Title: Associate Director, CMC Synthetic Chemistry – Small Molecule Location: Boston, Massachusetts, United States; Durham, North Carolina, United States Job Description: About Beeline Medicines: Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully. Job Summary: The Associate Director, CMC Synthetic Chemistry – Small Molecule is a senior scientific individual contributor responsible for the hands-on development, optimization, and scale-up of synthetic routes for small molecule drug candidates. Reporting to the Executive Director, CMC Synthetic Chemistry, this individual plays a central role in advancing API process chemistry from early development through clinical manufacturing, ensuring that synthetic routes are robust, scalable, safe, and regulatory-ready. This role carries no direct reports but serves as the primary technical owner for assigned programs and is the key scientific interface with CDMO process chemistry partners. It requires deep expertise in organic and process chemistry, direct experience with CDMO technical management, and the ability to operate with scientific independence and collaborative agility in a pre-commercial biotech environment. Work Arrangement & Location: Hybrid - This position follows a hybrid work schedule, requiring a minimum of two (2) days on-site per week — currently designated as Tuesday and Wednesday. Additional on-site days may be required based on business needs, team priorities, or leadership direction. Essential Duties and Responsibilities: - Lead the design, evaluation, and optimization of synthetic routes for small molecule APIs, applying mechanistic understanding and process chemistry principles to develop robust, scalable, and cost-efficient manufacturing processes. - Execute and oversee process development campaigns including reaction optimization, solvent selection, intermediate characterization, and process safety assessments from lab scale through CDMO kilo-lab and pilot plant operations. - Serve as the primary technical interface with CDMO process chemistry teams, providing day-to-day scientific oversight of API synthesis campaigns, reviewing batch records, and driving rapid resolution of process deviations and out-of-specification events. - Author and contribute to drug substance sections of regulatory filings (IND, IMPD, NDA) including synthetic route descriptions, process development summaries, control strategy justifications, and raw material specifications. - Design and execute Design of Experiments (DoE) studies to define process parameters, establish proven acceptable ranges, and support the development of a robust process control strategy in alignment with QbD principles. - Conduct and document process hazard evaluations, reaction safety assessments, and scale-up risk analyses in collaboration with process safety and engineering functions at CDMO partners. - Oversee the sourcing, qualification, and quality assessment of starting materials, reagents, and key intermediates, partnering with Quality and Regulatory Affairs on supplier qualification and control strategy. - Contribute to intellectual property strategy for synthetic routes and manufacturing processes by working closely with IP/Legal to identify patentable innovations. - Operate as a self-directed scientific contributor — managing API route scouting, process development and optimization studies and providing technical oversight of external manufacturing campaigns independently while coordinating effectively with cross-functional and external partners to advance program deliverables on schedule. - Perform other duties and responsibilities as assigned Qualifications: - Education: Ph.D. in Organic Chemistry preferred; or equivalent industry experience in pharmaceutical process development. - 7+ years of API development and process chemistry and experience in pharmaceutical and/or biotechnology industry - Demonstrated track record of serving as the primary scientific lead on synthetic chemistry programs from development through GMP manufacture.. - Deep expertise in synthetic route design and optimization for complex small molecule APIs, including multi-step synthesis, chiral chemistry, and heterocyclic chemistry. - Hands-on experience executing and overseeing API process development campaigns at CDMO sites, including batch record review, technical troubleshooting, and scale-up support. - Proficiency with cGMP expectations for drug substance manufacture. - Experience authoring drug substance sections of INDs, IMPDs, or NDA filings and responding to associated agency questions. - Strong written and verbal communication skills, with the ability to clearly present scientific data, development recommendations, and program updates to senior leadership and cross-functional partners. - Effective collaborator with a track record of building productive working relationships across CMC functions, Clinical Development, Regulatory Affairs, and Quality in a team-oriented environment. - Organized and detail-oriented communicator who can manage competing priorities, proactively flag risks, and keep cross-functional stakeholders aligned on timelines and deliverable status. Salary Range: The expected annual salary range for this position is listed below. Actual pay will be determined based on experience, qualifications, location, and other job-related factors permitted by law. A discretionary annual bonus and long-term incentive award (e.g., equity) may be available based on individual and Company performance. Salary Range $220,000 - $232,575 USD Benefits: We offer a comprehensive benefits package including: - Medical, Dental & Vision insurance (employee premiums 100% covered by company) - 20 accrued days combined time off (PTO/Sick), 12 company holidays, & winter recharge - Flexible work arrangements / hybrid schedule - Health Savings Account (HSA) *Benefits are subject to eligibility requirements and plan terms. Additional details provided during the offer process* Equal Employment Opportunity: Beeline Medicines is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability, age, protected veteran status, or any other characteristic protected by applicable federal, state, or local law. Privacy Upon submission of this form I understand that Beeline Medicines is based in the United States and personal data submitted in the form will be transferred and accessed in the U.S., Information about Beeline Medicines privacy practices can be found at Privacy Policy - Beeline Medicines

