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Scientist, Functional Genomics, Virtual Cell Initiative
Location
United States
Posted
107 days ago
Salary
0
No structured requirement data.
Job Description
Scientist, Functional Genomics, Virtual Cell Initiative
Arc Institute
We are seeking a highly skilled and motivated Scientist with a strong background in functional genomics and single-cell sequencing to join the Virtual Cell Initiative at Arc Institute. The initiative aims to create the first foundational model that makes accurate predictions of cellular states and their response to intervention. Lead the generation of massive single-cell perturbation datasets across 50+ cancer cell lines to train Virtual Cell models. Responsible for the end-to-end experimental workflow—from mammalian cell culture and large-scale CRISPR screening to single-cell library preparation and sequencing. Exceptional project management capabilities, proficient in organizing complex data streams and adhering to timelines. Collaborate daily with other wet lab scientists, automation engineers, and computational biologists. Bridge the gap between experimental biology and computational innovation.
Job Requirements
- PhD in Cell Biology, Molecular Biology, Genomics, or another relevant field.
- 0-3 years of post-PhD experience in academia or industry.
- Extensive experience with large-scale pooled CRISPR screening, preferably with scRNA-seq readouts (e.g. Perturb-seq, CROP-seq).
- Expertise in mammalian cell culture and ability to manage multiple cell lines simultaneously.
- Experience in multi-color flow cytometry.
- Experience with mammalian cell line engineering using transfection, lentivirus production and transduction, and other common approaches.
- Experience with different molecular biology techniques (cloning, PCR, etc).
- Demonstrated ability to work both independently and in a highly collaborative multidisciplinary environment.
- Strong project management skills with the ability to independently plan, execute, and deliver results on time.
- Excellent written and verbal communication skills.
- Hands-on experience with downstream genomics protocols, especially scRNA-seq (preferably 10X Genomics workflows).
- Experience designing and cloning large pooled CRISPR sgRNA libraries.
- Experience optimizing different CRISPR-Cas9 effector systems, such as CRISPRi and CRISPRa, including vector design and delivery.
- Experience performing FACS-based cell sorting.
- Ability to analyze large datasets using Python, R, or similar tools.
- Familiarity with different NGS technologies (Illumina, Ultima).
- Experience using automation to scale, streamline, and optimize large-scale experiments.
Benefits
- The base salary range for this position is $121,250 - $159,500.
- This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.
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Ramsey County is hiring two Government Relations Specialists within the Government Relations Department. Under the direction of the Government Relations Director develop, advocate for and present information on county board initiatives and positions; participate in the development and operation of county processes for state and federal government relations functions; assist in the coordination and logistical operation of the legislative program; and to perform related duties as assigned. To view or print a copy of the complete Ramsey County job (class) description for this position, go to: Job Descriptions . Once at this page, you can browse the alphabetical list or search for a job description. Flexible Workplace : This position is identified under the designation of ‘flex work eligible’, meaning that the employee can formally opt to be in-office full-time or work a flex schedule in which at least two-days per week are performed in office and other days can be performed in a remote-first environment. Regardless of selection, the position carries expectations regarding on-site responsibilities and will require schedule flexibility beyond the minimum expectations set forth in the county’s flexible workplace policy. To view Ramsey County’s Flexible Workplace policy, go to: Flexible Workplace Policy Ramsey County is hiring two Government Relations Specialists within the Government Relations Department. 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Participate in the tracking of the progress and status of relevant state and federal legislation and develop related documentation; coordinate the annual distribution of all enacted state legislation to county departments that have primary responsibility for implementation. Represent Ramsey County at meetings with staff from other governmental entities, public and private foundations (i.e., Association of Minnesota Counties, National Association of Counties, and the Saint Paul Area Chamber of Commerce). Convene, facilitate, and participate in work teams that develop legislative proposals or policy options related to legislation for the Ramsey County Board of Commissioners, including directing efforts of staff from other county departments over whom there is no supervisory relationship. (The work assigned to a position in this classification may not include all possible tasks in this description and does not limit the assignment of any additional tasks in this classification. Regular attendance according to the position’s management approved work schedule is required.) ESSENTIAL FUNCTIONS : 1, 2, 3, 4, 5, 6, 7, 8. Collaborate with the Government Relations Director in the development and implementation of the county board’s annual federal and state legislative platforms, including identification and analysis of county priorities for advocacy. Help to assess the policy impact of a response to proposed legislation affecting the county in coordination with department staff. Prepare summaries, analyses, and updates of state or federal legislation that could impact Ramsey County programs, services, and operations. 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Each case is considered on its individual merits and the type of work sought. However, making false statements or withholding information will cause you to be barred from employment, or removed from employment. E-Verify Participation : Ramsey County participates in the federal E-Verify program. This means that Ramsey County will provide the Social Security Administration (SSA) and, if necessary, the Department of Homeland Security (DHS), with information from each new employee's Form I-9 to confirm work authorization. If the Government cannot confirm that you are authorized to work, Ramsey County is required to give you written instructions and an opportunity to contact DHS and/or the SSA before taking adverse action against you, including terminating your employment. Employers may not use E-Verify to pre-screen job applicants and may not limit or influence the choice of documents you present for use on the Form I-9. Equal Opportunity Employer : Ramsey County provides equal access to employment, programs, and services without regard to race, color, creed, religion, age, sex (except when sex is a Bona Fide Occupational Qualification), disability, familial or marital status, sexual orientation or gender identity, public assistance status, place of residence, political affiliation, or national origin. Ramsey County is deeply committed to advancing racial equity and promoting diversity and inclusion within all areas of its workforce. The county strives being equitable, inclusive, transparent, respectful, and impactful in how we serve and engage with residents, as well as Ramsey County employees. Advancing racial equity ensures all people who need access to opportunities and services we provide, will receive them. Racial equity is achieved when race can no longer be used to predict life outcomes, and outcomes for all are improved. To print a paper application for this posting click Paper Application You will need to print this posting and answer the supplemental questions associated with this exam and submit them with your completed paper application. For further information regarding this posting, please contact: Crystal.Diaz@co.ramsey.mn.us Criminal Background Checks : All employment offers are conditioned upon the applicant passing a criminal background check. Convictions are not an automatic bar to employment. Each case is considered on its individual merits and the type of work sought. However, making false statements or withholding information will cause you to be barred from employment, or removed from employment. E-Verify Participation : Ramsey County participates in the federal E-Verify program. 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