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Apheris

Governed, private, secure data access for ML and analytics

Technical Lead – Large Molecule AI Systems

Full-stack EngineerSoftware EngineerFull TimeRemoteSeniorTeam 11-50Since 2019H1B No SponsorCompany SiteLinkedIn

Location

Europe

Posted

5 days ago

Salary

0

Seniority

Senior

Postgraduate Degree5 yrs expEnglishKubernetesPythonPyTorch

Job Description

Technical Lead – Large Molecule AI Systems

Apheris

• Lead teams building and delivering federated large molecule AI systems, staying hands-on across antibody modeling, co-folding, binder prediction, and developability • Build and implement ML applications large biomolecular foundation models such as OpenFold, Boltz-2 and ESM • Own delivery of these against committed milestones and ensure high-quality model releases ship on time • Translate ambiguous scientific and technical goals into clear plans, priorities, workstreams, and decisions • Guide evaluation decisions and build on them to deliver results packages to external stakeholders • Surface risks, blockers, bugs, timeline changes, and technical trade-offs early, with clear recommendations • Align consortium members on objectives, evaluation criteria, data requirements, timelines, and delivery expectations • Work with product, engineering, research, and leadership to ensure application requirements shape the model roadmap.

Job Requirements

  • PhD, MSc, or equivalent experience in a relevant field
  • 5+ years applying ML to complex scientific or biological problems, ideally in structural biology, antibody engineering, biologics discovery, developability prediction, binder prediction or protein design
  • Hands-on experience with modern ML systems in Python and PyTorch
  • Worked with or extended large-scale models such as OpenFold, AlphaFold, Boltz, ESM, or similar
  • MLOps or ML infrastructure experience, particularly with Kubernetes-based training, evaluation, or deployment workflows
  • Define success criteria, validate model quality, and ensure ML releases are robust enough for real-world use
  • Led delivery of complex ML projects, including setting technical direction, managing risks and dependencies, and driving teams toward high-quality releases
  • Comfortable operating as a player-coach: mentoring engineers and ML scientists while contributing directly to modeling, experimentation, or architecture when needed
  • Work effectively with product, research, leadership, customers, and scientific stakeholders to turn ambiguous requirements into clear technical plans.

Benefits

  • Industry-competitive compensation, including early-stage virtual share options
  • Remote-first working – work where you work best
  • Wellbeing budget, mental health support, work-from-home budget, co-working stipend, and learning budget
  • Generous holiday allowance
  • Office Days at our Berlin HQ or a different European location (3x per year)
  • A high-calibre, execution-focused team with experience from leading organizations

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