Role Description We are seeking an experienced and strategic Head of Chemistry, Manufacturing, and Controls (CMC) to lead the development and execution of global CMC strategy across a diverse therapeutic portfolio. This individual will provide technical and organizational leadership for biologics, combination products, oligonucleotides, and cell and gene therapy programs, spanning early development through late-stage development and commercialization readiness. The successful candidate will combine deep drug development expertise, strong cross-functional leadership, and proven experience building, managing, and developing teams. Consulting experience is a plus. Key Responsibilities - Define and lead phase-appropriate global CMC strategies across modalities for a diverse range of global clients - Provide thought leadership to raise the VCLS profile, including speaking at conferences, presenting webinars, and meeting VCLS clients Technical Oversight - Enable our clients’ development of biologics, oligonucleotides, combination products, and cell & gene therapies - Guide scalable manufacturing and analytical strategies - Write and review technical documentation, and provide input and support for CMC team members Regulatory Leadership - Oversee IND, CTA, BLA, NDA, MAA, and IMPD CMC documentation - Represent CMC in health authority interactions Vendor Management - Manage external partners, including external auditing and consulting partners - Drive performance and issue resolution People Leadership - Lead and develop a team of 5–10 staff - Build a high-performing and collaborative culture Cross-functional Collaboration - Partner with Regulatory, non-clinical, clinical, and business development teams to bring phase-appropriate solutions to VCLS clients and build the VCLS business Qualifications - Degree in a relevant scientific discipline - Significant industry experience in CMC and drug development - Expertise across biologics, oligonucleotides, combination products, and cell & gene therapies - Experience managing mid to large teams - Strong regulatory submission experience (US and/or UK/EU) - Knowledge of GMP and global regulatory requirements - Experience with CDMOs

Title: AI Design Lead Location: San Francisco United States Job Description: Highwire is reimagining what a creative designer can be. We are an AI-native, sector-expert, outcome-obsessed partner to the world's most innovative companies. As our AI Design Lead, you sit at the intersection of human-centered creative craft and machine-driven scale. You are a designer and a systems architect, defining how we build repeatable creative workflows that turn potential into influence. You will play a central role in operationalizing AI across our creative workflows, ensuring that our work maintains its gravity and cultural relevance while accelerating delivery. About You: You are a design hybrid with a deep appreciation for the traditional craft of visual communication and a forward-thinking mastery of AI. You have spent the last three years in the trenches of LLM-driven platforms, moving beyond simple prompting to build scalable, production-ready creative systems. Your portfolio proves your ability to command large-scale brand work that resonates, and your experience demonstrates that you understand how to harness technology to amplify-not replace-the human element. Key Responsibilities - Architect AI-Native Creative Systems: Partner with our Innovation and Creative teams to build and refine workflows that translate approved human-first designs into scalable, multi-format asset systems. - Bridge Craft and Scale: Maintain Highwire's standard for high-quality, high-gravity creative output while overseeing the automated generation, versioning, and adaptation of assets for global campaigns. - Human Oversight: Execute AI-assisted production workflows in accordance with client branding and compliance requirements, with mandatory human review and approval at all production stages before submission. - Operationalize AI Integration: Deeply integrate LLMs and design APIs (Figma, Canva, Adobe Firefly, etc.) into our daily creative lifecycle, streamlining the journey from concept to execution. - Brand Compliance: Maintain and execute AI-assisted compliance checks against client brand guidelines and visual standards. - Modular Production: Build and version modular asset systems that can support scaled campaign production across formats and channels, with the flexibility to surge as launch volume fluctuates. - Guardrails Maintenance: Maintain and update AI production guardrails libraries and brand standards documentation as brands and campaigns evolve, documenting prompt structures, workflow decisions, and asset versioning for team knowledge and QA purposes. - Creative Governance & QA: Conduct quality assessment of AI-generated output across diverse client industries (B2B tech, healthcare, financial services), ensuring assets meet brand standards and strategic intent before escalating to senior Creative leads for final approval. - Cross-Functional Collaboration: Partner with senior Creative leads and account teams to ensure all AI outputs align with client-specific marketing objectives, ensuring our technology-enabled services increase multi-service attachment and client ROI. - Mentorship: Champion the use of AI tools across the wider creative team, fostering a culture of experimentation and raising the baseline of our agency's