• Considered as the primary point of contact for the investigative site. • High level of competency or experience in providing contextual information on the clinical trials, connects stakeholder to the investigative sites and strengthens AbbVie’s positioning. • Aligns, trains and motivates the site staff and principal investigator on the goals of the clinical trial program, protocol and patient treatment principles for the trial ensuring a trusted partnership. • Conducts site evaluation, site training, routine, and site closure monitoring activities with compliance to the protocol and monitoring plans, in accordance with applicable regulations, Good Clinical Practices (GCPs), ICH Guidelines, AbbVie Standard Operating Procedures (SOPs), and quality standards, ensuring safety and protection of study subjects. • Advanced understanding of site engagement and ability to customize site engagement strategy for assigned study (ies). • Gather local/site insights and utilize site engagement tools such as the Customer Relationship Management (CRM) tool, to report/track progress and measure impact of that strategy. • Advanced level of competency connecting the study protocol, scientific principles and clinical trial requirements to the day-to-day clinical trial execution activities. • Evaluate and ensure effective recruitment and retention techniques/plans based on the patient disease journey. • Develop solid knowledge of therapeutic area, asset and clinical landscape / patient journey to enable successful patient recruitment and overall protocol compliance. • Possesses experienced level of competency to mentor and train less experienced CRAs on various aspects of work and provides input into their development. • May participate in global/local task forces and initiatives. • Responsible for activities as assigned by manager. • Responsible for continuous risk-assessment proactively, and in collaboration with Central Monitoring team, monitor activities conducted by clinical sites to detect early overall study performance or patient safety issues. • Advanced ability to think critically to resolve site risk signals while having robust understanding of site processes to drive study execution. • Ensures preventative and corrective action plans are put into place, as needed, to mitigate risk and promote compliance using a customer centric approach. • Identifies, evaluates and recommends new/potential investigators/sites on an on going basis. Potential sites may be identified through networking or internal AbbVie requests to assist in the placement of planned clinical studies with qualified investigators. • Ensures quality of data submitted from study sites and assures timely submission of data, including appropriate reporting and follow-up for all safety events by site personnel. • Ensures audit and regulatory inspection readiness at assigned clinical site at all times. • Manages investigator payments as per executed contract obligations, as applicable.

• Considered as the primary point of contact for the investigative site. • High level of competency or experience in providing contextual information on the clinical trials, connects stakeholder to the investigative sites and strengthens AbbVie’s positioning. • Aligns, trains and motivates the site staff and principal investigator on the goals of the clinical trial program, protocol and patient treatment principles for the trial ensuring a trusted partnership. • Conducts site evaluation, site training, routine, and site closure monitoring activities with compliance to the protocol and monitoring plans, in accordance with applicable regulations, Good Clinical Practices (GCPs), ICH Guidelines, AbbVie Standard Operating Procedures (SOPs), and quality standards, ensuring safety and protection of study subjects. • Advanced understanding of site engagement and ability to customize site engagement strategy for assigned study (ies). • Gather local/site insights and utilize site engagement tools such as the Customer Relationship Management (CRM) tool, to report/track progress and measure impact of that strategy. • Advanced level of competency connecting the study protocol, scientific principles and clinical trial requirements to the day-to-day clinical trial execution activities. • Evaluate and ensure effective recruitment and retention techniques/plans based on the patient disease journey. • Develop solid knowledge of therapeutic area, asset and clinical landscape / patient journey to enable successful patient recruitment and overall protocol compliance. • Possesses experienced level of competency to mentor and train less experienced CRAs on various aspects of work and provides input into their development. • May participate in global/local task forces and initiatives. • Responsible for activities as assigned by manager. • Responsible for continuous risk-assessment proactively, and in collaboration with Central Monitoring team, monitor activities conducted by clinical sites to detect early overall study performance or patient safety issues. • Advanced ability to think critically to resolve site risk signals while having robust understanding of site processes to drive study execution. • Ensures preventative and corrective action plans are put into place, as needed, to mitigate risk and promote compliance using a customer centric approach. • Identifies, evaluates and recommends new/potential investigators/sites on an ongoing basis.

• Supervision of and continuous communication with investigational sites in the implementation of global clinical trials • Site management and monitoring activities such as on-site and remote site initiations • Monitoring and close-out visits for Phase I–IV clinical trials • Independent management of investigational sites; training study physicians and site staff prior to site activation • Preparation and updating of study-related documents • Support in site selection, collection of all relevant study documents, and preparation of submissions in CTIS • Ensuring compliance with all internal and external requirements as well as ICH-GCP guidelines • Documentation of visits and protocol deviations during the study

• Supporting and maintaining continuous communication with study sites in the implementation of global clinical trials • Site management and monitoring activities • Preparing and updating study-related documents • Compliance: ensuring adherence to all internal and external requirements