain a comprehensive, up‑to‑date understanding of the immunological disease landscape and emerging trends to inform program direction and target selection.  - Cross‑functional collaboration: Partner with discovery, translational, preclinical, CMC, and regulatory colleagues to progress programs and expand AstraZeneca’s immunology cell therapy portfolio.  - Team leadership: Build, mentor, and lead a high‑performing team; foster a culture of innovation, scientific rigor, accountability, and agility.  - Stakeholder engagement: Align strategies and milestones with internal and external stakeholders and consortia to accelerate delivery against R&D objectives.  - Compliance and governance: Ensure adherence to all applicable laws, regulations, and company policies related to the research and development of medicines.  - Assay and process development: Direct the development of in vitro assays and research processes to evaluate, optimize, and validate novel cell therapy modalities and mechanisms.  Required qualifications  - Education: PhD (or equivalent) in Immunology, Molecular or Cell Biology, Bioengineering, or a related field.  - 5-10 years of relevant industry experience. - Scientific expertise: Demonstrated in‑depth understanding of immunological disease biology, including B and T cell mediated immunological diseases such as multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis, allergy & asthma, fibrosis etc.  - Leadership: Proven track record of leading scientific teams and delivering on strategic initiatives in a dynamic, matrixed environment.  - Collaboration and communication: Excellent interpersonal, communication, and stakeholder‑management skills across functions and organizational levels.  - Regulatory understanding: Comprehensive knowledge of the regulatory landscape for cell therapy and genetic engineering.  Preferred qualifications  - Vector and construct design: Experience designing and engineering lentiviral, retroviral, or AAV vectors.  - Genetic engineering: Hands‑on experience applying CRISPR or related tools to innovate and refine cell therapies.  - External network: Established relationships within the cell therapy, genetic engineering, and immunology communities.  - Publications: Strong record of peer‑reviewed publications in vector engineering, cell therapy engineering, or related fields.    If you are passionate about leading and innovating in the field of immunology cell therapy, we invite you to consider this pivotal opportunity at AstraZeneca. Join us in our mission to transform patient outcomes through groundbreaking scientific discovery.   The annual base pay ranges from $225,208 - 337,812. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.    Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.