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Recursion

Decoding Biology to Radically Improve Lives

Director, Clinical Pharmacology

DirectorDirectorFull TimeRemoteLeadTeam 201-500Since 2013H1B SponsorCompany SiteLinkedIn

Location

United States

Posted

19 days ago

Salary

$212.9K - $297K / year

Seniority

Lead

No structured requirement data.

Job Description

Director, Clinical Pharmacology

Recursion

Role Description Your work will change lives. Including your own. The Impact You’ll Make: - You will join an innovative and passionate clinical development team dedicated to improving the lives of patients suffering from devastating diseases. - You will lead the innovative clinical pharmacology and pharmacometrics strategy and execution for a portfolio of rare disease and oncology clinical programs. In this role, you will: - Develop: the clinical pharmacology and pharmacometric strategies to accelerate and support the overall product development plan. You’ll be the Clinical Pharmacology lead for various programs in clinical development, the representative for regulatory interactions, and propose innovative strategies to get therapies to patients faster. - Design: clinical studies. You’ll provide (clinical) pharmacology input on all clinical study designs, from Phase 1-3 and dedicated Phase 1 clinical pharmacology studies. - Author: review relevant clinical pharmacology sections for regulatory documents, including Investigator's Brochures (IB), INDs, NDAs, and other regulatory submissions. Act as the clinical pharmacology expert during interactions with health authorities. - Interface: with cross-functional teams. You’ll work closely with clinical study teams, translational teams (DMPK, Translational Modeling and Toxicology), preclinical teams and due diligence teams to ensure clinical pharmacology-related considerations are addressed. - Solve: drug development questions/problems by overseeing and/or performing modeling and simulation with various tools to expedite decision making. The Team You’ll Join: - You will join the Development Sciences team within Recursion comprising clinical pharmacology, pharmacometrics, translational modeling and clinical biomarkers. - The Development Sciences group sits within Recursion’s Clinical Development organization. - Team members get to sit on both Discovery and Development projects and work in a seamless end-to-end environment at Recursion. - The team collaborates closely with clinical development functions (clinical science, clinical operations, regulatory affairs, biostatistics, etc.), as well as discovery functions (DMPK, Biology, Chemistry and Translational Biomarkers). Qualifications - Ph.D. in Pharmaceutical Sciences, Pharmacokinetics or related discipline, M.D with a Clinical Pharmacology expertise, or a Pharm D. with a Clinical Pharmacology fellowship, with 5-9+ years of experience in biotech/pharmaceutical drug development. - Demonstrated success leading all clinical pharmacology related aspects of drug development. - Ability to work closely with internal and external stakeholders to manage PK, PK-PD, and PK-safety analyses, including non-compartmental analysis, population PK modeling, and PK-PD modeling and simulations to support dose selection, exposure-response and exposure-safety analyses through various phases of drug development. - Proficiency with WinNonlin, Monolix, NONMEM, R or other modeling software. - Effective skills directed toward driving collaboration, achieving results, influencing, and resolving conflicts across internal and external stakeholders. - Demonstrated experience responding to regulatory agency questions, preparing clinical pharmacology aspects of regulatory submissions and attending regulatory meetings. - Highly motivated, decisive, and results-oriented individual who is proactive, resourceful, and efficient with the flexibility and creativity to excel in and contribute to a rapidly growing drug discovery and development company. - Experience in oncology is preferred, but not an absolute requirement. Requirements - Making SLC or NYC your home base is ideal; however, we will consider remote work for this position. - We ask that remote employees commit to regular on-site visits for routine work and departmental events. - At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is $212,900 to $297,000. - You will also be eligible for an annual bonus and equity compensation, as well as a comprehensive benefits package. Benefits - Annual bonus and equity compensation. - Comprehensive benefits package. Company Description Recursion (NASDAQ: RXRX) is a clinical-stage TechBio company decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Recursion’s platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation.

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