AI fluency. Candidate Requirements - LLM Deep-Dive: 3+ years of professional, hands-on experience working directly with LLM-driven platforms and AI-integrated design apps (e.g., generative image models, LLM-based layout tools). - Prompt Art Direction Engineering: Demonstrated fluency in structuring, iterating, and version-controlling prompts within production AI environments, beyond what general LLM platforms can do. - Proven Design Craft: A robust portfolio of large-scale brand work that demonstrates mastery of typography, layout, motion design, and visual storytelling-competing with top-tier agency work. - Strategic & Technical Fluency: Proven ability to translate creative strategy into technical workflows; you don't just understand the "what," but the "how" of automating high-quality design. - Production Scalability: Comfort operating in a high-volume, deadline-driven environment with fluctuating production demands and the ability to adapt quickly to shifting campaign priorities. - Agency Experience: Experience working in a fast-paced agency environment, comfortable with shifting priorities, tight deadlines, and complex, multi-stakeholder feedback loops. - Team Integration: Experience working as an embedded contributor, executing within defined systems and escalating creative decisions to senior leads appropriately. - System-First Mindset: Experience in building design systems, template libraries, and component-based creative architectures that scale. - Collaborative Spirit: A demonstrated history of partnering across disciplines (Content, Strategy, Accounts) to ensure design is a primary driver of business outcomes. The salary range for this position is $80,000 to $105,000, with the final offer based on a combination of factors, including education, relevant experience, skills, prior training, internal equity, and local geographic market data. This role also includes a competitive benefits package with medical, dental, and vision coverage, 401(k) matching, generous paid time off, and additional perks designed to support your overall well-being and growth. #LI-Hybrid About Highwire Highwire is a strategic marketing communications agency at the intersection of innovation and industry. We partner with ambitious companies and established brands to navigate complexity, lead markets, and grow with purpose. With integrated expertise in strategic marketing and communications, corporate reputation, creative, and insights, we cut through the noise to deliver bold ideas and measurable impact across B2B technology, healthcare, cybersecurity, energy, professional and financial services, and more. At Highwire, we believe that storytelling fuels transformation. We know that the most impactful stories represent all voices and perspectives. As a values-driven agency, we foster an inclusive environment where everyone-regardless of age, race/ethnicity, size, shape, gender identity, sexual orientation, religion and different abilities-can feel safe, celebrated and worthy. We ensure that every Highwire Walker has the requisite support to soar in their careers. Our commitment to diversity, inclusion and belonging is foundational and embedded in our business and culture. We aspire to change our industry and build a better future for all. Our people-first culture is driven by four core values: - Team Empowerment - Growth Mindset - Inclusion Always - Fierce Distinction We're looking for individuals with big ideas, strong opinions, and the energy to bring them to life. If you thrive in an environment that values personal accountability, high standards, and boundless motivation, this is the opportunity for you. Be part of our award-winning culture and contribute to an exciting and growing business where you can make a real impact. Highwire. Above all. Our people-first culture is reflected in the meaningful benefits, flexibility, and support we offer: - Competitive salary with merit-based opportunities for growth - Flexible hybrid work model tailored to your schedule and lifestyle - Generous vacation policy, including extended summer and winter breaks - Early log-off on Fridays through our Empower Hours program - 401(k) plan with employer matching - Comprehensive medical, dental, and vision coverage, plus FSA options - Paid parental leave benefits - Commuter benefits - Annual Growth Mindset stipend for books, events, or learning experiences - Monthly technology reimbursement - Wellness benefit program for mental and physical health - 501c3 donation matching program - Mentorship and ongoing professional development opportunities - Monthly recognition and team celebrations - Employee referral and new business referral bonuses - Quarterly Highwire events and team gatherings - Dog-friendly office environment - A supportive, inclusive, and collaborative workplace where you can grow and do your best work Location & Work Environment Highwire offers both remote and hybrid work options, depending on where you live. Hybrid: Candidates located within commuting distance of our New York, NY or San Francisco, CA offices follow a hybrid schedule, with three in-office days per week. Remote: We hire for fully remote roles in the following states: California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa, Kansas, Maryland, Massachusetts, Michigan, New Hampshire, New Jersey, New York, North Carolina, Ohio, Oregon, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, Washington, and Washington, D.C..

