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Natera

We are a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health.

Principal Scientist, Translational Oncology – Single Cell and Spatial Genomics

Research ScientistResearch ScientistFull TimeRemoteLeadTeam 1,001-5,000Since 2004H1B SponsorCompany SiteLinkedIn

Location

California

Posted

9 days ago

Salary

$171.9K - $215.0K / year

Seniority

Lead

Postgraduate Degree6 yrs expEnglish

Job Description

Principal Scientist, Translational Oncology – Single Cell and Spatial Genomics

Natera

• Drive discovery and translational projects in collaboration with AI and internal research teams with a primary focus on integrating scRNA-seq and spatial biology into Natera’s pipeline. • Collaborate with external translational teams on building single-cell and spatial biology workflows into their early phase clinical studies. • Leverage novel technologies to inform collaborative reverse and forward translation efforts as well as internal target discovery and validation projects. • Design and execute lab-based research programs that bridge clinical observations with mechanistic hypotheses, supporting asset progression and CDP expansion • Lead and contribute to technology area team focused on single cell genomics and spatial omics, building out multiomics capabilities to support foundational models and RWD efforts • Partner with internal and external collaborators to establish, optimize, and deploy cutting-edge platforms for translational applications • Serve as an internal expert and thought leader on emerging genomics technologies relevant to oncology drug discovery and development • Represent translational science on life cycle, RWD, and BioPharma BD teams • Collaborate with Clinical, Biomarker, Discovery, and Regulatory colleagues to shape clinical trial design and biomarker plans • Build and maintain external scientific partnerships and advisory relationships as appropriate • Lead and mentor a team of scientists and contractors, with a strong commitment to career development and scientific growth • Foster a collaborative, high-performance team culture with clear goals and accountability

Job Requirements

  • Ph.D. in Cancer Biology, Molecular/Cellular Biology, Immunology, Bioengineering, or a closely related field
  • 6+ years of experience post-Ph.D. in oncology translational research within biotech or pharma, including demonstrated growth into senior or principal scientist roles
  • Deep scientific expertise in at least one of the following: cancer cell biology, tumor immunology, cell engineering, or neoantigen biology
  • Hands-on experience with single cell genomics, spatial transcriptomics, or multiomics platforms; experience building or scaling these capabilities in an organizational context is strongly preferred
  • Strong publication and/or patent record reflecting independent scientific contribution
  • Demonstrated experience leading cross-functional programs and influencing without authority across Research, Clinical, and Biomarker teams
  • Prior experience managing and mentoring scientists at multiple career stages
  • Exceptional scientific communication skills; ability to synthesize complex data and present compellingly to diverse audiences

Benefits

  • Annual performance incentive bonus
  • Long-term equity awards
  • Comprehensive health benefits (medical, dental, vision)
  • 401(k) with company match
  • Generous paid time off and company holidays
  • Additional wellness and work-life benefits

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