Ardelyx, Inc.

• Drive product adoption within targeted dialysis organizations, hospital-based dialysis programs, large physician groups, Veterans Affairs (VA) facilities and Indian Health Services (IHS) • Build and maintain detailed account profiles • Develop a deep understanding of dialysis-administered therapies • Evaluate the unique clinical, operational, and economic needs of dialysis providers • Engage dialysis clinic administrators, medical directors, pharmacy leaders, formulary decision makers • Develop and execute account-specific business plans for all target accounts • Work collaboratively with Zone Directors, Area Business Directors, MSLs, and other field and cross-functional colleagues • Partner with National Key Account Director and Managed Markets leadership

• Develop and execute KOL engagement strategy by identifying, profiling, cultivating and maintaining long-term relationships with KOLs in the field and at key congresses • Manage speaker’s bureau, congresses, and recommend faculty and advisors for advisory boards • Assist with thought leader development, including training and coaching of promotional speakers with approved slide decks and materials • Attend live and virtual HCP programming to observe, coach, and help the speaker where necessary to ensure compliant execution of content • Conduct business discussions with thought leaders relating to on-label product information, disease state, and general corporate overviews • Plan and execute strategic key thought leader engagements at local, regional, and national conferences • Gain and record insights from thought leaders and provide feedback – to enhance and optimize marketing strategies/tactics • Work with the Marketing team on new content creation and existing content updates, as well as new programing ideas • Collaborate with Commercial team on large group practice engagement • Work collaboratively with marketing, sales, medical affairs, and market access on strategic thought leader initiatives

• Provide strategic leadership and operational oversight to a national team of zone access managers (ZAMs) • Ensure patient access to company products by developing and executing access and reimbursement strategies • Educate healthcare providers (HCPs) on coverage and coding • Resolve access barriers within a complex healthcare landscape • Serve as a key subject matter expert on the payer landscape • Collaborate cross-functionally with internal stakeholders to align field activities with overall brand and business objectives • Hire, train, and develop a high performing ZAM team • Maintain deep expertise in the dynamic regional and local access and payer landscape

• Define and lead the strategic vision and roadmap for patient access programs • Architect scalable Patient Services Models that enhance patient access and experience • Establish and evolve performance frameworks and KPIs to drive strategic decision-making • Oversee governance and optimization of operating models and compliance frameworks • Analyze macro trends in patient access and reimbursement to shape innovative strategies • Serve as a strategic advisor to executive leadership and cross-functional stakeholders • Lead cross-functional collaboration with Commercial, Market Access, Trade & Distribution • Drive innovation and digital transformation in patient services with tech-enabled solutions • Develop and guide long-term patient engagement and adherence strategies • Provide strategic oversight of external vendors and partners

Title: Associate Director, Process Chemistry Location: Waltham United States, Manufacturing Waltham, Massachusetts Job Description: Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA (tenapanor) and XPHOZAH (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada. Position Summary: The Associate Director, Process Chemistry will lead small-molecule process development and manufacturing efforts supporting clinical-stage drug substance programs, with a primary focus on early-phase clinical manufacturing. This role spearheads the design, development and technical oversight of synthetic routes for programs ranging from IND-enabling studies through Phase 2, ensuring that Drug Substance supply is delivered with speed, quality, and phase-appropriate controls. The Associate Director will work closely with cross-functional teams across CMC, analytical development, quality, regulatory, and manufacturing to advance development programs and support clinical timelines. Responsibilities: - Partner with cross-functional teams to provide technical oversight of early phase Drug Substance (DS) process development, ensuring successful scale-up and manufacture of clinical trial materials - Provide evaluation and support the identification and selection of "fit-for-purpose" synthetic routes, balancing speed to clinic with long-term scalability, safety, and manufacturability - Develop, manage, and drive the successful execution of phase-appropriate DS project plans, including the preparation of RFPs and the technical evaluation of potential vendors - Support the preparation of the DS sections of various regulatory and contribute to technical briefing materials for regulatory agency interactions - Effectively integrate DS activities with those of sister CMC functions, including Pharmaceutics (to support formulation screening), Analytical Development, Quality Assurance, and Regulatory Affairs - Direct external technical staff at contract manufacturing organizations (CMOs) to ensure effective execution of activities and attainment of clinical supply goals - Effectively and professionally represent the Process Chemistry function on various cross-functional teams, including internal project teams and external operating teams with contract manufacturing and/or corporate partners - Please note: this position is hybrid-based out of our Waltham, MA office and requires a presence on-site 2-3 days per week. Qualifications: - Ph.D. in organic chemistry or related discipline with 8+ years of pharmaceutical industry experience with a strong emphasis on small-molecule process development - Proven track record in developing scalable, safe, and efficient synthetic processes within a cGMP operational environment - Demonstrated experience working in close collaboration with technical, regulatory, quality, clinical, project management, and supply chain functions, in a cGMP operational environment - Experience leading and managing outsourced development and manufacturing efforts and associated operating budgets - Experience preparing and defending regulatory documents including briefing books for regulatory meetings - Demonstrated track record of setting priorities, meeting timelines and motivating others - Excellent communication skills and the ability to shape, frame, and present to diverse internal and external audiences are required - Periodic travel to manufacturing and other partner sites is required (approximately 10-20 % of time) The anticipated annualized base pay range for this full-time position is $183,000 - $223,000 Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers. Actual base pay will be determined based on a variety of factors, including years of relevant experience, training, qualifications, and internal equity. The compensation package may also include an annual bonus target and equity awards, subject to eligibility and other requirements. Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays. Ardelyx is an equal opportunity employer.