Title: Senior Director, Bioanalysis Location: Boston, Massachusetts, United States Work Type: Hybrid Job Description: About Beeline Medicines: Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully. Job Summary: We are seeking an experienced Senior Director, Bioanalysis to lead bioanalytical strategy and execution across small molecule and biologics programs. This role will be responsible for the development, validation, and oversight of bioanalytical assays supporting pharmacokinetics (PK), toxicokinetics (TK), and immunogenicity across preclinical and clinical studies, including Phase 1–3. The ideal candidate will bring deep expertise in bioanalysis together with a familiarity of DMPK and PK interpretation, enabling close partnership across Clinical Pharmacology, Translational Sciences, and Regulatory to support program decisions and regulatory submissions. Work Arrangement & Location: Hybrid - This position follows a hybrid work schedule, requiring a minimum of two (2) days on-site per week — currently designated as Tuesday and Wednesday. Additional on-site days may be required based on business needs, team priorities, or leadership direction Essential Duties and Responsibilities: - Lead bioanalytical strategy across preclinical and clinical-stage programs for small molecules and biologics - Oversee development, qualification, validation, transfer, and lifecycle management of assays for: - Small molecules PK/TK using LC-MS/MS - Biologics PK assay using ligand-binding and/or hybrid assay platforms - Immunogenicity assays, including ADA and neutralizing antibody assessments - Provide scientific oversight for bioanalytical activities supporting preclinical and clinical programs i - Select and manage external bioanalytical partners and ensure high-quality, timely execution - Support investigations and root cause analyses for any out-of-specification (OOS) results, deviations, or process failure - Review and approve assay plans, validation reports, sample analysis plans, data packages, and final study reports - Partner closely with Clinical Pharmacology and translational sciences to support PK/TK interpretation and sampling strategy. - Contribute to study design and execution across preclinical toxicology, clinical pharmacology, and clinical development - Author and review bioanalytical contributions to IND, NDA, and BLA submissions and support responses to health authorities - Ensure bioanalytical activities are conducted in compliance with applicable GLP, GCP, and global regulatory guidance - Perform other duties and responsibilities as assigned Qualifications: - Education: Ph.D. in Bioanalytical Chemistry, Pharmacokinetics, Biochemistry, Pharmaceutical Sciences, or related discipline (or MS with significant relevant industry experience) - 12+ years of relevant experience in bioanalysis supporting drug development within pharmaceutical and/or biotechnology industry - Deep expertise in bioanalysis across preclinical and clinical development - Strong experience with LC-MS/MS assays for small molecules, ligand-binding and/or hybrid assays for biologics, and Immunogenicity assays, including ADA and neutralizing antibody methods - Experience overseeing bioanalytical work across multiple programs and development stages - Strong understanding of regulatory expectations for bioanalytical method validation, sample analysis, and reporting - Experience interpreting PK/TK data and applying bioanalytical results to broader development questions - Experienced in cross-functional collaboration with Clinical Development, Regulatory Affairs, and Translational Medicine teams to integrate clinical pharmacology strategy — including PK/PD, dose selection, and modeling — into program-level decision-making - Demonstrated ability to set strategic direction for clinical pharmacology operations, including study design, data interpretation, and regulatory strategy, while maintaining accountability for quality, compliance, and delivery across competing program priorities - Exceptional ability to synthesize complex PK/PD, exposure-response, and modeling and simulation data and communicate findings clearly to cross-functional audiences ranging from bench scientists to senior R&D leadership, clinical teams, and health authorities - Establishes and models a culture of scientific rigor and open communication within the clinical pharmacology team, ensuring data interpretations, assumptions, and limitations are transparently conveyed and appropriately documented across regulatory and internal deliverables Salary Range: The expected annual salary range for this position is listed below. Actual pay will be determined based on experience, qualifications, location, and other job-related factors permitted by law. A discretionary annual bonus and long-term incentive award (e.g., equity) may be available based on individual and Company performance. Salary Range $249,000 - $268,750 USD Benefits: We offer a comprehensive benefits package including: - Medical, Dental & Vision insurance (employee premiums 100% covered by company) - 20 accrued days combined time off (PTO/Sick), 12 company holidays, & winter recharge - Flexible work arrangements / hybrid schedule - Health Savings Account (HSA)

