• Partnering with Senior Leadership to define Amgen’s early oncology pipeline commercial strategy to ensure investments in research and early development align with long-term business objectives and patient needs • Partnering closely with R&D, global marketing, and corporate development teams to assess external innovation and business development opportunities, ensuring alignment with Amgen’s portfolio strategy • Supporting portfolio investment decisions for relevant therapeutic areas in coordination with the Enterprise Portfolio Governance function • Developing commercial frameworks and business cases to inform progression decisions for early-stage assets, integrating insights from market dynamics, patient needs, and competitive intelligence • Building a best-in-class commercial function for oncology early pipeline strategy, ensuring Amgen maintains a leadership position in bringing first-in-class and best-in-class therapies to market • Create and leverage frameworks for evaluating and prioritizing early-stage oncology assets • Support the assessment of commercial viability and differentiation of assets in early development, ensuring alignment with evolving market needs and payer landscapes • Provide commercial input to research-stage investment decisions, ensuring a clear path to differentiated and commercially viable products • Partner with Amgen’s Business Development team to evaluate in-licensing, partnerships, and acquisitions for early-stage assets

Role Description The Advisor role requires competence across a broad spectrum of governance initiatives, with a focus on the design and roll out of enterprise level requirements for policy controls and data governance maturity. The incumbent will partner with business and technical leaders and subject matter experts to drive practices that support the standardization of operational information and the execution of enterprise-wide data governance policies and standards. - Leverage expertise in business and technical knowledge, as well as influencing skills to support the development, roll-out and management of EDG Policy Controls; including their processes and tooling in order to standardize the approach and document the assessment and evidence of critical EDG controls. - Support the development, tooling, roll-out and management of an enterprise-wide Data governance Maturity assessment; develop communications and supportive documentation. - Identify gaps and alignment between Controls, EDG Policy(ies) and industry leading Maturity models and their respective results. - Collaborate with critical stakeholders to design and develop a methodology to identify, quantify and escalate potential data risk issues in alignment with Enterprise Risk Management practices. - Apply critical thinking to assess and optimize the use of data governance tooling innovations to best advance the objectives of the Enterprise Data Strategy and Management organization. - Lead and develop effective plans for communication and engagement with prioritized organizations, act as a go-to person and provide consultative services to ensure business and data process owners can capitalize on, or align with data governance best practices. - Contribute to create a big-picture approach to ensure effective communication and escalation of key opportunities which support the dual needs of both business and governance leadership to improve data governance and data quality. Qualifications - Experience with data governance, controls, metadata, data quality, and/or reporting processes and tools. - Knowledge of Cigna/Evernorth lines of business or products; and/or hands-on experience with data management (medical, provider, claims, clinical, pharmacy, eligibility etc.). - Demonstrated communications and/or change management experience. - Must have High School Diploma or equivalent. - Minimum of 3 years’ experience in a healthcare business environment. - Minimum of 3 years’ experience in Data Governance. - Ability to convey complex data concepts via visual techniques to succinctly communicate. - Self-motivated to do what it takes to achieve success and navigate in a highly-matrixed environment. - Ability to manage timelines and meet tight deadlines. - In-depth knowledge and experience with healthcare terminology, concepts and business processes. - Familiarity with healthcare industry standards and regulations. - Experience working in Agile project management (SAFe experience a plus). - Ability to demonstrate and honor principles of Service, Innovation, Diversity, Empowerment, Integrity, Self-motivation, and Passion. - Some travel required. Requirements - If you will be working at home occasionally or permanently, the internet connection must be obtained through a cable broadband or fiber optic internet service provider with speeds of at least 10Mbps download/5Mbps upload. Benefits - Annual salary of 102,400 - 170,600 USD / yearly, depending on relevant factors, including experience and geographic location. - Eligible to participate in an annual bonus plan. - Comprehensive range of benefits, with a focus on supporting your whole health. - Health-related benefits including medical, vision, dental, and well-being and behavioral health programs starting on day one of employment. - 401(k) and company paid life insurance. - Tuition reimbursement. - A minimum of 18 days of paid time off per year and paid holidays.