• Lead the development and implementation of B2B access marketing tactics and pull-through resources, including materials for teams calling on payers, dialysis organizations, or health care providers (for reimbursement needs) • Develop account-specific tactical recommendations based on customer type, business needs, and competitive landscape, ensuring timely and profitable access • Work closely within Market Access & Patient services and other cross-functional commercial partners, including brand leadership, commercial operations, and HEOR, medical, Regulatory, Patient Services, Finance, Trade, Account Management to ensure alignment of payer marketing strategies with overall business objectives • Identify and execute marketing needs for field access managers, including reimbursement marketing materials that support access and pull-through objectives • Implement key tactics for various payer channels (e.g., government, commercial) • Partner with Data Analytics to deliver market insights that inform payer strategies, tactics, and promotional plans • Partner with Data, Analytics, and Operations to execute market research needs and gaps (e.g., Advisory Boards) • Support cross-functional brand teams, fostering collaboration and ensuring market access representation • Represent Market Access in Medical, Legal, and Regulatory (LMR) review meetings • Manage the payer marketing budget, agency of record, and external vendors as necessary

• Lead the development and implementation of B2B access marketing tactics and pull-through resources • Develop account-specific tactical recommendations based on customer type, business needs, and competitive landscape • Partner within Market Access & Patient services and other cross-functional commercial partners • Lead strategic alignment and execution with National and Regional Market Access account teams on tactical plans • Identify and execute marketing needs for field access managers • Implement key tactics for various payer channels • Partner with Data Analytics to deliver market insights that inform payer strategies • Manage the payer marketing budget, agency of record, and external vendors

• Provide strategic operational leadership for key Medical Affairs initiatives • Implement continual process improvements for Medical Affairs functions and areas of responsibility • Establish trusted peer-to-peer relationships with internal partners • Effectively manage multiple vendor and agency relationships, ensuring that Ardelyx interests are well represented and addressed • Organize departmental meetings including setting agendas and managing project updates • Develop and maintain monthly departmental reports for all functional areas • Manage MRC process using Veeva MedComms • Support Medical Education Grant and Investigator Sponsored Trial (IST) process • Support partnerships with external agencies and partners • Manage departmental training activities, including maintenance of learning management system • Oversee contracting and processing of SOWs and consultant agreements • Support monthly and annual budget tracking • Represent Medical Affairs on cross-functional teams

• Oversee the on-the-ground execution and deployment of brand specific training experiences • Assist in the development and execution of comprehensive strategic and tactical plans to support the short and long term objectives of the IBSRELA Field Sales team • Manage implementation and continuous improvement relating to Brand specific, IBSRELA new hire training programs and curriculum, including continuing education with ongoing learning programs • Administer advanced training for ongoing learning of product and disease knowledge and customer interaction capabilities • Develop classroom training programs, including customer interaction capabilities as well as disease and product education via live training experiences, e-learning modules, etc. • Manage continued development of IBSRELA sales training programs mentorships, coaching, and field assessment in partnership with Sales Leadership and Zone Directors • Ensure that training programs are consistent with, and supporting of, company legal, regulatory and compliance guidelines • Work closely with Sales and Market Access to ensure appropriate integration of sales and marketing materials into all new hire and ongoing learning training programs • Provide strategic analysis and planning with the ability to work with and manage demands and expectations from multiple internal customers • Design and attend certification training for relevant training programs and vendors

• Providing strategic leadership and operational oversight to a team of field reimbursement managers (FRMs) • Ensuring patient access to company products by developing and executing field reimbursement strategies • Educating healthcare providers (HCPs) on coverage and coding • Resolving access barriers within a complex healthcare landscape • Serving as a key subject matter expert on the regional payer landscape • Partnering closely with Market Access, Sales, Marketing, Medical Affairs, Legal, and Patient Support Hub teams • Proactively educating providers and office staff on patient support programs, coding, billing, and prior authorization requirements