Role Description The TO Programme Director will be a senior change leader responsible for driving Nearform's internal AI transformation. This is a strategic, hands-on role that bridges programme governance, workforce planning, talent strategy, and cultural change — ensuring our Delivery and GTM organisations are equipped, structured, and empowered to operate as a truly AI-native business and our back office functions are embracing AI and realising the efficiencies. This role will lead the planning, coordination and execution of complex, cross-functional transformation programmes — working in close partnership with Delivery leadership, People & Talent, GTM teams, shared services and the Executive team. Programme Leadership & Governance - Working with Nearform's Transformation Office to establish clear programme structures, governance frameworks, and operating rhythms. - Own the integrated programme plan across all TO workstreams, ensuring dependencies, risks, and milestones are actively managed. - Provide executive-level reporting and insight on transformation progress, blockers, and strategic decisions required. - Define and embed change management practices that enable sustained adoption of new ways of working across the business. Qualifications - Significant experience (10+ years) leading large-scale transformation programmes in a technology, consulting, or digital services environment. - Proven track record of delivering complex, cross-functional change programmes — ideally including technology or engineering transformation at scale. - Experience in workforce planning and talent strategy, with the ability to translate business strategy into people and capability plans. - Exposure to AI, ML, or AI-native engineering concepts and the ability to engage credibly with engineering leaders on these topics. - Background in a digital consultancy, technology services firm, or fast-scaling product organisation is strongly preferred. Skills & Capabilities - Exceptional programme management capability — able to hold complexity, manage multiple workstreams, and maintain momentum across a diverse stakeholder landscape. - Strategic thinker with the operational discipline to translate vision into delivery-ready plans. - Strong data literacy — able to interpret workforce, utilisation, and transformation metrics to drive decisions. - Strong AI skills across a range of tools and an ability to apply AI across multiple disciplines. - Outstanding communication and storytelling skills — comfortable influencing at C-suite level and engaging engineering teams alike. - Skilled at navigating change and ambiguity, with the resilience to drive progress in fast-moving environments. - Collaborative leader who builds trust quickly, operates with high EQ, and brings people along through change. Benefits - Annual Company Bonus - We all help Nearform to hit company goals so we all receive a share of the profits on an annual basis in line with company performance. - Work Remotely and Flexibly - We have a genuine dedication to work/life balance. Our flexible working culture allows you to work around what matters - school run, no problem! - Paid Time Off Package - We offer an annual leave of 24 days plus public holidays. We also offer sick leave, marriage leave and many more. - Remote Working Allowance - Every 2 years, you will have a budget of up to €1250 to help you set up a comfortable and productive workspace in addition to your essential equipment provided by Nearform when you join. - Training and Development Allowance - Nearform is committed to supporting and investing in employees’ ongoing learning and professional development. You will be encouraged to pursue relevant learning opportunities that support your growth and the growth of others, subject to manager approval. - Healthcare - It’s important to always take care of your health, so we offer additional private healthcare here at Nearform. If you wish to learn more about the plan offered feel free to reach out to our team. - Pension & Insurances - We offer a pension match of up to 5% and Income Protection and Death in Service for peace of mind. Our Interview Process - Talent Call (30 mins, Zoom) - An introductory conversation with a member of our Talent Team to learn more about your background, experience, and career goals. We'll also provide a high-level overview of Nearform and answer any questions you may have. This step helps us assess initial alignment. - Hiring Manager Interview (1 hour, Zoom) - A conversation with the Chief Transformation Officer. - Panel Interview (1.5 hours, Zoom) - Final Interview (45 mins, Zoom) - A final chat with the Managing Director for the region to discuss the plans for this role, Nearform’s strategy, and any questions you may have. Ready to Join Us? If you're passionate about building high-quality applications, solving complex challenges, and driving innovation in enterprise development, we’d love to hear from you. Apply now via our careers page at Nearform and be part of a team that values technical excellence, collaboration, and continuous learning. Nearform is committed to shaping a better world in all that we do. Our global team is built based on respect, inclusivity, diversity and excellence. If you require any adjustments to the interview process as part of your application, please let someone from our Talent Team know so they can help.

• Recruit, hire, and develop world-class sales talent while fostering a culture that embraces DE&I • Solve customer pain points through Zscaler's unique value proposition • Accurately forecast business monthly, quarterly, and yearly while building development plans for each sales representative • Collaborate with Product Marketing, Product Management, Demand Generation, and other key functional roles • Act as executive sponsor for key partners to create joint plans, generate pipeline, and drive opportunities to closure