Role Description This role can be located anywhere within the US. Do you like helping global software vendors and healthcare organizations design and implement the best AI/ML solutions? Would you like to do this using the latest cloud computing technologies? Do you have a technical vision for what the future of healthcare AI/ML looks like and how it can enhance global healthcare? Amazon Web Services is looking for a highly motivated Solutions Architect to help accelerate our growing healthcare AI/ML business as part of the World Wide Public Sector group. As a Solutions Architect within AWS, you will have the opportunity to: - Help shape and deliver on a strategy to build broad use of Amazon's utility computing web services (e.g., AWS EC2, AWS S3, AWS EBS) directly with customers and our ecosystem of system integrators and solution providers. - Own the technical engagement and ultimate success of specific global customer implementation projects. - Define implementation architectures, build prototypes, and develop a deep expertise in the AWS technologies. - Be a subject matter expert on security as it relates to healthcare AI/ML. As a Solutions Architect on our team, you will provide exceptional technical design and thought leadership to the global healthcare market for cloud computing, while working with a world-class sales and business development team. You will be a global technical leader on medical imaging within AWS, building and leading internal communities to deliver for healthcare organizations and software vendors. The role will work with an assortment of health AI/ML-focused partners and customers, including some of the leading providers of health AI/ML systems. We are looking for someone who is passionate about the following: - Helping healthcare organizations achieve their mission of better patient health. - Designing and creating system architectures using cloud computing. - Our company credo: “Work hard. Have fun. Make history.” It’s critical to love what you do and take pride in your value proposition to our customers. - Deep-dive technical discussions around design and an intellectual curiosity to always keep your technical skills current while maintaining a pulse on healthcare industry trends. Qualifications - 3+ years of design, implementation, or consulting in applications and infrastructures experience. - 4+ years of specific technology domain areas (e.g. software development, cloud computing, systems engineering, infrastructure, security, networking, data & analytics) experience. - 5+ years of specific technology domain areas (e.g. software development, cloud computing, systems engineering, infrastructure, security, networking, data & analytics) experience. Requirements - Experience working within software development or Internet-related industries. - Experience migrating or transforming legacy customer solutions to the cloud. - Experience working with AWS technologies from a dev/ops perspective. - Ability to travel 30% - The Solutions Architect role will work with customers anywhere in the world. Benefits - Comprehensive health insurance (medical, dental, vision, prescription). - Basic Life & AD&D insurance and option for Supplemental life plans. - EAP, Mental Health Support, Medical Advice Line. - Flexible Spending Accounts. - Adoption and Surrogacy Reimbursement coverage. - 401(k) matching. - Paid time off. - Parental leave.

Role Description The Clinical Trial Management Principal is responsible for leading global or regional-based activities on complex clinical trials across a range of study phases (Phases 1 through 4, including Real World Evidence trials) and therapeutic areas. In the global role, the Clinical Trial Management Principal leads the global cross-functional Study Team, ensuring that deliverables are met, quality is maintained throughout the lifecycle of the trial, and the study budget is maintained. The role is also responsible for contributing to Clinical Trial Management department initiatives, often as leader. Key Duties and Responsibilities - Accountable for execution of assigned clinical trial(s) at the global or regional level, according to agreed operational strategy. - Coordinates internal and external clinical trial management activities of all assigned study team members involved in the study planning, start up, conduct, and closure of assigned clinical trials or study regions. - Assists Clinical Operations Program Lead (COPL) or global Clinical Operations Study Lead (gCOSL) in the development of operational strategy and initial timeline. - Creates detailed study timeline with minimal support; monitors progress of timeline with cross-functional Study Team input. - Drives study level operational strategy, oversees development and execution of study operational plan(s). - Authors study documentation and patient recruitment materials. - Drives cross-functional vendor identification and set up and ensures appropriate ongoing oversight, including invoicing. - Responsible for global clinical trial budget for assigned trial(s) and proactively identifies and manages any anticipated cost overruns. - Manages ongoing vendor invoice reconciliation and scope of work review; works cross-functionally to initiate vendor contract changes and review revised scope of work and budgets. - Takes lead role in investigator identification and selection. - Contributes significantly to the development of study documentation including clinical trial protocols and clinical study reports. - Proactively identifies study risks and implements contingency plans with minimal supervision. - Organizes/hosts and presents at Investigator Meetings and Site Engagement Meetings. - Travels to investigational sites, as requested, to develop relationships with site personnel. - Participates in cross functional study data review where appropriate. - Prepares weekly study operational dashboards for senior executives and regularly presents global study status to senior executives. - Represents Clinical Trial Management department as a technical resource in cross-functional initiatives or process improvement efforts (e.g., SOP and WI updates), often as leader. - Acts as a resource for Clinical trial management staff with less experience. - May function as representative for Clinical Trial Management on vendor-related Joint Operating Committees. Qualifications - Strong clinical trial management track record showing clear proficiency in project management skills, cross-functional study operations and vendor management. - In-depth understanding of GCP, CFR and ICH Guidelines. - Demonstrates detailed understanding of clinical protocol, intended study populations and drug development. - Demonstrates ability to effectively interface with key medical personnel at investigational site(s). - Excellent interpersonal skills and communications skills to explain difficult information and works to build alignment. - Ability to effectively problem solve within a cross-functional team. - Demonstrates ability to effectively manage issue identification and resolution. - Excellent attention to detail. - Ability to work successfully under pressure with tight timelines. - Proficiency in Microsoft Office applications including Outlook, Excel, Word, and PowerPoint. - Periodic travel to research sites and investigator meetings. Education and Experience - Bachelor's degree in life sciences discipline or relevant discipline. - Typically requires 6 years of relevant work experience in the biopharmaceutical industry, or the equivalent combination of education and experience. Pay Range $140,000 - $210,000 Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. Benefits At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation Remote-Eligible Flex Eligibility Status In this Remote-Eligible role, you can choose to be designated as: - Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on-site; - Hybrid: work remotely up to two days per week; - On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.