Role Description We are looking for a visionary Film Director & Showrunner to lead the creation of a high-end short-drama series. This role is for a cinematic powerhouse who understands deep storytelling, blocking, and dramatic structure, but is also ready to embrace Generative AI as their primary production engine. You don't need to be a software engineer, but you must be digitally native and tech-curious. We need a storyteller who can translate a traditional director's "eye" into the world of AI-assisted filmmaking, turning scripts into seamless, prestige-quality visuals. As the lead creative, you will act as a "one-person studio." You'll take a project from concept to final master, using AI tools to build worlds, maintain character consistency, and direct virtual "performances." You are the bridge between classic film theory and the future of automated production. Responsibilities - Lead the narrative strategy and maintain a cohesive "look and feel" across a complete short drama series. - Apply your mastery of lighting, composition, and performance to AI outputs, ensuring they mirror the quality of high-end television. - Use AI-assisted tools to build storyboards, shot lists, and backplates that align with your directorial vision. - Personally responsible for the final "director's cut." While you'll have support, you should be comfortable getting hands-on with generation, assembly, and refinement. - Oversee (and perform) the cleanup of AI artifacts to ensure visual consistency and a seamless cinematic experience. - Ensure all content meets brand guidelines and respects intellectual property standards. Qualifications - Proven experience as a Film Director or Showrunner with a portfolio that demonstrates a deep grasp of "the language of film." - An expert understanding of film theory, pacing, and how to evoke human emotion through a lens. - You should have a basic, functional understanding of AI tools (like Midjourney, Runway, or Luma) and a massive appetite to learn more. - Expert-level skills in industry-standard software like Adobe Premiere Pro, DaVinci Resolve, or Avid. - High-level proficiency in After Effects or similar tools for masking, compositing, and "fixing it in post." - The ability to find creative workarounds for the current limitations of AI technology. Bonus Skills - Experience with AI audio/music tools (e.g., ElevenLabs, Udio, Suno). - A "hacker" mentality — someone who loves testing new tools the day they drop. Language Requirements - Good English required for reading scripts. - Experience working in remote creative teams in English. Portfolio Requirements - Portfolio with relevant work is required. - Strong personal creative projects using AI tools. - 1–5 minute AI video or experimental film in portfolio. - Instagram profile with updated videos. - Explanation of what was your responsibility in the video content.

Role Description As Head of AI, you will define what artificial intelligence means for a portfolio holding company operating at the intersection of gaming, performance advertising, and developer infrastructure. Reporting directly to the CEO, you will build and lead the AI function across three core domains: - Strategic AI resource for portfolio companies. - Business OS improvements and automation. - Shared AI infrastructure. This is a rare opportunity to shape how a multi-business portfolio operationalizes AI from the ground up. You will set the direction, build the function, and leave a lasting mark on how FIRY competes and operates. Responsibilities - Define and drive the AI strategy. - Build the enterprise AI foundation. - Elevate portfolio companies. - Build and lead a world-class AI organization. - Drive enterprise-wide AI adoption. Qualifications - Strategic vision paired with hands-on execution. - Cross-functional leadership across engineering, product, data, and business teams. - Ability to translate complex AI and ML concepts clearly for executive and non-technical audiences. - Builder's mentality, thrives in ambiguous, resource-constrained environments. - Proven ability to build and scale high-performing teams. Requirements - Strong ML engineering background with hands-on experience building and deploying production ML systems at scale. - Deep knowledge of LLM orchestration, API-first architecture, prompt engineering at scale, and model routing. - Experience building or scaling an AI function at a startup or growth-stage company is a strong plus. - Proficient coder with the ability to write and review production-quality code. - Gaming, adtech, or consumer tech experience strongly preferred. Benefits - 100% coverage for medical, dental, and vision for you and your dependents. - 401K matching, equity incentives, pre-tax benefit options, and more. - Meditation and mental health resources, physical fitness coaching and classes, family planning assistance, virtual therapy sessions, and more. - Competitive PTO and company holidays. - Collaborative office environment at our Las Vegas headquarters with free daily catered lunch, snacks, a full-size gym with showers, commuter benefits, team events, and more.